Mucus Hypersecretion In Respiratory Disease
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Mucus Hypersecretion In Respiratory Disease
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Author : Derek J. Chadwick
language : en
Publisher: John Wiley & Sons
Release Date : 2003-07-07
Mucus Hypersecretion In Respiratory Disease written by Derek J. Chadwick and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-07-07 with Science categories.
A number of chronic respiratory diseases including chronic bronchitis, asthma, cystic fibrosis and bronchiectasis are characterized by mucus hypersecretion. Following damage to the airway epithelium, a repair process of dedifferentiation, regenerative proliferation and redifferentiation takes place that is invariably accompanied by mucus hypersecretion as a key element in the host defence mechanism. In chronic respiratory diseases, however, excessive mucus production leads to a pathological state with increased risk of infection, hospitalization and morbidity. An understanding of the mechanisms that underlie and maintain this hypersecretory phenotype is therefore crucial for the development of rational approaches to therapy. Despite a high and increasing prevalence and cost to healthcare services and society, mucus hypersecretion in chronic respiratory disease has received little attention until recently, probably because of the difficulties inherent in studying this pathology. Only in the last few years have some of the genes involved in mucus secretion been characterized. The recent availability of genomic sequence information and specific antibodies has led to an explosion of interest in this area making this publication particularly timely. This book draws together contributions from an international and interdisciplinary group of experts, whose work is focused on both basic and clinical aspects of the problem. Coverage includes epidemiology, airways infection and mucus hypersecretion, the genetics and regulation of mucus production, models of mucus hypersecretion, and the implications of new knowledge for the development of novel therapies.
Airway Mucus Basic Mechanisms And Clinical Perspectives
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Author : D.F. Rogers
language : en
Publisher: Springer Science & Business Media
Release Date : 1997-09-23
Airway Mucus Basic Mechanisms And Clinical Perspectives written by D.F. Rogers and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-09-23 with Medical categories.
Conceptually unsavoury, airway mucus is vital to homeostasis in the respiratory tract. In contrast, when abnormal, mucus contributes significantly to the pathophysiology of a number of severe bronchial diseases, including asthma, chronic bronchitis and cystic fibrosis. This volume provides wide ranging and in-depth coverage of the scientific and clinical aspects of airway mucus. It commences with introductory chapters which address the biochemical and molecular biological basis of airway mucus and continues with comprehensive coverage of the various physiological and rheological aspects of respiratory secretions. The clinical aspects of the topic are then considered, with chapters discussing the involvement of mucus secretions in bacterial infection and in hypersecretory diseases of the airway. The volume concludes with a discussion of the therapeutic aspects of the topic, both in terms of the possible approaches to the treatment of mucus hypersecretion and the interaction of these drugs with airway mucus. Written by leading experts in the field, each contribution provides a comprehensive review of its particular subject. Reflecting the latest advances in this important area of respiratory research, this volume will be of great interest to scientists and clinicians working in the field of airway secretions and related areas.
Airway Secretion
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Author : Tamotsu Takishima
language : en
Publisher: CRC Press
Release Date : 1994-01-12
Airway Secretion written by Tamotsu Takishima and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-01-12 with Medical categories.
This superior single-source reference provides in-depth, up-to-date information on the cellular, molecular, morphological, and physiological aspects of airway secretion, in addition to the biochemistry, rheology, and gene expression of airway mucus. Examining submucosal gland secretion, surface goblet cell secretion, and ion (or fluid) transport across the epithelium, Airway Secretion... explores the molecular and cellular concepts of exocrine glands applicable to airway secretion describes the rheological and biochemical aspects of airway secretion defense mechanisms discusses airway secretion in pathologic conditions analyzes airway hypersecretion in cystic fibrosis, chronic bronchitis, and bronchial asthma surveys the possibilities of treating airway hypersecretion and more!
Respiratory Tract Mucus
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Author : Ruth Porter
language : en
Publisher: John Wiley & Sons
Release Date : 2009-09-16
Respiratory Tract Mucus written by Ruth Porter and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-16 with Medical categories.
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
Recent Advances In The Pathophysiology Of Copd
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Author : Trevor T. Hansel
language : en
Publisher: Springer
Release Date : 2012-12-06
Recent Advances In The Pathophysiology Of Copd written by Trevor T. Hansel and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Chronic obstructive pulmonary disease (COPD) ranges amongst the commonest diseases in the world. The relentless progression of the disease causes a pressing need for a better understanding of and therapies for COPD. This volume provides state-of-the-art information on the pathophysiology of COPD including an outlook on new therapies. It is of interest to researchers and clinicians in academia as well as in the pharmaceutical industry.
Chronic Obstructive Pulmonary Disease Pocketbook
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Author : Peter Barnes
language : en
Publisher: CRC Press
Release Date : 2023-07-14
Chronic Obstructive Pulmonary Disease Pocketbook written by Peter Barnes and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-14 with Medical categories.
This book provides an up-to-date perspective on the inflammatory cells, mediators, and molecular pathology of Chronic obstructive pulmonary disease (COPD), emphasizing the urgent need to clearly understand the underlying cellular and molecular mechanisms involved in COPD.
Chronic Obstructive Pulmonary Disease Exacerbations
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Author : Jadwiga A. Wedzicha
language : en
Publisher: CRC Press
Release Date : 2008-09-22
Chronic Obstructive Pulmonary Disease Exacerbations written by Jadwiga A. Wedzicha and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-22 with Medical categories.
Chronic Obstructive Pulmonary Disease Exacerbations covers the definition, diagnosis, epidemiology, mechanisms, and treatment associated with COPD exacerbations. This text also addresses imaging and how it plays a pivotal role in the diagnosis and study of exacerbations.Written by today's top experts, Chronic Obstructive Pulmonary Disease Exacerbat
How Tobacco Smoke Causes Disease
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Author :
language : en
Publisher:
Release Date : 2010
How Tobacco Smoke Causes Disease written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Government publications categories.
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Chronic Obstructive Pulmonary Disease
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Author : Derek J. Chadwick
language : en
Publisher: John Wiley & Sons
Release Date : 2001-01-25
Chronic Obstructive Pulmonary Disease written by Derek J. Chadwick and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-01-25 with Medical categories.
Chronic obstructive pulmonary disease (COPD) is the most common respiratory disorder of adults in the developed world and is the fourth main cause of death in the USA. It is also associated with high morbidity, and poses an enormous burden of suffering and expense. Despite this, the disease has received little attention compared with other respiratory conditions such as asthma and lung cancer. Current treatment can offer some marginal symptomatic relief but does not address the underlying disease process. Indeed, smoking cessation is the only intervention known to alter the rate of disease progression. There is clearly great need, and potential, for the development of superior therapies for symptomatic relief and disease modification. This book brings together leading researchers and physicians to discuss the most recent advances in our understanding of COPD, and draws together basic and clinical aspects relevant to the topic. Coverage includes the basic pathology, current and potential therapies, and detailed consideration of the major theories for the pathogenesis of COPD.
Abc Of Copd
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Author : Graeme P. Currie
language : en
Publisher: John Wiley & Sons
Release Date : 2010-11-04
Abc Of Copd written by Graeme P. Currie and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-04 with Medical categories.
Chronic Obstructive Pulmonary Disease (COPD) is a progressive, largely irreversible lung condition characterised by airflow obstruction. Although cigarette smoking is the single most important risk factor in its development, other associations and risk factors are thought to have increasing relevance throughout the world. COPD is usually managed in primary care, although it is commonly under-diagnosed, and is one of the most common medical conditions necessitating admission to hospital. The second edition of the ABC of COPD provides the entire multidisciplinary team with a reliable, up-to-date and accessible account of COPD. Extensively updated by experienced clinicians - including new chapters on spirometry, inhalers, oxygen, death, dying and end of life issues - this ABC is an authoritative and practical guide for general practitioners, practice nurses, specialist nurses, medical students, paramedical staff, junior doctors, non-specialist doctors and all other health professionals working in both primary and secondary care.