Advances In The Genetic And Epigenetic Of Bone And Joint Diseases
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Advances In The Genetic And Epigenetic Of Bone And Joint Diseases
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Author : Fang Fang Yu
language : en
Publisher: Frontiers Media SA
Release Date : 2023-10-04
Advances In The Genetic And Epigenetic Of Bone And Joint Diseases written by Fang Fang Yu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-04 with Science categories.
Genetics Of Bone Biology And Skeletal Disease
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Author : Rajesh V. Thakker
language : en
Publisher: Academic Press
Release Date : 2017-10-31
Genetics Of Bone Biology And Skeletal Disease written by Rajesh V. Thakker and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-31 with Medical categories.
Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets. Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder
Dna Methylation And Complex Human Disease
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Author : Michel Neidhart
language : en
Publisher: Academic Press
Release Date : 2015-08-11
Dna Methylation And Complex Human Disease written by Michel Neidhart and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-11 with Science categories.
DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease. Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. In addition, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases such as rheumatoid arthritis. Discusses breaking biomarker research in major disease families of current health concern and research interest, including obesity, type II diabetes, schizophrenia, and autoimmunity Summarizes advances not only relevant to cancer, but also in non-neoplastic disease, currently an emerging field Describes wholly new concepts, including the linking of metabolic pathways with epigenetics Provides translational researchers with the knowledge of both basic research and clinic applications of DNA methylation in human diseases
Novel Therapies For Combating Bone Diseases Through Advances In Bone Remodeling
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Author : Chao Liang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-17
Novel Therapies For Combating Bone Diseases Through Advances In Bone Remodeling written by Chao Liang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-17 with Science categories.
Genes Behavior And The Social Environment
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2006-12-07
Genes Behavior And The Social Environment written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-12-07 with Social Science categories.
Over the past century, we have made great strides in reducing rates of disease and enhancing people's general health. Public health measures such as sanitation, improved hygiene, and vaccines; reduced hazards in the workplace; new drugs and clinical procedures; and, more recently, a growing understanding of the human genome have each played a role in extending the duration and raising the quality of human life. But research conducted over the past few decades shows us that this progress, much of which was based on investigating one causative factor at a time—often, through a single discipline or by a narrow range of practitioners—can only go so far. Genes, Behavior, and the Social Environment examines a number of well-described gene-environment interactions, reviews the state of the science in researching such interactions, and recommends priorities not only for research itself but also for its workforce, resource, and infrastructural needs.
Community Series In Epigenetics Of The Immune Component Of Inflammation Volume Ii
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Author : Guan-Jun Yang
language : en
Publisher: Frontiers Media SA
Release Date : 2023-09-08
Community Series In Epigenetics Of The Immune Component Of Inflammation Volume Ii written by Guan-Jun Yang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-08 with Medical categories.
Epigenetics Of Aging
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Author : Trygve O. Tollefsbol
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-11-11
Epigenetics Of Aging written by Trygve O. Tollefsbol and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-11 with Medical categories.
Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.
Organotypic Models In Drug Development
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Author : Monika Schäfer-Korting
language : en
Publisher:
Release Date : 2021
Organotypic Models In Drug Development written by Monika Schäfer-Korting and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with Drug development categories.
This book provides latest findings in organotypic models in drug development and provides the scientific resonance needed in an emerging field of research in disciplines, such as molecular medicine, physiology, and pathophysiology. Today the research on human-based test systems has gained major interest and funding in the EU and the US has increased over the last years. Moreover, so-called 3R (reduce, replace, refine animal experiments) centres have been established worldwide.
Oxford Textbook Of Rheumatology
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Author : Richard A. Watts
language : en
Publisher: OUP Oxford
Release Date : 2013-10-31
Oxford Textbook Of Rheumatology written by Richard A. Watts and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-31 with Medical categories.
The field of rheumatology has undergone numerous exciting advances in recent years, especially the development of biological drugs with novel targets, made possible by rapid advances in the basic science of musculoskeletal diseases together with improved imaging techniques. This thoroughly revised fourth edition of the Oxford Textbook of Rheumatology reflects the changing face of the specialty and the many recent advances in the science, treatment, and understanding of rheumatic diseases. The focus of this comprehensive reference work is the presentation and management of rheumatic conditions at all ages. Where relevant, treatment approaches are evidence-based and cross-referenced to national and international guidelines. Each clinical chapter provides up-to-date treatment advice illustrated with clinical vignettes as appropriate, and the authors consistently emphasize the overlap of rheumatology with other disciplines. With full colour illustrations throughout and a complementary online version, the Oxford Textbook of Rheumatology, Fourth Edition is an essential reference for all trainees and specialists in the field.
Neumann S Kinesiology Of The Musculoskeletal System E Book
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Author : Donald A. Neumann
language : en
Publisher: Elsevier Health Sciences
Release Date : 2024-02-14
Neumann S Kinesiology Of The Musculoskeletal System E Book written by Donald A. Neumann and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-14 with Medical categories.
With a focus on the normal and abnormal mechanical interactions between the muscles and joints of the body, Neumann’s Kinesiology of the Musculoskeletal System, 4th Edition provides a foundation for the practice of physical rehabilitation. This comprehensive, research-based core text explores kinesiology as it relates to physical rehabilitation in a clinically relevant and accessible manner. It presents the language of human movement — and acts as a bridge between basic science and clinical management. It helps clinicians effectively address the mechanical-based changes in movement across a person’s lifespan, whether in the context of rehabilitation, recreation, or promotion of health and wellness. Full-color anatomic and kinesiologic illustrations clearly demonstrate the anatomy, functional movement, and biomechanical principles underlying movement and posture. An eBook version, included with print purchase, provides access to all the text, figures, and references, with the ability to search, customize content, make notes and highlights, and have content read aloud. The eBook included with print purchase also features multiple excellent videos of anatomic and kinesiologic principles, answers to study questions from the print book, and additional tables and figures. Evidence-based approach emphasizes the importance of research in PT decision-making. More than 900 high-quality illustrations provide visual accompaniments to clarify the material. Clinical Connections boxes at the end of each chapter highlight or expand upon a particular clinical concept associated with the kinesiology covered in the chapter. Special Focus boxes throughout the text provide numerous clinical examples to demonstrate why kinesiologic information is needed. Critical thinking questions for selected chapters reinforce the main concepts. UPDATED! Current, evidence-based content closes the gap in kinesiology and anatomy science with clinical practice. NEW! Additional Special Focus boxes and Clinical Connections boxes present kinesiology in a clinical context. UPDATED! Modified artwork and new figures visually reinforce key concepts. NEW! An eBook version, included with print purchase, provides access to all the text, figures, and references, with the ability to search, customize content, make notes and highlights, and have content read aloud. It also features videos, answers to study questions from the print book, and additional tables and figures.