Acetylcholine Sigma Receptors Cck And Eicosanoids Neurotoxins
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Acetylcholine Sigma Receptors Cck And Eicosanoids Neurotoxins
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Author : T. W. Stone
language : en
Publisher: Taylor & Francis
Release Date : 1993
Acetylcholine Sigma Receptors Cck And Eicosanoids Neurotoxins written by T. W. Stone and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Acetylcholine categories.
Alzheimer Disease
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Author : Ezio Giacobini
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Alzheimer Disease written by Ezio Giacobini and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Since the apoE4 allele is a risk factor or susceptibility gene in late-onset familial and sporadic AD, the mechanism of disease expression may involve metabolic effects that are isoform specific. Isoform-specific interactions of apoE therefore become critical in the mechanism of AD pathogenesis. Detailed characterization of the binding of the apoE isoforms with proteins and peptides relevant to the pathology of the disease may be critical in understanding disease pathogenesis. These critical isoform-specific interactions of apoE may involve interactions with proteins and pep tides in the defining neuropathologic lesions of the disease, the neurofibrillary tangle and senile plaque. Other possible critical isoform-specific interactions include the mechanism of internalization, intracellular trafficking, and subsequent metabolism. In addition, differential post-translational modifications of apoE isoforms may determine differences in metabolism contributing to the pathogenesis of the disease. Oxidation of apoE may confer several isoform-specific, biochemically distinct properties. Since {3A peptide binds apoE in the lipoprotein binding domain of the protein and not in the receptor-binding domain, apoE could target bound {3A4 peptide to neurons via the LRP receptor. Internalization of the apoEI {3A peptide complex into the cell, by the same route as the apoE-containing lipoproteins, would result in incorporation into primary lysosomes and pH dependent dissociation. The demonstration of apoE in the cytoplasm of neurons, with isoform-specific interactions of apoE with the microtubule-binding protein tau demonstrated in vitro, suggest additional, testable hypotheses of disease pathogenesis.
Neuropharmacology Of Polyamines
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Author : Chris Carter
language : en
Publisher: Academic Press
Release Date : 1994-09-16
Neuropharmacology Of Polyamines written by Chris Carter and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-09-16 with Medical categories.
Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields of life sciences. Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas. Polyamines have had a hard time competing for research interest. As anyone who has studied polyamines knows, it is possible to observe some sort of polyamine effects in almost any assay system at high concentrations, and their generality of action has obviously been a deterrent to intensive research. Most of the research is concentrated in the field of cancer and relatively little polyamine research is neuroscience related, although in 1926 spermine (then known as neuridine) was first isolated from brain tissue. Further research revealed the existence of uptake and release mechanisms for brain polyamines, as seen with other substances more commonly accepted as neurotransmitters. Polyamines were also found to lay a regulatory role in cellular calcium homeostasis and to have a metabolism that is deregulated in response to cerebral trauma or ischaemia, and finally to modulate the NMDA receptor. It was this last effect which tipped the balance in favour of intensive research into polyamines in the brain. Despite their ubiquity and demonstrated links with many important physiological regulatory processes, there is no coherent hypothesis to explain their presence or role in cellular physiology. This book does not provide such a hypothesis, but attempts to group the known effects and properties of polyamines as applied to neuroscience and to stimulate interest in this field. The polyamines are deliberately treated as neuromodulators or neurotransmitters with an important and specific function in brain. This assumption is far from proven, but it is hoped that enough interest in this research area will be stimulated which will result in a more precise definition of polyamine function in the future.
British Book News
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Author : British Council
language : en
Publisher:
Release Date : 1993
British Book News written by British Council and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Best books categories.
Includes no. 53a: British wartime books for young people.
Index Of Conference Proceedings
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Author : British Library. Document Supply Centre
language : en
Publisher:
Release Date : 1993
Index Of Conference Proceedings written by British Library. Document Supply Centre and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Congresses and conventions categories.
The Journal Of Neuroscience
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Author :
language : en
Publisher:
Release Date : 1995
The Journal Of Neuroscience written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Neurology categories.
Whitaker S Books In Print
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Author :
language : en
Publisher:
Release Date : 1998
Whitaker S Books In Print written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Bibliography, National categories.
Sigma Receptors
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Author : Rae R. Matsumoto
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-02-15
Sigma Receptors written by Rae R. Matsumoto and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-02-15 with Medical categories.
This book provides an update on sigma receptors, and summarizes recent advances in the medicinal chemistry, molecular biology, and cell biology of sigma receptors. It describes the functional effects mediated by these receptors and the potential clinical implications of these actions. The information is put in a historical perspective. This provides a launching point from which future studies and research directions can easily be developed.
Drug Discovery And Evaluation Pharmacological Assays
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Author : Hans Vogel
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-10-30
Drug Discovery And Evaluation Pharmacological Assays written by Hans Vogel and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-30 with Medical categories.
The new edition of this successful reference offers both cutting-edge and classic pharmacological methods. Thoroughly revised and expanded to two volumes, it offers an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Every chapter has been updated, and numerous assays have been added. Each of the more than 1,000 assays comprises a detailed protocol outlining purpose and rationale, and a critical assessment of the results and their pharmacological and clinical relevance.
Neurotransmitters Drugs And Brain Function
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Author : Roy Webster
language : de
Publisher: John Wiley & Sons
Release Date : 2001-11-28
Neurotransmitters Drugs And Brain Function written by Roy Webster and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-11-28 with Medical categories.
Neurotransmitters, Drugs and Brain Function aims to link basic aspects of the activity of neurotransmitters at the receptor and synaptic level with their role in normal brain function, disease states, and drug action. Thus, the material considers to what extent our knowledge of the central synaptic action of certain drugs can explain their possible roles in the cause of diseases and in the modes of action of drugs effective in those conditions. It offers a working explanation of drug and neurotransmitter action in CNS function, with a clear, comprehensive, and challenging style of writing. The authors review the chemical basis for drugs and the conditions they treat. It also, includes numerous illustrations and schematic diagrams.