Analytical Methods In Combinatorial Chemistry
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Analytical Methods In Combinatorial Chemistry
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Author : Bing Yan
language : en
Publisher: CRC Press
Release Date : 2000-01-05
Analytical Methods In Combinatorial Chemistry written by Bing Yan and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-01-05 with Science categories.
This volume summarizes most analytical technologies that are applied to solving various problems in broad areas of combinatorial chemistry: chemistry optimization, library synthesis, lead selection, and lead optimization. It also suggests many avenues for further research, especially the need for major breakthroughs to resolve the incompatibility between parallel synthesis and the serial analysis and purification. Filling the tremendous need for analytical methodologies in various phases of combinatorial chemistry, this book will be a necessary addition to the library of anyone using combinatorial chemistry. While there are several resources available on the subject, there are no other books that deal specifically with analytical issues in combinatorial chemistry. Not only an ideal companion to the comprehensive reference books used by chemists in combinatorial chemistry, it is a timely textbook for university and graduate students, introducing them to the updated applications of modern analytical technologies in the rapidly growing field of combinatorial chemistry. From the Preface: This book is organized according to the operation process of combinatorial chemistry starting with the description of the basic properties of solid supports and their effects on solid-phase organic reactions in Chapter 2. Chapters 3-5 describe analytical methods routinely applied to the tedious process of reaction optimization. These techniques are various FTIR and Raman methods, MS, NMR, UV-Vis, fluorescence, and other analytical methods. . . . Then the discussions move to the analytical control of the library quality in Chapter 6. The various methods for selecting active lead components from combinatorial libraries and the ways to reveal their structure or identity are discussed next in Chapter 7. . . . The applications of analytical methods in the optimization of the in vitro activity and physicochemical properties of lead compounds are then illustrated in Chapter 8. . . . Some promising new technologies and future perspectives are presented in Chapter 9.
Analytical Methods In Combinatorial Chemistry
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Author : Bing Yan
language : en
Publisher: CRC Press
Release Date : 2010-08-09
Analytical Methods In Combinatorial Chemistry written by Bing Yan and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-08-09 with Science categories.
Since the publication of the benchmark first edition of this book, chemical library and combinatorial chemistry methods have developed into mature technologies. There have also been significant shifts in emphasis in combinatorial synthesis. Reflecting the growth in the field and the heightened focus on select areas, Analytical Methods in Combinator
Analytical Techniques In Combinatorial Chemistry
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Author : Michael E. Swartz
language : en
Publisher: CRC Press
Release Date : 2000-02-18
Analytical Techniques In Combinatorial Chemistry written by Michael E. Swartz and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-02-18 with Medical categories.
This volume presents the necessary tools for developing methods and analyzing results in the drug discovery process, and supports documenting and managing the process in a combinatorial setting. It describes the chromatographic and spectroscopic techniques used to generate chemical and molecular diversity in new compounds, focusing on applications
Combinatorial Chemistry
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Author : Günther Jung
language : en
Publisher: John Wiley & Sons
Release Date : 2008-07-11
Combinatorial Chemistry written by Günther Jung and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-07-11 with Science categories.
The story of success goes on and on - with a new book on combinatorial chemistry, edited by Gunther Jung! Combinatorial chemistry is a proven time- and resource-saving synthetic method of outstanding importance for industrial processes. Compound libraries help to save time and money, especially in the search for new drugs, and therefore play a pivotal role in solving the problem of the worldwide increasing demand for new and more active drugs. Not only substances, which are of interest for pharmaceutical chemistry, but also materials, catalysts, and biomolecules such as DNA or oligosaccharides are readily available with high structural diversities. The broad scope of combinatorial sciences is reflected by this book, edited by Gunther Jung: The synthetic methods discussed range from solid-phase to solution-phase synthesis, from preparations of small molecules such as amines or alcohols to those of complex biomolecules. Feasible methods, efficient techniques, new trends in automation, and state-of-the-art fast instrumental analytical and screening methods are presented with many practical tips and tricks for everybody working in combinatorial chemistry. This is the book written by specialists for specialists and for everyone aspiring to become an insider! It is an indispensible source of information for researchers working in organic synthesis, catalysis, biochemistry, and biotechnology, pharmaceutical and clinical chemistry, material sciences, and analytical chemistry.
Analysis And Purification Methods In Combinatorial Chemistry
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Author : Bing Yan
language : en
Publisher: John Wiley & Sons
Release Date : 2004-02-03
Analysis And Purification Methods In Combinatorial Chemistry written by Bing Yan and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-02-03 with Science categories.
Quality measurement, control, and improvement in combinatorial chemistry Combinatorial chemistry has developed rapidly in the past decade, with great advances made by scientists working on analysis and purification of a large number of compounds and the analysis of polymer-bound compounds. However, formidable challenges lie ahead of today's researcher. For example, high-throughput analysis and purification technologies must be further developed to ensure combinatorial libraries are "purifiable," and "drugable." To this end, Analysis and Purification Methods in Combinatorial Chemistry describes various analytical techniques and systems for the development, validation, quality control, purification, and physicochemical testing of combinatorial libraries. A new volume in Wiley's Chemical Analysis series, this text has four parts covering: * Various approaches to monitoring reactions on solid support and optimizing reactions for library synthesis * High-throughput analytical methods used to analyze the quality of libraries * High-throughput purification techniques * Analytical methods applied in post-synthesis and post-purification stages Drawing from the contributions of respected experts in combinatorial chemistry, this comprehensive book provides coverage of applications of Nuclear Magnetic Resonance (NMR), liquid chromatography/mass spectrometry (LC/MS), Fourier Transform Infrared (FTIR), micellar electrokinetic chromatography (MEKC) technologies, as well as other analytical techniques. This eminently useful volume is an essential addition to the library of students and researchers studying or working in analytical chemistry, combinatorial chemistry, medicinal chemistry, organic chemistry, biotechnology, biochemistry, or biophysics.
Analytical Techniques In Combinatorial Chemistry
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Author : Michael E. Swartz
language : en
Publisher: CRC Press
Release Date : 2000-02-18
Analytical Techniques In Combinatorial Chemistry written by Michael E. Swartz and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-02-18 with Science categories.
This volume aims to provide the necessary tools for developing methods and analyzing results in the drug discovery process, and supports documenting and managing the process in a combinatorial setting. It describes the chromatographic and spectroscopic techniques used to generate chemical and molecular diversity in new compounds, focusing on applications of information management systems, instrumentation, and robotics.
Analytical Methods In Combinatorial Chemistry
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Author :
language : en
Publisher:
Release Date : 2009
Analytical Methods In Combinatorial Chemistry written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.
Combinatorial Library
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Author : Lisa B. English
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-04
Combinatorial Library written by Lisa B. English and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-04 with Science categories.
The continued successes of large- and small-scale genome sequencing projects are increasing the number of genomic targets available for drug d- covery at an exponential rate. In addition, a better understanding of molecular mechanisms—such as apoptosis, signal transduction, telomere control of ch- mosomes, cytoskeletal development, modulation of stress-related proteins, and cell surface display of antigens by the major histocompatibility complex m- ecules—has improved the probability of identifying the most promising genomic targets to counteract disease. As a result, developing and optimizing lead candidates for these targets and rapidly moving them into clinical trials is now a critical juncture in pharmaceutical research. Recent advances in com- natorial library synthesis, purification, and analysis techniques are not only increasing the numbers of compounds that can be tested against each specific genomic target, but are also speeding and improving the overall processes of lead discovery and optimization. There are two main approaches to combinatorial library production: p- allel chemical synthesis and split-and-mix chemical synthesis. These approaches can utilize solid- or solution-based synthetic methods, alone or in combination, although the majority of combinatorial library synthesis is still done on solid support. In a parallel synthesis, all the products are assembled separately in their own reaction vessels or microtiter plates. The array of rows and columns enables researchers to organize the building blocks to be c- bined, and provides an easy way to identify compounds in a particular well.
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Author :
language : en
Publisher: EduGorilla Community Pvt. Ltd.
Release Date :
written by and has been published by EduGorilla Community Pvt. Ltd. this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.