Solid Phase Peptide Synthesis
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Peptide Synthesis
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Author : Waleed M. Hussein
language : en
Publisher: Humana
Release Date : 2019-12-27
Peptide Synthesis written by Waleed M. Hussein and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-27 with Science categories.
This book provides a variety of procedures for synthetically producing peptides and their derivatives, ensuring the kind of precision that is of paramount importance for successful synthesis. Numerous techniques relevant to drugs and vaccines are explored, such as conjugation and condensation methodologies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Peptide Synthesis: Methods and Protocols serves as an essential guide to the many crucial processes that will allow researchers to efficiently prepare, purify, characterize, and use peptides for chemical, biochemical, and biological studies.
Solid Phase Peptide Synthesis
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Author : E. Atherton
language : en
Publisher: Oxford University Press, USA
Release Date : 1989
Solid Phase Peptide Synthesis written by E. Atherton and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Peptides categories.
Side Reactions In Peptide Synthesis
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Author : Yi Yang
language : en
Publisher: Academic Press
Release Date : 2015-09-01
Side Reactions In Peptide Synthesis written by Yi Yang and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-01 with Science categories.
Side Reactions in Peptide Synthesis, based on the author's academic and industrial experience, and backed by a thorough review of the current literature, provides analysis of, and proposes solutions to, the most frequently encountered side reactions during peptide and peptidomimetic synthesis. This valuable handbook is ideal for research and process chemists working with peptide synthesis in diverse settings across academic, biotech, and pharmaceutical research and development. While peptide chemistry is increasingly prevalent, common side reactions and their causes are often poorly understood or anticipated, causing unnecessary waste of materials and delay. Each chapter discusses common side reactions through detailed chemical equations, proposed mechanisms (if any), theoretical background, and finally, a variety of possible solutions to avoid or alleviate the specified side reaction. - Provides a systematic examination on how to troubleshoot and minimize the most frequent side reactions in peptide synthesis - Gives chemists the background information and the practical tools they need to successfully troubleshoot and improve results - Includes optimization-oriented analysis of side reactions in peptide synthesis for improved industrial process development in peptidyl API (active pharmaceutical ingredient) production - Answers the growing, global need for improved, replicable processes to avoid impurities and maintain the integrity of the end product. - Presents a thorough discussion of critical factors in peptide synthesis which are often neglected or underestimated by chemists - Covers solid phase and solution phase methodologies, and provides abundant references for further exploration
Peptide Synthesis And Applications
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Author : John Howl
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-02
Peptide Synthesis And Applications written by John Howl and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-02 with Science categories.
Hands-on experts describe in step-by-step detail the key methodologies of contemporary peptide synthesis and illustrate their numerous applications. The techniques presented include protocols for chemical ligation, the synthesis of cyclic and phosphotyrosine-containing peptides, lipoamino acid- and sugar-conjugated peptides, and peptide purification and analyses. Additional chapters detail methodologies and instrumentation for high-throughput peptide synthesis, many different applications of peptides as novel research tools and biological probes, and the design and application of fluorescent substrate-based peptides that can be used to determine the selectivity and activity of peptidases. A practical guide to the identification of proteins using mass spectrometric analyses of peptide mixtures is also included.
Solid Phase Peptide Synthesis
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Author : Gregg B. Fields
language : en
Publisher: Academic Press
Release Date : 1997-10-21
Solid Phase Peptide Synthesis written by Gregg B. Fields and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-10-21 with Medical categories.
The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volumehas been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 275 volumes have been published (all of them still in print) and much of the material is relevant even today-truly an essential publication for researchers in all fields of life sciences. Key Features * Solid-phase peptide synthesis * Applications of peptides for structural and biological studies * Characterization of synthetic peptides
Chemical Approaches To The Synthesis Of Peptides And Proteins
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Author : Paul Lloyd-Williams
language : en
Publisher: CRC Press
Release Date : 1997-04-23
Chemical Approaches To The Synthesis Of Peptides And Proteins written by Paul Lloyd-Williams and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-04-23 with Medical categories.
Organic chemists working on the synthesis of natural products have long found a special challenge in the preparation of peptides and proteins. However, more reliable, more efficient synthetic preparation methods have been developed in recent years. This reference evaluates the most important synthesis methods available today, and also considers methods that show promise for future applications. This text describes the state of the art in efficient synthetic methods for the synthesis of both natural and artificial large peptide and protein molecules. Subjects include an introduction to basic topics, linear solid-phase synthesis of peptides, peptide synthesis in solution, convergent solid-phase synthesis, methods for the synthesis of branched peptides, formation of disulfide bridges, and more. The book emphasizes strategies and tactics that must be considered for the successful synthesis of peptides.
Fmoc Solid Phase Peptide Synthesis
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Author : W. Chan
language : en
Publisher: OUP Oxford
Release Date : 1999-12-16
Fmoc Solid Phase Peptide Synthesis written by W. Chan and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-12-16 with Science categories.
Since the publication of Atherton and Sheppard's volume, the technique of Fmoc solid-phase peptide synthesis has matured considerably and is now the standard approach for the routine production of peptides. The focus of this new volume is much broader, and covers the essential procedures.
Solid Phase Synthesis
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Author : Fernando Albericio
language : en
Publisher: CRC Press
Release Date : 2000-04-28
Solid Phase Synthesis written by Fernando Albericio and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-04-28 with Science categories.
This volume provides the information needed to synthesize peptides by solid-phase synthesis (SPS) - employing polymeric support (resins), anchoring linkages (handles), coupling reagents (activators), and protection schemes. It presents strategies for creating a wide variety of compounds for drug discovery and analyzes peptides, DNA, carbohydrates, conjugates of biomolecules, and small molecules.
Chemistry Of Peptide Synthesis
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Author : N. Leo Benoiton
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Chemistry Of Peptide Synthesis written by N. Leo Benoiton and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
Chemistry of Peptide Synthesis is a complete overview of how peptides are synthesized and what techniques are likely to generate the most desirable reactions. Incorporating elements from the author's role of Career Investigator of the Medical Research Council of Canada and his extensive teaching career, the book emphasizes learning rather th
Peptides
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Author : Bernd Gutte
language : en
Publisher: Elsevier
Release Date : 1995-10-24
Peptides written by Bernd Gutte and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-10-24 with Science categories.
In recent years, research has shown the importance of peptides in neuroscience, immunology, and cell biology. Active research programs worldwide are now engaged in developing peptide-based drugs and vaccines using modification of natural peptides and proteins, design of artificial peptides and peptide mimetics, and screening of peptide and phage libraries. In this comprehensive book, the authors discuss peptide synthesis and application within the context of their increasing importance to the pharmaceutical industry. Peptides: Synthesis, Structures, and Applications explores the broad growth of information in modern peptide synthetic methods and the structure-activity relationships of synthetic polypeptides. - The history of peptide chemistry - Amide formation, deprotection, and disulfide formation in peptide synthesis - Solid-phase peptide synthesis - a-helix formation by peptides in water - Stability and dynamics of peptide conformation - An overview of structure-function studies of peptide hormones - Neuropeptides:peptide and nonpeptide analogs - Reversible inhibitors of serine proteinases - Design of polypeptides - Current capabilities and future possibilities of soluble chemical combinatorial libraries - Epitope mapping with peptides - Synthesis and applications of branched peptides in immunological methods and vaccines