Aacr 2019 Proceedings Abstracts 1 2748


Aacr 2019 Proceedings Abstracts 1 2748
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Aacr 2019 Proceedings Abstracts 1 2748


Aacr 2019 Proceedings Abstracts 1 2748
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Author : American Association for Cancer Research
language : en
Publisher: Coe Truman International, LLC
Release Date : 2019-03-08

Aacr 2019 Proceedings Abstracts 1 2748 written by American Association for Cancer Research and has been published by Coe Truman International, LLC this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-08 with categories.


American Association for Cancer Research 2019 Proceedings: Abstracts 1-2748 - Part A



Metronomic Chemotherapy


Metronomic Chemotherapy
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Author : Guido Bocci
language : en
Publisher: Springer
Release Date : 2014-09-04

Metronomic Chemotherapy written by Guido Bocci and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-04 with Medical categories.


This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.



The Basics Of Cancer Immunotherapy


The Basics Of Cancer Immunotherapy
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Author : Haidong Dong
language : en
Publisher: Springer
Release Date : 2018-01-05

The Basics Of Cancer Immunotherapy written by Haidong Dong and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-05 with Medical categories.


This book provides patients and their physicians (especially “non-oncologist” health care providers) with a clear and concise introduction to cancer immunotherapy, which, unlike traditional forms of cancer therapy, acts by boosting the patient’s own immune system to fight cancer. The unique features of cancer immunotherapy make its management, monitoring and side-effects different from those of traditional cancer therapy. Especially novel are the side effects of cancer immunotherapy, necessitating greater awareness for both patients and physicians in order to minimize complications of therapy. The patient-friendly, concise, easy-to-understand, and up-to-date knowledge presented in this book will inform patients about the benefits and risks of cancer immunotherapy, and help them and their care providers to understand how immunotherapy would control their unique disease. Researchers and academic professionals in the field of cancer immunotherapy will also find clear and useful information to help them communicate with patients or address unresolved problems. Some key features of the book are: Expertise. All editors and authors are scientists and oncologists specializing in cancer immunotherapy, and are involved in scientific discovery from the early stage of immune-checkpoint inhibitors to today’s daily patient care. Their insights, expertise and experience guarantee the high quality and authority in the science, medicine and practice of cancer immunotherapy. Patient-friendly. This book is written for cancer patients in order to meet their needs when considering immunotherapy. As an educational tool, this book will help the reader balance the risks and benefits based on both science and clinical facts, and therefore to make the best choice in receiving or withdrawing from immunotherapy. Disease Specificity. Cancer is a complicated disease involving multiple stages and pathology. Its response to immunotherapy is individualized and varies depending on cancer types. The authors’ expertise in treating different types of cancers, including melanoma, lung, kidney, bladder, and lymphoma, provides disease-specific insights in applying immunotherapy to each disease.



Inflammation Oxidative Stress And Cancer


Inflammation Oxidative Stress And Cancer
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Author : Ah-Ng Tony Kong
language : en
Publisher: CRC Press
Release Date : 2016-04-19

Inflammation Oxidative Stress And Cancer written by Ah-Ng Tony Kong and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.


Increasing scientific evidence suggests that the majority of diseases including cancer are driven by oxidative stress and inflammation, attributed to environmental factors. These factors either drive genetic mutations or epigenetically modify expression of key regulatory genes. These changes can occur as early as gestational fetal development, and



Monoclonal Antibodies In Cancer


Monoclonal Antibodies In Cancer
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Author : Stewart Sell
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Monoclonal Antibodies In Cancer written by Stewart Sell and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.


This represents the third volume in a series on cancer markers pub lished by the Humana Press. The first volume, published in 1980, stressed the relationship of development and cancer as reflected in the production of markers by cancer that are also produced by normal cells during fetal development. The concept that cancer represents a problem of differentiation was introduced by Barry Pierce in describing differenti ation of teratocarcinomas. Highlighted were lymphocyte markers, alphafetoprotein, carcinoembryonic antigen, ectopic hormones, enzymes and isozymes, pregnancy proteins, and fibronectin. The second volume, published in 1982 and coedited with Britta Wahren, focused on the diagnostic use of oncological markers in human cancers, which were systematically treated on an organ by organ basis. At that time, the application of monoclonal antibodies to the identification of cancer markers was still in a very preliminary stage. A general introduc tion to monoclonal antibodies to human tumor antigens was given there by William Raschke, and other authors included coverage of those mark ers then detectable by monoclonal antibodies in their chapters.



Antibody Drug Conjugates And Immunotoxins


Antibody Drug Conjugates And Immunotoxins
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Author : Gail Lewis Phillips
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-13

Antibody Drug Conjugates And Immunotoxins written by Gail Lewis Phillips and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-13 with Medical categories.


This volume gathers the leading research on antibody-drug conjugates and immunotoxins. Following a rigorous overview, the volume delves into focused sections on all aspects of ADCs and ITs from clinical development through to targeted therapeutic applications and the latest technologies.



Targeted Therapies In Cancer


Targeted Therapies In Cancer
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Author : Manfred Dietel
language : en
Publisher: Springer
Release Date : 2014-11-23

Targeted Therapies In Cancer written by Manfred Dietel and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-23 with Medical categories.


From its introduction, oncological chemotherapy has been encumbered by poor selectivity because antiproliferative drugs are often toxic not only to tumor cells but also to important populations of the body’s non-neoplastic cells. Modern targeted therapies interact with defined molecules present on cancer cells, adding increased selectivity to their toxic effects. This book presents an integrated critical view on the theories, mechanisms, problems and pitfalls of the targeted therapy approach.



Atlas Of Nuclear Cardiology


Atlas Of Nuclear Cardiology
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Author : Vasken Dilsizian
language : en
Publisher: Springer Nature
Release Date : 2021-03-27

Atlas Of Nuclear Cardiology written by Vasken Dilsizian and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-27 with Medical categories.


The fifth edition of this book presents clinical data, image acquisition, and interpretation of nuclear cardiology procedures through high quality illustrative image examples. It includes up-to-date and comprehensive coverage of advances in instrumentation, radiotracers, protocols, and clinical studies. New content includes indications in imaging cardiac sarcoidosis, amyloidosis, and device infections as well as recent advances in instrumentation (Hybrid PET/MR). It also provides fresh chapters on the history of nuclear cardiology imaging, radionuclide handling techniques and radiation safety, PET-based myocardial perfusion imaging, and vascular imaging. The entire field is presented in pictographic form that is visually pleasing and conforming to current trends of medical education. The fifth edition of the Atlas of Nuclear Cardiology is an essential reference for cardiologists, radiologists, and nuclear medicine physicians interested in the latest approaches to noninvasive diagnostic cardiovascular nuclear imaging techniques. It also serves as a ready reference textbook for medical students and residents as well as nuclear physicists, nuclear medicine technologists, and radiopharmacists.



Innovations For Next Generation Antibody Drug Conjugates


Innovations For Next Generation Antibody Drug Conjugates
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Author : Marc Damelin
language : en
Publisher: Springer
Release Date : 2018-05-29

Innovations For Next Generation Antibody Drug Conjugates written by Marc Damelin and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-29 with Medical categories.


Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the innovations that will enable them. The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies. While the book primarily addresses ADCs for solid tumors, the last chapter explores the emerging interest in using ADCs to treat other diseases. The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (and away from normal tissues) by conjugation to antibodies or other targeting moieties. However, the combination of small and large molecules imposes deep complexity to lead optimization, pharmacokinetics, toxicology, analytics and manufacturing. The field has made significant advances in all of these areas by improving target selection, ADC design, manufacturing methods and clinical strategies. These innovations will inspire and educate scientists who are designing next-generation ADCs with the potential to transform the lives of patients.



Targeted Therapies In Oncology Second Edition


Targeted Therapies In Oncology Second Edition
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Author : Giuseppe Giaccone
language : en
Publisher: CRC Press
Release Date : 2013-10-21

Targeted Therapies In Oncology Second Edition written by Giuseppe Giaccone and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-21 with Medical categories.


Since the last edition of this book, major advances have been made in our understanding of key pathways that control tumor progression. This has led to the development of new anticancer agents that have the ability to block the activity of proteins involved in neoplastic cell development and proliferation. Targeted Therapies in Oncology, Second Edition provides a concise timely panorama of existing targeted therapies and progress into future anticancer treatments. These therapies notably include: Targeted agents of immune checkpoints Signal-transduction inhibitors Antiangiogenic agents Vascular-disrupting agents Apoptosis modulators Stem cell inhibitors Tumor profiling for drug development The book emphasizes the biology behind this new class of drugs as well as the clinical achievements obtained. The contributors to this volume stand at the cutting edge of cancer research and treatment around the world.