Airway Mucus Basic Mechanisms And Clinical Perspectives
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Airway Mucus Basic Mechanisms And Clinical Perspectives
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Author : D.F. Rogers
language : en
Publisher: Springer Science & Business Media
Release Date : 1997-09-23
Airway Mucus Basic Mechanisms And Clinical Perspectives written by D.F. Rogers and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-09-23 with Medical categories.
Conceptually unsavoury, airway mucus is vital to homeostasis in the respiratory tract. In contrast, when abnormal, mucus contributes significantly to the pathophysiology of a number of severe bronchial diseases, including asthma, chronic bronchitis and cystic fibrosis. This volume provides wide ranging and in-depth coverage of the scientific and clinical aspects of airway mucus. It commences with introductory chapters which address the biochemical and molecular biological basis of airway mucus and continues with comprehensive coverage of the various physiological and rheological aspects of respiratory secretions. The clinical aspects of the topic are then considered, with chapters discussing the involvement of mucus secretions in bacterial infection and in hypersecretory diseases of the airway. The volume concludes with a discussion of the therapeutic aspects of the topic, both in terms of the possible approaches to the treatment of mucus hypersecretion and the interaction of these drugs with airway mucus. Written by leading experts in the field, each contribution provides a comprehensive review of its particular subject. Reflecting the latest advances in this important area of respiratory research, this volume will be of great interest to scientists and clinicians working in the field of airway secretions and related areas.
Asthma
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Author : Peter J. Barnes
language : en
Publisher: Elsevier
Release Date : 1998-04-20
Asthma written by Peter J. Barnes and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-04-20 with Medical categories.
Now available in its Third Edition, Asthma: Basic Mechanisms and Clinical Management has become the reference text in asthma. This highly successful text sheds new light on the basic physiological and molecular mechanisms of asthma, how current treatments work, and how best to apply the latest knowledge to control this important disease. The Third Edition has undergone radical revision and includes several new chapters. It retains the virtues of the previous volumes by bringing together all of the recent research findings by internationally recognized experts on the causative mechanisms of asthma, including in-depth clinical aspects and therapy. The book presents an integrated approach toward the treatment of this disease with new concepts, changes in asthma management, and the development of new therapeutic agents. Asthma provides extensive references for researchers and clinicians who need to keep abreast of recent developments in this rapidly expanding field. Comprehensive coverage of both basic science and clinical aspects of asthma Extensively referenced throughout
Clinical And Biological Basis Of Lung Cancer Prevention
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Author : Yves Martinet
language : en
Publisher: Birkhäuser
Release Date : 2012-12-06
Clinical And Biological Basis Of Lung Cancer Prevention written by Yves Martinet and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Lung cancer is a disease with pandemic public health implications as it is now the leading cause of cancer mortality throughout the world. This book results from two recent International Association for the Study of Lung Cancer (IASLC) Workshops on lung cancer prevention. It strikes a balance between considering public health approaches to tobacco control and population-based screening, advances in clinical evaluation of chemoprevention approaches, and the biology of lung carcinogenesis. Indeed, while the science of smoking cessation is evolving as new pharmacological tools are moving into clinical evaluation, the current impact of molecular diagnostics is profound. The rapidly-evolving diagnostic technologies are revolutionizing basic scientific investigation of cancer, and this trend is expected to soon spill over into the clinical practice of medicine. The evolution of economical diagnostic platforms to allow for direct bronchial epithelial evaluation in high-risk populations promises to improve the diagnostic lead-time for this disease. The hope is that enough progress will occur to permit lung cancer detection in advance of clinical cancer so that the disease can be addressed early on, while it is still confined to the site of origin. Chemoprevention, which is designed to intervene in the early phase of carcinogenesis prior to any subjective clinical manifestation of a cancer, is also generating greater research interest. Moreover, the benefit of aerosolized administration of chemoprevention agents over conventional oral administration has strong appeal and may result in the reduction of the incidence of cancer when combined with new diagnostic technologies.
Inhalation Aerosols
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Author : Anthony J. Hickey
language : en
Publisher: CRC Press
Release Date : 2019-03-21
Inhalation Aerosols written by Anthony J. Hickey and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-21 with Medical categories.
Inhalation aerosols continue to be the basis for successful lung therapy for several diseases, with therapeutic strategies and the range of technology significantly evolving in recent years. In response, this third edition takes a new approach to reflect the close integration of technology with its application. After briefly presenting the general considerations that apply to aerosol inhalation, the central section of the book uses the focus on disease and therapeutic agents to illustrate the application of specific technologies. The final integrated strategies section draws the major points from the applications for disease targets and drug products.
Mucus Hypersecretion In Respiratory Disease
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Author : Derek J. Chadwick
language : en
Publisher: John Wiley & Sons
Release Date : 2003-07-07
Mucus Hypersecretion In Respiratory Disease written by Derek J. Chadwick and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-07-07 with Science categories.
A number of chronic respiratory diseases including chronic bronchitis, asthma, cystic fibrosis and bronchiectasis are characterized by mucus hypersecretion. Following damage to the airway epithelium, a repair process of dedifferentiation, regenerative proliferation and redifferentiation takes place that is invariably accompanied by mucus hypersecretion as a key element in the host defence mechanism. In chronic respiratory diseases, however, excessive mucus production leads to a pathological state with increased risk of infection, hospitalization and morbidity. An understanding of the mechanisms that underlie and maintain this hypersecretory phenotype is therefore crucial for the development of rational approaches to therapy. Despite a high and increasing prevalence and cost to healthcare services and society, mucus hypersecretion in chronic respiratory disease has received little attention until recently, probably because of the difficulties inherent in studying this pathology. Only in the last few years have some of the genes involved in mucus secretion been characterized. The recent availability of genomic sequence information and specific antibodies has led to an explosion of interest in this area making this publication particularly timely. This book draws together contributions from an international and interdisciplinary group of experts, whose work is focused on both basic and clinical aspects of the problem. Coverage includes epidemiology, airways infection and mucus hypersecretion, the genetics and regulation of mucus production, models of mucus hypersecretion, and the implications of new knowledge for the development of novel therapies.
Autoimmune Aspects Of Lung Disease
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Author : D.A. Isenberg
language : en
Publisher: Springer
Release Date : 2012-12-06
Autoimmune Aspects Of Lung Disease written by D.A. Isenberg and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The lung forms an integral part of the body's immune system and is subject to a range of diseases which are either autoimmune in nature or have clear-cut immunological abnormalities. "Autoimmune Aspects of Lung Disease" provides a concise review of the lung's role in the immune system and a detailed account of both primary and secondary lung diseases which are characterised by immunological perturbation or frank autoimmunity. The volume presents a detailed, up-to-date account of disorders ranging from infection to neoplasia and is written in both an informative and stimulating style by a prestigious group of authors. The chapters are extensively referenced and provide numerous insights into the aetiopathogenesis and clinical features and treatment of immunologically-linked pulmonary disease. The book is intended as both an overview for physicians and scientists with an established interest in diseases of the lung, immunologists seeking to learn more about relevant disorders in the lung and general physicians, whether specialists or in training, seeking to enrich their knowledge of the links between the pulmonary and immune systems.
Muscarinic Receptors In Airways Diseases
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Author : Johan Zaagsma
language : en
Publisher: Springer
Release Date : 2013-03-08
Muscarinic Receptors In Airways Diseases written by Johan Zaagsma and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-08 with Medical categories.
What are the different muscarinic acetylcholine receptor subtypes and how are they distributed in the airways and molecular signalling mechanisms? What is their function in neurogenic and non-neurogenic control of the airways and in inflammatory mechanisms? How is their gene expression regulated? The great importance of muscarinic acetylcholine receptors for the pathophysiology and treatment of chronic inflammatory obstructive airways diseases calls for a comprehensive and integrated overview of the current knowledge to address such questions, to discuss the role of these receptor subtypes in diseases such as asthma and COPD, and to present novel perspectives on antimuscarinic drug development. The present book is the worthy result of this need. It points out innovative insights into the hitherto poorly understood role of postjunctional muscarinic M2 receptors in airway smooth muscle contraction and sheds some light on the novel concepts of antimuscarinic drug development, with special reference to the l
Clinical Management Of Chronic Obstructive Pulmonary Disease
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Author : Thomas Similowski
language : en
Publisher: CRC Press
Release Date : 2002-04-25
Clinical Management Of Chronic Obstructive Pulmonary Disease written by Thomas Similowski and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-04-25 with Medical categories.
This reference presents a comprehensive review of the most recent strategies used to assess, treat, and manage patients in each phase of chronic obstructive pulmonary disease (COPD)-offering the latest diagnostic modalities to identify and distinguish components of COPD in earlier, more reversible stages. Contains perspectives from the World Health Organization on the epidemiology and control of COPD in Africa, South America, and Eastern Europe!
Cellular Mechanisms In Airways Inflammation
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Author : Clive P. Page
language : en
Publisher: Birkhäuser
Release Date : 2013-03-11
Cellular Mechanisms In Airways Inflammation written by Clive P. Page and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-11 with Medical categories.
Airways inflammation is a complex biological phenomenon resulting from the recruitment and activation of numerous cell types. Airways inflammation contributes to the pathophysiology of airways disease. An understanding of the mechanisms that regulate inflammatory cell function is essential for the development of novel anti-inflammatory drugs for the treatment of common respiratory diseases such as asthma and COPD. This book provides a collection of valuable reviews on the major inflammatory cells involved in airways disease and examines the pharmacology of current anti-inflammatory drugs used in the treatment of airways disease. Moreover, an insight into the development of emerging drug therapies is also highlighted. This book is a must for the library of any researcher or clinician interested in the pathophysiology of airways disease.
Physiologic Basis Of Respiratory Disease
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Author : Qutayba Hamid
language : en
Publisher: PMPH-USA
Release Date : 2005
Physiologic Basis Of Respiratory Disease written by Qutayba Hamid and has been published by PMPH-USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Lung diseases categories.
Accompanying CD-ROM contains ... "the complete text and illustrations ... in fully searchable PDF files."--Page 4 of cover.