Anticancer Agents From Natural Products Second Edition
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Anticancer Agents From Natural Products Second Edition
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Author : Gordon M. Cragg
language : en
Publisher: CRC Press
Release Date : 2011-10-10
Anticancer Agents From Natural Products Second Edition written by Gordon M. Cragg and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-10-10 with Science categories.
The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons, but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design. In summarizing the status of natural products as cancer chemotherapeutics, Anticancer Agents from Natural Products, Second Edition covers the: History of each covered drug—a discussion of its mechanism on action, medicinal chemistry, synthesis, and clinical applications Potential for novel drug discovery through the use of genome mining as well as future developments in anticancer drug discovery Important biosynthetic approaches to "unnatural" natural products Anticancer Agents from Natural Products, Second Edition discusses how complex target-oriented synthesis—enabled by historic advances in methodology—has enormously expanded the scope of the possible. This book covers the current clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. It also reviews drug candidates currently in clinical development since many of these will be clinically used drugs in the future. Examples include the drugs etoposide and teniposide derived from the lead compound podophyllotoxin; numerous analogs derived from taxol; topotecan, derived from camptothecin; and the synthetic clinical candidates, E7389 and HTI-286, developed from the marine leads, halichondrin B and hemiasterlin.
Natural Products For Cancer Prevention And Therapy
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Author : Anupam Bishayee
language : en
Publisher: MDPI
Release Date : 2018-11-07
Natural Products For Cancer Prevention And Therapy written by Anupam Bishayee and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-07 with Medical categories.
This book is a printed edition of the Special Issue "Natural Products for Cancer Prevention and Therapy" that was published in Nutrients
Bioactive Compounds From Natural Sources
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Author : Corrado Tringali
language : en
Publisher: CRC Press
Release Date : 2011-09-27
Bioactive Compounds From Natural Sources written by Corrado Tringali and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-27 with Health & Fitness categories.
The first edition of Bioactive Compounds from Natural Sources was published in a period of renewed attention to biologically active compounds of natural origin. This trend has continued and intensified-natural products are again under the spotlight, in particular for their possible pharmacological applications. Largely focusing on natural products
Bioactive Compounds From Natural Sources Second Edition
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Author : Corrado Tringali
language : en
Publisher: CRC Press
Release Date : 2011-09-27
Bioactive Compounds From Natural Sources Second Edition written by Corrado Tringali and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-27 with Science categories.
The first edition of Bioactive Compounds from Natural Sources was published in a period of renewed attention to biologically active compounds of natural origin. This trend has continued and intensified—natural products are again under the spotlight, in particular for their possible pharmacological applications. Largely focusing on natural products as lead compounds in drug discovery, Bioactive Compounds from Natural Sources, Second Edition: Natural Products as Lead Compounds in Drug Discovery is actually a completely new volume containing surveys of selected recent advances in an interdisciplinary area covering chemistry of natural products, medicinal chemistry, biochemistry, and other related topics. Written by some of the most reputed scientists in the field, this second edition includes new chapters from authors who contributed to the first edition as well as many chapters compiled by new authors. Introducing the reader to strategies and methods in the search for bioactive natural products, this book covers topics including: Natural sources of bioactive compounds such as aquatic cyanobacteria, filamentous fungi, and tropical plants, The tremendous potentiality of metabolic engineering of natural products biosynthesis The contribution of emerging or developing technologies to the study of bioactive natural compounds, namely computational methods and circular dichroism The potential of natural or natural-derived compounds for specific therapeutic applications: treatment of viral diseases, regulation of hypoxia-inducible factor, antimalarials, modulation of angiogenesis, and antitumor and wound-healing activity Selected examples of natural product families and related synthetic analogues, namely polyphenols and campthotecins Compiled for researchers and Ph.D. students working in interdisciplinary fields, this book will also be appreciated by readers without a background in chemistry interested in bioactive natural products, their biological and pharmacological properties, and their possible use as chemopreventive or chemotherapeutic agents. Conversely, the biological and pharmacological data and methods are accessible by chemists.
Medicinal Chemistry Of Anticancer Drugs
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Author : Carmen Avendano
language : en
Publisher: Elsevier Science
Release Date : 2015-04-28
Medicinal Chemistry Of Anticancer Drugs written by Carmen Avendano and has been published by Elsevier Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-28 with Science categories.
Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design.
Basic Pharmacokinetics Second Edition
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Author : Mohsen A. Hedaya
language : en
Publisher: CRC Press
Release Date : 2012-02-09
Basic Pharmacokinetics Second Edition written by Mohsen A. Hedaya and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-09 with Medical categories.
Knowledge of pharmacokinetics is critical to understanding the absorption, distribution, metabolism, and excretion of drugs. It is therefore vital to those engaged in the discovery, development, and preclinical and clinical evaluation of drugs, as well as practitioners involved in the clinical use of drugs. Using different approaches accessible to a wide variety of readers, Basic Pharmacokinetics: Second Edition demonstrates the quantitative pharmacokinetic relations and the interplay between pharmacokinetic parameters. After a basic introduction to pharmacokinetics and its related fields, the book examines: Mathematical operations commonly used in pharmacokinetics Drug distribution and clearance and how they affect the rate of drug elimination after a single dose Factors affecting drug absorption following extravascular drug administration, the rate and extent of drug absorption, and drug bioequivalence The steady-state concept during constant rate intravenous infusion and during multiple drug administration Renal drug elimination, drug metabolism, multicompartment models, nonlinear pharmacokinetics, and drug administration by intermittent intravenous infusion Pharmacokinetic-pharmacodynamic modeling, noncompartmental pharmacokinetic data analysis, clearance concept from the physiological point of view, and physiological modeling Clinical applications of pharmacokinetics, including therapeutic drug monitoring, drug pharmacokinetics in special populations, pharmacokinetic drug-drug interactions, pharmacogenomics, and applications of computers in pharmacokinetics Accompanying the book is a CD-ROM with self-instructional tutorials and pharmacokinetic and pharmacokinetic-pharmacodynamic simulations, allowing visualization of concepts for enhanced comprehension. This learning tool received an award from the American Association of Colleges of Pharmacy for innovation in teaching, making it a valuable supplement to this essential text.
Phytochemistry Of Australia S Tropical Rainforest
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Author : Cheryll J. Williams
language : en
Publisher: CSIRO PUBLISHING
Release Date : 2021-12-01
Phytochemistry Of Australia S Tropical Rainforest written by Cheryll J. Williams and has been published by CSIRO PUBLISHING this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-01 with Science categories.
Rare, unique and irreplaceable – precious native rainforests occupy a precariously small part of Australia while retaining a remarkable level of both biological and chemical diversity unrivalled by any other ecosystem. Australia's ancient history and traditions are intimately intertwined with the rainforest plants that humans have utilised as both food and medicine. Phytochemistry of Australia's Tropical Rainforest is a record of this history and details how our understanding of these plants has led to the discovery of anaesthetics, analgesics, steroids, antimalarials and more. It provides an insight into the habitat, ecology and family associations of hundreds of species and explores their future therapeutic potential, alongside phytochemical studies of the ancient plant lineages. Toxicological evaluations of important poisonous plants are also included. Rainforests provide shelter for unique flora and fauna that are counted among the rarest species on Earth, many of which are illustrated in this book. This comprehensive work is an essential reference for phytochemists, ethnobotanists and those with an interest in rainforests and their medicinal and botanical potential.
New Strategies Targeting Cancer Metabolism
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Author : Galal H. Elgemeie
language : en
Publisher: Elsevier
Release Date : 2022-05-17
New Strategies Targeting Cancer Metabolism written by Galal H. Elgemeie and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-17 with Science categories.
New Strategies Targeting Cancer Metabolism: Anticancer Drugs, Synthetic Analogues and Antitumor Agents presents up-to-date synthetic strategies for three categories of antimetabolites: antifolates, purines and pyrimidines, the main classes of antimetabolites which are integrated into various pharmaceutical agents. Many of these antimetabolites are considered potent chemotherapeutic agents which have great potential impact on medical research. These main classes of antimetabolites are used in the treatment of critical diseases including cancer, malignancies, autoimmune diseases, and many other non-malignant diseases. Antineoplastic drugs such as alkylating agents which have significant effects are described. Novel synthetic strategies for many anticancer alkylating agents including nitrogen mustards, chlorambucil, melphalan, ifosamide, oxaliplatin and temozolomide are explored. Natural products have offered some of the most significant drugs for treating cancer, as many drugs currently in clinical use are derived from natural products as camptothecins, vinca alkaloids, and derivatives of podophyllotoxin. They provide a contribution that is essential for modern drug discovery and development. In this book, insights into a broad array of novel compounds are reviewed, well-recognized synthetic approaches are emphasized for further anticancer drug development and discovery, and the biological evaluation of novel synthesized compounds are included. This comprehensive reference is a valuable resource for medical chemists working in drug discovery and development, as well as pharmacologists and biochemists working in related fields. - Provides the only resource dedicated to synthetic strategies of antimetabolites - Features synthetic strategies for nucleosides and their analogues - Includes coverage of purine-, pyrimidine- and antifolate-based anticancer drugs - The most significant anticancer alkylating agents and natural products are demonstrated
Plants That Fight Cancer Second Edition
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Author : Spyridon E. Kintzios
language : en
Publisher: CRC Press
Release Date : 2019-06-26
Plants That Fight Cancer Second Edition written by Spyridon E. Kintzios and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-26 with Science categories.
An increasing amount of cancer research is being directed towards the investigation of plant-derived anticancer compounds, many of which have been used in traditional herbal treatments for centuries. Plants that Fight Cancer is an up-to-date, extensive review of plant genera and species with documented anti-tumor and anti-leukaemic properties. Following an overview of the disease and the diverse methods of therapy and clinical testing, the book provides a detailed examination of the plants whose compounds are currently used in conventional cancer treatment, the species which show the greatest potential as future candidates, and other species with established anticancer properties. The third section explores each of more than 150 terrestrial plant genera and species, with a review of their traditional uses, mythology, botany, active ingredients, and product applications, along with photographs and illustrations and an analysis of expected results and risks. The text closes with a discussion of algal extracts and isolated metabolites with anticancer activity, a summary of published research for each species, and chemical structures of the most important compounds.
Natural Product Treatment Of Gastrointestinal Diseases 2nd Edition
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Author : Mingyu Sun
language : en
Publisher: Frontiers Media SA
Release Date : 2023-07-18
Natural Product Treatment Of Gastrointestinal Diseases 2nd Edition written by Mingyu Sun and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-18 with Science categories.
Gastrointestinal (GI) cancers, including esophageal, gastric, and colorectal cancers, are one of the major malignant diseases detrimental to health and account for almost 20% of all cancers worldwide. Besides their high incidence, GI cancers are related to high mortality rates, placing these malignancies among the most prominent public health issues of our time. Gastrointestinal diseases are prevalent, especially functional gastrointestinal disorders. Natural product has been used for thousands of years in the treatment of gastrointestinal diseases including cancer. To discover and develop the natural product with therapeutic selectivity and without toxicity are very important steps in the treatment of GI diseases. Because of their wide range of pharmacologic activities and low toxicity in animal models, many natural products have been used as alternative treatments for gastrointestinal diseases and cancers. Growing evidence has shown that natural products are beneficial for patients with gastrointestinal diseases or cancer, but it is still unconvincing and the mechanism behind the effect has not been fully revealed. In this Research Topic, we emphasize: (1) evaluation of clinical effectiveness of natural products in the treatment of gastrointestinal diseases including cancer; (2) mechanism of action of natural products; (3) translation of natural products into routine practice.