A Practical Guide To Combinatorial Chemistry
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A Practical Guide To Combinatorial Chemistry
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Author : Anthony W. Czarnik
language : en
Publisher:
Release Date : 1997
A Practical Guide To Combinatorial Chemistry written by Anthony W. Czarnik and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Combinatorial chemistry categories.
Combinatorial chemistry is the ability to simultaneously synthesize vast numbers of diverse compounds. Its techniques have revolutionized the drug discovery process, and are widely used throughout the biotechnology community. Aimed at a wide audience, this text is a down-to-earth introductionto small molecule combinatorial chemistry. It uses a tutorial approach to provide a detailed survey of solid-phase peptide synthesis and solution-phase synthesis. It also reviews current automated approaches and equipment for both solid- and solution-phase library synthesis.
Combinatorial Chemistry
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Author : Hicham Fenniri
language : en
Publisher: OUP Oxford
Release Date : 2000-10-05
Combinatorial Chemistry written by Hicham Fenniri and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-10-05 with Science categories.
Combinatorial Chemistry is a genuine practical guide covering all the major areas of combinatorial chemistry from an experimental and conceptual point of view. Being one of the most powerful of modern technologies, combinatorial chemistry has had implications to many areas of chemistry and biology and the current approaches to drug, catalyst, receptor, and materials development and discovery are all included in this volume. It also contains protocols on solid, liquid, and solution phase synthesis and expedient methods of library screening and evaluation. The use of automation and robotics is also explained. It is written at a level easily accessible to novices and will enable readers to use combinatorial techniques to the best advantage.
Combinatorial Chemistry
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Author : Hicham Fenniri
language : en
Publisher:
Release Date : 2000
Combinatorial Chemistry written by Hicham Fenniri and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Combinatorial chemistry categories.
Combinatorial chemistry is the synthesizing and testing of arrays of compounds. The high throughput means that combinatorial techniques are increasingly used in the biomedical sciences, especially drug discovery and related pharmaceutical research. This volume is the first practical guide to combinatorial chemistry that will enable novices to carry out successful experiments.
Combinatorial Chemistry
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Author : Willi Bannwarth
language : en
Publisher: Wiley-VCH
Release Date : 2000-09-13
Combinatorial Chemistry written by Willi Bannwarth and has been published by Wiley-VCH this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-09-13 with Science categories.
As we enter the new millennium, combinatorial chemistry is providing significant impetus to new innovations in synthetic chemistry. Combinatorial chemistry has rapidly become the rising star among research methods, allowing scientists to efficiently test the feasibility of a multitude of new compounds. The pursuit of new drugs is but one challenging field in which these combinatorial methods are particularly advantageous, helping researchers meet the modern-day demands of a highly competitive environment. This book emphasises that modern combinatorial synthesis is possible not only in the solid phase, but also in solutions. Moreover, it discusses computer-assisted methods as well as the apparatus and instrumentation required for the combinatorial method. Successful and experienced researchers in the leading pharmaceutical companies and most renowned research institutes offer a solid insight and perspective into this diverse field. A 'must' for every scientist in the area of pharmaceutical research
Combinatorial Chemistry
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Author : Nicholas K. Terrett
language : en
Publisher:
Release Date : 1998
Combinatorial Chemistry written by Nicholas K. Terrett and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Combinatorial chemistry categories.
Combinatorial chemistry, by accelerating the process of chemical synthesis, is having a profound effect on all branches of chemistry, but especially on drug discovery. This informative text explains the origins of combinatorial chemistry and puts the many diverse library methods into context.It explains why some techniques are generally applicable and others are for specialists only. It also focuses on the renaissance of solid phase chemistry and describes the range of available reactions. This is the first single author book in this important, growing field and it describes thebeneficial impact of combinatorial chemistry, especially for the discovery and optimisation of biologically active molecules. This concise and comprehensive overview of combinatorial techniques is an essential text for final year undergraduates, postgraduates, academics and industrialists inchemistry, bio-orgainc chemistry, medicinal chemistry and drug discovery. It provides an accessible introduction to the area for those new to these methods and a valuable reference text to those experienced in this field.
A Practical Guide To Assay Development And High Throughput Screening In Drug Discovery
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Author : Taosheng Chen
language : en
Publisher: CRC Press
Release Date : 2009-12-21
A Practical Guide To Assay Development And High Throughput Screening In Drug Discovery written by Taosheng Chen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-21 with Medical categories.
The development of suitable assays, the integration of appropriate technology, and the effective management of the essential infrastructure are all critical to the success of any high-throughput screening (HTS) endeavor. However, few scientists have the multidisciplinary experience needed to control all aspects of an HTS drug discovery project. A P
Combinatorial Libraries
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Author :
language : en
Publisher:
Release Date : 1995
Combinatorial Libraries written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Combinatorial chemistry categories.
Solid Phase Synthesis
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Author : Fernando Albericio
language : en
Publisher: CRC Press
Release Date : 2000-04-28
Solid Phase Synthesis written by Fernando Albericio and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-04-28 with Medical categories.
This volume provides the information needed to synthesize peptides by solid-phase synthesis (SPS) - employing polymeric support (resins), anchoring linkages (handles), coupling reagents (activators), and protection schemes. It presents strategies for creating a wide variety of compounds for drug discovery and analyzes peptides, DNA, carbohydrates,
Combinatorial Chemistry And Technology
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Author : Stanislav Miertus
language : en
Publisher: CRC Press
Release Date : 1999-07-01
Combinatorial Chemistry And Technology written by Stanislav Miertus and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-07-01 with Science categories.
"Provides comprehensive coverage of the current combinatorial methodologies and technologies employed for the design, synthesis, and screening of molecular ""libraries."" Features assessments of computer-assisted approaches to guiding library synthesis. Designed to satisfy the demand to create, produce in high yield and purity, and rapidly screen huge numbers of molecules."
Cross Coupling Reactions
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Author : Norio Miyaura
language : en
Publisher: Springer
Release Date : 2010-12-01
Cross Coupling Reactions written by Norio Miyaura and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-01 with Science categories.
In 1972, a very powerful catalytic cycle for carbon-carbon bond formation was 2 first discovered by the coupling reaction of Grignard reagents at the sp -carbon. Over the past 30 years, the protocol has been substantially improved and expanded to other coupling reactions of Li,B,N,O,Al,Si,P,S,Cu,Mn,Zn,In,Sn, and Hg compounds. These reactions provided an indispensable and simple methodology for preparative organic chemists. Due to the simplicity and rel- bility in the carbon-carbon, carbon-heteroatom, and carbon-metalloid bo- formations,as well as high efficiency of the catalytic process,the reactions have been widely employed by organic chemists in various fields. Application of the protocol ranges from various syntheses of complex natural products to the preparation of biologically relevant molecules including drugs, and of sup- molecules, and to functional materials. The reactions on solid surfaces allow robot synthesis and combinatorial synthesis. Now, many organic chemists do not hesitate to use transition metal complexes for the transformation of org- ic molecules. Indeed, innumerable organic syntheses have been realized by the catalyzed reactions of transition metal complexes that are not achievable by t- ditional synthetic methods. Among these, the metal-catalyzed cross-coupling reactions have undoubtedly contributed greatly to the development of such a new area of “metal-catalyzed organic syntheses”. An excellent monograph for the cross-coupling reactions and other met- catalyzed C-C bond-forming reactions recently appeared in Metal-catalyzed Cross-coupling Reactions (Wiley-VCH,1998).