Antipsychotic Drugs And Their Side Effects
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Antipsychotic Drugs And Their Side Effects
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Author : Thomas R.E. Barnes
language : en
Publisher: Academic Press
Release Date : 2013-10-22
Antipsychotic Drugs And Their Side Effects written by Thomas R.E. Barnes and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Medical categories.
In line with other volumes in the Neuroscience Perspectives Series, this volume covers the background, pharmacology, molecular biology, and biochemistry of antipsychotic drugs, together with an overview assessment of the therapeutic considerations. Over the past 40 years, the effectiveness of conventional neuroleptic agents for psychotic illness has been offset by a wide range of adverse side-effects, including motor side-effects like parkinsonism. Studies show that lowering doses may still produce the antipsychotic effect while lessening the risk of side-effects. As all available antispychotic drugs are able to block dopamine, specifically D2 receptors, doses below the threshold level for producing acute motor disorder can still be therapeutically effective. With the identification and characterization of multiple dopamine receptors, the possibility of more selective drugs with better side-effect potential has arisen. Other novel antipsychotic agents include D1 receptor blockers, partial dopamine agonists and non-dopamine drugs such as 5-HT receptor blockers, sigma receptor antagonists and NMDA receptor agonists. This volume reviews both the basic science of the conventional and atypical neuroleptics and their present and potential therapeutic use.
Antipsychotics And Their Side Effects
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Author : David M. Gardner
language : en
Publisher: Cambridge University Press
Release Date : 2010-11-11
Antipsychotics And Their Side Effects written by David M. Gardner and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-11 with Medical categories.
With the remarkable expansion in the use of antipsychotics, concerns about their immediate, intermediate, and long-term adverse effects have intensified. Despite this, studies consistently show that monitoring of patients taking antipsychotics can be inadequate, haphazard, or worse. This book provides a comprehensive review of the adverse effects of this pharmacologically complex therapeutic class, covering all commonly used conventional and atypical agents. In the first section, each chapter provides background information about an adverse effect, reviews the evidence linking the effect to various antipsychotics, and provides specific detection and monitoring recommendations. The second section provides unique monitoring guides for each antipsychotic. The third section provides the clinician with a program to monitor patients over the long-term. By supporting rational treatment decisions and systematic adverse effect monitoring, Antipsychotics and their Side Effects provides the clinician with the necessary information and tools for optimizing the safe and effective long-term use of antipsychotic drugs.
Life Threatening Effects Of Antipsychotic Drugs
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Author : Peter Manu
language : en
Publisher: Academic Press
Release Date : 2016-08-16
Life Threatening Effects Of Antipsychotic Drugs written by Peter Manu and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-16 with Medical categories.
Life-Threatening Effects of Antipsychotic Drugs describes in detail more than 20 life-threatening effects associated with antipsychotics, presents the best available data on their incidence and case fatality, and gives comprehensive advice on diagnosis, management and preventive strategies. In addition, the book discusses the benefit of antipsychotic medication in a range of therapeutic indications, and demonstrates the gain in life-expectancy associated with clozapine use in severe mental illness despite its serious, potentially life-threatening adverse effects. Covers cardiovascular, neurological, muscular, hematological, gastrointestinal, autonomic and metabolic effects Gives advice on risk factors, confounding diagnoses and measures to minimise seriousness Discusses clozapine rechallenge after each of its serious adverse reactions Makes suggestions for optimum management of somatic disease in those with severe mental illness, to improve life-expectancy Includes data on post-mortem considerations
A Guide To The Extrapyramidal Side Effects Of Antipsychotic Drugs
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Author : D. G. Cunningham Owens
language : en
Publisher: Cambridge University Press
Release Date : 1999-03-11
A Guide To The Extrapyramidal Side Effects Of Antipsychotic Drugs written by D. G. Cunningham Owens and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-03-11 with Medical categories.
A very readable and well illustrated 1999 clinical guide to the common side effects of antipsychotic medication.
Antipsychotics And Their Side Effects
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Author : David Martin Gardner
language : en
Publisher:
Release Date : 2011
Antipsychotics And Their Side Effects written by David Martin Gardner and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Antipsychotic drugs categories.
"With the remarkable expansion in the use of antipsychotics, concerns about their immediate, intermediate, and long-term adverse effects have intensified. Despite this, studies consistently show that monitoring of patients taking antipsychotics can be inadequate, haphazard, or worse. This book provides a comprehensive review of the adverse effects of this pharmacologically complex therapeutic class, covering all commonly used conventional and atypical agents. In the first section, each chapter provides background information about an adverse effect, reviews the evidence linking the effect to various antipsychotics, and provides specific detection and monitoring recommendations. The second section provides unique monitoring guides for each antipsychotic. The third section provides the clinician with a program to monitor patients over the long-term. By supporting rational treatment decisions and systematic adverse effect monitoring, Antipsychotics and their Side Effects provides the clinician with the necessary information and tools for optimizing the safe and effective long-term use of antipsychotic drugs"--EBL.
Antipsychotic Drugs
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Author : Thomas L. Schwartz
language : en
Publisher: Nova Science Publishers
Release Date : 2013
Antipsychotic Drugs written by Thomas L. Schwartz and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Antipsychotic drugs categories.
Since the mid-1990s, a revolution in regards to prescribing antipsychotics has taken place. Once utilized only for schizophrenia, the newer, second generation antipsychotics have now been approved for the treatment of bipolar disorders, depressive disorders, and autism spectrum disorders. They are often utilised elsewhere for the treatment of anxiety disorders, sleep disorders, and to calm agitated patients when dangerous behaviours occur. Prescription rates have soared making them some of the most advertised, prescribed and profitable drugs on the market. This book was developed with input of international authors of varying backgrounds to review the history and development of these agents and to focus on the utilization of these drugs in various disorders, age groups, and clinical situations.
Antipsychotic Drugs
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Author : Thomas L. Schwartz
language : en
Publisher: Nova Science Publishers
Release Date : 2014-05-14
Antipsychotic Drugs written by Thomas L. Schwartz and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-14 with Medical categories.
Since the mid-1990s, a revolution in regards to prescribing antipsychotics has taken place. Once utilized only for schizophrenia, the newer, second generation antipsychotics have now been approved for the treatment of bipolar disorders, depressive disorders, and autism spectrum disorders. They are often utilized elsewhere for the treatment of anxiety disorders, sleep disorders, and to calm agitated patients when dangerous behaviors occur. Prescription rates have soared making them some of the most advertised, prescribed and profitable drugs on the market. This book was developed with input of international authors of varying backgrounds to review the history and development of these agents and to focus on the utilization of these drugs in various disorders, age groups, and clinical situations.
Antipsychotics And Their Side Effects
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Author : David M. Gardner
language : en
Publisher: Cambridge University Press
Release Date : 2010-11-11
Antipsychotics And Their Side Effects written by David M. Gardner and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-11 with Medical categories.
With the remarkable expansion in the use of antipsychotics, concerns about their immediate, intermediate, and long-term adverse effects have intensified. Despite this, studies consistently show that monitoring of patients taking antipsychotics can be inadequate, haphazard, or worse. This book provides a comprehensive review of the adverse effects of this pharmacologically complex therapeutic class, covering all commonly used conventional and atypical agents. In the first section, each chapter provides background information about an adverse effect, reviews the evidence linking the effect to various antipsychotics, and provides specific detection and monitoring recommendations. The second section provides unique monitoring guides for each antipsychotic. The third section provides the clinician with a program to monitor patients over the long-term. By supporting rational treatment decisions and systematic adverse effect monitoring, Antipsychotics and Their Side Effects provides the clinician with the necessary information and tools for optimizing the safe and effective long-term use of antipsychotic drugs.
Antipsychotic Long Acting Injections
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Author : Peter Haddad
language : en
Publisher: Oxford University Press
Release Date : 2016-05-10
Antipsychotic Long Acting Injections written by Peter Haddad and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-10 with Medical categories.
Antipsychotic Long-acting Injections (LAIs) were introduced in the 1960s to improve treatment adherence in schizophrenia. Subsequently, first-generation antipsychotic LAIs became widely used in many countries. Since the initial publication of Antipsychotic Long-acting Injections in 2010, new trial data have been published on long-acting injection (LAI) preparations of the drugs Risperidone, Paliperidone, and Olanzapine. Furthermore, a new LAI preparation of the drug Aripiprazole has recently been approved for clinical use in the United States and is likely to be approved in Europe soon. The second edition of this successful book has been fully updated to include this new data, with reference to both observational studies and randomized controlled trials, as well as other new developments in the clinical use of antipsychotic LAIs. New chapters have been added covering the comparison between oral and injectable antipsychotics, Olanzapine LAI, Aripiprazole LAI, and the practicalities of organizing a specialized clinic for long-acting injectable antipsychotics. Existing chapters have also been thoroughly updated to take into account the most recently published research. Antipsychotic Long-acting Injections, Second edition brings together clinical and research findings on LAIs in a comprehensive volume, with chapters written by international experts.
Current Antipsychotics
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Author : Gerhard Gross
language : en
Publisher: Springer
Release Date : 2014-12-14
Current Antipsychotics written by Gerhard Gross and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-14 with Medical categories.
Six decades after the serendipitous discovery of chlorpromazine as an antipsychotic and four decades after the launch of clozapine, the first atypical or second generation antipsychotic, psychopharmacology has arrived at an important crossroad. It is clear that pharmacological research and pharmaceutical development must now focus on complementary or even alternative mechanisms of action to address unmet medical needs, i.e. poorly treated domains of schizophrenia, improved acceptance by patients, better adherence to medication, safety in psychoses in demented patients, and avoiding cardiac and metabolic adverse effects. The first completely novel mechanisms evolving from our insights into the pathophysiology of psychotic disorders, especially the role of glutamatergic mechanisms in schizophrenia, are now under development, and further principles are on the horizon. This situation, in many respects similar to that when the initial second-generation antipsychotics became available, can be rewarding for all. Preclinical and clinical researchers now have the opportunity to confirm their hypotheses and the pharmaceutical industry may be able to develop really novel classes of therapeutics. When we were approached by the publishers of the Handbook of Experimental Pharmacology to prepare a new volume on antipsychotics, our intention was to capture both, the accumulated preclinical and clinical knowledge about current antipsychotics as well as prospects for new and potentially more specific antischizophrenia principles. These efforts should be based on the pathophysiology of the diseases and the affected neurotransmitter systems. Since preclinical research on antipsychotic compounds is only reliable when intimately linked through translational aspects to clinical results, we decided to include clinical science as well. It turned out that that this endeavor could not be covered by a single volume. We thank the editorial board and the publishers for supporting our decision to prepare two volumes: Current Antipsychotics and Novel Antischizophrenia Treatments. These topics cannot really be separated from one another and should be seen as a composite entity despite the somewhat arbitrary separation of contributions into two volumes. The continuing challenges of developing improved and safer antipsychotic medications remain of concern and are discussed in the first volume. The new opportunities for the field to develop and license adjunctive treatments for the negative symptoms and cognitive deficits that are treated inadequately by existing compounds have been incentivized recently and provide the focus for the second volume. We hope these collective contributions will facilitate the development of improved treatments for the full range of symptomatology seen in the group of schizophrenias and other major psychotic disorders. Gerhard Gross, Ludwigshafen, Germany Mark A. Geyer, La Jolla, CA This volume will try to put current therapy - achievements, shortcomings, remaining medical needs - and emerging new targets into the context of increasing knowledge regarding the genetic and neurodevelopmental contributions to the pathophysiology of schizophrenia. Some of the chapters will also deal with respective experimental and clinical methodology, biomarkers, and translational aspects of drug development. Non-schizophrenia indications will be covered to some extent, but not exhaustively.