Antigen Processing And Mhc I Restricted Presentation Of Influenza Pa Polymerase

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Antigen Processing And Mhc I Restricted Presentation Of Influenza Pa Polymerase

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Author : Dominic Mark Justewicz
language : en
Publisher:
Release Date : 1993

Antigen Processing And Mhc I Restricted Presentation Of Influenza Pa Polymerase written by Dominic Mark Justewicz and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with categories.

Antigen Processing And Recognition

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Author : James McCluskey
language : en
Publisher: CRC Press
Release Date : 1991-09-03

Antigen Processing And Recognition written by James McCluskey and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-09-03 with Medical categories.

This book provides a state-of-the-art review of the processing, presentation, and subsequent recognition of antigens by T cells. Topics discussed include the structure of MHC molecules, the nature and specificity of human class II molecule interactions with peptide antigens, the class II invariant chain, antigen processing and presentation by class I MHC molecules, the biology of antigen processing, and the presentation and role of accessory molecules in T cell recognition. Other chapters feature discussions about the T cell allorecognition of MHC molecules, the recognition of minor antigens, and the concept of "superantigens." Color plates demonstrate the three-dimensional structure of MHC molecules and peptide antigen interaction with MHC molecules. Diagrams illustrate antigen presentation pathways, T cell receptor-MHC interaction and accessory molecule interactions. Antigen Processing and Recognition will be a valuable addition to the libraries of students and teachers of immunology, as well as cell biologists who are looking for a unified view of this rapidly expanding subject.

American Doctoral Dissertations

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Author :
language : en
Publisher:
Release Date : 1993

American Doctoral Dissertations written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Dissertation abstracts categories.

Dissertation Abstracts International

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Author :
language : en
Publisher:
Release Date : 1994

Dissertation Abstracts International written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Dissertations, Academic categories.

Cumulated Index Medicus

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Author :
language : en
Publisher:
Release Date : 1996

Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Medicine categories.

Abstracts Of Papers Presented At The 1991 Meeting On Modern Approaches To New Vaccines Including Prevention Of Aids

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Author :
language : en
Publisher:
Release Date : 1991

Abstracts Of Papers Presented At The 1991 Meeting On Modern Approaches To New Vaccines Including Prevention Of Aids written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with AIDS vaccines categories.

Cytotoxic T Lymphocytes In Human Viral And Malaria Infections

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Author : Michael B.A. Oldstone
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11

Cytotoxic T Lymphocytes In Human Viral And Malaria Infections written by Michael B.A. Oldstone and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Science categories.

Cytotoxic T lymphocytes (CTL) control several viral infections in animals based on deletion and reconstitution experiments with CTL clones and use of CD8 genetically deficient (knock-out) mice. In this volume, data for the role that CTL play in human infectious diseases is presented. As such, this represents the first volume in which such information from several different viral and protozoan infections is brought together.

Influenza Virus Vaccines And Immunotherapies

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Author : Arun Kumar
language : en
Publisher: Frontiers Media SA
Release Date : 2016-03-15

Influenza Virus Vaccines And Immunotherapies written by Arun Kumar and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-15 with Immunologic diseases. Allergy categories.

Influenza virus infections lead to thousands of deaths worldwide annually and billions of dollars economic burden. Despite continuing advances in our understanding of the immune evasion mechanism, the disease remains one of the foremost threat for human being. Traditional vaccines (attenuated and inactivated) mainly provide protection by inducing virus neutralizing antibodies, targeting ever changing surface antigens: Haemagultinin (HA) and Neuraminidase (NA). Due to genetic shift and immune selection pressure, prevalence of circulating influenza virus subtypes changes every year. Therefore, mismatch between circulating strain and vaccine strain can critically affect the success rate of these conventional flu vaccines, and requires continuous monitoring of circulating influenza virus subtypes and change in the vaccine formulations accordingly. The collective limitations of existing flu vaccines urgently call for the development of a novel universal vaccines that might provide the required protective immunity to a range of influenza virus subtypes. New approaches are being investigated mainly targeting conserved regions of flu proteins. Some of these approaches include universally conserved epitopes of HA, nucleoprotein (NP), capsid protein (M1) and ion channel protein (M2) that induced strong immune responses in animal models. Some attention and progress appears to be focused on vaccines based on the M2 ectodomain (M2e) employing a variety of constructs, adjuvants and delivery systems, including M2e-hepatitis B core antigen, flagellin constructs, and virus-like particles (VLP). Animal studies with these M2e candidate vaccines demonstrated that these vaccine candidates can prevent severe illness and death but not infection, which may pose difficulties in both the evaluation of clinical efficacy and approval by the regulatory authorities. VLP vaccines appear to be promising, but still are mostly limited to animal studies. The discovery and development of new and improved vaccines have been greatly facilitated by the application of new technologies. The use of nucleic acid-based vaccines, to combine the benefits of in-situ expression of antigens with the safety of inactivated and subunit vaccines, has been a key advancement. Upon their discovery more than 20 years ago, nucleic acid vaccines promised to be a safe and effective mean to mimic immunization with a live organism vaccine, particularly for induction of T cell immunity. In addition, the manufacturing of nucleic acid-based vaccines offered the potential to be relatively simple, inexpensive and generic. Reverse Vaccinology and in-silico designing of vaccines are very innovative approaches and being considered as future of vaccines. Furthermore, various immuno-therapeutic agents also being developed to treat and minimize immuno-pathological damage in patients suffering from life threatening complications. For the treatment of such pathological conditions, various novel approaches such as administration of immune suppressive cytokines, blocking co-stimulatory signals or activating co-inhibitory signal of T cell activation, are being tested both in lab and clinics. The Research Topic on influenza virus vaccine and therapeutics will give an insight in to the current status and future scope of these new innovative approaches and technologies. Moreover, these new methods will also serve as a reference tool for the development of future vaccines against several other pathogens.

The Journal Of Immunology

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Author :
language : en
Publisher:
Release Date : 2006-10

The Journal Of Immunology written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-10 with Immunology categories.

Antigen Presentation

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Author : J. Lindsay Whitton
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-07

Antigen Presentation written by J. Lindsay Whitton and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Medical categories.

Antigen presentation is central to the immune response, and is instrumental in ensuring that the response mounted is that best suited to the eradication of the particular microbe faced. In this volume, experts in the field provide state-of-the-art descriptions of the antigen presentation pathways. How do viruses disrupt these critical pathways, and to what effect? Do all tissues present antigen in the same way? If not, why? What are the consequences of dysfunctional antigen presentation, seen in certain genetic disorders? This book considers not only the molecular details, but also their relevance to the whole organism.