Alternative Toxicological Methods
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Alternative Toxicological Methods
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Author : Harry Salem
language : en
Publisher: CRC Press
Release Date : 2003-03-26
Alternative Toxicological Methods written by Harry Salem and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-03-26 with Medical categories.
Bringing together the recent and relevant contributions of over 125 scientists from industry, government, and academia in North America and Western Europe, Alternative Toxicological Methods explores the development and validation of replacement, reduction, and refinement alternatives (the 3Rs) to animal testing. Internationally recognized scientist
Alternative Methods For Toxicity Testing
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Author :
language : en
Publisher:
Release Date : 1986
Alternative Methods For Toxicity Testing written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with Animal experimentation categories.
The History Of Alternative Test Methods In Toxicology
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Author :
language : en
Publisher: Academic Press
Release Date : 2018-10-20
The History Of Alternative Test Methods In Toxicology written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-20 with Medical categories.
The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement,Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated, miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing, capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialized areas, such as inhalation toxicity studies. The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement, Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now-classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialised areas, such as inhalation toxicity studies.
Validation Of Alternative Methods For Toxicity Testing
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Author : Chantra Eskes
language : en
Publisher: Springer
Release Date : 2016-09-26
Validation Of Alternative Methods For Toxicity Testing written by Chantra Eskes and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-26 with Medical categories.
This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing. It covers the validation of experimental and computational methods and integrated approaches to testing and assessment. Validation strategies are discussed for methods employing the latest technologies such as tissue-on-a-chip systems, stem cells and transcriptomics, and for methods derived from pathway-based concepts in toxicology. Validation of Alternative Methods for Toxicity Testing is divided into two sections, in the first, practical insights are given on the state-of-the-art and on approaches that have resulted in successfully validated and accepted alternative methods. The second section focuses on the evolution of validation principles and practice that are necessary to ensure fit-for-purpose validation that has the greatest impact on international regulatory acceptance of alternative methods. In this context validation needs to keep pace with the considerable scientific advancements being made in toxicology, the availability of sophisticated tools and techniques that can be applied in a variety of ways, and the increasing societal and regulatory demands for better safety assessment. This book will be a useful resource for scientists in the field of toxicology, both from industry and academia, developing new test methods, strategies or techniques, as well as Governmental and regulatory authorities interested in understanding the principles and practicalities of validation of alternative methods for toxicity testing.
Alternative Methods For Toxicity Testing
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Author : United States Environmental Protection Agency (EPA)
language : en
Publisher: Createspace Independent Publishing Platform
Release Date : 2018-07-10
Alternative Methods For Toxicity Testing written by United States Environmental Protection Agency (EPA) and has been published by Createspace Independent Publishing Platform this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-10 with categories.
Alternative Methods for Toxicity Testing: Regulatory Policy Issues
The Status Of Alternative Methods In Toxicology
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Author : Diana Anderson
language : en
Publisher:
Release Date : 1995
The Status Of Alternative Methods In Toxicology written by Diana Anderson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Animal experimentation categories.
This book discusses the status of alternative methods in toxicology and outlines the most well established and most promising in vitro tests currently available.
Alternatives To Animal Testing
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Author : R E Hester
language : en
Publisher: Royal Society of Chemistry
Release Date : 2007-10-31
Alternatives To Animal Testing written by R E Hester and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-31 with Science categories.
Animal experimentation has long been a controversial issue with impassioned arguments on both sides of the debate. Increasingly it has become more expedient and feasible to develop new methods that avoid the use of animals. There is agreement on both sides that reduction and refinement of experiments on animals should be an important goal for the industries involved. Alternatives to Animal Testing, written by leading experts in the field, discusses the issues involved and approaches that can be taken. Topics include; the safety evaluation of chemicals, international validation and barriers to the validation of alternative tests, in vitro testing for endocrine disruptors, intelligent approaches to safety evaluation of chemicals, alternative tests and the regulatory framework. The book provides an up-to-date discussion of the current state of development of alternatives to animal testing and is ideal for professionals and academics in the field. It would also be of use for graduate students wishing to pursue a career in the pharmaceutical and cosmetic industries.
Reducing Refining And Replacing The Use Of Animals In Toxicity Testing
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Author : David G. Allen
language : en
Publisher: Royal Society of Chemistry
Release Date : 2013
Reducing Refining And Replacing The Use Of Animals In Toxicity Testing written by David G. Allen and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Medical categories.
This thought-provoking book describes the ever-expanding "toolbox" of methods now available to reduce, refine, or replace animal usage in toxicity testing.
Validation And Regulatory Acceptance Of Toxicological Test Methods
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Author : DIANE Publishing Company
language : en
Publisher: DIANE Publishing
Release Date : 1998-02
Validation And Regulatory Acceptance Of Toxicological Test Methods written by DIANE Publishing Company and has been published by DIANE Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-02 with categories.
Ntp Workshop On Validation And Regulatory Acceptance Of Alternative Toxicological Test Methods
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Author : Kenneth Olden
language : en
Publisher:
Release Date : 1997-02
Ntp Workshop On Validation And Regulatory Acceptance Of Alternative Toxicological Test Methods written by Kenneth Olden and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-02 with categories.
The purpose of the NTP Workshop on Validation & Regulatory Acceptance of Alternative Toxicological Test Methods was to receive comments & recommendations from the public & invited experts on their draft report. It provided recommended criteria & processes for the validation & regulatory acceptance of new & revised toxicological testing methods. This report is a summary of the recommend. developed by the workshop participants. One of the goals of the NTP is developing & validating improved alternative toxicological test methods. The NTP Revit. Act directed NIEHS to: establish criteria for the validation & regulatory acceptance of alternative testing methods: & to recommend a process through which scientifically validated alternative methods can be accepted for regulatory use.