Extrasynaptic Gabaa Receptors
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Extrasynaptic Gabaa Receptors
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Author : Adam C. Errington
language : en
Publisher: Springer
Release Date : 2014-09-22
Extrasynaptic Gabaa Receptors written by Adam C. Errington and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-22 with Medical categories.
GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed “tonic” inhibition, has been described. Whereas synaptic GABAA receptors underlie classical “phasic” GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes.
Diversity And Functions Of Gaba Receptors A Tribute To Hanns M Hler Part A
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Author :
language : en
Publisher: Academic Press
Release Date : 2015-01-12
Diversity And Functions Of Gaba Receptors A Tribute To Hanns M Hler Part A written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-12 with Medical categories.
This new volume of Advances in Pharmacology presents the diversity and functions of GABA Receptors. The volume looks at research performed in the past 20 years which has revealed specific physiological and pharmacological functions of individual GABAA receptor subtypes, providing novel opportunities for drug development. Contributions from the best authors in the field An essential resource for pharmacologists, immunologists, and biochemists
Diversity And Functions Of Gaba Receptors A Tribute To Hanns M Hler Part B
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Author :
language : en
Publisher: Academic Press
Release Date : 2015-01-27
Diversity And Functions Of Gaba Receptors A Tribute To Hanns M Hler Part B written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-27 with Science categories.
Diversity and Functions of GABA Receptors: A Tribute to Hanns Möhler, Part B, a new volume of Advances in Pharmacology, presents the diversity and functions of GABA Receptors. The volume looks at research performed in the past 20 years, which has revealed specific physiological and pharmacological functions of individual GABAA receptor subtypes, providing novel opportunities for drug development. Contributions from the best authors in the field An essential resource for pharmacologists, immunologists, and biochemists
Gaba Receptors Advances In Research And Application 2012 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-12-26
Gaba Receptors Advances In Research And Application 2012 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-26 with Medical categories.
GABA Receptors—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about GABA Receptors. The editors have built GABA Receptors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about GABA Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of GABA Receptors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Gaba Receptors Advances In Research And Application 2013 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2013-06-21
Gaba Receptors Advances In Research And Application 2013 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-21 with Medical categories.
GABA Receptors—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about GABA-A Receptors. The editors have built GABA Receptors—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about GABA-A Receptors in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of GABA Receptors—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Gaba Receptors Advances In Research And Application 2011 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-01-09
Gaba Receptors Advances In Research And Application 2011 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-09 with Medical categories.
GABA Receptors: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about GABA Receptors in a concise format. The editors have built GABA Receptors: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about GABA Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of GABA Receptors: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Gaba
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Author : Chikako Tanaka
language : en
Publisher: Springer Science & Business Media
Release Date : 1996
Gaba written by Chikako Tanaka and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Medical categories.
Highlighting the current developments and future directions in GABA research, the ambitious aim of this topical volume is to cover GABA from the molecular mechanisms of its transmission to new targets for pharmaceutical research. Distinguished scientists at the forefront of GABA research were invited to contribute reviews on glutamate decarboxylase and autoimmunity, molecular structure and functional regulation of GABA transporters, transmitter release and GABA receptor regulation, GABA receptor subtypes and functional regulation, and GABA receptor ligands and their therapeutic application. Describing the latest advances in what has become a rapidly-evolving field, this volume will prove immensely valuable to neuroscientists, pharmacologists, biochemists, and physiologists working in the field of GABA research.
Gaba And The Basal Ganglia
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Author : J. M. Tepper
language : en
Publisher: Elsevier
Release Date : 2007-04-17
Gaba And The Basal Ganglia written by J. M. Tepper and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-04-17 with Science categories.
Over the past 25 years the amount of data pertaining to the GABAergic function in the basal ganglia has increased dramatically. GABA and the Basal Ganglia - From Molecules to Systems is a comprehensive review of the current state-of-the-art of knowledge about the neuroanatomy, neuropharmacology and neurophysiology of the basal ganglia, focusing on its GABAergic microcircuitry. It serves as a complete reference to the body of knowledge about the basal ganglia, its constituent neurons, and their interconnections. This volume is designed to serve as a convenient all-in-one review and reference for experienced basal ganglia researchers as well as an introduction to the functional organization of the basal ganglia and its GABAergic circuitry for students and researchers new to the field. * Reviews the anatomy, physiology and pharmacology of the basal ganglia itself in addition to focusing on the GABAergic circuitry of the basal ganglia * Authors of each chapter leading internationally acclaimed experts in basal ganglia research
The Gaba Receptors
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Author : Salvatore J. Enna
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-17
The Gaba Receptors written by Salvatore J. Enna and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-17 with Medical categories.
The Gaba Receptors, Third Edition, presents a critical appraisal of our current understanding of the molecular, behavioral, biochemical, clinical, and pharmacological properties of GABA receptors. Emphasis is placed on exploring cutting-edge findings on the structureal properties of receptor sites, mechanisms of receptor expression, chemical agents that differentiate receptor subtypes, and phenotypes displayed by GABA receptor null mice. Chapters in this updated and expanded edition examine such topics as GABA receptor subypes, trafficking postsynaptic GABA receptors, GABA receptor mutations associated with idiopathic generalized epilepsies and febrile seizures, and GABA receptors as a potential therapeutic target.
Tonic Gaba Subscript A Receptors In Hippocampal Pyramidal Neurons And Their Sensitivity To General Anesthetics Microform
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Author : Valerie Bessy Caraiscos
language : en
Publisher: Library and Archives Canada = Bibliothèque et Archives Canada
Release Date : 2004
Tonic Gaba Subscript A Receptors In Hippocampal Pyramidal Neurons And Their Sensitivity To General Anesthetics Microform written by Valerie Bessy Caraiscos and has been published by Library and Archives Canada = Bibliothèque et Archives Canada this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
Gamma-Aminobutyric acid (GABA) plays a key role in mediating inhibitory neurotransmission in the central nervous system (CNS). Several studies have shown that GABA mediates two distinct forms of inhibition: transient inhibitory postsynaptic currents (IPSCs) and tonic inhibition that is thought to be generated by extrasynaptic GABA type A (GABAA) receptors. Here, we demonstrate that the tonic form of inhibition in hippocampal pyramidal neurons is generated by a distinct subpopulation of GABAA receptors, specifically, alpha5 subunit-containing GABAA (alpha5GABAA) receptors that have different pharmacological and kinetic properties compared to postsynaptic receptors. Tonic GABAA receptors have alpha5beta2/3gamma2 pharmacological characteristics. alpha5GABAA receptors are well-suited to detect low, persistent, ambient concentrations of GABA in the extracellular space as they are highly sensitive to GABA and desensitize slowly. Several studies have shown that alpha5GABAA receptors are important in memory processes, as reduced expression or pharmacological inhibition is associated with improved memory performance. We examine the effects of low concentrations of the volatile anesthetic, isoflurane (ISO), on the tonic current and show that the alpha5 subunit is necessary for enhancement of the tonic conductance by low concentrations of ISO in hippocampal pyramidal neurons. Studies of human recombinant GABAA receptors show that low concentrations of ISO potentiate GABA-evoked current mediated by alpha5beta3gamma2L but not alpha1beta3gamma2L receptors and that ISO is more efficacious at alpha5GABAA receptors. These studies provide the foundation for investigating an association between increased tonic GABAergic inhibition in the hippocampus and the effects of anesthetics on memory.