Solid Phase Synthesis
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Solid Phase Synthesis And Combinatorial Technologies
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Author : Pierfausto Seneci
language : en
Publisher: John Wiley & Sons
Release Date : 2003-05-28
Solid Phase Synthesis And Combinatorial Technologies written by Pierfausto Seneci and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-05-28 with Science categories.
A unique, integrated look at solid-phase synthesis and advances in combinatorial chemistry and technologies The last decade has seen a rapid expansion in combinatorial technologies, a field where chemistry disciplines intersect with automation, statistics, and information science, as well as certain biological disciplines. Reflecting these multidisciplinary trends, this new work provides a comprehensive overview of the most important aspects of solid-phase synthesis (SPS), combinatorial chemistry, and related combinatorial technologies. It clearly demonstrates how SPS and combinatorial chemistry have extended their application from the pharmaceutical arena to new areas, including biotechnology, material sciences, catalysis, and agrochemical industries, and explores in detail strategies for planning, designing, preparing, and testing of combinatorial libraries in various disciplines. Designed to meet the needs of both experienced combinatorial chemists and newcomers to the field, Solid-Phase Synthesis and Combinatorial Technologies: * Surveys the most recent developments in SPS and combinatorial chemistry * Explains the entire process, from determining the need for a library to the details necessary for synthesis of the library * Discusses choice of format, size, and the rationale behind the design of each synthetic step * Surveys the analytical techniques and the purification methods used to characterize and purify combinatorial libraries * Employs a large number of examples to illustrate important concepts * Includes problems geared toward applying acquired knowledge and designing the steps to SPS/library synthesis * Describes the quality control and activity screening of combinatorial libraries for various applications * Features a detailed bibliography of more than 1,700 relevant sources
Solid Phase Synthesis
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Author : Fernando Albericio
language : en
Publisher: CRC Press
Release Date : 2000-04-28
Solid Phase Synthesis written by Fernando Albericio and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-04-28 with Science categories.
This volume provides the information needed to synthesize peptides by solid-phase synthesis (SPS) - employing polymeric support (resins), anchoring linkages (handles), coupling reagents (activators), and protection schemes. It presents strategies for creating a wide variety of compounds for drug discovery and analyzes peptides, DNA, carbohydrates, conjugates of biomolecules, and small molecules.
Fmoc Solid Phase Peptide Synthesis
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Author : W. Chan
language : en
Publisher: OUP Oxford
Release Date : 1999-12-16
Fmoc Solid Phase Peptide Synthesis written by W. Chan and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-12-16 with Science categories.
Since the publication of Atherton and Sheppard's volume, the technique of Fmoc solid-phase peptide synthesis has matured considerably and is now the standard approach for the routine production of peptides. The focus of this new volume is much broader, and covers the essential procedures.
Solid Phase Peptide Synthesis
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Author : E. Atherton
language : en
Publisher: Oxford University Press, USA
Release Date : 1989
Solid Phase Peptide Synthesis written by E. Atherton and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Peptides categories.
Solid Phase Synthesis
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Author : Fernando Albericio
language : en
Publisher: CRC Press
Release Date : 2000-04-28
Solid Phase Synthesis written by Fernando Albericio and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-04-28 with Medical categories.
This volume provides the information needed to synthesize peptides by solid-phase synthesis (SPS) - employing polymeric support (resins), anchoring linkages (handles), coupling reagents (activators), and protection schemes. It presents strategies for creating a wide variety of compounds for drug discovery and analyzes peptides, DNA, carbohydrates,
Solid Phase Peptide Synthesis
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Author : Gregg B. Fields
language : en
Publisher: Academic Press
Release Date : 1997-10-21
Solid Phase Peptide Synthesis written by Gregg B. Fields and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-10-21 with Medical categories.
The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volumehas been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 275 volumes have been published (all of them still in print) and much of the material is relevant even today-truly an essential publication for researchers in all fields of life sciences. Key Features * Solid-phase peptide synthesis * Applications of peptides for structural and biological studies * Characterization of synthetic peptides
Chemical Approaches To The Synthesis Of Peptides And Proteins
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Author : Paul Lloyd-Williams
language : en
Publisher: CRC Press
Release Date : 1997-04-23
Chemical Approaches To The Synthesis Of Peptides And Proteins written by Paul Lloyd-Williams and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-04-23 with Medical categories.
Organic chemists working on the synthesis of natural products have long found a special challenge in the preparation of peptides and proteins. However, more reliable, more efficient synthetic preparation methods have been developed in recent years. This reference evaluates the most important synthesis methods available today, and also considers methods that show promise for future applications. This text describes the state of the art in efficient synthetic methods for the synthesis of both natural and artificial large peptide and protein molecules. Subjects include an introduction to basic topics, linear solid-phase synthesis of peptides, peptide synthesis in solution, convergent solid-phase synthesis, methods for the synthesis of branched peptides, formation of disulfide bridges, and more. The book emphasizes strategies and tactics that must be considered for the successful synthesis of peptides.
Peptide Synthesis
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Author : Waleed M. Hussein
language : en
Publisher: Humana
Release Date : 2019-12-27
Peptide Synthesis written by Waleed M. Hussein and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-27 with Science categories.
This book provides a variety of procedures for synthetically producing peptides and their derivatives, ensuring the kind of precision that is of paramount importance for successful synthesis. Numerous techniques relevant to drugs and vaccines are explored, such as conjugation and condensation methodologies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Peptide Synthesis: Methods and Protocols serves as an essential guide to the many crucial processes that will allow researchers to efficiently prepare, purify, characterize, and use peptides for chemical, biochemical, and biological studies.
Side Reactions In Peptide Synthesis
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Author : Yi Yang
language : en
Publisher: Academic Press
Release Date : 2015-09-01
Side Reactions In Peptide Synthesis written by Yi Yang and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-01 with Science categories.
Side Reactions in Peptide Synthesis, based on the author's academic and industrial experience, and backed by a thorough review of the current literature, provides analysis of, and proposes solutions to, the most frequently encountered side reactions during peptide and peptidomimetic synthesis. This valuable handbook is ideal for research and process chemists working with peptide synthesis in diverse settings across academic, biotech, and pharmaceutical research and development. While peptide chemistry is increasingly prevalent, common side reactions and their causes are often poorly understood or anticipated, causing unnecessary waste of materials and delay. Each chapter discusses common side reactions through detailed chemical equations, proposed mechanisms (if any), theoretical background, and finally, a variety of possible solutions to avoid or alleviate the specified side reaction. - Provides a systematic examination on how to troubleshoot and minimize the most frequent side reactions in peptide synthesis - Gives chemists the background information and the practical tools they need to successfully troubleshoot and improve results - Includes optimization-oriented analysis of side reactions in peptide synthesis for improved industrial process development in peptidyl API (active pharmaceutical ingredient) production - Answers the growing, global need for improved, replicable processes to avoid impurities and maintain the integrity of the end product. - Presents a thorough discussion of critical factors in peptide synthesis which are often neglected or underestimated by chemists - Covers solid phase and solution phase methodologies, and provides abundant references for further exploration
Peptide Protein And Enzyme Design
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Author :
language : en
Publisher: Academic Press
Release Date : 2016-08-27
Peptide Protein And Enzyme Design written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-27 with Science categories.
De Novo Enzyme Design, the newest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume includes the design of metal binding maquettes, insertion of non-natural cofactors, Cu metallopeptides, non-covalent interactions in peptide assemblies, peptide binding and bundling, heteronuclear metalloenzymes, florinated peptides, De Novo imaging agents, and protein-protein interaction. - Continues the legacy of this premier serial with quality chapters on de novo enzyme design - Represents the newest volume in the Methods in Enzymology series, providing premier, quality chapters authored by leaders in the field - Ideal reference for those interested in the study of enzyme design that looks at both structure and mechanism