Abc Transporters Of Human Physiology And Disease The Genetics And Biochemistry Of Atp Binding Cassette Transporters
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Abc Transporters Of Human Physiology And Disease The Genetics And Biochemistry Of Atp Binding Cassette Transporters
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Author : Kenneth J Linton
language : en
Publisher: World Scientific
Release Date : 2011-09-19
Abc Transporters Of Human Physiology And Disease The Genetics And Biochemistry Of Atp Binding Cassette Transporters written by Kenneth J Linton and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-19 with Science categories.
ATP Binding Cassette (ABC) transporters are a family of integral membrane proteins present in all cells of all species of archaea, eubacteria and eukaryota. The vast majority of these proteins control the transport across cellular membranes of molecules ranging from small ions to drugs, lipids and proteins. The human genome encodes 48 ABC transporter genes and mutations in most have been linked to disease. This book — that brings together state-of-the-art knowledge on ABC proteins in one volume — will provide students, professors and medical professionals with a background to the human ABC transporters that are known to be relevant to disease. Each of the 14 chapters is written by a leading researcher in the field. The genetics, structure and function of the proteins, and the future direction of research including the implications for human health are discussed in depth.
The Abc Transporters Of Human Physiology And Disease
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Author : Kenneth J. Linton
language : en
Publisher:
Release Date : 2011
The Abc Transporters Of Human Physiology And Disease written by Kenneth J. Linton and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with ATP-binding cassette transporters categories.
ATP Binding Cassette (ABC) transporters are a family of integral membrane proteins present in all cells of all species of archaea, eubacteria and eukaryota. The vast majority of these proteins control the transport across cellular membranes of molecules ranging from small ions to drugs, lipids and proteins. The human genome encodes 48 ABC transporter genes and mutations in most have been linked to disease. This book - that brings together state-of-the-art knowledge on ABC proteins in one volume - will provide students, professors and medical professionals with a background to the human ABC transporters that are known to be relevant to disease. Each of the 14 chapters is written by a leading researcher in the field. The genetics, structure and function of the proteins, and the future direction of research including the implications for human health are discussed in depth.
Abc Transporters In Human Disease
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Author : Karobi Moitra
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2012-04-20
Abc Transporters In Human Disease written by Karobi Moitra and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-20 with Medical categories.
The ATP-binding cassette (ABC) transporter genes are ubiquitous in the genomes of all vertebrates so far studied. The human ABC transporter superfamily contains 48 genes, subdivided into 7 subfamilies ranging from A to G (based on sequence homology of their nucleotide binding domains). The ABC proteins encoded by these genes are ATP-driven transmembrane pumps, some of which possess the capacity to efflux harmful toxic substances and therefore play a key role in xenobiotic defense. ABC proteins have been evolutionarily conserved from bacteria to humans and multiple gene duplication and deletion events in the ABC genes indicate that the process of gene evolution is still ongoing. Polymorphisms and variations in these genes are linked to variations in expression, function, drug disposition, and drug response. Single nucleotide polymorphisms (SNPs) in these genes could be markers of individual risk for adverse drug reactions or susceptibility to complex diseases. The pharmacogenetics of this unique family of transporters is still under study; however, in the context of human health, it is a well-known fact that variations in these transporters are the underlying cause for several human diseases including cystic fibrosis, Pseudoxanthoma elasticum (PXE), and X-linked adenoleukodystrophy (X-ALD). Table of Contents: Introduction to the Human ATP-Binding Cassette (ABC) Transporter Superfamily / Evolution of ABC Transporters / Overview of ABC Transporters in Human Disease / The Cystic Fibrosis Transmembrane Conductance Regulator-ABCC7 / PXE / X-linked Adrenoleukodystrophy / ABC Proteins: A Global Perspective / References / Titles of Related Interest
Abc Transporters 40 Years On
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Author : Anthony M. George
language : en
Publisher: Springer
Release Date : 2015-12-16
Abc Transporters 40 Years On written by Anthony M. George and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-16 with Science categories.
This book provides new structural, biochemical, and clinical information on ABC transporters. The authors explore and describe the state of the art of research, knowledge, and prospects for the future for this important family of proteins. The first ABC transporter was discovered in 1973 and was named P-glycoprotein. It elicits resistance to cytotoxic drugs, chiefly in human tumours, within which chemotherapy failure is observed in about 50% of cases. Together with its complex pharmacology, and even a suspected role in Alzheimer’s disease, this ABC transporter still eludes a clinical solution to its multidrug resistance property. ABC transporters are integral membrane active proteins and they belong to one of the largest protein families across all species. Their myriad roles encompass the import or export of a diverse range of allocrites, including ion, nutrients, peptides, polysaccharides, lipids, and xenobiotics. They are of major medical importance with many members elaborating multidrug resistance in bacteria, fungi, yeast, parasites, and humans. Other ABC transporters are involved in a number of inherited diseases, including cystic fibrosis, macular degeneration, gout, and several other metabolic disorders
Abc Transporters Biochemical Cellular And Molecular Aspects
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Author : Suresh V. Ambudkar
language : en
Publisher: Gulf Professional Publishing
Release Date : 1998-07-31
Abc Transporters Biochemical Cellular And Molecular Aspects written by Suresh V. Ambudkar and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-07-31 with Medical categories.
The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 285 volumes have been published (all of them still in print) and much of the material is relevant even today-truly an essential publication for researchersin all fields of life sciences. Prokaryotic ABC Transporters Eukaryotic ABC Transporters Nonmammalian ABC Transport Systems Mammalian P-Glycoproteins Multidrug Resistance Associated Protein Cystic Fibrosis Transmembrane Conductance Regulator Sulfonylurea Receptor Intracellular ABC Transporters
The Human Atp Binding Cassette Abc Transporter Superfamily
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Author : Michael Carlton Dean
language : en
Publisher:
Release Date : 2002
The Human Atp Binding Cassette Abc Transporter Superfamily written by Michael Carlton Dean and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with ATP-binding cassette transporters categories.
Drug Transporters In Drug Disposition Effects And Toxicity
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Author : Xiaodong Liu
language : en
Publisher: Springer Nature
Release Date : 2019-09-30
Drug Transporters In Drug Disposition Effects And Toxicity written by Xiaodong Liu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-30 with Medical categories.
This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and efficacy/toxicity. In general, they are divided into solute carrier (SLC) and ATP binding cassette (ABC) families, and are located along cell membranes, where they mediate drug uptake into cells and export out of cells. Drug transporters are essential in maintaining cell homeostasis, and their gene mutations may cause or contribute to severe human genetic disorders, such as cystic fibrosis, neurological disease, retinal degeneration, anemia, and cholesterol and bile transport defects. Conversely, some diseases may also alter transporter functions and expressions, in turn aggravating disease process. Further, since over-expression of some ABC transporters is a potential contributor to multidrug-resistance (MDR), the book presents a number of strategies to overcome MDR, including ABC transporter inhibitors and applying epigenetic methods to modulate transporter expressions and functions. This book is useful for graduate students and professionals who are looking to refresh or expand their knowledge of this exciting field.
Abc Transporters In Human Diseases
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Author : Thomas Falguières
language : en
Publisher: Mdpi AG
Release Date : 2022-04-26
Abc Transporters In Human Diseases written by Thomas Falguières and has been published by Mdpi AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-26 with Science categories.
Mammalian ATP-binding cassette (ABC) transporters constitute a superfamily of proteins involved in many essential cellular processes. Most of these transporters are transmembrane proteins and allow the active transport of solutes, small molecules, and lipids across biological membranes. On the one hand, some of these transporters are involved in drug resistance (also referred to as MDR or multidrug resistance), a process known to be a major brake in most anticancer treatments, and the medical challenge is thus to specifically inhibit their function. On the other hand, molecular defects in some of these ABC transporters are correlated with several rare human diseases, the most well-documented of which being cystic fibrosis, which is caused by genetic variations in ABCC7/CFTR (cystic fibrosis transmembrane conductance regulator). In the latter case, the goal is to rescue the function of the deficient transporters using various means, such as targeted pharmacotherapies and cell or gene therapy. The aim of this Special Issue, "ABC Transporters in Human Diseases", is to present, through original articles and reviews, the state-of-the-art of our current knowledge about the role of ABC transporters in human diseases and the proposed therapeutic options based on studies ranging from cell and animal models to patients.
Functional Analysis Of Atp Binding Cassette Abc Transporters In Caenorhabditis Elegans
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Author : Zhongying Zhao
language : en
Publisher:
Release Date : 2005
Functional Analysis Of Atp Binding Cassette Abc Transporters In Caenorhabditis Elegans written by Zhongying Zhao and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with ATP-binding cassette transporters categories.
This thesis deals with functional analysis of ABC transporter genes in Caenorhabditis elegans. ABC transporters constitute one of the largest gene families in C. elegans. Sixty ABC genes have been identified and classified into eight different subfamilies. Fifty-seven orthologous pairs can be found between C. elegans and C. briggsae. As an initial step toward understanding the functions of the ABC genes, I generated transgenic animals containing prornoter::GFP/DsRed fusion constructs for the whole family in order to address when and where these genes are turned on in vivo. I observed frequent expression of ABC genes in intestine, pharynx and excretory cell, especially for those in subfamilies B and C. Sixteen of the 60 ABC genes are tandemly duplicated genes, forming two 4-gene and four 2-gene clusters. Interestingly, the majority of the promoters from the same clusters drive temporally andfor spatially differential expressions, suggesting active function of these duplicated genes in different tissues or stages rather than their being inactivated, as is typical for duplicated genes. Currently 18 single ABC gene mutants have been created. All of them are wild type under normal laboratory conditions. I used one of the ABC genes, pgp-12, an excretory cell-expressing gene, to characterize its transcriptional regulation. A 10 base pair (bp) cis-element, Ex-1 and its binding protein C26C6.5a, were isolated. C26C6.5a is also expressed in the excretory cell and binds Ex-l in vitro. RNAi analysis revealed that the C26C6.5a protein functions as a trans-activator for excretory cell specific expression. The only member of subfamily E is the ABCE gene that has been annotated as an RNase L inhibitor. This annotation is unlikely to be correct because of the lack of the inhibitor gene in C. elegans. Functional analysis of the gene reveals that it is essential for life, possibly involved in transcription and translation, and may function as a nucleocytoplasrnic transporter. RNAi data implies that the protein functions in both germline and vulvae.
Characterization And Genetic Studies Of Four Atp Binding Cassette Abc Transporters
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Author : Jaana Männik
language : en
Publisher:
Release Date : 2003
Characterization And Genetic Studies Of Four Atp Binding Cassette Abc Transporters written by Jaana Männik and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.