Side Reactions In Peptide Synthesis
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Side Reactions In Peptide Synthesis
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Author : Yi Yang
language : en
Publisher: Academic Press
Release Date : 2015-09-01
Side Reactions In Peptide Synthesis written by Yi Yang and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-01 with Science categories.
Side Reactions in Peptide Synthesis, based on the author’s academic and industrial experience, and backed by a thorough review of the current literature, provides analysis of, and proposes solutions to, the most frequently encountered side reactions during peptide and peptidomimetic synthesis. This valuable handbook is ideal for research and process chemists working with peptide synthesis in diverse settings across academic, biotech, and pharmaceutical research and development. While peptide chemistry is increasingly prevalent, common side reactions and their causes are often poorly understood or anticipated, causing unnecessary waste of materials and delay. Each chapter discusses common side reactions through detailed chemical equations, proposed mechanisms (if any), theoretical background, and finally, a variety of possible solutions to avoid or alleviate the specified side reaction. Provides a systematic examination on how to troubleshoot and minimize the most frequent side reactions in peptide synthesis Gives chemists the background information and the practical tools they need to successfully troubleshoot and improve results Includes optimization-oriented analysis of side reactions in peptide synthesis for improved industrial process development in peptidyl API (active pharmaceutical ingredient) production Answers the growing, global need for improved, replicable processes to avoid impurities and maintain the integrity of the end product. Presents a thorough discussion of critical factors in peptide synthesis which are often neglected or underestimated by chemists Covers solid phase and solution phase methodologies, and provides abundant references for further exploration
Aspects Of The Merrifield Peptide Synthesis
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Author : C. Birr
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Aspects Of The Merrifield Peptide Synthesis written by C. Birr and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
This book was written in the context of the daily confrontation with problems in the utilization of polymeric supports for the synthesis of pep tides. Therefore, views and experiences which usually are not mentioned in scientific journals are collected in these pages. The author has deliberately discussed in detail the possible influence of the polymer phase on the varying reaction conditions in the Merrifield synthesis; this aspect is neglected in most publications dealing with peptide synthesis. However, in view of the growing body of information on the chemistry of polymer-supported peptide syntheses, the international readership should regard the author's arguments as open to discussion. I am very much indebted to all of my colleagues with whom I have had the opportunity to cooperate in studying the potential of the Merrifield synthesis. Above all I like to express my gratitude to my teacher, Professor Dr. Theodor Wieland, Heidelberg, for his boundless encouragement and support in my ef forts in the field of peptide synthesis, particularly in its polymer phase bound version. Last but not at least I wish to thank Miss Hildegard Leyden. With in finite patience and great accuracy she typed the manuscript in addition to her daily duties. The work which influenced this book was performed under the auspices of the Max-Planck-Gesellschaft, of which the financial support is gratefully ac knowledged.
Principles Of Peptide Synthesis
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Author : M. Bodanszky
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Principles Of Peptide Synthesis written by M. Bodanszky and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
A look at the shelves of a major library awakens doubts in the author of this small volume about the importance of writing a new introduction to peptide synthesis. This rather narrow area of bio-organic chemistry already has received considerable attention. A whole series of books deals with the synthesis of peptides. Some of these are textbooks written to support lecture courses on peptide synthesis. Others try to help the beginner, otherwise well versed in organic chemistry, to embark on some experimental project that requires the construction of peptide chains. Not less useful are the monographs which were compiled to aid the adept practitioner and to provide him with references to the growing literature of a very active field. Is there any need for a new book on peptide synthesis? Should we add a new volume to an already impressive and certainly useful series? The answer is not obvious. The author has already participated in two similar en deavors. The first edition! of "Peptide Synthesis", with M. A. Ondetti as coauthor, was meant to serve as an introduction for the beginner. It was rather well received by researchers who joined the field of peptide chemistry and were looking for initiation. While working on the 2 second edition with Drs. Klausner and Ondetti, we became painfully aware of the impossibility of the task.
Chemistry Of Peptide Synthesis
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Author : N. Leo Benoiton
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Chemistry Of Peptide Synthesis written by N. Leo Benoiton and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
Chemistry of Peptide Synthesis is a complete overview of how peptides are synthesized and what techniques are likely to generate the most desirable reactions. Incorporating elements from the author's role of Career Investigator of the Medical Research Council of Canada and his extensive teaching career, the book emphasizes learning rather th
Chemical Approaches To The Synthesis Of Peptides And Proteins
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Author : Paul Lloyd-Williams
language : en
Publisher: CRC Press
Release Date : 2020-08-18
Chemical Approaches To The Synthesis Of Peptides And Proteins written by Paul Lloyd-Williams and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-18 with Cooking categories.
Organic chemists working on the synthesis of natural products have long found a special challenge in the preparation of peptides and proteins. However, more reliable, more efficient synthetic preparation methods have been developed in recent years. This reference evaluates the most important synthesis methods available today, and also considers methods that show promise for future applications. This text describes the state of the art in efficient synthetic methods for the synthesis of both natural and artificial large peptide and protein molecules. Subjects include an introduction to basic topics, linear solid-phase synthesis of peptides, peptide synthesis in solution, convergent solid-phase synthesis, methods for the synthesis of branched peptides, formation of disulfide bridges, and more. The book emphasizes strategies and tactics that must be considered for the successful synthesis of peptides.
Peptide Chemistry
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Author : Miklos Bodanszky
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Peptide Chemistry written by Miklos Bodanszky and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Analysis of peptides and determination of their primary structure. Conformational analysis: secondary-tertiary structure. Peptide synthesis: protection, activation and coupling, undesired reactions and their prevention, design of synthetic schemes.
The World Of Peptides
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Author : Theodor Wieland
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The World Of Peptides written by Theodor Wieland and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Almost two centuries ago proteins were recognized as the primary materials (proteios = primary) oflife, but the significance and wide role of peptides (from pepsis = digestion) in practically all life pro cesses has only become apparent in the last few decades. Biologi cally active peptides are now being discovered at rapid intervals in the brain and in other organs including the heart, in the skin of amphibians and many other tissues. Peptides and peptide-like compounds are found among toxins and antibiotics. It is unlikely that this process, an almost explosive broadening of the field, will come to a sudden halt. By now it is obvious that Nature has used the combination of a small to moderate number of amino acids to generate a great variety of agonists with specific and often highly sophisticated functions. Thus, peptide chemistry must be regarded as a discipline in its own right, a major branch of biochemistry, fairly separate from the chemistry of proteins. Because of the important role played by synthesis both in the study and in the practical preparation of peptides, their area can be considered as belonging to bio-organic chemistry as well. The already overwhelming and still increasing body of know ledge renders an account of the history of peptide chemistry more and more difficult. It appears therefore timely to look back, to take stock and to recall the important stages in the development of a new discipline.
Life During A Golden Age Of Peptide Chemistry
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Author : Bruce Merrifield
language : en
Publisher:
Release Date : 1993
Life During A Golden Age Of Peptide Chemistry written by Bruce Merrifield and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Biography & Autobiography categories.
Thirteenth in a series of autobiographies of 22 eminent organic chemists, the present volume chronicles the life and contributions to the field of Bruce Merrifield, winner of the 1984 Nobel Prize for chemistry. Subtitled The Concept and Development of Solid-Phase Peptide Synthesis. Highly illustrated with diagrams, tables, graphs and (bandw) photographs. Annotation copyright by Book News, Inc., Portland, OR
The Chemical Synthesis Of Peptides
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Author : John Jones
language : en
Publisher: Oxford University Press, USA
Release Date : 1991
The Chemical Synthesis Of Peptides written by John Jones and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Language Arts & Disciplines categories.
This book focuses on the chemical principles behind the more important methods of peptide synthesis, and it provides a critical, concise, and up-to-date survey of the field.
Solid Phase Peptide Synthesis
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Author : E. Atherton
language : en
Publisher: Oxford University Press, USA
Release Date : 1989
Solid Phase Peptide Synthesis written by E. Atherton and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Language Arts & Disciplines categories.
As thousands of individuals worldwide become involved with the study of peptides, and the demand for synthetic peptides rapidly increases, so too does the need for a practical, single-volume treatment of this growing field. This title is the first published account of an approach which has quickly been accepted as the industry standard. Written by the originators of this popular new method, the book provides readers with convenient, coverage of the practical considerations affecting solid phase peptide synthesis, and will be of great interest to students and researchers alike.