Anticancer Agents From Natural Products
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Anticancer Agents From Natural Products
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Author : Gordon M. Cragg
language : en
Publisher: CRC Press
Release Date : 2005-06-13
Anticancer Agents From Natural Products written by Gordon M. Cragg and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-06-13 with Medical categories.
Plants, marine organisms, and microorganisms have evolved complex chemical defense and signaling systems that are designed to protect them from predators and provide other biological benefits. These organisms thus produce substances containing novel chemotypes that may have beneficial effects for humans. As collection methods improve and new screen
Anticancer Agents From Natural Products Second Edition
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Author : Gordon M. Cragg
language : en
Publisher: CRC Press
Release Date : 2011-10-10
Anticancer Agents From Natural Products Second Edition written by Gordon M. Cragg and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-10-10 with Science categories.
The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons, but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design. In summarizing the status of natural products as cancer chemotherapeutics, Anticancer Agents from Natural Products, Second Edition covers the: History of each covered drug—a discussion of its mechanism on action, medicinal chemistry, synthesis, and clinical applications Potential for novel drug discovery through the use of genome mining as well as future developments in anticancer drug discovery Important biosynthetic approaches to "unnatural" natural products Anticancer Agents from Natural Products, Second Edition discusses how complex target-oriented synthesis—enabled by historic advances in methodology—has enormously expanded the scope of the possible. This book covers the current clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. It also reviews drug candidates currently in clinical development since many of these will be clinically used drugs in the future. Examples include the drugs etoposide and teniposide derived from the lead compound podophyllotoxin; numerous analogs derived from taxol; topotecan, derived from camptothecin; and the synthetic clinical candidates, E7389 and HTI-286, developed from the marine leads, halichondrin B and hemiasterlin.
Natural Products And Cancer Drug Discovery
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Author : Frank E. Koehn
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-11-09
Natural Products And Cancer Drug Discovery written by Frank E. Koehn and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-09 with Medical categories.
This volume will cover the natural products as they relate to cancer chemotherapy. The topics will include history and current status , recent launches, new clinical candidates and approved drugs directly derived from natural products, current and future cancer target opportunities for natural products, leveraging natural products as tools for new target generation , new approaches to cancer drug discovery through natural products based lead generation, and enabling technologies which leverage the unique attributes of natural products.
Discovery And Development Of Anti Breast Cancer Agents From Natural Products
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Author : Goutam Brahmachari
language : en
Publisher: Elsevier
Release Date : 2021-06-24
Discovery And Development Of Anti Breast Cancer Agents From Natural Products written by Goutam Brahmachari and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-24 with Science categories.
Discovery and Development of Anti-Breast Cancer Agents from Natural Products presents cutting-edge research advances in the field of bioactive natural products and natural drug formulations. This volume in the Natural Products Drug Discovery series focuses on molecules of natural origin and their synthetic analogs that show promising potential to act as anti-breast cancer and chemotherapeutic agents. Combining foundational background information on cancer mechanisms with details of medicinal structures from natural products, this volume compiles the latest developments from across interdisciplinary fields. Discovery and Development of Anti-Breast Cancer Agents from Natural Products will serve as a valuable resource for researchers working to discover promising leads for the development of novel pharmaceuticals for breast cancer, highlighting a number of key structures from natural products and exploring possible future developments in the area. Highlights active agents from natural sources for development as novel anti-cancer agents Features contributions from active researchers and leading experts working in the field Includes foundational background information on both breast cancer mechanisms and natural product structures to support researchers from different disciplines
Discovery And Development Of Anti Cancer Agents From Natural Products
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Author : Felix Cliburn
language : en
Publisher: American Medical Publishers
Release Date : 2023-09-26
Discovery And Development Of Anti Cancer Agents From Natural Products written by Felix Cliburn and has been published by American Medical Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-26 with Medical categories.
Natural products, with remarkable chemical diversity have played a dominant role in the treatment of human ailments. They are considered as a reservoir of bioactive compounds and are extensively investigated for their therapeutic potentials, most notably in the area of cancer therapy. They cannot function as effective drugs in isolation but they can be converted into a drug through chemical modification. There are a variety of widely-used anticancer agents that originate from natural sources, which are structurally unique and function by novel action mechanisms. Some examples of these natural anticancer agents are camptothecin, irinotecan, vincristine, etoposide and paclitaxel derived from plants; actinomycin D and mitomycin C obtained from bacteria; as well as marine-derived bleomycin. Camptothecin is a naturally occurring quinolone alkaloid isolated from wood and bark of Camptotheca acuminate. It is used as a chemotherapeutic agent for treating leukemia. This book is a compilation of chapters that discuss the most vital concepts and emerging trends in the discovery and development of anti-cancer agents from natural products. It includes contributions of experts and scientists which will provide innovative insights into this area of study.
Anticancer Agents Based On Natural Product Models
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Author : John M. Cassady
language : en
Publisher:
Release Date : 1980
Anticancer Agents Based On Natural Product Models written by John M. Cassady and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with Antibiotics categories.
Anticancer Plants Natural Products And Biotechnological Implements
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Author : Mohd Sayeed Akhtar
language : en
Publisher: Springer
Release Date : 2018-07-02
Anticancer Plants Natural Products And Biotechnological Implements written by Mohd Sayeed Akhtar and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-02 with Science categories.
This volume provides summarized scientific evidence of the different classes of plant-derived phytocompounds, their sources, chemical structures, anticancer properties, mechanisms of action, methods of extraction, and their applications in cancer therapy. It also discusses endophyte-derived compounds as chemopreventives to treat various cancer types. In addition, it provides detailed information on the enhanced production of therapeutically valuable anticancer metabolites using biotechnological interventions such as plant cell and tissue culture approaches, including in vitro-, hairy root- and cell-suspension culture; and metabolic engineering of biosynthetic pathways. Anticancer Plants: Natural Products and Biotechnological Implements – Volume 2” explores the natural bioactive compounds isolated from plants as well as fungal endophytes, their chemistry, and preventive effects to reduce the risk of cancer. Moreover, it highlights the genomics/proteomics approaches and biotechnological implementations. Providing solutions to deal with the challenges involved in cancer therapy, the book benefits a wide range of readers including academics, students, and industrial experts working in the area of natural products, medicinal plant chemistry, pharmacology, and biotechnology.
New Approaches To Natural Anticancer Drugs
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Author : Soodabeh Saeidnia
language : en
Publisher: Springer
Release Date : 2015-02-05
New Approaches To Natural Anticancer Drugs written by Soodabeh Saeidnia and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-05 with Medical categories.
This book provides an up-to-date review of recently identified natural anti-tumor compounds from various natural origins including plants, fungi, endophytic fungi and marine organisms. It also includes discussion of new areas such as biotechnology and nanoparticles. Chapters explain the challenges and developments in anti-cancer drug discovery approaches, traditional remedies for prevention and treatment of cancer, marine-derived anti-cancer compounds, and antibiotics used as anti-cancer agents, as well as different classes of terpenoids and carbohydrates, which have been the subject of discussion in this field as efficient anti-cancer candidates. This book will be a concise guide for researchers in the field of pharmaceutical sciences, students and residents in pharmacy and medicine as well as those researching phytochemistry and natural products.
Marine Natural Products As Anticancer Agents 2 0
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Author : Celso Alves
language : en
Publisher: Mdpi AG
Release Date : 2023-06-12
Marine Natural Products As Anticancer Agents 2 0 written by Celso Alves and has been published by Mdpi AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-12 with categories.
Global cancer incidence and death are expected to increase in the next decades. Inappropriate therapeutic regimens and tumor recurrence due to the development of drug resistance are two major clinical challenges impacting poor patient outcomes, which is critical to the discovery and development of new anticancer drugs. Over the last few decades, the marine environment has proved to be a key source of molecules with potent anticancer properties. The Special Issue, "Marine Natural Products as Anticancer Agents 2.0", gathered eleven publications, including two reviews and nine research articles, about the anticancer activities of marine natural and/or derived products on in vitro 2D and 3D cellular models, and/or in vivo models of colorectal, breast, lung, myeloma, liver, leukemia, and melanoma cancers. Altogether, the eleven scientific papers published in this Special Issue provide an exciting overview of marine natural products as potential anticancer agents.
Anticancer Drug Discovery And Development Natural Products And New Molecular Models
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Author : Frederick A. Valeriote
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Anticancer Drug Discovery And Development Natural Products And New Molecular Models written by Frederick A. Valeriote and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
With the publication of these proceedings from the Second Drug Discovery and Development Symposium, this forum has become the main mechanism for bringing together the principal groups involved in both discovering and developing new approaches to the treatment of cancer. This Second Symposium emphasized the types of materials being discovered and their therapeutic activity. This is especially evident in the natural product discovery programs, where unique and active structures are being identified. The major contributors to the meeting were the investigators participating in the National Cooperative (Natural Products) Drug Discovery Groups [NC(NP)DDG]. These groups reflect an association among researchers at universities or cancer centers, pharmaceutical companies and the National Cancer Institute. Their sources of materials are varied, reflecting chemical inventories of pharmaceutical companies, organic synthetic compounds from the laboratory, cytotoxics as well as biologics and their hybrids, and natural products obtained from plants, marine organisms and microorganisms. The models employed in the discovery systems vary from broadly cellular based to specific enzymes to defined cellular functions. Each of them is believed important to the malignant state and will allow for the discovery of compounds which will have efficacy in cancer therapy. The goal of the participants is both to discover new anticancer agents and to develop them as efficiently as possible into clinically useful additions to treatment. Of importance is the fact that there are a number of promising leads which will soon be moving into the clinic thereby testing the effectiveness of this NC (NP) DDG approach.