Anticancer Agents From Natural Products

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Anticancer Agents From Natural Products Second Edition

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Author : Gordon M. Cragg
language : en
Publisher: CRC Press
Release Date : 2011-10-10

Anticancer Agents From Natural Products Second Edition written by Gordon M. Cragg and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-10-10 with Science categories.

The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons, but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design. In summarizing the status of natural products as cancer chemotherapeutics, Anticancer Agents from Natural Products, Second Edition covers the: History of each covered drug—a discussion of its mechanism on action, medicinal chemistry, synthesis, and clinical applications Potential for novel drug discovery through the use of genome mining as well as future developments in anticancer drug discovery Important biosynthetic approaches to "unnatural" natural products Anticancer Agents from Natural Products, Second Edition discusses how complex target-oriented synthesis—enabled by historic advances in methodology—has enormously expanded the scope of the possible. This book covers the current clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. It also reviews drug candidates currently in clinical development since many of these will be clinically used drugs in the future. Examples include the drugs etoposide and teniposide derived from the lead compound podophyllotoxin; numerous analogs derived from taxol; topotecan, derived from camptothecin; and the synthetic clinical candidates, E7389 and HTI-286, developed from the marine leads, halichondrin B and hemiasterlin.

Anticancer Plants Natural Products And Biotechnological Implements

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Author : Mohd Sayeed Akhtar
language : en
Publisher: Springer
Release Date : 2018-07-02

Anticancer Plants Natural Products And Biotechnological Implements written by Mohd Sayeed Akhtar and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-02 with Science categories.

This volume provides summarized scientific evidence of the different classes of plant-derived phytocompounds, their sources, chemical structures, anticancer properties, mechanisms of action, methods of extraction, and their applications in cancer therapy. It also discusses endophyte-derived compounds as chemopreventives to treat various cancer types. In addition, it provides detailed information on the enhanced production of therapeutically valuable anticancer metabolites using biotechnological interventions such as plant cell and tissue culture approaches, including in vitro-, hairy root- and cell-suspension culture; and metabolic engineering of biosynthetic pathways. Anticancer Plants: Natural Products and Biotechnological Implements – Volume 2” explores the natural bioactive compounds isolated from plants as well as fungal endophytes, their chemistry, and preventive effects to reduce the risk of cancer. Moreover, it highlights the genomics/proteomics approaches and biotechnological implementations. Providing solutions to deal with the challenges involved in cancer therapy, the book benefits a wide range of readers including academics, students, and industrial experts working in the area of natural products, medicinal plant chemistry, pharmacology, and biotechnology.

Natural Products For Cancer Prevention And Therapy

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Author : Anupam Bishayee
language : en
Publisher: MDPI
Release Date : 2018-11-07

Natural Products For Cancer Prevention And Therapy written by Anupam Bishayee and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-07 with Medical categories.

This book is a printed edition of the Special Issue "Natural Products for Cancer Prevention and Therapy" that was published in Nutrients

Anticancer Agents From Natural Products

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Author : Gordon M. Cragg
language : en
Publisher: CRC Press
Release Date : 2005-06-13

Anticancer Agents From Natural Products written by Gordon M. Cragg and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-06-13 with Medical categories.

Plants, marine organisms, and microorganisms have evolved complex chemical defense and signaling systems that are designed to protect them from predators and provide other biological benefits. These organisms thus produce substances containing novel chemotypes that may have beneficial effects for humans. As collection methods improve and new screen

Marine Natural Products As Anticancer Agents

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Author : Celso Alves
language : en
Publisher:
Release Date : 2021

Marine Natural Products As Anticancer Agents written by Celso Alves and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.

Cancer remains one of the most significant threats to human health and one of the deadliest diseases worldwide, making it crucial to develop new drugs. Over the last few decades, natural products have become one of the key drivers in the development of innovative cancer treatments. Despite drug development from terrestrial resources, the marine environment only recently emerged as a prolific source of unparalleled structurally active metabolites. Due to their excellent scaffold diversity, structural complexity, and ability to act on multiple cell signaling networks involved in carcinogenesis, marine natural products (MNPs) are ideal candidates to inspire the development of novel anticancer medicines. This book gathers nine publications of the Special Issue "Marine Natural Products as Anticancer Agents," providing an excellent overview of the chemical richness offered by marine organisms, such as sponges, myxobacteria, fungi, and soft corals. MNPs or derived products belong to distinct chemical classes, including terpenoids, alkaloids, cyclodepsipeptides, polyketides, and hydroxyphenylacetic acid derivatives. These compounds modulate cancer cell mechanisms in in vitro and in vivo models, exhibiting high specificity and great affinity to interact with biological targets linked to specific intracellular signaling pathways, including mitochondrial dysfunction, autophagy, endoplasmic reticulum stress induction, apoptosis, inflammation, migration, and invasion. This volume provides an exciting overview of marine natural products as potential therapeutic agents for cancer treatment.

Anticancer Agents From Natural Products

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Author : Gordon M. Cragg
language : en
Publisher: CRC Press
Release Date : 2011-10-10

Anticancer Agents From Natural Products written by Gordon M. Cragg and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-10-10 with Medical categories.

The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons, but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design.

Natural Products And Cancer Drug Discovery

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Author : Frank E. Koehn
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-11-09

Natural Products And Cancer Drug Discovery written by Frank E. Koehn and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-09 with Medical categories.

This volume will cover the natural products as they relate to cancer chemotherapy. The topics will include history and current status , recent launches, new clinical candidates and approved drugs directly derived from natural products, current and future cancer target opportunities for natural products, leveraging natural products as tools for new target generation , new approaches to cancer drug discovery through natural products based lead generation, and enabling technologies which leverage the unique attributes of natural products.

Chemistry Of Biologically Potent Natural Products And Synthetic Compounds

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Author : Shahid Ul Islam
language : en
Publisher: John Wiley & Sons
Release Date : 2021-06-29

Chemistry Of Biologically Potent Natural Products And Synthetic Compounds written by Shahid Ul Islam and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-29 with Science categories.

In view of their promising biological and pharmaceutical activities, natural product inspired and heterocyclic compounds have recently gained a reputation in the field of medicinal chemistry. Over the past decades, intensive research efforts have been ongoing to understand the synthesis, biochemistry and engineering involved in their preparation and action mechanisms. Several novel natural product derivatives, heterocyclic and other synthetic compounds, have been reported to have shown interesting biological activities including anticancer, antimicrobial, anti-inflammatory, anti-glycemic, anti-allergy and antiviral etc. Chemistry of Biologically Potent Natural Products and Synthetic Compounds provides up-to-date information on new developments and most recent medicinal applications of the natural products and derivatives, as well as the chemistry and synthesis of heterocyclic and other related compounds.

Bioactive Natural Products Opportunities And Challenges In Medicinal Chemistry

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Author : Goutam Brahmachari
language : en
Publisher: World Scientific
Release Date : 2011-10-17

Bioactive Natural Products Opportunities And Challenges In Medicinal Chemistry written by Goutam Brahmachari and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-10-17 with Science categories.

Bioactive natural products are a rich source of novel therapeutics. Thus, the search for bioactive molecules from nature continues to play an important role in fashioning new medicinal agents. This volume, which comprises sixteen chapters written by active researchers and leading experts in natural products chemistry, brings together an overview of current discoveries in this remarkable field. It also provides information on the industrial application of natural products for medicinal purposes. This book will serve as a valuable resource for researchers to predict promising leads for developing pharmaceuticals to treat various ailments and disease manifestations.

Natural Product Chemistry For Drug Discovery

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Author : Antony D. Buss
language : en
Publisher: Royal Society of Chemistry
Release Date : 2010

Natural Product Chemistry For Drug Discovery written by Antony D. Buss and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Medical categories.

This text provides a comprehensive summary of where natural product chemistry is today in drug discovery. It covers emerging technologies and case studies and is a source of up-to-date information on the topical subject of natural products.