Advances In Natural Products Discovery
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Lead Molecules From Natural Products
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Author :
language : en
Publisher: Elsevier
Release Date : 2006-07-07
Lead Molecules From Natural Products written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-07-07 with Science categories.
Lead Molecules from Natural Products: Discovery and New Trends provides the reader with a thorough overview of current discoveries and trends in Natural Products research. This book consists of 22 chapters from well known scientists all over the world, with topics ranging from Natural Product Chemistry and Phytochemistry in their most basic form, to Molecular Biology and in silico drug design. Contributors describe their own laboratory experiences, revealing their findings, the legal issues encountered. The chapters, all of equally high quality, summarize years of extensive research in each area, and provide insight in the new themes of natural product research. The information will help to predict promising leads, useful for physicians in the treatment of different diseases and disease manifestations. * Explains the effects of plant extracts on gene expression profiling. * Details medicinal plant research from around the world * Explores a variety of medicinal uses of plants from traditional remedies, to anti-cancer agents and anti-salmonella agents.
Advances In Natural Products Discovery
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Author : Ana Rita Gomes
language : en
Publisher: Nova Publishers
Release Date : 2016
Advances In Natural Products Discovery written by Ana Rita Gomes and has been published by Nova Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with MEDICAL categories.
The largely unexplored natural world harbors great biodiversity, and provides a unique and rich source of natural products with interesting pharmaceutical activities as well as potential applications for environmental protection. Over the last few years, much attention has been paid to unraveling the structural, compositional and sequential properties of bioactive compounds, but the exploration of new natural resources needs to be developed wisely while keeping sustainability principles in mind. With the help of some developed isolation techniques, researchers have been able to elucidate new extraction methods applicable to both aquatic and terrestrial organisms. Natural products have often been used in medicine, food, fragrances, and pest control. Most likely due to their easy accessibility, terrestrial plants have been the major source of medicinal products, especially for traditional or folk medicine. However, only 10% of over 250,000 plants have been investigated for biological activity. On the other hand, aquatic environments contain over 80% of world's plant and animal species. In recent years, several bioactive compounds have been extracted from various marine organisms, such as tunicates, sponges, starfish, soft corals, bryozoans, and sea cucumbers, among others. The search for new metabolites from marine organisms has resulted in the isolation of more than 10,000 metabolites, many of which are endowed with pharmacodynamic properties. These natural products are of high commercial value due to their natural source, complete biodegradable properties, lower or no toxicity, and in most cases lower cost compared to synthetic chemicals. Despite the biodiversity in the marine environment overcoming that of the terrestrial environment, the research into the use of natural marine products as pharmaceutical agents and for environmental applications is still in its early stages. In this context, this book highlights some of the most recent advances in natural product discovery over the past few years.
Natural Products
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Author : Lixin Zhang
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-17
Natural Products written by Lixin Zhang and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-17 with Medical categories.
A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.
Pharmacological Advances In Natural Product Drug Discovery
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Author :
language : en
Publisher: Academic Press
Release Date : 2020-02-21
Pharmacological Advances In Natural Product Drug Discovery written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-21 with Medical categories.
Pharmacological Advances in Natural Product Drug Discovery, Volume 87 in the Advances in Pharmacology series, presents the latest pharmacological research progresses of 8 medicinal compounds from natural products, including salvianolic acid, tanshinone, paeonol, chlorogenic acid, astragaloside, icariin, ganoderan, and febrifugine. Specific chapters to this new release include Potential Role of Paeonol on Atherosclerosis Related Cells, A Review on Salvianolic Acid, Pharmacological Advances of Tanshinones, the Natural Product of Salvia Miltiorrhiza, Pharmacological Action and Potential Targets Analysis of Major Pharmacological Effects of Chlorogenic Acid, Modern TCM: Identifying and Defining the "Medicinal Mix", Pharmacological Advances in Astragaloside IV Derived from Astragalus Membranaceus, and much more. Includes the authority and expertise of leading contributors in natural product pharmacology Provides the latest pharmacological research progresses of eight medicinal compounds from natural products Presents a thorough discussion on the compatibility of traditional medicines
Natural Products And Drug Discovery
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Author : Subhash C. Mandal
language : en
Publisher: Elsevier
Release Date : 2018-02-16
Natural Products And Drug Discovery written by Subhash C. Mandal and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-16 with Science categories.
Natural Products and Drug Discovery: An Integrated Approach provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active compounds in new ways, they are once again coming to the forefront of drug discovery. Combining the potential of traditional medicine with the refinement of modern chemical technology, the use of natural products as the basis for drugs can help in the development of more environmentally sound, economical, and effective drug discovery processes. Natural Products & Drug Discovery: An Integrated Approach reflects on the current changes in this field, giving context to the current shift and using supportive case studies to highlight the challenges and successes faced by researchers in integrating traditional medicinal sources with modern chemical technologies. It therefore acts as a useful reference to medicinal chemists, phytochemists, biochemists, pharma R&D professionals, and drug discovery students and researchers. Reviews the changing role of natural products in drug discovery, integrating traditional knowledge with modern molecular technologies Highlights the potential future role of natural products in preventative medicine Supported by real world case studies throughout
Recent Advances In Natural Products Analysis
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Author : Seyed Mohammad Nabavi
language : en
Publisher: Elsevier
Release Date : 2020-03-07
Recent Advances In Natural Products Analysis written by Seyed Mohammad Nabavi and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-07 with Science categories.
Recent Advances in Natural Products Analysis is a thorough guide to the latest analytical methods used for identifying and studying bioactive phytochemicals and other natural products. Chemical compounds, such as flavonoids, alkaloids, carotenoids and saponins are examined, highlighting the many techniques for studying their properties. Each chapter is devoted to a compound category, beginning with the underlying chemical properties of the main components followed by techniques of extraction, purification and fractionation, and then techniques of identification and quantification. Biological activities, possible interactions, levels found in plants, the effects of processing, and current and potential industrial applications are also included. Focuses on the latest analytical techniques used for studying phytochemical and other biological compounds Authored and edited by the top worldwide experts in their field Discusses the current and potential applications and predicts future trends of each compound group
Natural Products In Clinical Trials
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Author : Atta-ur- Rahman
language : en
Publisher: Bentham Science Publishers
Release Date : 2018-03-03
Natural Products In Clinical Trials written by Atta-ur- Rahman and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-03 with Medical categories.
Natural products continue to play a key role in drug development. A recent analysis of the drug market in the developed world revealed that 40% of total clinically approved drugs were either unmodified natural products or their semi-synthetic derivatives. This book series focuses on reviews of exciting new bioactive natural products that have huge potential as drugs. It highlights the everlasting importance of natural products in our lives. Each volume brings reviews contributed by eminent scientists in the field. The first volume covers the following topics: - bioactive compounds from marine invertebrates - natural product derived drugs for immunological and inflammatory diseases - clinical trials of curcumin, camptothecin, astaxanthin, and biochanin - antibacterial and antifungal drugs from natural sources - natural products as anti-HIV medicines.
Drug Discovery From Natural Products
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Author : Olga Genilloud
language : en
Publisher: Royal Society of Chemistry
Release Date : 2012
Drug Discovery From Natural Products written by Olga Genilloud and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.
An integrated review of the most recent trends in natural products, drug discovery, and key lead candidates that are outstanding for their chemistry and biology in novel drug development.
Plant Derived Natural Products
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Author : Anne E. Osbourn
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-07-07
Plant Derived Natural Products written by Anne E. Osbourn and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-07-07 with Science categories.
Plants produce a huge array of natural products (secondary metabolites). These compounds have important ecological functions, providing protection against attack by herbivores and microbes and serving as attractants for pollinators and seed-dispersing agents. They may also contribute to competition and invasiveness by suppressing the growth of neighboring plant species (a phenomenon known as allelopathy). Humans exploit natural products as sources of drugs, flavoring agents, fragrances and for a wide range of other applications. Rapid progress has been made in recent years in understanding natural product synthesis, regulation and function and the evolution of metabolic diversity. It is timely to bring this information together with contemporary advances in chemistry, plant biology, ecology, agronomy and human health to provide a comprehensive guide to plant-derived natural products. Plant-derived natural products: synthesis, function and application provides an informative and accessible overview of the different facets of the field, ranging from an introduction to the different classes of natural products through developments in natural product chemistry and biology to ecological interactions and the significance of plant-derived natural products for humans. In the final section of the book a series of chapters on new trends covers metabolic engineering, genome-wide approaches, the metabolic consequences of genetic modification, developments in traditional medicines and nutraceuticals, natural products as leads for drug discovery and novel non-food crops.
Natural Product Chemistry For Drug Discovery
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Author : Antony D. Buss
language : en
Publisher: Royal Society of Chemistry
Release Date : 2010
Natural Product Chemistry For Drug Discovery written by Antony D. Buss and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Medical categories.
This text provides a comprehensive summary of where natural product chemistry is today in drug discovery. It covers emerging technologies and case studies and is a source of up-to-date information on the topical subject of natural products.