Advances In The Pathogenesis And Treatment Of Osteoporosis From Bench To Bedside
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Advances In The Pathogenesis And Treatment Of Osteoporosis From Bench To Bedside
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Author : Dasheng Lin
language : en
Publisher: Frontiers Media SA
Release Date : 2025-06-05
Advances In The Pathogenesis And Treatment Of Osteoporosis From Bench To Bedside written by Dasheng Lin and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-05 with Medical categories.
Osteoporosis is a progressive systemic skeletal disease characterized by bone loss, microstructural damage, decreased bone mass, and an increased risk of fracture. This condition primarily results from weakened bone formation and increased bone resorption due to various factors. With the global population aging, the incidence of osteoporosis is on the rise. It is recognized as a critical public health issue, particularly affecting the health of middle-aged and elderly individuals due to its insidious symptoms and the high risk of fractures it entails. Globally, an osteoporotic fracture occurs approximately every three seconds, encompassing vertebral fractures, hip fractures, distal forearm fractures, and more. Particularly concerning is the one-year mortality rate of individuals who experience hip fractures, reaching 20% due to various complications. Furthermore, about 50% of survivors face disability, rendering them unable to care for themselves and significantly diminishing their quality of life. This results in a substantial increase in the social and economic burden. Despite these challenges, osteoporosis remains inadequately recognized, and current drug and surgical treatments have limitations. Consequently, addressing osteoporosis and osteoporotic fractures presents an ongoing challenge. Therefore, this Research Topic invites researchers to delve into the latest advancements in understanding the pathogenesis and treatment of osteoporosis and osteoporotic fractures, with the aim of overcoming current obstacles. We welcome submissions on a wide range of topics, including but not limited to: - Research on the pathogenesis of osteoporosis, including clinical studies, basic research, and biomechanical investigations. - Advances in the treatment of osteoporotic fractures, encompassing drug therapy, surgical interventions, and applications of polymer materials.
Bone Cancer
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Author : Dominique Heymann
language : en
Publisher: Academic Press
Release Date : 2021-09-23
Bone Cancer written by Dominique Heymann and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-23 with Science categories.
Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside, Third Edition comprehensively investigates key discoveries in the field of bone biology. New aspects of bone cancer biology are treated in new chapters covering exosomes, autophagy, and metabolism. These have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Third Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with 40% new material. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases. This revision opens the door to myeloma with two short chapters dedicated to this bone-associated disease. - Covers the broad field of bone sarcomas and bone metastases from basic research to clinical approaches - Presents comprehensive and translational overview of biological and clinical aspects of bone cancers, discussing pathophysiology from genetic and molecular levels using the most recent evidence - Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system - Offers insights to research clinicians (oncologists and radiologists) into understanding the molecular basis of bone cancer, leading to more well-informed diagnoses and treatment of tumors and metastases - Offers insights to bone biologists into how clinical observations and practices can feed back into the research cycle and, therefore, can contribute to the development of more targeted genomic and proteomic assays
Innovative Bioceramics In Translational Medicine Ii
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Author : Andy H. Choi
language : en
Publisher: Springer Nature
Release Date : 2022-01-01
Innovative Bioceramics In Translational Medicine Ii written by Andy H. Choi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-01 with Science categories.
This book is part of a two-part volume book that highlights the latest advances in innovative bioceramics applied in the highly interdisciplinary area referred to as “translational medicine”. This volume predominantly written by surgeons in the fields of craniomaxillofacial, orthopedics, and spinal surgery, examines the translation of innovative bioceramics and bioceramics-based composite from the laboratory to a personalized surgical environment for the repair of damaged and diseased bone tissues. This book also covers the topic of osteoporosis, a skeletal disorder in which the World Health Organization (WHO) has recognized it as a public health emergency due to the high number of subjects who exhibited the disease and the morbidity and mortality related to fractures. The book caters to biomaterials researchers and medical clinicians who are interested in incorporating innovative bioceramics to the above-mentioned applications.
Latest Research On Breast Cancer Molecular Insights Diagnostic Advances And Therapeutic Innovations
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Author :
language : en
Publisher: BoD – Books on Demand
Release Date : 2025-05-28
Latest Research On Breast Cancer Molecular Insights Diagnostic Advances And Therapeutic Innovations written by and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-28 with Medical categories.
Latest Research on Breast Cancer - Molecular Insights, Diagnostic Advances and Therapeutic Innovations brings together innovative and multidisciplinary contributions addressing one of the most complex and heterogeneous diseases in modern oncology. This volume presents a comprehensive overview of recent advances in breast cancer research, spanning from tumor biology and molecular heterogeneity to the development of diagnostic technologies and novel therapeutic strategies. The book includes state-of-the-art discussions on imaging modalities such as MRI, ultrasound, and artificial intelligence-based diagnostic tools, as well as in-depth analyses of molecular mechanisms, signaling pathways, drug resistance, and tumor microenvironmental interactions. Contributions also explore emerging strategies in drug delivery, biomarker discovery, gene expression profiling, and immunological insights into metastasis, including the role of the microbiota and immune cell interactions in the bone metastatic niche. By integrating basic science, translational research, and clinical applications, this volume provides valuable perspectives for researchers, clinicians, and health professionals working in oncology, molecular biology, immunology, and precision medicine. The book aims to foster interdisciplinary dialogue and promote the development of innovative approaches for improving diagnosis, treatment, and patient outcomes in breast cancer. Edited by Prof. Ana Carolina Monteiro and Prof. Lulu Wang, the volume reflects contributions from international experts and provides a timely reference for those committed to advancing breast cancer research and care.
Translational Autoimmunity Volume 6
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Author : Nima Rezaei
language : en
Publisher: Elsevier
Release Date : 2023-02-20
Translational Autoimmunity Volume 6 written by Nima Rezaei and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-20 with Medical categories.
Translational Autoimmunity: Advances in Autoimmune Rheumatic Diseases, Volume Six addresses autoimmune diseases classified under the category of rheumatic diseases. Rheumatic diseases are heterogeneous groups of disorders in which inflammation affects not only joints, but also tendons, ligaments and bones. This updated release focuses on immunopathogenesis and clinical and laboratory details of rheumatic diseases, including rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis, osteoarthritis and Sjogren's syndrome, and will be of interest to researchers, students and clinicians interested in autoimmune diseases, especially rheumatic diseases. From an introduction to rheumatic diseases to diagnostic laboratory tests, and from the microbiota-immunity to cell-based therapies, the bench to bedside approach to rheumatic diseases is the main subject of discussion in this comprehensive resource. - Gives an introduction on rheumatic diseases, from bench to bedside - Describes diagnostic laboratory tests in rheumatic diseases - Meets the needs of basic scientists, clinicians and translational scientists and industry partners - Focuses on immunopathogenesis and clinical and laboratory details of rheumatic diseases
Inflammatory Immune Disease Molecular Mechanisms Translational Approaches And Therapeutics Volume Ii
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Author : Tao Xu
language : en
Publisher: Frontiers Media SA
Release Date : 2023-03-17
Inflammatory Immune Disease Molecular Mechanisms Translational Approaches And Therapeutics Volume Ii written by Tao Xu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-17 with Science categories.
Pharmacological Interventions For Osteoporosis
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Author : Andy H. Choi
language : en
Publisher: Springer Nature
Release Date : 2023-09-21
Pharmacological Interventions For Osteoporosis written by Andy H. Choi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-21 with Technology & Engineering categories.
This book provides readers a fundamental insight into the basic properties of the pharmaceutical agents used in the treatment of osteoporosis. It provides insight into mechanisms of action, updated information on clinical utility, and possible side effects associated with the use of these pharmaceutical agents. In particular, it highlights the use of two monoclonal antibodies romosozumab and denosumab in activating osteoblast differentiation and inhibiting osteoclasts. It also discusses two anabolic pharmaceutical agents, teriparatide and abaloparatide to treat osteoporosis. They have been shown to reduce the incidence of non-vertebral and vertebral fractures significantly after they were administered to patients daily as subcutaneous injections. The content of this book caters to researchers, scientists, and clinical practitioners who are interested in the treatment of osteoporosis using pharmaceutical agents.
Innate Immunity In The Context Of Osteoimmunology 2nd Edition
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Author : Cristina Sobacchi
language : en
Publisher: Frontiers Media SA
Release Date : 2021-07-01
Innate Immunity In The Context Of Osteoimmunology 2nd Edition written by Cristina Sobacchi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-01 with Science categories.
We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS. Part of the APCs for articles in this collection were financed by the Fondazione Beppe e Nuccy Angiolini ONLUS. Publisher’s note: In this 2nd edition, acknowledgment for the Fondazione Beppe e Nuccy Angiolini ONLUS has been added.
Advances In The Genetic And Epigenetic Of Bone And Joint Diseases
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Author : Fang Fang Yu
language : en
Publisher: Frontiers Media SA
Release Date : 2023-10-04
Advances In The Genetic And Epigenetic Of Bone And Joint Diseases written by Fang Fang Yu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-04 with Science categories.
Osteoporosis And The Role Of Muscle
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Author : Gordon L. Klein
language : en
Publisher: Frontiers Media SA
Release Date : 2022-07-26
Osteoporosis And The Role Of Muscle written by Gordon L. Klein and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-26 with Medical categories.