Abc Transporters In Human Disease

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Abc Transporters In Human Disease

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Author : Karobi Moitra
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2012-04-20

Abc Transporters In Human Disease written by Karobi Moitra and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-20 with Medical categories.

The ATP-binding cassette (ABC) transporter genes are ubiquitous in the genomes of all vertebrates so far studied. The human ABC transporter superfamily contains 48 genes, subdivided into 7 subfamilies ranging from A to G (based on sequence homology of their nucleotide binding domains). The ABC proteins encoded by these genes are ATP-driven transmembrane pumps, some of which possess the capacity to efflux harmful toxic substances and therefore play a key role in xenobiotic defense. ABC proteins have been evolutionarily conserved from bacteria to humans and multiple gene duplication and deletion events in the ABC genes indicate that the process of gene evolution is still ongoing. Polymorphisms and variations in these genes are linked to variations in expression, function, drug disposition, and drug response. Single nucleotide polymorphisms (SNPs) in these genes could be markers of individual risk for adverse drug reactions or susceptibility to complex diseases. The pharmacogenetics of this unique family of transporters is still under study; however, in the context of human health, it is a well-known fact that variations in these transporters are the underlying cause for several human diseases including cystic fibrosis, Pseudoxanthoma elasticum (PXE), and X-linked adenoleukodystrophy (X-ALD). Table of Contents: Introduction to the Human ATP-Binding Cassette (ABC) Transporter Superfamily / Evolution of ABC Transporters / Overview of ABC Transporters in Human Disease / The Cystic Fibrosis Transmembrane Conductance Regulator-ABCC7 / PXE / X-linked Adrenoleukodystrophy / ABC Proteins: A Global Perspective / References / Titles of Related Interest

The Abc Transporters Of Human Physiology And Disease

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Author : Kenneth J. Linton
language : en
Publisher:
Release Date : 2011

The Abc Transporters Of Human Physiology And Disease written by Kenneth J. Linton and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with ATP-binding cassette transporters categories.

ATP Binding Cassette (ABC) transporters are a family of integral membrane proteins present in all cells of all species of archaea, eubacteria and eukaryota. The vast majority of these proteins control the transport across cellular membranes of molecules ranging from small ions to drugs, lipids and proteins. The human genome encodes 48 ABC transporter genes and mutations in most have been linked to disease. This book - that brings together state-of-the-art knowledge on ABC proteins in one volume - will provide students, professors and medical professionals with a background to the human ABC transporters that are known to be relevant to disease. Each of the 14 chapters is written by a leading researcher in the field. The genetics, structure and function of the proteins, and the future direction of research including the implications for human health are discussed in depth.

Abc Transporters Of Human Physiology And Disease The Genetics And Biochemistry Of Atp Binding Cassette Transporters

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Author : Kenneth J Linton
language : en
Publisher: World Scientific
Release Date : 2011-09-19

Abc Transporters Of Human Physiology And Disease The Genetics And Biochemistry Of Atp Binding Cassette Transporters written by Kenneth J Linton and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-19 with Science categories.

ATP Binding Cassette (ABC) transporters are a family of integral membrane proteins present in all cells of all species of archaea, eubacteria and eukaryota. The vast majority of these proteins control the transport across cellular membranes of molecules ranging from small ions to drugs, lipids and proteins. The human genome encodes 48 ABC transporter genes and mutations in most have been linked to disease. This book — that brings together state-of-the-art knowledge on ABC proteins in one volume — will provide students, professors and medical professionals with a background to the human ABC transporters that are known to be relevant to disease. Each of the 14 chapters is written by a leading researcher in the field. The genetics, structure and function of the proteins, and the future direction of research including the implications for human health are discussed in depth.

Abc Transporters 40 Years On

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Author : Anthony M. George
language : en
Publisher: Springer
Release Date : 2015-12-16

Abc Transporters 40 Years On written by Anthony M. George and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-16 with Science categories.

This book provides new structural, biochemical, and clinical information on ABC transporters. The authors explore and describe the state of the art of research, knowledge, and prospects for the future for this important family of proteins. The first ABC transporter was discovered in 1973 and was named P-glycoprotein. It elicits resistance to cytotoxic drugs, chiefly in human tumours, within which chemotherapy failure is observed in about 50% of cases. Together with its complex pharmacology, and even a suspected role in Alzheimer’s disease, this ABC transporter still eludes a clinical solution to its multidrug resistance property. ABC transporters are integral membrane active proteins and they belong to one of the largest protein families across all species. Their myriad roles encompass the import or export of a diverse range of allocrites, including ion, nutrients, peptides, polysaccharides, lipids, and xenobiotics. They are of major medical importance with many members elaborating multidrug resistance in bacteria, fungi, yeast, parasites, and humans. Other ABC transporters are involved in a number of inherited diseases, including cystic fibrosis, macular degeneration, gout, and several other metabolic disorders

Abc Transporters In Human Diseases

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Author : Thomas Falguières
language : en
Publisher:
Release Date : 2022

Abc Transporters In Human Diseases written by Thomas Falguières and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.

Mammalian ATP-binding cassette (ABC) transporters constitute a superfamily of proteins involved in many essential cellular processes. Most of these transporters are transmembrane proteins and allow the active transport of solutes, small molecules, and lipids across biological membranes. On the one hand, some of these transporters are involved in drug resistance (also referred to as MDR or multidrug resistance), a process known to be a major brake in most anticancer treatments, and the medical challenge is thus to specifically inhibit their function. On the other hand, molecular defects in some of these ABC transporters are correlated with several rare human diseases, the most well-documented of which being cystic fibrosis, which is caused by genetic variations in ABCC7/CFTR (cystic fibrosis transmembrane conductance regulator). In the latter case, the goal is to rescue the function of the deficient transporters using various means, such as targeted pharmacotherapies and cell or gene therapy. The aim of this Special Issue, "ABC Transporters in Human Diseases", is to present, through original articles and reviews, the state-of-the-art of our current knowledge about the role of ABC transporters in human diseases and the proposed therapeutic options based on studies ranging from cell and animal models to patients.

Abc Proteins

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Author : I Barry Holland
language : en
Publisher: Elsevier
Release Date : 2003-01-07

Abc Proteins written by I Barry Holland and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-01-07 with Science categories.

ABC Proteins is an in-depth, up-to-date analysis of all that is known about the subject to date. It discusses and compares evolution, biology and mechanism of action of all known ABC proteins, including the first structural studies as well as clinical implications. It will be useful to anyone trying to stay abreast of the latest findings. This book is sure to become a classic and will regularly be updated. Phylogeny and Evoloution of ABC Transporters Fundamental Aspects of the Mechanism of Action of ABC Transporters Prokaryote ABC Transporters Non-Mammalian Transporters Multidrug Transporters ABC Transporters, Physiological Roles and Human Disease Full color throughout

The Human Atp Binding Cassette Abc Transporter Superfamily

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Author : Michael Carlton Dean
language : en
Publisher:
Release Date : 2002

The Human Atp Binding Cassette Abc Transporter Superfamily written by Michael Carlton Dean and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.

Plant Abc Transporters

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Author : Markus Geisler
language : en
Publisher: Springer
Release Date : 2014-09-06

Plant Abc Transporters written by Markus Geisler and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-06 with Science categories.

This book is devoted to the fascinating superfamily of plant ATP-binding cassette (ABC) transporters and their variety of transported substrates. It highlights their exciting biological functions, covering aspects ranging from cellular detoxification, through development, to symbiosis and defense. Moreover, it also includes a number of chapters that center on ABC transporters from non-Arabidopsis species. ABC proteins are ubiquitous, membrane-intrinsic transporters that catalyze the primary (ATP-dependent) movement of their substrates through biological membranes. Initially identified as an essential aspect of a vacuolar detoxification process, genetic work in the last decade has revealed an unexpectedly diverse variety of ABC transporter substrates, which include not only xenobiotic conjugates, but also heavy metals, lipids, terpenoids, lignols, alkaloids and organic acids. The discovery that members of the ABCB and ABCG family are involved in the movement of phytohormones has further sparked their exploration and provided a new understanding of the whole family. Accordingly, the trafficking, regulation and structure-function of ABCB-type auxin transporters are especially emphasized in this book.

Abc Transporters And Multidrug Resistance

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Author : Ahcène Boumendjel
language : en
Publisher: John Wiley & Sons
Release Date : 2009-06-17

Abc Transporters And Multidrug Resistance written by Ahcène Boumendjel and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-17 with Medical categories.

A comprehensive review of the most current scientific research on ABC transporters and multidrug resistance ATP-binding cassette transporter genes (ABC transporters) are known to play a crucial role in the development of multidrug resistance (MDR). MDR is the ability of pathologic cells, such as tumors, to withstand chemicals designed to target and destroy such cells. In MDR, patients who are on medication eventually develop resistance to not only the drug they are taking, but to several different types of drugs. ABC Transporters and Multidrug Resistance offers an essential resource for pharmaceutical researchers who are working to discover drugs to counteract multidrug resistance in diseases such as cancer. In one comprehensive volume, this book contains a collection of the most current knowledge on the involvement of ABC transporters in drug transport and resistance. This comprehensive volume provides an overview on the description of the structure, the genome, normal tissue expression, physiological aspect, and mechanism of action of the ABC protein. The expert contributors explore the expression, detection, and implications of ABC proteins in hematological malignancies and solid tumors and ABC proteins and pathogenic microorganisms. This volume also explains MDR modulation through inhibition of ABC transporters and the design of inhibitors and mechanism of action. In addition, the book offers essential information on the biological and clinical aspect of multidrug resistance.

Encyclopedia Of Molecular Pharmacology

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Author : Stefan Offermanns
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-08-14

Encyclopedia Of Molecular Pharmacology written by Stefan Offermanns and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-08-14 with Medical categories.

An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.