Admixture Dynamics Natural Selection And Diseases In Admixed Populations
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Admixture Dynamics Natural Selection And Diseases In Admixed Populations
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Author : Wenfei Jin
language : en
Publisher: Springer
Release Date : 2015-10-20
Admixture Dynamics Natural Selection And Diseases In Admixed Populations written by Wenfei Jin and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-20 with Medical categories.
In this thesis, Dr. Jin presents the distribution of ancestral chromosomal segments in the admixed genome, which could provide the information needed to explore population admixture dynamics. The author derives accurate population histories of African Americans and Mexicans using genome-wide single nucleotide polymorphisms (SNPs) data. Mapping the genetic background facilitates the study of natural selection in the admixed population, and the author identifies the signals of selection in African Americans since their African ancestors left for America. He further demonstrates that many of the selection signals were associated with African American-specific high-risk diseases such as prostate cancer and hypertension, suggesting an important role these disease-related genes might have played in adapting to their new environment. Lastly, the author reveals the complexity of natural selection in shaping human susceptibility to disease. The thesis significantly advances our understanding of the recent population admixture, adaptation to local environment and its health implications.
Admixture Dynamics Natural Selection And Diseases In Admixed Populations
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Author : Wenfei Jin
language : en
Publisher:
Release Date : 2015
Admixture Dynamics Natural Selection And Diseases In Admixed Populations written by Wenfei Jin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
In this thesis, Dr. Jin presents the distribution of ancestral chromosomal segments in the admixed genome, which could provide the information needed to explore population admixture dynamics. The author derives accurate population histories of African Americans and Mexicans using genome-wide single nucleotide polymorphisms (SNPs) data. Mapping the genetic background facilitates the study of natural selection in the admixed population, and the author identifies the signals of selection in African Americans since their African ancestors left for America. He further demonstrates that many of the selection signals were associated with African American-specific high-risk diseases such as prostate cancer and hypertension, suggesting an important role these disease-related genes might have played in adapting to their new environment. Lastly, the author reveals the complexity of natural selection in shapinghuman susceptibility to disease. The thesis significantly advances our understanding of the recent population admixture, adaptation to local environment and its health implications.
Population Genetics And Microevolutionary Theory
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Author : Alan R. Templeton
language : en
Publisher: John Wiley & Sons
Release Date : 2021-05-04
Population Genetics And Microevolutionary Theory written by Alan R. Templeton and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-04 with Science categories.
Population Genetics and Microevolutionary Theory Explore the fundamentals of the biological implications of population genetic theory In the newly revised Second Edition of Population Genetics and Microevolutionary Theory, accomplished researcher and author Alan R. Templeton delivers a fulsome discussion of population genetics with coverage of exciting new developments in the field, including new discoveries in epigenetics and genome-wide studies. The book prepares students to successfully apply population genetics analytical tools by providing a solid foundation in microevolutionary theory. The book emphasizes that population structure forms the underlying template upon which quantitative genetics and natural selection operate and is a must-read for future population and evolutionary geneticists and those who wish to work in genetic epidemiology or conservation biology. You’ll learn about a wide array of topics, including quantitative genetics, the interactions of natural selection with other evolutionary forces, and selection in heterogeneous environments and age-structured populations. Appendices that cover genetic survey techniques and probability and statistics conclude the book. Readers will also benefit from the inclusion of: A thorough introduction to population genetics, including the scope of the subject, its premises, and the Hardy-Weinberg Model of Microevolution An exploration of systems of mating, including a treatment of the use of runs of homozygosity to show pedigree inbreeding in distant ancestors A practical discussion of genetic drift, including the use of effective sizes in conservation biology (with a discussion of African rhinos as an example) A concise examination of coalescence, including a treatment of the infinite sites model Perfect for graduate students in genetics and evolutionary biology programs and advanced undergraduate biology majors, Population Genetics and Microevolutionary Theory will also earn a place in the libraries of students taking courses in conservation biology, human genetics, bioinformatics, and genomics.
Human Population Genetics And Genomics
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Author : Alan R. Templeton
language : en
Publisher: Academic Press
Release Date : 2018-11-08
Human Population Genetics And Genomics written by Alan R. Templeton and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-08 with Science categories.
Human Population Genetics and Genomics provides researchers/students with knowledge on population genetics and relevant statistical approaches to help them become more effective users of modern genetic, genomic and statistical tools. In-depth chapters offer thorough discussions of systems of mating, genetic drift, gene flow and subdivided populations, human population history, genotype and phenotype, detecting selection, units and targets of natural selection, adaptation to temporally and spatially variable environments, selection in age-structured populations, and genomics and society. As human genetics and genomics research often employs tools and approaches derived from population genetics, this book helps users understand the basic principles of these tools. In addition, studies often employ statistical approaches and analysis, so an understanding of basic statistical theory is also needed. - Comprehensively explains the use of population genetics and genomics in medical applications and research - Discusses the relevance of population genetics and genomics to major social issues, including race and the dangers of modern eugenics proposals - Provides an overview of how population genetics and genomics helps us understand where we came from as a species and how we evolved into who we are now
Cardiovascular Disease In Racial And Ethnic Minorities
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Author : Keith C. Ferdinand
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-07-07
Cardiovascular Disease In Racial And Ethnic Minorities written by Keith C. Ferdinand and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-07-07 with Medical categories.
Cardiovascular heart disease mortality in African Americans is the highest of all major racial/ethnic subpopulations in the United States. Examining race and ethnicity, Cardiovascular Disease in Racial and Ethnic Minorities will reveal that there are unacceptable healthcare disparities in risk factor prevalence, disease states, and cardiovascular outcomes in the United States. Written by a team of experts, Cardiovascular Disease in Racial and Ethnic Minorities examines to what degree biomedical and scientific literature can clarify the impact of genetic variation versus environment as related to cardiovascular disease. Chapters illustrate the magnitude of cardiovascular and metabolic disparities and the effect of environment on diseases.
Pharmacogenomics In Admixed Populations
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Author : Dr. G. Suarez-Kurtz
language : en
Publisher: CRC Press
Release Date : 2007-08-03
Pharmacogenomics In Admixed Populations written by Dr. G. Suarez-Kurtz and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-08-03 with Science categories.
Ethnic specificity has become an integral part of research in the overlapping sciences of pharmacogenetics and pharmacogenomics. Pharmacogenomics in Admixed Populations was conceived to compile pharmacogenetic/-genomic (PGx) data from peoples of four continents: Africa, America, Asia and Oceania, where admixture and population stratification occurs
Genetics And Evolution Of Infectious Diseases
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Author : Michel Tibayrenc
language : en
Publisher: Elsevier
Release Date : 2024-07-09
Genetics And Evolution Of Infectious Diseases written by Michel Tibayrenc and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-09 with Medical categories.
Genetics and Evolution of Infectious Diseases, Third Edition discusses the evolving field of infectious diseases and their continued impact on the health of populations, especially in resource-limited areas of the world where they must confront the dual burden of death and disability due to infectious and chronic illnesses. Although substantial gains have been made in public health interventions for the treatment, prevention, and control of infectious diseases, in recent decades the world has witnessed the emergence of the human immunodeficiency virus (HIV) and the COVID-19 pandemic, increasing antimicrobial resistance, and the emergence of many new bacterial, fungal, parasitic, and viral pathogens.Fully updated and revised, this new edition presents the consequences of such diseases, the evolution of infectious diseases, the genetics of host-pathogen relationship, and the control and prevention strategies that are, or can be, developed. This book offers valuable information to biomedical researchers, clinicians, public health practitioners, decisions-makers, and students and postgraduates studying infectious diseases, microbiology, medicine, and public health that is relevant to the control and prevention of neglected and emerging worldwide diseases. - Takes an integrated approach to infectious diseases - Provides the latest developments in the field of infectious diseases - Focuses on the contribution of evolutionary and genomic studies for the study and control of transmissible diseases - Includes updated and revised contributions from leading authorities, along with six new chapters
Genome Research
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Author :
language : en
Publisher:
Release Date : 2009
Genome Research written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Gene amplification categories.
On Human Nature
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Author : Michel Tibayrenc
language : en
Publisher: Academic Press
Release Date : 2016-09-12
On Human Nature written by Michel Tibayrenc and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-12 with Science categories.
On Human Nature: Biology, Psychology, Ethics, Politics, and Religion covers the present state of knowledge on human diversity and its adaptative significance through a broad and eclectic selection of representative chapters. This transdisciplinary work brings together specialists from various fields who rarely interact, including geneticists, evolutionists, physicians, ethologists, psychoanalysts, anthropologists, sociologists, theologians, historians, linguists, and philosophers. Genomic diversity is covered in several chapters dealing with biology, including the differences in men and apes and the genetic diversity of mankind. Top specialists, known for their open mind and broad knowledge have been carefully selected to cover each topic. The book is therefore at the crossroads between biology and human sciences, going beyond classical science in the Popperian sense. The book is accessible not only to specialists, but also to students, professors, and the educated public. Glossaries of specialized terms and general public references help nonspecialists understand complex notions, with contributions avoiding technical jargon. - Provides greater understanding of diversity and population structure and history, with crucial foundational knowledge needed to conduct research in a variety of fields, such as genetics and disease - Includes three robust sections on biological, psychological, and ethical aspects, with cross-fertilization and reciprocal references between the three sections - Contains contributions by leading experts in their respective fields working under the guidance of internationally recognized and highly respected editors
Index Medicus
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Author :
language : en
Publisher:
Release Date : 2004
Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medicine categories.
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.