An Evidence Framework For Genetic Testing

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An Evidence Framework For Genetic Testing

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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2017-03-21

An Evidence Framework For Genetic Testing written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-21 with Medical categories.

Advances in genetics and genomics are transforming medical practice, resulting in a dramatic growth of genetic testing in the health care system. The rapid development of new technologies, however, has also brought challenges, including the need for rigorous evaluation of the validity and utility of genetic tests, questions regarding the best ways to incorporate them into medical practice, and how to weigh their cost against potential short- and long-term benefits. As the availability of genetic tests increases so do concerns about the achievement of meaningful improvements in clinical outcomes, costs of testing, and the potential for accentuating medical care inequality. Given the rapid pace in the development of genetic tests and new testing technologies, An Evidence Framework for Genetic Testing seeks to advance the development of an adequate evidence base for genetic tests to improve patient care and treatment. Additionally, this report recommends a framework for decision-making regarding the use of genetic tests in clinical care.

Assessing Genetic Risks

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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 1994-02-01

Assessing Genetic Risks written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-02-01 with Medical categories.

Raising hopes for disease treatment and prevention, but also the specter of discrimination and "designer genes," genetic testing is potentially one of the most socially explosive developments of our time. This book presents a current assessment of this rapidly evolving field, offering principles for actions and research and recommendations on key issues in genetic testing and screening. Advantages of early genetic knowledge are balanced with issues associated with such knowledge: availability of treatment, privacy and discrimination, personal decision-making, public health objectives, cost, and more. Among the important issues covered: Quality control in genetic testing. Appropriate roles for public agencies, private health practitioners, and laboratories. Value-neutral education and counseling for persons considering testing. Use of test results in insurance, employment, and other settings.

The Evaluation Of Forensic Dna Evidence

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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 1996-12-12

The Evaluation Of Forensic Dna Evidence written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-12-12 with Science categories.

In 1992 the National Research Council issued DNA Technology in Forensic Science, a book that documented the state of the art in this emerging field. Recently, this volume was brought to worldwide attention in the murder trial of celebrity O. J. Simpson. The Evaluation of Forensic DNA Evidence reports on developments in population genetics and statistics since the original volume was published. The committee comments on statements in the original book that proved controversial or that have been misapplied in the courts. This volume offers recommendations for handling DNA samples, performing calculations, and other aspects of using DNA as a forensic toolâ€"modifying some recommendations presented in the 1992 volume. The update addresses two major areas: Determination of DNA profiles. The committee considers how laboratory errors (particularly false matches) can arise, how errors might be reduced, and how to take into account the fact that the error rate can never be reduced to zero. Interpretation of a finding that the DNA profile of a suspect or victim matches the evidence DNA. The committee addresses controversies in population genetics, exploring the problems that arise from the mixture of groups and subgroups in the American population and how this substructure can be accounted for in calculating frequencies. This volume examines statistical issues in interpreting frequencies as probabilities, including adjustments when a suspect is found through a database search. The committee includes a detailed discussion of what its recommendations would mean in the courtroom, with numerous case citations. By resolving several remaining issues in the evaluation of this increasingly important area of forensic evidence, this technical update will be important to forensic scientists and population geneticistsâ€"and helpful to attorneys, judges, and others who need to understand DNA and the law. Anyone working in laboratories and in the courts or anyone studying this issue should own this book.

Forensic Dna Evidence Interpretation

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Author : Christopher M. Triggs
language : en
Publisher: CRC Press
Release Date : 2004-11-29

Forensic Dna Evidence Interpretation written by Christopher M. Triggs and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-11-29 with Law categories.

Forensic DNA Evidence Interpretation is the most comprehensive resource for DNA casework available today. Written by leaders in the fields of biology and statistics, the book emphasizes the interpretation of test results and provides the necessary formulae in an easily accessible manner. The book begins by reviewing all pertinent biology, a

The Evidence Base Of Clinical Diagnosis

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Author : J. Andre Knottnerus
language : en
Publisher: BMJ Books
Release Date : 2009-01-26

The Evidence Base Of Clinical Diagnosis written by J. Andre Knottnerus and has been published by BMJ Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-01-26 with Medical categories.

This unique book presents a framework for the strategy and methodology of diagnostic research, in relation to its relevance for practice. Now in its second edition The Evidence Base of Clinical Diagnosis has been fully revised and extended with new chapters covering the STARD guidelines (STAndards for the Reporting of Diagnostic accuracy studies) and the multivariable analysis of diagnostic data. With contributions from leading international experts in evidence-based medicine, this book is an indispensable guide on how to conduct and interpret studies in clinical diagnosis. It will serve as a valuable resource for all investigators who want to embark on diagnostic research and for clinicians, practitioners and students who want to learn more about its principles and the relevant methodological options available.

Evidence Under The Rules

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Author : Christopher B. Mueller
language : en
Publisher: Aspen Publishers
Release Date : 2008

Evidence Under The Rules written by Christopher B. Mueller and has been published by Aspen Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Law categories.

Evidence Under the Rules, Sixth Edition, frames engaging problems and seminal cases in an eminently clear organization that adapts to a variety of teaching approaches. Smart and unassuming, Evidence Under the Rules continues to feature: a respected and well-known author team —Mueller and Kirkpatrick are experts and trusted authors in the field of evidence a logical and clear organization structured around the Federal Rules of Evidence effectively balanced pedagogy —lucid exposition, problems, and carefully edited cases numerous and engaging problems that give students practice applying the Federal Rules of Evidence focused case excerpts that home in on the relevant evidentiary aspects of the case a flexible organization that adapts to a variety of teaching approaches a detailed Teacher's Manual a new guide to excerpts from the media demonstrating the FRE being applied—or misapplied a companion 2008 Statutory and Case Supplement The Sixth Edition offers renewed timeliness and excellence, through: numerous new and highly teachable problems A DVD, available to professors for classroom use, featuring movie clips that illustrate and dramatize important points of evidence new material on post-Crawford developments regarding the right of confrontation coverage of the 2006 amendments To The FRE 404, 408, 606, and 609 revised treatment of scientific evidence recent and significant case law For a well-constructed problem-based casebook that won’t throw a veil over the Federal Rules of Evidence, examine the Sixth Edition of Evidence Under the Rules . You’ll discover that it supports your teaching.

The Use Of Analysis Of Deoxyribonucleic Acid Dna Within The Framework Of The Criminal Justice System

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Author : Council of Europe. Committee of Ministers
language : en
Publisher:
Release Date : 1993

The Use Of Analysis Of Deoxyribonucleic Acid Dna Within The Framework Of The Criminal Justice System written by Council of Europe. Committee of Ministers and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Chemistry, Forensic categories.

Evaluating Genetic Testing For Susceptibility To Occupationally Induced Disease

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Author : Geoffrey Peter Lomax
language : en
Publisher:
Release Date : 2002

Evaluating Genetic Testing For Susceptibility To Occupationally Induced Disease written by Geoffrey Peter Lomax and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.

Evidence Based Cancer Care And Prevention

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Author : Charles W. Given
language : en
Publisher:
Release Date : 2003

Evidence Based Cancer Care And Prevention written by Charles W. Given and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Health & Fitness categories.

The goal of behavioral oncology is to understand and explain the role and impact of behaviors at all phases in the cancer trajectory -- from prevention and detection to diagnosis and early treatment, to survivorship, recurrence, and/or death. Each chapter includes summaries of recent research on cancer-related behavioral interventions, discussions of the studies summarized, and suggestions for future research. The book is a product of collaboration among members of the Behavioral Cooperative Oncology Group of the Mary Margaret Walther Program for Cancer Care Research at the Walther Cancer Institute in Indianapolis, Indiana.

Clinical Genomics Practical Applications For Adult Patient Care

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Author : Michael T. Murray
language : en
Publisher: McGraw Hill Professional
Release Date : 2013-10-22

Clinical Genomics Practical Applications For Adult Patient Care written by Michael T. Murray and has been published by McGraw Hill Professional this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Medical categories.

Convert the latest genomic data to the most effective patient management and treatment approaches Clinical Genomics helps healthcare providers translate the vast amount of new genomic data into successful clinical application. It is a comprehensive textbook and practical guide to the use of this information across a broad spectrum of adult diseases – from individual differences in drug responses, cardiac andcancer risks to Alzheimer's and other neurological and psychiatric disorders. While traditional textbooks on medical genetics focus on classic Mendelian disorders, Clinical Genomics discusses the everyday application of genetic assessment and the diagnostic, therapeutic, and preventiveimplications to the most common adult diseases that healthcare providers encounter. Covering approximately 200 conditions, it is a true clinical text for use across all of internal medicine. Coverage of each condition is presented in a consistent,clinically relevant manner and includes: Key Points Diagnostic Criteria and Clinical Characteristics Screening and C ounseling Management and Treatment Molecular Genetics and Molecular Mechanism Supplementary Information More than ten valuable appendices, include Genetic Privacy; Race, Ancestry, and Genetics; Personalized Medicine in Clinical Practice; Clinical Interpretationof Genomic Data; and Genetic Risk Profiling in the Genomics Era. Clinical Genomics is essential for internists, primary care physicians, and other healthcare providers who wish to increase their knowledge of the gene-and-protein level care of patients in a clinical setting.