Adenylyl Cyclase Isoforms As Potential Drug Targets
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Adenylyl Cyclase Isoforms As Potential Drug Targets
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Author : Tarsis Brust
language : en
Publisher: Frontiers Media SA
Release Date : 2023-01-09
Adenylyl Cyclase Isoforms As Potential Drug Targets written by Tarsis Brust and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-09 with Science categories.
Neuropathology Of Drug Addictions And Substance Misuse Volume 3
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Author : Victor R. Preedy
language : en
Publisher: Academic Press
Release Date : 2016-04-25
Neuropathology Of Drug Addictions And Substance Misuse Volume 3 written by Victor R. Preedy and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-25 with Science categories.
Neuropathology of Drug Addictions and Substance Misuse, Volume 3: General Processes and Mechanisms, Prescription Medications, Caffeine and Areca, Polydrug Misuse, Emerging Addictions and Non-Drug Addictions is the third of three volumes in this informative series and offers a comprehensive examination of the adverse consequences of the most common drugs of abuse. Each volume serves to update the reader’s knowledge on the broader field of addiction as well as to deepen understanding of specific addictive substances. Volume 3 addresses prescription medications, caffeine, polydrug misuse, and non-drug addictions. Each section provides data on the general, molecular, cellular, structural, and functional neurological aspects of a given substance, with a focus on the adverse consequences of addictions. Research shows that the neuropathological features of one addiction are often applicable to those of others, and understanding these commonalties provides a platform for studying specific addictions in more depth and may ultimately lead researchers toward new modes of understanding, causation, prevention and treatment. However, marshalling data on the complex relationships between addictions is difficult due to the myriad of material and substances. Offers a modern approach to understanding the pathology of substances of abuse, offering an evidence-based ethos for understanding the neurology of addictions Fills an existing gap in the literature by serving as a “one-stop-shopping synopsis of everything to do with the neuropathology of drugs of addiction and substance misuse Includes in each chapter: list of abbreviations, abstract, introduction, applications to other addictions and substance misuse, mini-dictionary of terms, summary points, 6+ figures and tables, full references Offers coverage of preclinical, clinical, and population studies, from the cell to whole organs, and from the genome to whole body
The Neuroscience Of Depression
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Author : Colin R Martin
language : en
Publisher: Academic Press
Release Date : 2021-03-05
The Neuroscience Of Depression written by Colin R Martin and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-05 with Psychology categories.
The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is a comprehensive reference to the aspects, features and effects of depression. This book provides readers with the behavior and psychopathological effects of depression, linking anxiety, anger and PSTD to depression. Readers are provided with a detailed outline of the genetic aspects of depression including synaptic genes and the genome-wide association studies (GWAS) of depression, followed by a thorough analysis of the neurological and imaging techniques used to study depression. This book also includes three full sections on the various effects of depression, including diet, nutrition and molecular and cellular effects. The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is the only resource for researchers and practitioners studying depression. Features a section on neurological and imaging, including SPECT Neuroimaging Analyzes how diet and nutrition effect depression Examines the molecular and cellular effects of depression Covers genetics of depression Includes more than 250 illustrations and tables
Encyclopedia Of Signaling Molecules
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Author :
language : en
Publisher:
Release Date : 19??
Encyclopedia Of Signaling Molecules written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 19?? with categories.
Phosphodiesterases As Drug Targets
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Author : Sharron H. Francis
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-06-21
Phosphodiesterases As Drug Targets written by Sharron H. Francis and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-06-21 with Medical categories.
Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.
Carotid Body A New Target For Rescuing Neural Control Of Cardiorespiratory Balance In Disease
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Author : Rodrigo Del Rio
language : en
Publisher: Frontiers Media SA
Release Date : 2016-12-12
Carotid Body A New Target For Rescuing Neural Control Of Cardiorespiratory Balance In Disease written by Rodrigo Del Rio and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-12 with Physiology categories.
The carotid body (CB) is in charge of adjusting ventilatory and cardiovascular function during changes in arterial blood gases. Regardless this essential function, the CB has been implicated in the sensing of other physiological signals such as changes in blood flow and glucose levels. More important, malfunction of the CB chemoreceptors has been associated with the progression and deterioration of several disease states such as hypertension, heart failure, renal failure, insulin resistance, diabetes and sleep apnea. Although the mechanisms involved in the alterations of the CB function in pathophysiology are currently under intense research, the development of therapeutic approaches to restore normal CB chemoreflex function remains unsolved. Recent studies showing the effect of CB denervation in pathophysiology have unveiled a key role of these arterial chemoreceptors in the development of autonomic imbalance and respiratory disturbances, and suggest that targeting the CB could represent a novel strategy to improve disease outcome. Unfortunately, classical pharmacotherapy intended to normalize CB function may be hard to establish since several cellular pathways are involved in the CB dysfunction. Augmented levels of angiotensin II, endothelin-1, cytokines and free radicals along with decreases in nitric oxide had all been related to the CB dysfunction. Moreover, changes in expression of angiotensin receptors, nitric oxide synthases and cytokines that take place within the CB tissue in pathological states also contribute to the enhanced CB chemoreflex drive. It has been shown in heart failure, hypertension and obstructive sleep apnea that the CB becomes tonically hyper-reactive. During the progression of the disease this CB chemosensory facilitation process induces central nervous system plasticity. The altered autonomic-respiratory control leads to increased cardiorespiratory distress and the deterioration of the condition. The focus of this e-book will be to cover the role of the CB in pathophysiology and to provide new evidence of the pathways involved in the maladaptive potentiation of the CB chemoreflex function. In memory of Professor Mashiko Shirahata and Professor Constancio Gonzalez.
Psychiatry
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Author : Allan Tasman
language : en
Publisher: John Wiley & Sons
Release Date : 2011-10-11
Psychiatry written by Allan Tasman and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-10-11 with Medical categories.
Extensively revised and updated this edition reflects the progress and developments in the field. With 127 chapters and over 400 contributors this book is a truly comprehensive exposition of the specialty of psychiatry. Written by well-known and highly regarded experts from around the world, it takes a patient-centered approach making it an indispensable resource for all those involved in the care of patients with psychiatric disorders. For this new edition, the section on the Neuroscientific Foundations of Psychiatry has been completely revised, with a new author team recruited by Section Editors Jonathan Polan and Eric Kandel. The final section, Special Populations and Clinical Settings, features important new chapters on today’s most urgent topics, including the homeless, restraint and geriatric psychiatry. Key features include: Coverage of the entire field of psychiatry, from psychoanalysis to pharmacology and brain imaging, including family relations, cultural influence and change, epidemiology, genetics and behavioral medicine Clinical vignettes describing current clinical practice in an attractive design Numerous figures and tables that facilitate learning and comprehension appear throughout the text Clear comparisons of the DSM-IV-TR and ICD-10 criteria for easy understanding in a global context Diagnostic and treatment decision trees to help both the novice and experienced reader The chapter on Cognitive Behavioral Therapies by Edward Friedman, Michael Thase and Jesse Wright is freely available. Please click on Read Excerpt 2 above to read this superb exposition of these important therapies.
Protein Protein Interactions As New Drug Targets
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Author : Enno Klussmann
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-05-20
Protein Protein Interactions As New Drug Targets written by Enno Klussmann and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-05-20 with Medical categories.
Disease-relevant intracellular protein-protein interactions occurring at defined cellular sites possess great potential as drug targets. They permit highly specific pharmacological interference with defined cellular functions. Drugs targeting such interactions are likely to act with fewer side effects than conventional medication influencing whole cell functions. This book discusses therapeutically relevant protein-protein interactions with a major focus on scaffolding proteins tethering signal transduction processes to defined cellular compartments by direct protein-protein interactions. Recent advances in the development of pharmacological agents interfering with protein-protein interactions are highlighted.
Xivth International Symposium On Medicinal Chemistry
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Author : F. Awouters
language : en
Publisher: Elsevier
Release Date : 1997-09-12
Xivth International Symposium On Medicinal Chemistry written by F. Awouters and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-09-12 with Science categories.
Vaso-occlusive disorders including unstable angina, myocardial infarction, transient ischemic attacks, stroke and peripheral artery disease remain the major sources of morbidity and mortality in western civilization. Platelet activation and resulting platelet aggregation play a major role in the pathogenesis of these thromboembolic diseases. Recognition of the contribution of platelets to the pathophysiology of cardiovascular disease has provided impetus for the continued search for new antiplatelet agents. Hence, over the past two decades many strategies have been evaluated in the search for efficacious mechanisms to reduce platelet function. The medical need for more efficacious antithrombotic drugs and the growing understanding of the role of platelets in vascular injury have catalyzed the extensive evaluation of novel approaches to control platelet function. Along these lines, the volume therefore provides an in-depth assessment of ongoing clinical trials, new and clinically established agents, and other developments in this rapidly developing field.
Psychiatry 2 Volume Set
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Author : Allan Tasman
language : en
Publisher: John Wiley & Sons
Release Date : 2015-03-30
Psychiatry 2 Volume Set written by Allan Tasman and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-30 with Medical categories.
Now in a new Fourth Edition, Psychiatry remains the leading reference on all aspects of the current practice and latest developments in psychiatry. From an international team of recognised expert editors and contributors, Psychiatry provides a truly comprehensive overview of the entire field of psychiatry in 132 chapters across two volumes. It includes two new sections, on psychosomatic medicine and collaborative care, and on emergency psychiatry, and compares Diagnostic and Statistical Manual (DSM-5) and International Classification of Diseases (ICD10) classifications for every psychiatric disorder. Psychiatry, Fourth Edition is an essential reference for psychiatrists in clinical practice and clinical research, residents in training, and for all those involved in the treatment psychiatric disorders. Includes a a companion website at www.tasmanpsychiatry.com featuring PDFs of each chapter and downloadable images