Analysis Of Aggregates And Particles In Protein Pharmaceuticals
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Analysis Of Aggregates And Particles In Protein Pharmaceuticals
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Author : Hanns-Christian Mahler
language : en
Publisher: John Wiley & Sons
Release Date : 2011-12-20
Analysis Of Aggregates And Particles In Protein Pharmaceuticals written by Hanns-Christian Mahler and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-20 with Medical categories.
This book describes how to address the analysis of aggregates and particles in protein pharmaceuticals, provides a comprehensive overview of current methods and integrated approaches used to quantify and characterize aggregates and particles, and discusses regulatory requirements. Analytical methods covered in the book include separation, light scattering, microscopy, and spectroscopy.
Analysis Of Aggregates And Particles In Protein Pharmaceuticals
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Author : Hanns-Christian Mahler
language : en
Publisher: John Wiley & Sons
Release Date : 2012-01-24
Analysis Of Aggregates And Particles In Protein Pharmaceuticals written by Hanns-Christian Mahler and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-24 with Medical categories.
This book describes how to address the analysis of aggregates and particles in protein pharmaceuticals, provides a comprehensive overview of current methods and integrated approaches used to quantify and characterize aggregates and particles, and discusses regulatory requirements. Analytical methods covered in the book include separation, light scattering, microscopy, and spectroscopy.
Biophysical Characterization Of Proteins In Developing Biopharmaceuticals
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Author : Damian J. Houde
language : en
Publisher: Elsevier
Release Date : 2019-11-13
Biophysical Characterization Of Proteins In Developing Biopharmaceuticals written by Damian J. Houde and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-13 with Medical categories.
Biophysical Characterization of Proteins in Developing Biopharmaceuticals, Second Edition, presents the latest on the analysis and characterization of the higher-order structure (HOS) or conformation of protein based drugs. Starting from the very basics of protein structure, this book explains the best way to achieve this goal using key methods commonly employed in the biopharmaceutical industry. This book will help today's industrial scientists plan a career in this industry and successfully implement these biophysical methodologies. This updated edition has been fully revised, with new chapters focusing on the use of chromatography and electrophoresis and the biophysical characterization of very large biopharmaceuticals. In addition, best practices of applying statistical analysis to biophysical characterization data is included, along with practical issues associated with the concept of a biopharmaceutical's developability and the technical decision-making process needed when dealing with biophysical characterization data. - Presents basic protein characterization methods and tools applicable to (bio)pharmaceutical research and development - Highlights the capabilities and limitations of each technique - Discusses the underlining science of each tool - Empowers industrial biophysical chemists by providing a roadmap for applying biophysical tools - Outlines the needs for new characterization and analytical tools in the biopharmaceutical industry
Pharmaceutical Formulation Development Of Peptides And Proteins
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Author : Lars Hovgaard
language : en
Publisher: CRC Press
Release Date : 2012-11-14
Pharmaceutical Formulation Development Of Peptides And Proteins written by Lars Hovgaard and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-14 with Medical categories.
The rapid advances in recombinant DNA technology and the increasing availability of peptides and proteins with therapeutic potential are a challenge for pharmaceutical scientists who have to formulate these compounds as drug products. Pharmaceutical Formulation Development of Peptides and Proteins, Second Edition discusses the development of therap
The Hidden World Of Protein Aggregation
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Author :
language : en
Publisher: Elsevier
Release Date : 2024-05-30
The Hidden World Of Protein Aggregation written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-30 with Science categories.
The Hidden World of Protein Aggregation, Volume 206 provides a comprehensive exploration of protein aggregation, uncovering the factors behind the formation of amorphous aggregates and ordered structures called amyloid fibrils. It delves into the advantages and disadvantages of protein aggregates, addressing topics such as cytotoxicity and disorders linked to misfolding. Specific chapters in this release include Protein Aggregation: An Overview, Pathways of Amyloid Fibril Formation and Aggregation, Factors Influencing Amyloid Fibril Formation, Morphological Features and Types of Aggregated Structures, Each big journey starts with a first step: Importance of Oligomerization, Liquid-Liquid Phase Separation as Triggering Factor of Fibril Formation, and more.Additional sections cover Experimental Techniques for Detecting and Evaluating the Amyloid Fibrils, Prediction of Protein Aggregation, Amyloid Fibril Cytotoxicity and Associated Disorders, Inhibitors of Amyloid Fibril Formation, Therapeutic Approaches in Proteinopathies, Functional Amyloids, Biotechnological Applications of Amyloid Fibrils, and The Hidden World of Protein Aggregation. - Provides an introduction to the folding of protein and associated conditions leading to aggregation and linked pathology - Discusses structural biology and computational methodologies for analysis of protein (mis)folding and aggregation - Describes functional amyloids and their biotechnological applications
Protein Pharmaceuticals
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Author : Hanns-Christian Mahler
language : en
Publisher:
Release Date : 2010
Protein Pharmaceuticals written by Hanns-Christian Mahler and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Aufsatzsammlung categories.
Pharmaceutical Biotechnology
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Author : Daan J. A. Crommelin
language : en
Publisher: Springer
Release Date : 2019-04-13
Pharmaceutical Biotechnology written by Daan J. A. Crommelin and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-13 with Science categories.
This introductory text explains both the basic science and the applications of biotechnology-derived pharmaceuticals, with special emphasis on their clinical use. It serves as a complete one-stop source for undergraduate/graduate pharmacists, pharmaceutical science students, and for those in the pharmaceutical industry. The Fifth Edition completely updates the previous edition, and also includes additional coverage on the newer approaches such as oligonucleotides, siRNA, gene therapy and nanotech and enzyme replacement therapy.
Monoclonal Antibodies
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Author : Steven Shire
language : en
Publisher: Woodhead Publishing
Release Date : 2015-04-24
Monoclonal Antibodies written by Steven Shire and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-24 with Medical categories.
Monoclonal antibodies (MAbs) are currently the major class of protein bio therapeutic being developed by biotechnology and pharmaceutical companies. Monoclonal Antibodies discusses the challenges and issues revolving around development of a monoclonal antibody produced by recombinant DNA technology into a therapeutic agent.This book covers downstream processing which includes design of processes to manufacture the formulation, formulation design, fill and finish into closure systems and routes of administration. The characterization of the final drug product is covered where the use of biophysical methods combined with genetic engineering is used to understand the solution properties of the formulation. The latter has become very important since many indications such as arthritis and asthma require the development of formulations for subcutaneous delivery (SC). The development of formulations for IV delivery is also important and comes with a different set of challenges. The challenges and strategies that can overcome these limitations are discussed in this book, starting with an introduction to these issues, followed by chapters detailing strategies to deal with them. Subsequent chapters explore the processing and storage of mAbs, development of delivery device technologies and conclude with a chapter on the future of mAbs in therapeutic remedies. - Discusses the challenges to develop MAbs for intravenous (IV) and subcutaneous delivery (SC) - Presents strategies to meet the challenges in development of MAbs for SC and IV administration - Discusses the use of biophysical analytical tools coupled with MAb engineering to understand what governs MAb properties at high concentration
Parenteral Medications Fourth Edition
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Author : Sandeep Nema
language : en
Publisher: CRC Press
Release Date : 2019-07-19
Parenteral Medications Fourth Edition written by Sandeep Nema and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-19 with Business & Economics categories.
Parenteral Medications is an authoritative, comprehensive reference work on the formulation and manufacturing of parenteral dosage forms, effectively balancing theoretical considerations with practical aspects of their development. Previously published as a three-volume set, all volumes have been combined into one comprehensive publication that addresses the plethora of changes in the science and considerable advances in the technology associated with these products and routes of administration. Key Features: Provides a comprehensive reference work on the formulation and manufacturing of parenteral dosage forms Addresses changes in the science and advances in the technology associated with parenteral medications and routes of administration Includes 13 new chapters and updated chapters throughout Contains the contributors of leading researchers in the field of parenteral medications Uses full color detailed illustrations, enhancing the learning process The fourth edition not only reflects enhanced content in all the chapters but also highlights the rapidly advancing formulation, processing, manufacturing parenteral technology including advanced delivery and cell therapies. The book is divided into seven sectionss: Section 1 - Parenteral Drug Administration and Delivery Devices; Section 2 - Formulation Design and Development; Section 3 - Specialized Drug Delivery Systems; Section 4 - Primary Packaging and Container Closure Integrity; Section 5 - Facility Design and Environmental Control; Section 6 - Sterilization and Pharmaceutical Processing; Section 7 - Quality Testing and Regulatory Requirements
Proceedings Of The 3rd International Conference On Cardiovascular Diseases Iccvd 2021
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Author : Heri Nurdiyanto
language : en
Publisher: Springer Nature
Release Date : 2023-02-10
Proceedings Of The 3rd International Conference On Cardiovascular Diseases Iccvd 2021 written by Heri Nurdiyanto and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-10 with Medical categories.
This is an open access book. The objectives of the conference are as follows. to update knowledge about the relevant program priorities for addressing CVD burden in developing countries to explore options for the comprehensive management of primary cardiovascular risk factors such as high blood pressure, high blood glucose level, smoking, and sedentary lifestyle to discuss the latest guidance and evidence on the early detection and management of CVD and its implementation in the context of developing countries, including the impact of the COVID-19 pandemic on the management of CVD to strengthen interprofessional collaboration in addressing challenges using multidisciplinary approaches for the prevention, treatment, and rehabilitation of patients with CVD to update knowledge about health technology science and innovation related to the management and rehabilitation of patients with CVD.