Advances In Dna Sequence Specific Agents
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Advances In Dna Sequence Specific Agents
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Author : M. Palumbo
language : en
Publisher: Elsevier
Release Date : 1997-11-19
Advances In Dna Sequence Specific Agents written by M. Palumbo and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-11-19 with Science categories.
In this volume the entire focus is devoted to the macromolecule target specificity of DNA interactive developmental therapeutic agents of current interest. A brief introduction to DNA interactive anticancer agents is included for readers who may benefit from an overview surrounding the developments that have contributed to our general understanding of this field. The following nine chapters have been carefully chosen so that they describe topics which are at the forefront of development in DNA-targeted cancer chemotherapy. Issues that have been addressed include the mechanisms of selective DNA topoisomerase I and II poisoning by antitumor agents (Chapters 1 and 2), sequence-specific recognition of DNA by groove-binding drugs and drug-conjugates (Chapters 3 and 4), recent developments in nitrogen mustard alkylating agents and their potential use for antibody-directed enzyme-prodrug therapy (Chapter 5), nonclassical platinum anticancer complexes, including dinuclear and trans-platinum derivatives (Chapter 6), DNA cleaving antitumor chromoproteins containing reactive enediyne moieties, which exhibit interesting free-radical chemistry along with selective targeting (Chapter 7), the potential of new sequence-specific antisense and antigene therapy in oncology (Chapter 8), and finally the conceivable chemotherapeutic use of mimetics of the DNA structure, obtained by substitution of the sugar-phosphate natural chain with a peptide backbone, the so-called peptide nucleic acids (Chapter 9). Important approaches being currently investigated for selective cancer treatment, such as gene therapy and immunochemotherapy, are not discussed in this volume since they fall beyond its scope.
Advances In Dna Sequence Specific Agents
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Author : B.J. Chapman
language : en
Publisher: Elsevier
Release Date : 2002-09-17
Advances In Dna Sequence Specific Agents written by B.J. Chapman and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-09-17 with Science categories.
This series encompasses design, synthesis, application, and analytical methods (including clinical and in vitro) for the study of these critical interactions. As our understanding of the genome and proteome expands, general developments in the field of DNA sequence specific interaction are likely to play an increasingly important role. Accordingly, manuscripts have been solicited from experts covering a diverse range of fields, reflecting the cross-disciplinary and dynamic nature of the series.Volume 4 describes work on the modification of DNA by AT specific anticancer drugs, DNA alkylation events which involve metabolite generation, DNA sequence recognition by two selective binders, bulged DNA microenvironments as molecular targets, DNA sequence specific binding by short peptides and the analysis of DNA-protein interactions using DNase I footprinting methodology.Features include:• Expert contributors from the Biomedical world• Emerging areas of drug design and therapeutic applications• Nucleic acid-protein interactions• Color graphics of molecular modeling analyses• New and emerging methodologies
Advances In Dna Sequence Specific Agents
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Author : J.B. Chaires
language : en
Publisher: Elsevier
Release Date : 1996-07-09
Advances In Dna Sequence Specific Agents written by J.B. Chaires and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-07-09 with Science categories.
DNA sequence specificity is a sub-specialty in the general area of molecular recognition. This area includes macromolecular-molecular interactions (e.g., protein-DNA), oligomer-DNA interacitons (e.g., triple strands), and ligand-DNA interactions (e.g., drug-DNA). It is this latter group of DNA sequence specificity interactions that is the subject of Volumes 1 and 2 of Advances in DNA Sequence Specific Agents. As was the case for Volume 1, Part A also covers methodology, but in Volume 2 we include calorimetric titrations, molecular modeling, X-ray crystallographic and NMR structural studies, and transcriptional assays. Part B also follows the same format as Volume 1 and describes the sequence specificities and covalent and noncovalent interactions of small ligands with DNA.This volume is aimed in general at scientists who have an interest in deciphering the molecular mechanisms for sequence recognition of DNA. The methods have general applicability to small molecules as well as oligomers and proteins, while the examples provide general principles involved in sequence recognition.
Advances In Dna Sequence Specific Agents
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Author : B.J. Chapman
language : en
Publisher: Elsevier Science
Release Date : 2002-09-17
Advances In Dna Sequence Specific Agents written by B.J. Chapman and has been published by Elsevier Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-09-17 with Science categories.
This series encompasses design, synthesis, application, and analytical methods (including clinical and in vitro) for the study of these critical interactions. As our understanding of the genome and proteome expands, general developments in the field of DNA sequence specific interaction are likely to play an increasingly important role. Accordingly, manuscripts have been solicited from experts covering a diverse range of fields, reflecting the cross-disciplinary and dynamic nature of the series. Volume 4 describes work on the modification of DNA by AT specific anticancer drugs, DNA alkylation events which involve metabolite generation, DNA sequence recognition by two selective binders, bulged DNA microenvironments as molecular targets, DNA sequence specific binding by short peptides and the analysis of DNA-protein interactions using DNase I footprinting methodology. Features include: . Expert contributors from the Biomedical world . Emerging areas of drug design and therapeutic applications . Nucleic acid-protein interactions . Color graphics of molecular modeling analyses . New and emerging methodologies
Advanced Ceramics And Applications
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Author : Rainer Gadow
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2021-10-04
Advanced Ceramics And Applications written by Rainer Gadow and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-04 with Technology & Engineering categories.
New ceramic materials are highly appreciated due to their manifold features including mechanical properties, environmental uses, energy applications and many more. This work presents the latest research development and covers a broad range of topics from stabilized zirconia ceramics with enhanced functional properties to ceramic components in medical/biological applications.
Advances In Dna Sequence Specific Agents
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Author : Jones
language : en
Publisher: JAI Press
Release Date : 1999-09
Advances In Dna Sequence Specific Agents written by Jones and has been published by JAI Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-09 with Molecular biology categories.
In this volume the entire focus is devoted to the macromolecule target specificity of DNA interactive developmental therapeutic agents of current interest. A brief introduction to DNA interactive anticancer agents is included for readers who may benefit from an overview surrounding the developments that have contributed to our general understanding of this field. The following nine chapters have been carefully chosen so that they describe topics which are at the forefront of development in DNA-targeted cancer chemotherapy. Issues that have been addressed include the mechanisms of selective DNA topoisomerase I and II poisoning by antitumor agents (Chapters 1 and 2), sequence-specific recognition of DNA by groove-binding drugs and drug-conjugates (Chapters 3 and 4), recent developments in nitrogen mustard alkylating agents and their potential use for antibody-directed enzyme-prodrug therapy (Chapter 5), nonclassical platinum anticancer complexes, including dinuclear and trans-platinum derivatives (Chapter 6), DNA cleaving antitumor chromoproteins containing reactive enediyne moieties, which exhibit interesting free-radical chemistry along with selective targeting (Chapter 7), the potential of new sequence-specific antisense and antigene therapy in oncology (Chapter 8), and finally the conceivable chemotherapeutic use of mimetics of the DNA structure, obtained by substitution of the sugar-phosphate natural chain with a peptide backbone, the so-called peptide nucleic acids (Chapter 9). Important approaches being currently investigated for selective cancer treatment, such as gene therapy and immunochemotherapy, are not discussed in this volume since they fall beyond its scope.
Advances In Dna Sequence Specific Agents
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Author :
language : en
Publisher:
Release Date : 1992
Advances In Dna Sequence Specific Agents written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with categories.
Metallopharmaceuticals I
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Author : Michael J. Clarke
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-14
Metallopharmaceuticals I written by Michael J. Clarke and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-14 with Science categories.
Biological inorganic chemistry is a field of research at the interface of inorganic and biological chemistry. The rapidly developing insights into the role of metals in biological systems has far-reaching implications not only for biological science but also for related disciplines, ranging from molecular medicine to the environment. In each volume the reader, whether engaged in chemistry, biochemistry, biology or molecular medicine, receives a comprehensive summary and critical overview of a topic of high current interest written by leading international experts.
Advances In Dna Sequence Specific Agents
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Author : Laurence H. Hurley
language : en
Publisher: Elsevier Science Limited
Release Date : 1996
Advances In Dna Sequence Specific Agents written by Laurence H. Hurley and has been published by Elsevier Science Limited this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Science categories.
DNA sequence specificity is a sub-specialty in the general area of molecular recognition. This area includes macromolecular-molecular interactions (e.g., protein-DNA), oligomer-DNA interacitons (e.g., triple strands), and ligand-DNA interactions (e.g., drug-DNA). It is this latter group of DNA sequence specificity interactions that is the subject of Volumes 1 and 2 of Advances in DNA Sequence Specific Agents. As was the case for Volume 1, Part A also covers methodology, but in Volume 2 we include calorimetric titrations, molecular modeling, X-ray crystallographic and NMR structural studies, and transcriptional assays. Part B also follows the same format as Volume 1 and describes the sequence specificities and covalent and noncovalent interactions of small ligands with DNA. This volume is aimed in general at scientists who have an interest in deciphering the molecular mechanisms for sequence recognition of DNA. The methods have general applicability to small molecules as well as oligomers and proteins, while the examples provide general principles involved in sequence recognition.
Advances In Dna Sequence Specific Agents Volume 4
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Author : Chapman B. Jones
language : en
Publisher:
Release Date : 2002
Advances In Dna Sequence Specific Agents Volume 4 written by Chapman B. Jones and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.