A Textbook Of From Bench To Bedside Translational Approaches In Modern Pharmaceutics
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A Textbook Of From Bench To Bedside Translational Approaches In Modern Pharmaceutics
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Author : Dr. Dipti Gohil
language : en
Publisher: Chyren Publication
Release Date : 2025-07-10
A Textbook Of From Bench To Bedside Translational Approaches In Modern Pharmaceutics written by Dr. Dipti Gohil and has been published by Chyren Publication this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-07-10 with Antiques & Collectibles categories.
Principles Of Translational Science In Medicine
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Author : Martin Wehling
language : en
Publisher: Academic Press
Release Date : 2015-04-02
Principles Of Translational Science In Medicine written by Martin Wehling and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-02 with Science categories.
Principles of Translational Science in Medicine: From Bench to Bedside, Second Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing numbers of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine. - Provides an in-depth description of novel tools for the assessment of translatability of trials to balance risk and improve projects at any given stage of product development - New chapters deal with translational issues in the fastest growing population (the elderly), case studies, translatability assessment tools, and advances in nanotherapies - Details IPR issues of translation, especially for public-private-partnerships - Contains contributions from world leaders in translational medicine, including the former NIH director and authorities from various European regulatory institutions
Translational Admet For Drug Therapy
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Author : Souzan B. Yanni
language : en
Publisher: John Wiley & Sons
Release Date : 2015-09-24
Translational Admet For Drug Therapy written by Souzan B. Yanni and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-24 with Medical categories.
Serving as a practical handbook about ADMET for drug therapy, this book presents effective technologies, methods, applications, data interpretation, and decision-making tactics for pharmaceutical and preclinical scientists. Chapters cover case studies and in vivo, in vitro, and computational tools for drug discovery and development, with new translational approaches to clinical drug investigations in various human populations. Illustrates ADME properties, from bedside to bench and bench to bedside, for the design of safe and effective medicine in human populations Provides examples that demonstrate the integration of in vitro, in vivo, and in silico data to address human PKPD and TKTD and help determine the proper therapeutic dosage Presents successful tools for evaluating drugs and covers current translational ADMET with regulatory guidelines Offers a hands-on manual for researchers and scientists to design and execute in vitro, in silico, preclinical, and clinical studies Includes discussion of IND / NDA filing and drug labeling to support drug registration and approval
Improving Outcomes In Cerebral Palsy With Early Intervention New Translational Approaches
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Author : Anna Purna Basu
language : en
Publisher: Frontiers E-books
Release Date : 2015-03-30
Improving Outcomes In Cerebral Palsy With Early Intervention New Translational Approaches written by Anna Purna Basu and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-30 with Medicine (General) categories.
The aim of this Research Topic was to collate articles describing prediction of outcomes of pre- and perinatal lesions leading to cerebral palsy, basic research in animal models and human subjects, and ideas for, and trials of, interventions in the first two years of life. CP arises from insults to the sensorimotor cortex, subcortical axon tracts and subplate. The aetiology is complex and often multifactorial. The outcome is not simply a loss of voluntary control due to disruption of descending pathways, but also involves abnormal development of reflex and corticospinal circuitry. CP may be viewed as aberrant plasticity in response to a lesion, indeed, abnormalities in movement are subtle at first but develop subsequently. It is misleading to suppose that developmental mechanisms are self-reparative. The challenge is to understand activitydependent fine tuning of neural circuitry during normal development and to find how to promote desirable plasticity whilst limiting undesirable effects following developmental lesions. However, before proposing interventions, we have to develop our ability to predict the severity of neonatal insults. We solicited a variety of articles, including long and short reviews, original research and opinion pieces, from both basic scientists and clinicians. Likewise we, as editors, have complementary knowledge and experience in this area. Anna Basu is an academic pediatric neurologist and Gavin Clowry is a developmental neuroscientist.
Translational Medicine
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Author : Dennis Cosmatos
language : en
Publisher: CRC Press
Release Date : 2008-12-17
Translational Medicine written by Dennis Cosmatos and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-17 with Mathematics categories.
Examines Critical Decisions for Transitioning Lab Science to a Clinical SettingThe development of therapeutic pharmaceutical compounds is becoming more expensive, and the success rates for getting such treatments approved for marketing and to the patients is decreasing. As a result, translational medicine (TM) is becoming increasingly important in
Peptide Drug Discovery And Development
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Author : Miguel Castanho
language : en
Publisher: John Wiley & Sons
Release Date : 2011-10-24
Peptide Drug Discovery And Development written by Miguel Castanho and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-10-24 with Medical categories.
Filling a real knowledge gap, this handbook and ready reference is both modern and forward-looking in its emphasis on the "bench to bedside" translational approach to drug development. Clearly structured into three major parts, the book stakes out the boundaries of peptide drug development in the preclinical as well as clinical stages. The first part provides a general background and focuses on the characteristic strengths and weaknesses of peptide drugs. The second section contains five cases studies of peptides from diverse therapeutic fields, and the lessons to be learned from them, while the final part looks at new targets and opportunities, discussing several drug targets and diseases for which peptide drugs are currently being developed.
Animal And Translational Models For Cns Drug Discovery
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Author : Robert A. McArthur
language : en
Publisher: Academic Press
Release Date : 2008-11-27
Animal And Translational Models For Cns Drug Discovery written by Robert A. McArthur and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-27 with Science categories.
Animal and Translational Models for CNS Drug Discovery combines the experience of academic, clinical and pharmaceutical neuroscientists in a unique collaborative approach to provide a greater understanding of the relevance of animal models of neuropsychiatric disorders and their role as translational tools for the discovery of CNS drugs being developed for the treatment of these disorders. The focus of this three-volume series of essays is to present a consensual picture of the translational value of animal models from leading experts actively involved in the use of animal models for understanding fundamental neurobiology of CNS disorders and the application of this knowledge to CNS drug discovery, and clinical investigators involved in clinical trials, drug development and eventual registration of novel pharmaceuticals. Each volume of the Animal and Translational Models for CNS Drug Discovery series is dedicated to the development and use of animal models in key therapeutic areas in psychiatric, neurologic and reward deficit disorders. Each volume has introductory chapters expressing the view of the role and relevance of animal models for CNS drug discovery and development from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in relevant therapeutic areas and discusses the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. - Provides clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process - Critical evaluation of animal and translational models improving transition from drug discovery and clinical development - Emphasizes what results mean to the overall drug discovery process - Explores issues in clinical trial design and conductance in each therapeutic area - Each volume is available for purchase individually.
Calcific Aortic Valve Disease
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Author : Elena Aikawa
language : en
Publisher: BoD – Books on Demand
Release Date : 2013-06-12
Calcific Aortic Valve Disease written by Elena Aikawa and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-12 with Medical categories.
Due to population aging, calcific aortic valve disease (CAVD) has become the most common heart valve disease in Western countries. No therapies exist to slow this disease progression, and surgical valve replacement is the only effective treatment. Calcific Aortic Valve Disease covers the contemporary understanding of basic valve biology and the mechanisms of CAVD, provides novel insights into the genetics, proteomics, and metabolomics of CAVD, depicts new strategies in heart valve tissue engineering and regenerative medicine, and explores current treatment approaches. As we are on the verge of understanding the mechanisms of CAVD, we hope that this book will enable readers to comprehend our current knowledge and focus on the possibility of preventing disease progression in the future.
Textbook Of Hospital Administration
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Author : Sonu Dr Goel
language : en
Publisher: Elsevier Health Sciences
Release Date : 2013-12-31
Textbook Of Hospital Administration written by Sonu Dr Goel and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-31 with Medical categories.
This work ushers in a change in the approach of books on hospital administration. To make the text interesting authors have used the case based learning approach. Apart from this many new topics have been introduced in this book which had not been addressed so far in the available books. For example:- due importance has been given to the role of engineering department in ensuring provision of good quality of medical care by the hospitals. New concepts in hospital administration like information therapy, use of information and communication technology, health promoting hospital approach, impact of globalization on hospital care etc. have also introduced through this book. USP of the book is giving due importance to the feedback from experienced hospital administrators across public and private hospitals of country. This book will surely be of use to medical superintendents and hospital administrators in government and private hospitals in India and other countries. Students as well as teachers of various courses namely, regular and distant learning courses of MBA in Health Care/Hospital Administration, Diploma of masters in Hospital Administrator, MD in hospital administrator , MD in community medicine, Diploma/masters in laws, master's in public health will also find this book of immense value. This book will also be helpful for civil surgeons and senior medical officers of state health services. The book comprehensively consolidates a lot of practical aspects by incorporating plenty of illustrations, photographs, case studies, real life situations etc. which will help the readers to get a realistic practical experience. Salient Features - New concepts in hospital administration like use of information and communication technology, health promoting hospital approach, impact of globalization on hospital care, role of engineering department and information therapy, etc. have been introduced - Case Studies presented in the chapters are useful for case based learning approach - Comprehensively consolidates a lot of practical aspects by incorporating plenty of Flowcharts, Figures and Tables help the readers to get a realistic practical experience
Biomarkers In Drug Development
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Author : Michael R. Bleavins
language : en
Publisher: John Wiley & Sons
Release Date : 2011-09-20
Biomarkers In Drug Development written by Michael R. Bleavins and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-20 with Medical categories.
Discover how biomarkers can boost the success rate of drug development efforts As pharmaceutical companies struggle to improve the success rate and cost-effectiveness of the drug development process, biomarkers have emerged as a valuable tool. This book synthesizes and reviews the latest efforts to identify, develop, and integrate biomarkers as a key strategy in translational medicine and the drug development process. Filled with case studies, the book demonstrates how biomarkers can improve drug development timelines, lower costs, facilitate better compound selection, reduce late-stage attrition, and open the door to personalized medicine. Biomarkers in Drug Development is divided into eight parts: Part One offers an overview of biomarkers and their role in drug development. Part Two highlights important technologies to help researchers identify new biomarkers. Part Three examines the characterization and validation process for both drugs and diagnostics, and provides practical advice on appropriate statistical methods to ensure that biomarkers fulfill their intended purpose. Parts Four through Six examine the application of biomarkers in discovery, preclinical safety assessment, clinical trials, and translational medicine. Part Seven focuses on lessons learned and the practical aspects of implementing biomarkers in drug development programs. Part Eight explores future trends and issues, including data integration, personalized medicine, and ethical concerns. Each of the thirty-eight chapters was contributed by one or more leading experts, including scientists from biotechnology and pharmaceutical firms, academia, and the U.S. Food and Drug Administration. Their contributions offer pharmaceutical and clinical researchers the most up-to-date understanding of the strategies used for and applications of biomarkers in drug development.