Analysis Of A Model For Epilepsy
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Analysis Of A Model For Epilepsy
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Author : Candace M. Kent
language : en
Publisher: CRC Press
Release Date : 2022-06-07
Analysis Of A Model For Epilepsy written by Candace M. Kent and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-07 with Mathematics categories.
In the 1960s and 1970s, mathematical biologists Sir Robert M. May, E.C. Pielou, and others utilized difference equations as models of ecological and epidemiological phenomena. Since then, with or without applications, the mathematics of difference equations has evolved into a field unto itself. Difference equations with the maximum (or the minimum or the "rank-type") function were rigorously investigated from the mid-1990s into the 2000s, without any applications in mind. These equations often involved arguments varying from reciprocal terms with parameters in the numerators to other special functions. Recently, the authors of Analysis of a Model for Epilepsy: Application of a Max-Type Difference Equation to Mesial Temporal Lobe Epilepsy and their colleagues investigated the first known application of a "max-type" difference equation. Their equation is a phenomenological model of epileptic seizures. In this book, the authors expand on that research and present a more comprehensive development of mathematical, numerical, and biological results. Additionally, they describe the first documented instance of a novel dynamical behavior that they call rippled almost periodic behavior, which can be described as an unpredictable pseudo-periodic behavior. Features: Suitable for researchers in mathematical neuroscience and potentially as supplementary reading for postgraduate students Thoroughly researched and replete with references
Models Of Seizures And Epilepsy
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Author : Asla Pitkänen
language : en
Publisher: Academic Press
Release Date : 2017-06-14
Models Of Seizures And Epilepsy written by Asla Pitkänen and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-14 with Science categories.
Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of epilepsy, and novel technologies to study seizures and epilepsies in animals. Provides a comprehensive reference detailing animal models of epilepsy and seizure Offers insights on the use of novel technologies that can be applied in experimental epilepsy research Edited by leading experts in the field that provide not only technical reviews of these models but also conceptual critiques Comments on the strengths and limitations of various models, including their relationship to clinical phenomenology and their value in developing better understanding and treatments
Epileptic Seizures And The Eeg
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Author : Andrea Varsavsky
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Epileptic Seizures And The Eeg written by Andrea Varsavsky and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
A study of epilepsy from an engineering perspective, this volume begins by summarizing the physiology and the fundamental ideas behind the measurement, analysis and modeling of the epileptic brain. It introduces the EEG and provides an explanation of the type of brain activity likely to register in EEG measurements, offering an overview of how these EEG records are and have been analyzed in the past. The book focuses on the problem of seizure detection and surveys the physiologically based dynamic models of brain activity. Finally, it addresses the fundamental question: can seizures be predicted? Based on the authors' extensive research, the book concludes by exploring a range of future possibilities in seizure prediction.
Computational Neuroscience In Epilepsy
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Author : Ivan Soltesz
language : en
Publisher: Academic Press
Release Date : 2011-09-02
Computational Neuroscience In Epilepsy written by Ivan Soltesz and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-02 with Science categories.
Epilepsy is a neurological disorder that affects millions of patients worldwide and arises from the concurrent action of multiple pathophysiological processes. The power of mathematical analysis and computational modeling is increasingly utilized in basic and clinical epilepsy research to better understand the relative importance of the multi-faceted, seizure-related changes taking place in the brain during an epileptic seizure. This groundbreaking book is designed to synthesize the current ideas and future directions of the emerging discipline of computational epilepsy research. Chapters address relevant basic questions (e.g., neuronal gain control) as well as long-standing, critically important clinical challenges (e.g., seizure prediction). Computational Neuroscience in Epilepsy should be of high interest to a wide range of readers, including undergraduate and graduate students, postdoctoral fellows and faculty working in the fields of basic or clinical neuroscience, epilepsy research, computational modeling and bioengineering. Covers a wide range of topics from molecular to seizure predictions and brain implants to control seizures Contributors are top experts at the forefront of computational epilepsy research Chapter contents are highly relevant to both basic and clinical epilepsy researchers
Comprehensive Analysis Of Swarm Based Classifiers And Bayesian Based Models For Epilepsy Risk Level Classification From Eeg Signals
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Author : Harikumar Rajaguru
language : en
Publisher: Anchor Academic Publishing
Release Date : 2017-02-17
Comprehensive Analysis Of Swarm Based Classifiers And Bayesian Based Models For Epilepsy Risk Level Classification From Eeg Signals written by Harikumar Rajaguru and has been published by Anchor Academic Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-17 with Computers categories.
This project presents the performance analysis of Particle swarm optimization (PSO), hybrid PSO and Bayesian classifier to calculate the epileptic risk level from electroencephalogram (EEG) inputs. PSO is an optimization technique which is initialized with a population of random solutions and searches for optima by updating generations. PSO is initialized with a group of random particles (solutions) and then searches for optima by updating generations. Hybrid PSO differs from ordinary PSO by calculating inertia weight to avoid the local minima problem. Bayesian classifier works on the principle of Bayes’ rule in which it is the probability based theorem. The results of PSO, hybrid PSO and Bayesian classifier are calculated and their performance is analyzed using performance index, quality value, cost function and classification rate in calculating the epileptic risk level from EEG.
Animal Models Of Epilepsy
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Author : Scott C. Baraban
language : en
Publisher: Humana
Release Date : 2009-05-29
Animal Models Of Epilepsy written by Scott C. Baraban and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-05-29 with Medical categories.
In this book, investigators examine several novel models of epilepsy in mice as well as in genetically tractable "simple" species. This is an ideal guide for scientists who wish to expand our understanding of the pathogenesis of this neurological disorder.
New Directions In The Management Of Status Epilepticus
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Author : Batool F. Kirmani
language : en
Publisher: Frontiers Media SA
Release Date : 2019-02-06
New Directions In The Management Of Status Epilepticus written by Batool F. Kirmani and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-06 with categories.
Status Epilepticus (SE) is a neurological emergency and has high morbidity and mortality. The International League Against Epilepsy (ILAE) recently updated their definition to specify that, “SE is a condition resulting either from the failure of the mechanisms responsible for seizure termination or from the initiation of mechanisms, which lead to abnormally, prolonged seizures.” Such phenomena can lead to long-term neurological complications due to neuronal death, glia, neurological injury, aberrant neuroplasticity, oxidative stress and inflammation, and alteration of neuronal networks. Depending upon the type and duration of SE, these mechanisms are quite variable. Therefore, in response to the updated definition of SE, novel avenues of research are required to address the specified involvement of the underlying mechanisms and pathophysiology resulting in the development of and outcomes from SE. Improving the basic science understanding of SE will facilitate essential clinical trials. One can envision such experiments to include device and compound-based technological interventions directed at aborting the seizure activity and improving clinical outcomes. Benzodiazepines remain one of the cornerstones of treatment, and studies are underway to study new delivery options, including intranasal, buccal, and intramuscular midazolam, in addition to rectal diazepam, with the goal of aborting the seizure activity outside the hospitals, as rapidly as possible. Approved and off-label anticonvulsants, such as phenytoin, phenobarbital, valproate, topiramate, levetiracetam, lacosamide, steroids, immunosuppressants, and neuroprotective compounds, have also shown some efficacy at treating SE. However, substantial challenges remain in optimally managing SE and minimizing the short- and long-term complications. Such difficulties can be overcome by innovative approaches targeting the underlying mechanisms of neuronal excitability, glia, neuronal death, neuroplasticity, oxidative stress, inflammation, and neuroinflammation.
Statistical Methods In Epilepsy
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Author : Sharon Chiang
language : en
Publisher: CRC Press
Release Date : 2024-03-25
Statistical Methods In Epilepsy written by Sharon Chiang and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-25 with Medical categories.
Epilepsy research promises new treatments and insights into brain function, but statistics and machine learning are paramount for extracting meaning from data and enabling discovery. Statistical Methods in Epilepsy provides a comprehensive introduction to statistical methods used in epilepsy research. Written in a clear, accessible style by leading authorities, this textbook demystifies introductory and advanced statistical methods, providing a practical roadmap that will be invaluable for learners and experts alike. Topics include a primer on version control and coding, pre-processing of imaging and electrophysiological data, hypothesis testing, generalized linear models, survival analysis, network analysis, time-series analysis, spectral analysis, spatial statistics, unsupervised and supervised learning, natural language processing, prospective trial design, pharmacokinetic and pharmacodynamic modeling, and randomized clinical trials. Features: Provides a comprehensive introduction to statistical methods employed in epilepsy research Divided into four parts: Basic Processing Methods for Data Analysis; Statistical Models for Epilepsy Data Types; Machine Learning Methods; and Clinical Studies Covers methodological and practical aspects, as well as worked-out examples with R and Python code provided in the online supplement Includes contributions by experts in the field The handbook targets clinicians, graduate students, medical students, and researchers who seek to conduct quantitative epilepsy research. The topics covered extend broadly to quantitative research in other neurological specialties and provide a valuable reference for the field of neurology.
Experimental Models Of Epilepsy And Related Comorbidities
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Author : Mohd. Farooq Shaikh
language : en
Publisher: Frontiers Media SA
Release Date : 2019-06-19
Experimental Models Of Epilepsy And Related Comorbidities written by Mohd. Farooq Shaikh and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-19 with categories.
Epileptic patients live with epilepsy-associated complications such as cognitive dysfunction, psychological discomfort, and sexual function decline, and are more likely to experience emotional and mental health issues problems, including depression and anxiety. Many antiepileptic drugs are found to have a role in aggravating psychiatric symptoms. Animal models, which inform translational questions about epilepsy comorbidities, are used to study the relationship between epilepsy and related comorbidities. The aim of this Research Topic was to highlight basic, clinical and interdisciplinary research involved in studying the disease and its comorbid effects. Various experimental models are used to understand the mechansims of disease and to discover newer antiepileptic drugs. These experimental models combines the input from behavioral, biochemical and molecular level including genetic.
Imaging Biomarkers In Epilepsy
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Author : Andrea Bernasconi
language : en
Publisher: Cambridge University Press
Release Date : 2019-01-10
Imaging Biomarkers In Epilepsy written by Andrea Bernasconi and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-10 with Medical categories.
Assembles world-class expertise on clinical and molecular imaging-derived biomarkers, presenting neuroimaging in epilepsy in a broad neuroscientific context.