An Optimization Primer
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An Optimization Primer
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Author : Johannes O. Royset
language : en
Publisher: Springer Nature
Release Date : 2022-03-28
An Optimization Primer written by Johannes O. Royset and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-28 with Mathematics categories.
This richly illustrated book introduces the subject of optimization to a broad audience with a balanced treatment of theory, models and algorithms. Through numerous examples from statistical learning, operations research, engineering, finance and economics, the text explains how to formulate and justify models while accounting for real-world considerations such as data uncertainty. It goes beyond the classical topics of linear, nonlinear and convex programming and deals with nonconvex and nonsmooth problems as well as games, generalized equations and stochastic optimization. The book teaches theoretical aspects in the context of concrete problems, which makes it an accessible onramp to variational analysis, integral functions and approximation theory. More than 100 exercises and 200 fully developed examples illustrate the application of the concepts. Readers should have some foundation in differential calculus and linear algebra. Exposure to real analysis would be helpful but is not prerequisite.
An Optimization Primer
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Author : Lawrence Nazareth
language : en
Publisher: Springer
Release Date : 2004-05-15
An Optimization Primer written by Lawrence Nazareth and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-05-15 with Mathematics categories.
This book introduces a general audience to the main facets of optimization. Very little mathematical background is assumed. It should appeal to students, teachers, and a general audience interested in how optimization affects their everyday life, such as people in business.
An Optimization Primer
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Author : Lawrence Nazareth
language : en
Publisher: Springer Science & Business Media
Release Date : 2004-05-18
An Optimization Primer written by Lawrence Nazareth and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-05-18 with Mathematics categories.
This book introduces a general audience to the main facets of optimization. Very little mathematical background is assumed. It should appeal to students, teachers, and a general audience interested in how optimization affects their everyday life, such as people in business.
Laboratory Methods For The Detection Of Mutations And Polymorphisms In Dna
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Author : Graham R. Taylor
language : en
Publisher: CRC Press
Release Date : 1997-01-24
Laboratory Methods For The Detection Of Mutations And Polymorphisms In Dna written by Graham R. Taylor and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-01-24 with Science categories.
The analysis of DNA sequence polymorphisms and mutations is of central importance in understanding biological systems. This book is devoted to the experimental analysis of DNA and presents easy-to-follow protocols. Various techniques from the simple to the highly complex are detailed in this volume, providing a wide spectrum of available methods and practical advice. The methods are described in terms of: History and background Principles and theory Equipment and reagents Protocols Troubleshooting Applications Improvements Results Comparisons with other methods Future prospects and developments This is an essential manual for researchers working in human, animal, or plant molecular genetics and is particularly valuable for hospital and commercial laboratories.
Real Time Pcr
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Author : M Tevfik Dorak
language : en
Publisher: Garland Science
Release Date : 2007-02-08
Real Time Pcr written by M Tevfik Dorak and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-02-08 with Science categories.
With a variety of detection chemistries, an increasing number of platforms, multiple choices for analytical methods and the jargon emerging along with these developments, real-time PCR is facing the risk of becoming an intimidating method, especially for beginners. Real-time PCR provides the basics, explains how they are exploited to run a real-time PCR assay, how the assays are run and where these assays are informative in real life. It addresses the most practical aspects of the techniques with the emphasis on 'how to do it in the laboratory'. Keeping with the spirit of the Advanced Methods Series, most chapters provide an experimental protocol as an example of a specific assay.
Pcr Primer Design
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Author : Anton Yuryev
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-03
Pcr Primer Design written by Anton Yuryev and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-03 with Science categories.
In the past decade, molecular biology has been transformed from the art of cloning a single gene to a statistical science measuring and calculating properties of entire genomes. New high-throughput methods have been developed for genome sequencing and studying the cell at different systematic levels such as transcriptome, proteome, metabolome and other -omes. At the heart of most high-throughput methods is the technique of polymerase chain reaction (PCR). PCR Primer Design focuses on primer design, which is critical to both the efficiency and the accuracy of the PCR. With intricate descriptions of basic approaches as well as specialized methods, this volume is an exceptional reference for all those involved in studying the genome. In PCR Primer Design, authors describe basic approaches for PCR primer design in addition to specialized methods. These state-of-the-art methods can be used for both genome-scale experiments and for small-scale individual PCR amplifications. This volume will be useful for organizations performing whole genome studies, companies designing instruments that utilize PCR, and individual scientists – geneticists, molecular biologists, molecular geneticists, and more – who routinely use PCR in their research.
Nuclear Reprogramming
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Author : Steve Pells
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-04
Nuclear Reprogramming written by Steve Pells and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-04 with Science categories.
A wide-ranging collection of readily reproducible methods for performing nuclear reprogramming by nuclear transfer in several different species, by fusion through both chemical treatment and electrically shocking cells, and by in vivo treatment of cells with cell extracts. Several methods of monitoring nuclear reprogramming are also presented, including the use of transgenic markers, activation of telomerase as an ES-specific marker, light and electron microscopic observation of structural changes in the nucleus, and verification of surface marker expression and the differentiation potential of stem cells. Biochemical methods are provided for the examination of chromatin protein modifications, nucleosomal footprinting, transcription factor binding, and the study of DNA methylation changes both at the specific locus level and at the level of the whole nucleus.
Concise Guide To Numerical Algorithmics
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Author : John Lawrence Nazareth
language : en
Publisher: Springer Nature
Release Date : 2023-01-02
Concise Guide To Numerical Algorithmics written by John Lawrence Nazareth and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-02 with Computers categories.
Numerical Algorithmic Science and Engineering (NAS&E), or more compactly, Numerical Algorithmics, is the theoretical and empirical study and the practical implementation and application of algorithms for solving finite-dimensional problems of a numeric nature. The variables of such problems are either discrete-valued, or continuous over the reals, or, and as is often the case, a combination of the two, and they may or may not have an underlying network/graph structure. This re-emerging discipline of numerical algorithmics within computer science is the counterpart of the now well-established discipline of numerical analysis within mathematics, where the latter’s emphasis is on infinite-dimensional, continuous numerical problems and their finite-dimensional, continuous approximates. A discussion of the underlying rationale for numerical algorithmics, its foundational models of computation, its organizational details, and its role, in conjunction with numerical analysis, in support of the modern modus operandi of scientific computing, or computational science & engineering, is the primary focus of this short monograph. It comprises six chapters, each with its own bibliography. Chapters 2, 3 and 6 present the book’s primary content. Chapters 1, 4, and 5 are briefer, and they provide contextual material for the three primary chapters and smooth the transition between them. Mathematical formalism has been kept to a minimum, and, whenever possible, visual and verbal forms of presentation are employed and the discussion enlivened through the use of motivating quotations and illustrative examples. The reader is expected to have a working knowledge of the basics of computer science, an exposure to basic linear algebra and calculus (and perhaps some real analysis), and an understanding of elementary mathematical concepts such as convexity of sets and functions, networks and graphs, and so on. Although this book is not suitable for use as the principal textbook for a course on numerical algorithmics (NAS&E), it will be of value as a supplementary reference for a variety of courses. It can also serve as the primary text for a research seminar. And it can be recommended for self-study of the foundations and organization of NAS&E to graduate and advanced undergraduate students with sufficient mathematical maturity and a background in computing. When departments of computer science were first created within universities worldwide during the middle of the twentieth century, numerical analysis was an important part of the curriculum. Its role within the discipline of computer science has greatly diminished over time, if not vanished altogether, and specialists in that area are now to be found mainly within other fields, in particular, mathematics and the physical sciences. A central concern of this monograph is the regrettable, downward trajectory of numerical analysis within computer science and how it can be arrested and suitably reconstituted. Resorting to a biblical metaphor, numerical algorithmics (NAS&E) as envisioned herein is neither old wine in new bottles, nor new wine in old bottles, but rather this re-emerging discipline is a decantation of an age-old vintage that can hopefully find its proper place within the larger arena of computer science, and at what appears now to be an opportune time.
In Situ Hybridization Histochemistry
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Author : Marie-Francoise Chesselet
language : en
Publisher: CRC Press
Release Date : 1990-07-03
In Situ Hybridization Histochemistry written by Marie-Francoise Chesselet and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990-07-03 with Medical categories.
The goal of this fascinating new book is to review the diversity of methods available to apply in situ hybridization histochemistry (ISHH) to a variety of experimental questions. This work includes topics such as synthesis and use of nick-translated DNA probes for ISHH, synthesis and use of oligomeric DNA probes for ISHH, and synthesis and use of RNA probes for ISHH. These interesting chapters describe the preparation of different radiolabeled probes for ISHH. They also discuss their respective advantages and limitations, and describe current results based on the use of these various probes. Sections of the text highlight low and high resolution autoradiography for ISHH, the use of biotin-labeled probes for ISHH, as well as the use of ISHH in combination with established anatomical techniques. In Situ Hybridization Histochemistry answers all of your questions regarding the quantification of ISHH. It also provides a practical description of typical protocols, both from molecular biology and histology. Investigators will understand and value this useful, powerful tool-whatever their backgrounds might be.
Mechanobiology Handbook
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Author : Jiro Nagatomi
language : en
Publisher: CRC Press
Release Date : 2011-03-15
Mechanobiology Handbook written by Jiro Nagatomi and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-03-15 with Medical categories.
Mechanobiology-the study of the effects of mechanical environments on the biological processes of cells-has evolved from traditional biomechanics via the incorporation of strong elements of molecular and cell biology. Currently, a broad range of organ systems are being studied by surgeons, physicians, basic scientists, and engineers. These mechanob