Altered Balance
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Altered Balance
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Author : Jeremy Reed
language : en
Publisher:
Release Date : 2019
Altered Balance written by Jeremy Reed and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Proposed Constitutional Amendments To Balance The Federal Budget
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Author :
language : en
Publisher:
Release Date : 1994
Proposed Constitutional Amendments To Balance The Federal Budget written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Business & Economics categories.
The Role Of Mitochondria Oxidative Stress And Altered Calcium Homeostasis In Amyotrophic Lateral Sclerosis From Current Developments In The Laboratory To Clinical Treatments
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Author : Manoj Kumar Jaiswal
language : en
Publisher: Frontiers Media SA
Release Date : 2017-04-17
The Role Of Mitochondria Oxidative Stress And Altered Calcium Homeostasis In Amyotrophic Lateral Sclerosis From Current Developments In The Laboratory To Clinical Treatments written by Manoj Kumar Jaiswal and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-17 with Electronic book categories.
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive, devastating and fatal disease characterized by selective loss of upper and lower motor neurons of the cerebral cortex, brainstem, spinal cord and muscle atrophy. In spite of many years of research, the pathogenesis of ALS is still not well understood. ALS is a multifaceted genetic disease, in which genetic susceptibility to motor neuron death interacts with environmental factors and there is still no cure for this deleterious disease. At present, there is only one FDA approved drug, Riluzole which according to past studies only modestly slows the progression of the disease, and improves survival by up to three months. The suffering of the ALS patients, and their families is enormous and the economic burden is colossal. There is therefore a pressing need for new therapies. Different molecular pathways and pathological mechanisms have been implicated in ALS. According to past studies, altered calcium homeostasis, abnormal mitochondrial function, protein misfolding, axonal transport defects, excessive production of extracellular superoxide radicals, glutamate-mediated excitotoxicity, inflammatory events, and activation of oxidative stress pathways within the mitochondria and endoplasmic reticulum can act as major contributor that eventually leads to loss of connection between muscle and nerve ultimately resulting to ALS. However, the detailed molecular and cellular pathophysiological mechanisms and origin and temporal progression of the disease still remained elusive. Ongoing research and future advances will likely advance our improve understanding about various involved pathological mechanism ultimately leading to discoveries of new therapeutic cures. Importantly, clinical biomarkers of disease onset and progression are thus also urgently needed to support the development of the new therapeutic agents and novel preventive and curative strategies. Effective translation from pre-clinical to clinical studies will further require extensive knowledge regarding drug activity, bioavailability and efficacy in both the pre-clinical and clinical setting, and proof of biological activity in the target tissue. During the last decades, the development of new therapeutic molecules, advance neuroimaging tools, patient derived induced stem cells and new precision medicine approaches to study ALS has significantly improved our understanding of disease. In particular, new genetic tools, neuroimaging methods, cellular probes, biomarker study and molecular techniques that achieve high spatiotemporal resolution have revealed new details about the disease onset and its progression. In our effort to provide the interested reader, clinician and researchers a comprehensive summaries and new findings in this field of ALS research, hereby we have created this electronic book which comprises of twenty seven chapters having various reviews, perspective and original research articles. All these chapters and articles in this book not only summarize the cutting-edge techniques, approaches, cell and animal models to study ALS but also provide unprecedented coverage of the current developments and new hypothesis emerging in ALS research. Some examples are novel genetic and cell culture based models, mitochondria-mediated therapy, oxidative stress and ROS mechanism, development of stem cells and mechanism-based therapies as well as novel biomarkers for designing and testing effective therapeutic strategies that can benefit ALS patients who are at the earlier stages in the disease. I am extremely grateful to all the contributors to this book and want to thank them for their phenomenal efforts. Manoj Kumar Jaiswal, Ph.D. February 5, 2017 New York, NY
The Electrolytic Balance Of Chemical Corrosion
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Author : G. Gore
language : en
Publisher:
Release Date : 1883
The Electrolytic Balance Of Chemical Corrosion written by G. Gore and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1883 with Electroforming categories.
Shifting Power In Asia Pacific
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Author : Enrico Fels
language : en
Publisher: Springer
Release Date : 2016-11-03
Shifting Power In Asia Pacific written by Enrico Fels and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-03 with Political Science categories.
This book investigates whether a power shift has taken place in the Asia-Pacific region since the end of the Cold War. By systematically examining the development of power dynamics in Asia-Pacific, it challenges the notion that a wealthier and militarily more powerful China is automatically turning the regional tides in its favour. With a special emphasis on Sino-US competition, the book explores the alleged linkage between the regional distribution of relevant material and immaterial capabilities, national power and the much-cited regional power shift. The book presents a novel concept for measuring power in international relations by outlining a composite index on aggregated power (CIAP) that includes 55 variables for 44 regional countries and covers a period of twenty years. Moreover, it develops a middle power theory that outlines the significance of middle powers in times of major power shifts. By addressing political, military and economic cooperation via a structured-focused comparison and by applying a comparative-historical analysis, the book analyses in depth the bilateral relations of six regional middle powers to Washington and Beijing.
Altered Tides
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Author : Harry F. Rey
language : en
Publisher: NineStar Press
Release Date : 2021-03-01
Altered Tides written by Harry F. Rey and has been published by NineStar Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-01 with Fiction categories.
A malfunctioning STAR drive strands Captain Ales in a new galaxy. Trapped on a dry, dusty red moon where the rains fall only once every forty years, the restless population barely survives on a teardrop ration of water. Now, the rains are years overdue, and the ruling clerics view Ales as a savior—or a devil. Just as Ales and the She-King’s brother discover a secret the clerics have been hiding for far too long, this world is invaded and torn apart from a most unlikely source. The blue moon is a world covered in water—water that flows over to the red moon as rain every forty years, thereby drying up the domain of King Sarlord. He’s finally had enough and gathers an army to sail into the sky on the waterspout, land on the red moon, and defeat the god who steals his ocean. His son, Prince Malar, will do anything to avoid staying behind, but even he gets much more than he bargained for when the world as he knows it is swept away on altered tides.
The Contemporary Review
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Author :
language : en
Publisher:
Release Date : 1897
The Contemporary Review written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1897 with Great Britain categories.
A Practical Treatise On The Poor Laws As Altered By The Poor Law Amendment Act And An Appendix Of The Statutes Etc
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Author : William Theobald
language : en
Publisher:
Release Date : 1836
A Practical Treatise On The Poor Laws As Altered By The Poor Law Amendment Act And An Appendix Of The Statutes Etc written by William Theobald and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1836 with categories.
Advanced Sports Nutrition
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Author : Dan Benardot
language : en
Publisher: Human Kinetics
Release Date : 2020-07-21
Advanced Sports Nutrition written by Dan Benardot and has been published by Human Kinetics this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-21 with Health & Fitness categories.
Use the most sophisticated sports nutrition information to help you reach your athletic performance goals. In Advanced Sports Nutrition, Third Edition, world-renowned sports nutritionist Dr. Dan Benardot combines the latest research, strategies, and sports nutrition information with his experience in academia and work with elite athletes to help you learn the following: The implications of relative energy deficiency in sport (RED-S) and within-day energy balance so you can maintain crucial energy balance throughout training and competition Optimal ratios and quantities of nutrients, vitamins, and minerals for achieving maximum power, strength, and performance How to avoid gastrointestinal distress during activity The most popular supplements and their effects on your athletic performance Strategies for balancing fluid and electrolytes to avoid dehydration and hyperhydration How to combat the effects of travel, such as jet lag, new foods, sleep disruption, and high altitude Weight-loss and body-composition issues so you can apply appropriate strategies to achieve the optimal strength-to-weight ratio for your sport Sport-specific guidelines for power sports, endurance sports, and those that require both power and endurance To further assist you in distilling the science into practice, you’ll find 13 practical nutrition guides in the appendix. Curious about pregame nutrition, hydration, high-carb snacks, or macronutrient intake? These quick reference sheets help you easily apply the principles to your own nutrition plan. With Advanced Sports Nutrition, Third Edition, you get practical advice for how best to put nutrition science to work for you. Earn continuing education credits/units! A continuing education exam that uses this book is also available. It may be purchased separately or as part of a package that includes both the book and exam.
Clinical Disorders Of Balance Posture And Gait 2ed
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Author : Adolfo Bronstein
language : en
Publisher: CRC Press
Release Date : 2004-03-29
Clinical Disorders Of Balance Posture And Gait 2ed written by Adolfo Bronstein and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-03-29 with Medical categories.
The diagnosis and treatment of the patient with critically impaired walking abilities present the busy physician with a formidable challenge. This book provides a comprehensive account of the various balance, posture and gait disorders, and of the methods for Their effective Read More ...management. The text is divided into five sections dealing wi