A Systems Theoretic Approach To Systems And Synthetic Biology Ii Analysis And Design Of Cellular Systems
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A Systems Theoretic Approach To Systems And Synthetic Biology Ii Analysis And Design Of Cellular Systems
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Author : Vishwesh V. Kulkarni
language : en
Publisher: Springer
Release Date : 2014-07-03
A Systems Theoretic Approach To Systems And Synthetic Biology Ii Analysis And Design Of Cellular Systems written by Vishwesh V. Kulkarni and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-03 with Medical categories.
The complexity of biological systems has intrigued scientists from many disciplines and has given birth to the highly influential field of systems biology wherein a wide array of mathematical techniques, such as flux balance analysis, and technology platforms, such as next generation sequencing, is used to understand, elucidate, and predict the functions of complex biological systems. More recently, the field of synthetic biology, i.e., de novo engineering of biological systems, has emerged. Scientists from various fields are focusing on how to render this engineering process more predictable, reliable, scalable, affordable, and easy. Systems and control theory is a branch of engineering and applied sciences that rigorously deals with the complexities and uncertainties of interconnected systems with the objective of characterising fundamental systemic properties such as stability, robustness, communication capacity, and other performance metrics. Systems and control theory also strives to offer concepts and methods that facilitate the design of systems with rigorous guarantees on these properties. Over the last 100 years, it has made stellar theoretical and technological contributions in diverse fields such as aerospace, telecommunication, storage, automotive, power systems, and others. Can it have, or evolve to have, a similar impact in biology? The chapters in this book demonstrate that, indeed, systems and control theoretic concepts and techniques can have a significant impact in systems and synthetic biology. Volume II contains chapters contributed by leading researchers in the field of systems and synthetic biology that concern modeling physiological processes and bottom-up constructions of scalable biological systems. The modeling problems include characterisation and synthesis of memory, understanding how homoeostasis is maintained in the face of shocks and relatively gradual perturbations, understanding the functioning and robustness of biological clocks such as those at the core of circadian rhythms, and understanding how the cell cycles can be regulated, among others. Some of the bottom-up construction problems investigated in Volume II are as follows: How should biomacromolecules, platforms, and scalable architectures be chosen and synthesised in order to build programmable de novo biological systems? What are the types of constrained optimisation problems encountered in this process and how can these be solved efficiently? As the eminent computer scientist Donald Knuth put it, "biology easily has 500 years of exciting problems to work on". This edited book presents but a small fraction of those for the benefit of (1) systems and control theorists interested in molecular and cellular biology and (2) biologists interested in rigorous modelling, analysis and control of biological systems.
A Systems Theoretic Approach To Systems And Synthetic Biology I Models And System Characterizations
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Author : Vishwesh V. Kulkarni
language : en
Publisher: Springer
Release Date : 2014-07-03
A Systems Theoretic Approach To Systems And Synthetic Biology I Models And System Characterizations written by Vishwesh V. Kulkarni and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-03 with Medical categories.
The complexity of biological systems has intrigued scientists from many disciplines and has given birth to the highly influential field of systems biology wherein a wide array of mathematical techniques, such as flux balance analysis, and technology platforms, such as next generation sequencing, is used to understand, elucidate, and predict the functions of complex biological systems. More recently, the field of synthetic biology, i.e., de novo engineering of biological systems, has emerged. Scientists from various fields are focusing on how to render this engineering process more predictable, reliable, scalable, affordable, and easy. Systems and control theory is a branch of engineering and applied sciences that rigorously deals with the complexities and uncertainties of interconnected systems with the objective of characterising fundamental systemic properties such as stability, robustness, communication capacity, and other performance metrics. Systems and control theory also strives to offer concepts and methods that facilitate the design of systems with rigorous guarantees on these properties. Over the last 100 years, it has made stellar theoretical and technological contributions in diverse fields such as aerospace, telecommunication, storage, automotive, power systems, and others. Can it have, or evolve to have, a similar impact in biology? The chapters in this book demonstrate that, indeed, systems and control theoretic concepts and techniques can have a significant impact in systems and synthetic biology. Volume I provides a panoramic view that illustrates the potential of such mathematical methods in systems and synthetic biology. Recent advances in systems and synthetic biology have clearly demonstrated the benefits of a rigorous and systematic approach rooted in the principles of systems and control theory - not only does it lead to exciting insights and discoveries but it also reduces the inordinately lengthy trial-and-error process of wet-lab experimentation, thereby facilitating significant savings in human and financial resources. In Volume I, some of the leading researchers in the field of systems and synthetic biology demonstrate how systems and control theoretic concepts and techniques can be useful, or should evolve to be useful, in order to understand how biological systems function. As the eminent computer scientist Donald Knuth put it, "biology easily has 500 years of exciting problems to work on". This edited book presents but a small fraction of those for the benefit of (1) systems and control theorists interested in molecular and cellular biology and (2) biologists interested in rigorous modelling, analysis and control of biological systems.
Monitoring Artificial Materials And Microbes In Marine Ecosystems Interactions And Assessment Methods
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Author : Toshiyuki Takahashi
language : en
Publisher: Bentham Science Publishers
Release Date : 2020-02-10
Monitoring Artificial Materials And Microbes In Marine Ecosystems Interactions And Assessment Methods written by Toshiyuki Takahashi and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-10 with Science categories.
Marine ecosystems offer several benefits to human communities. To make sustainable use of these benefits, it is necessary to elucidate and conserve marine ecology, and strive to maintain a sustainable natural resource management program. For this reason, understanding the diversity and behavior of both macro-ecosystems and micro-ecosystems are crucial. Monitoring Artificial Materials and Microbes in Marine Ecosystems explores microbial roles and their interaction with artificial materials in marine environments. After starting with simple topics for beginners, chapters explore methods to detect microorganisms in marine ecosystems and interactions of marine organisms with artificial materials. The sequential progression into advanced topics makes it easier to understand how to solve the reduction in marine-ecosystem viability caused by adverse events. Readers are provided with useful information for rehabilitating marine environments to make them sustainable for communities. Topics are covered in 3 parts: Part 1 is an introductory guide to marine ecosystems and environmental monitoring assessment. Readers are introduced to coral reef ecosystems, algal blooms and the role of environmental monitoring services in maintaining and restoring the quality of marine environments. This is followed by examples of sustainable marine environment assessment.Part 2 provides information about methods to detect microorganisms (viruses and bacteria) and evaluate marine environments. This includes sample enrichment methods, electrochemical analysis, and single cell imaging techniques. The highly sensitive and specific techniques presented in the book, are applicable in a wide variety of situations.Part 3 is dedicated to interactions between artificial metallic materials and microorganisms in marine environments. Chapters in this section share results from several experiments conducted to separate microorganisms and biofilms from such environments. This book is intended primarily for marine ecologists, microbiologists, environmental engineers, and engineers associated with industrial projects. This book is also useful as a text for undergraduate and graduate level courses in marine biology, ecology, and microbiology.
Synthetic Biology A Primer Revised Edition
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Author : Paul S. FREEMONT
language : en
Publisher: World Scientific
Release Date : 2015-08-24
Synthetic Biology A Primer Revised Edition written by Paul S. FREEMONT and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-24 with Science categories.
Synthetic Biology -- A Primer (Revised Edition) presents an updated overview of the field of synthetic biology and the foundational concepts on which it is built. This revised edition includes new literature references, working and updated URL links, plus some new figures and text where progress in the field has been made.The book introduces readers to fundamental concepts in molecular biology and engineering and then explores the two major themes for synthetic biology, namely 'bottom-up' and 'top-down' engineering approaches. 'Top-down' engineering uses a conceptual framework of systematic design and engineering principles focused around the Design-Build-Test cycle and mathematical modelling. The 'bottom-up' approach involves the design and building of synthetic protocells using basic chemical and biochemical building blocks from scratch exploring the fundamental basis of living systems.Examples of cutting-edge applications designed using synthetic biology principles are presented, including: The book also describes the Internationally Genetically Engineered Machine (iGEM) competition, which brings together students and young researchers from around the world to carry out summer projects in synthetic biology. Finally, the primer includes a chapter on the ethical, legal and societal issues surrounding synthetic biology, illustrating the integration of social sciences into synthetic biology research.Final year undergraduates, postgraduates and established researchers interested in learning about the interdisciplinary field of synthetic biology will benefit from this up-to-date primer on synthetic biology.
Foundations Of Theoretical Approaches In Systems Biology
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Author : Alberto Marin-Sanguino
language : en
Publisher: Frontiers Media SA
Release Date : 2019-01-11
Foundations Of Theoretical Approaches In Systems Biology written by Alberto Marin-Sanguino and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-11 with categories.
If biology in the 20th century was characterized by an explosion of new technologies and experimental methods, that of the 21st has seen an equally exuberant proliferation of mathematical and computational methods that attempt to systematize and explain the abundance of available data. As we live through the consolidation of a new paradigm where experimental data goes hand in hand with computational analysis, we contemplate the challenge of fusing these two aspects of the new biology into a consistent theoretical framework. Whether systems biology will survive as a field or be washed away by the tides of future fads will ultimately depend on its success to achieve this type of synthesis. The famous quote attributed to Kurt Lewin comes to mind: "there is nothing more practical than a good theory". This book presents a wide assortment of articles on systems biology in an attempt to capture the variety of current methods in systems biology and show how they can help to find answers to the challenges of modern biology.
Design And Analysis Of Biomolecular Circuits
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Author : Heinz Koeppl
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-05-21
Design And Analysis Of Biomolecular Circuits written by Heinz Koeppl and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-05-21 with Technology & Engineering categories.
The book deals with engineering aspects of the two emerging and intertwined fields of synthetic and systems biology. Both fields hold promise to revolutionize the way molecular biology research is done, the way today’s drug discovery works and the way bio-engineering is done. Both fields stress the importance of building and characterizing small bio-molecular networks in order to synthesize incrementally and understand large complex networks inside living cells. Reminiscent of computer-aided design (CAD) of electronic circuits, abstraction is believed to be the key concept to achieve this goal. It allows hiding the overwhelming complexity of cellular processes by encapsulating network parts into abstract modules. This book provides a unique perspective on how concepts and methods from CAD of electronic circuits can be leveraged to overcome complexity barrier perceived in synthetic and systems biology.
Systems Evolutionary Biology
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Author : Bor-Sen Chen
language : en
Publisher: Academic Press
Release Date : 2018-02-03
Systems Evolutionary Biology written by Bor-Sen Chen and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-03 with Medical categories.
Systems Evolutionary Biology: Biological Network Evolution Theory, Stochastic Evolutionary Game Strategies, and Applications to Systems Synthetic Biology discusses the evolutionary game theory and strategies of nonlinear stochastic biological networks under random genetic variations and environmental disturbances and their application to systematic synthetic biology design. The book provides more realistic stochastic biological system models to mimic the real biological systems in evolutionary process and then introduces network evolvability, stochastic evolutionary game theory and strategy based on nonlinear stochastic networks in evolution. Readers will find remarkable, revolutionary information on genetic evolutionary biology that be applied to economics, engineering and bioscience. - Explains network fitness, network evolvability and network robustness of biological networks from the systematic perspective - Discusses the evolutionary noncooperative and cooperative game strategies of biological networks - Offers detailed diagrams to help readers understand biological networks, their systematic behaviors and the simulational results of evolutionary biological networks - Includes examples in every chapter with computational simulation to illustrate the solution procedure of evolutionary theory, strategy and results
Systems Medicine
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Author :
language : en
Publisher: Academic Press
Release Date : 2020-08-24
Systems Medicine written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-24 with Science categories.
Technological advances in generated molecular and cell biological data are transforming biomedical research. Sequencing, multi-omics and imaging technologies are likely to have deep impact on the future of medical practice. In parallel to technological developments, methodologies to gather, integrate, visualize and analyze heterogeneous and large-scale data sets are needed to develop new approaches for diagnosis, prognosis and therapy. Systems Medicine: Integrative, Qualitative and Computational Approaches is an innovative, interdisciplinary and integrative approach that extends the concept of systems biology and the unprecedented insights that computational methods and mathematical modeling offer of the interactions and network behavior of complex biological systems, to novel clinically relevant applications for the design of more successful prognostic, diagnostic and therapeutic approaches. This 3 volume work features 132 entries from renowned experts in the fields and covers the tools, methods, algorithms and data analysis workflows used for integrating and analyzing multi-dimensional data routinely generated in clinical settings with the aim of providing medical practitioners with robust clinical decision support systems. Importantly the work delves into the applications of systems medicine in areas such as tumor systems biology, metabolic and cardiovascular diseases as well as immunology and infectious diseases amongst others. This is a fundamental resource for biomedical students and researchers as well as medical practitioners who need to need to adopt advances in computational tools and methods into the clinical practice. Encyclopedic coverage: ‘one-stop’ resource for access to information written by world-leading scholars in the field of Systems Biology and Systems Medicine, with easy cross-referencing of related articles to promote understanding and further research Authoritative: the whole work is authored and edited by recognized experts in the field, with a range of different expertise, ensuring a high quality standard Digitally innovative: Hyperlinked references and further readings, cross-references and diagrams/images will allow readers to easily navigate a wealth of information
Synthetic Gene Network
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Author : Bor-Sen Chen
language : en
Publisher: CRC Press
Release Date : 2014-05-02
Synthetic Gene Network written by Bor-Sen Chen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-02 with Mathematics categories.
This book develops a rational design and systematic approach to construct a gene network with desired behaviors. In order to achieve this goal, the registry of standard biological parts and experimental techniques are introduced at first. Then these biological components are characterized by a standard modeling method and collected in the component
Handbook Of Systems Biology
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Author : Marian Walhout
language : en
Publisher: Academic Press
Release Date : 2012-12-31
Handbook Of Systems Biology written by Marian Walhout and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-31 with Science categories.
This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Chapters organized around broader themes of Organelles and Organisms, Systems Properties of Biological Processes, Cellular Networks, and Systems Biology and Disease discuss the development of concepts, the current applications, and the future prospects. Emphasis is placed on concepts and insights into the multi-disciplinary nature of the field as well as the importance of systems biology in human biological research. Technology, being an extremely important aspect of scientific progress overall, and in the creation of new fields in particular, is discussed in 'boxes' within each chapter to relate to appropriate topics. - 2013 Honorable Mention for Single Volume Reference in Science from the Association of American Publishers' PROSE Awards - Emphasizes the interdisciplinary nature of systems biology with contributions from leaders in a variety of disciplines - Includes the latest research developments in human and animal models to assist with translational research - Presents biological and computational aspects of the science side-by-side to facilitate collaboration between computational and biological researchers