Activity Dependent Regulation Of Neuronal Excitability In Hippocampal Neurons
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Activity Dependent Regulation Of Neuronal Excitability In Hippocampal Neurons
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Author : Karunesh Ganguly
language : en
Publisher:
Release Date : 2002
Activity Dependent Regulation Of Neuronal Excitability In Hippocampal Neurons written by Karunesh Ganguly and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
Neuromodulation
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Author : Leonard K. Kaczmarek
language : en
Publisher: Oxford University Press, USA
Release Date : 1987
Neuromodulation written by Leonard K. Kaczmarek and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Medical categories.
This volume provides an introduction to the general principles of neuromodulation--the key neurobiological process for understanding how the brain works. Emphasizing ion channels and biochemical mechanisms of protein phosphorylation, the book shows how neurons regulate their intracellular calcium concentration by modulating the activity of certain ion channels. It goes on to explain the function of intracellular calcium and describes some fascinating neuromodulatory phenomena in the mammalian brain that have long awaited the kind of mechanistic investigations possible in simpler systems. Bridging the gap between neurochemistry and neurophysiology, the authors make complex concepts and research approaches comprehensible to scientists in either field.
Activity Dependent Regulation Of The Synaptic Action Of Neurotrophin
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Author : Lisa M. Boulanger
language : en
Publisher:
Release Date : 1998
Activity Dependent Regulation Of The Synaptic Action Of Neurotrophin written by Lisa M. Boulanger and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with categories.
Regulation Of Hippocampal Pyramidal Neuron Excitability By Subthreshold Voltage Dependent Conductances
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Author : Jason Yamada-Hanff
language : en
Publisher:
Release Date : 2015
Regulation Of Hippocampal Pyramidal Neuron Excitability By Subthreshold Voltage Dependent Conductances written by Jason Yamada-Hanff and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
The single neuron's decision of whether to fire an action potential is the central computation underlying neural function. This transformation of synaptic inputs into an output pattern of spikes is controlled by the interaction of synaptic input with the neuron's intrinsic membrane properties. During this process, the neural membrane is not just a passive receiver of input but reacts dynamically to input via the activity and modulation of ion channels that are active below the action potential threshold. The goal of this work was to examine how such subthreshold voltage-dependent conductances contribute to the electrical function of hippocampal CA1 pyramidal neurons.
Regulation Of Voltage Gated K Currents In Motor Neurons
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Author : Dalia Salloum
language : en
Publisher:
Release Date : 2017
Regulation Of Voltage Gated K Currents In Motor Neurons written by Dalia Salloum and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Neuronal output is shaped by extrinsic modulation as well as modulation of intrinsic properties of individual neurons, mediated by activity-dependent changes in the expression levels of voltage-gated ionic currents. Activity-dependent regulation of ionic currents is a mechanism by which electrical output of a neuron feeds back onto the expression of its own ion channels to alter cellular excitability in response to stimuli. Neurons alter their intrinsic properties to achieve long lasting changes involved in development, learning and memory formation and vital functions of organ systems such as locomotion and digestion. At the same time, plasticity of neuronal excitability driven by previous experience requires mechanisms to promote stability to maintain physiological function, and many examples of this type of homeostatic plasticity changes have been reported. At the same time, neuromodulation can alter electrical output indirectly via ligand-gated receptors and second messenger pathways and potentially affect activity-dependent effects. Activity-dependent regulation of ionic currents functions to allow neurons to track their own electrical activity and adjust their intrinsic properties in response to changing synaptic drive or other inputs to maintain their functional output. This phenomenon has been demonstrated to occur over the course of minutes and is a relatively fast process. Neuromodulators exert long-term effects on ionic currents via activation of cellular signaling pathways that do not directly affect ionic current levels. Neuromodulation and activity-dependent effects can alter neuronal networks on different time scales, e.g. over several hours to days to accommodate the needs of the behaving organism such as in transitions between sleep and waking states. However, this is not necessarily so, and the possibility of real-time interactions exist and needs to be examined.
Activity Dependent Plasticity Of The Intrinsic Membrane Excitability In Hippocampal Ca1 Pyramidal Neurons
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Author : Yuan Fan
language : en
Publisher:
Release Date : 2005
Activity Dependent Plasticity Of The Intrinsic Membrane Excitability In Hippocampal Ca1 Pyramidal Neurons written by Yuan Fan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with categories.
The Hippocampus Book
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Author : Per Andersen
language : en
Publisher: Oxford University Press
Release Date : 2007
The Hippocampus Book written by Per Andersen and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Medical categories.
The hippocampus is one of a group of remarkable structures embedded within the brain's medial temporal lobe. Long known to be important for memory, it has been a prime focus of neuroscience research for many years. The Hippocampus Book promises to facilitate developments in the field in a major way by bringing together, for the first time, contributions by leading international scientists knowledgeable about hippocampal anatomy, physiology, and function. This authoritative volume offers the most comprehensive, up-to-date account of what the hippocampus does, how it does it, and what happens when things go wrong. At the same time, it illustrates how research focusing on this single brain structure has revealed principles of wider generality for the whole brain in relation to anatomical connectivity, synaptic plasticity, cognition and behavior, and computational algorithms. Well-organized in its presentation of both theory and experimental data, this peerless work vividly illustrates the astonishing progress that has been made in unraveling the workings of the brain. The Hippocampus Book is destined to take a central place on every neuroscientist's bookshelf.
From Neuroscience To Neurology
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Author : Stephen Waxman
language : en
Publisher: Elsevier
Release Date : 2004-11-05
From Neuroscience To Neurology written by Stephen Waxman and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-11-05 with Medical categories.
The field of neurology is being transformed, from a therapeutically nihilistic discipline with few effective treatments, to a therapeutic specialty which offers new, effective treatments for disorders of the brain and spinal cord. This remarkable transformation has bridged neuroscience, molecular medicine, and clinical investigation, and represents a major triumph for biomedical research. This book, which contains chapters by more than 29 internationally recognized authorities who have made major contributions to neurotherapeutics, tells the stories of how new treatments for disabling disorders of the nervous system, such as stroke, multiple sclerosis, Parkinson’s disease, and migraine, were developed, and explores evolving themes and technologies that offer hope for even more effective treatments and ultimately cures for currently untreatable disorders of the brain and spinal cord. The first part of this book reviews the development of new therapies in neurology, from their inception in terms of basic science to their introduction into the clinical world. It also explores evolving themes and new technologies. This book will be of interest to everyone – clinicians and basic scientists alike – interested in diseases of the brain and spinal cord, and in the quest for new treatments for these disorders. * Presents the evolution of the field of neurology into a therapeutic discipline * Discusses lessons learned from past successes and applications to ongoing work* Explores the future of this field
Cellular And Molecular Neurophysiology
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Author : Constance Hammond
language : en
Publisher: Elsevier
Release Date : 2024-06-03
Cellular And Molecular Neurophysiology written by Constance Hammond and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-03 with Psychology categories.
Cellular and Molecular Neurophysiology, Fifth Edition is the only up-to-date textbook on the market that focuses on the molecular and cellular physiology of neurons and synapses. Hypothesis-driven rather than a dry presentation of the facts, the book promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in graduate-level courses on the topic alike. This new edition explains the molecular properties and functions of excitable cells in detail and teaches students how to construct and conduct intelligent research experiments. The content is firmly based on numerous experiments performed by top experts in the field. The new edition contains new chapters on recording neuronal activity, iconotrophic and metabotropic receptors for sensory transduction, and a section containing exercises for further learning. This book will be a useful resource for neurophysiologists, neurobiologists, neurologists, and students taking graduate-level courses on neurophysiology. Authoritative foundational coverage of basic cellular and molecular neurophysiology Includes new chapters on recording neuronal activity, iconotrophic and metabotropic receptors for sensory transduction Provides fifteen appendices that describe how neurobiological techniques are interspersed in the text Presents enhanced coverage of new methodologies and experimental techniques
Extrasynaptic Gabaa Receptors
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Author : Adam C. Errington
language : en
Publisher: Springer
Release Date : 2014-09-22
Extrasynaptic Gabaa Receptors written by Adam C. Errington and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-22 with Medical categories.
GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed “tonic” inhibition, has been described. Whereas synaptic GABAA receptors underlie classical “phasic” GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes.