Antipsychotics
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Antipsychotics
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Author : John G. Csernansky
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Antipsychotics written by John G. Csernansky and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Antipsychotic drugs were first discovered in 1953, and not since the late 1970s has the Handbook of Experimental Pharmacology taken up this topic. A new treatment of this topic would be due under any circumstances; however, this is now particularly true, since remarkable progress has been made on several fronts in furthering our understanding of the mechanisms of antipsychotic drug action. First, we have learned that schizophrenia is an illness with particu lar neuroanatomical abnormalities, many of which suggest that the illness is caused by errors in neurodevelopment. These findings have helped to form a context for understanding neurochemical aberrations in the illness and suggest new approaches for pharmacological treatment. Propelled forward by rapid advances in neurochemical anatomy, current pathophysiological hypotheses of schizophrenia and antipsychotic drug action have taken on the appearance of complex electrical circuit diagrams. Second, molecular biology studies have now revealed that there is a multiplicity of dopamine receptors (i. e. , D , DZshort' j DZlong, D , D , and D ), some of which may become entirely new targets for 3 4 s antipsychotic drug action. Ironically, the development of drugs that are selec tive for these receptors and that can be used to investigate their function lags behind; yet the discovery of these new receptors offers unparalleled opportu nities for developing drugs with improved efficacy and fewer side effects.
Antipsychotics And Their Side Effects
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Author : David M. Gardner
language : en
Publisher: Cambridge University Press
Release Date : 2010-11-11
Antipsychotics And Their Side Effects written by David M. Gardner and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-11 with Medical categories.
With the remarkable expansion in the use of antipsychotics, concerns about their immediate, intermediate, and long-term adverse effects have intensified. Despite this, studies consistently show that monitoring of patients taking antipsychotics can be inadequate, haphazard, or worse. This book provides a comprehensive review of the adverse effects of this pharmacologically complex therapeutic class, covering all commonly used conventional and atypical agents. In the first section, each chapter provides background information about an adverse effect, reviews the evidence linking the effect to various antipsychotics, and provides specific detection and monitoring recommendations. The second section provides unique monitoring guides for each antipsychotic. The third section provides the clinician with a program to monitor patients over the long-term. By supporting rational treatment decisions and systematic adverse effect monitoring, Antipsychotics and their Side Effects provides the clinician with the necessary information and tools for optimizing the safe and effective long-term use of antipsychotic drugs.
Antipsychotics
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Author : Jeffrey Kerner
language : en
Publisher: Bloomsbury Publishing USA
Release Date : 2017-01-26
Antipsychotics written by Jeffrey Kerner and has been published by Bloomsbury Publishing USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-26 with Medical categories.
The problem of serious mental illness is a widely discussed topic in the media and popular culture. This text provides a comprehensive analysis of antipsychotic medications, covering historical, social, and scientific viewpoints on this important and controversial class of medications. Antipsychotics are unique drugs with the ability to alter how people think and communicate. As a result, physicians must weigh a range of implications when prescribing antipsychotics. Antipsychotics: History, Science, and Issues offers a robust explanation of antipsychotic medications that covers the historical, ethical, medical, legal, and scientific dimensions of antipsychotics. The chapters explore topics ranging from the science of how examples of this class of drug actually work in the body to the social and legal implications of antipsychotics, making this subject understandable and relatable for lay readers who are not mental health practitioners. Readers will learn why prescribing antipsychotics is often a difficult decision due to the inherent risks of giving these medications to different types of patients and appreciate how mental health laws impact psychiatrists' prescribing practices.
Antipsychotic Long Acting Injections
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Author : Peter Haddad
language : en
Publisher: Oxford University Press, USA
Release Date : 2011
Antipsychotic Long Acting Injections written by Peter Haddad and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Medical categories.
Antipsychotic long-acting injections (LAIs) were introduced in the 1960s to improve treatment adherence in schizophrenia. This book brings together clinical and research findings on second generation LAIs in a comprehensive volume with chapters written by international experts.
The Bitterest Pills
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Author : J. Moncrieff
language : en
Publisher: Springer
Release Date : 2013-09-15
The Bitterest Pills written by J. Moncrieff and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-15 with Psychology categories.
A challenging reappraisal of the history of antipsychotics, revealing how they were transformed from neurological poisons into magical cures, their benefits exaggerated and their toxic effects minimized or ignored.
Current Antipsychotics
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Author : Gerhard Gross
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-11-05
Current Antipsychotics written by Gerhard Gross and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-05 with Medical categories.
Six decades after the serendipitous discovery of chlorpromazine as an antipsychotic and four decades after the launch of clozapine, the first atypical or second generation antipsychotic, psychopharmacology has arrived at an important crossroad. It is clear that pharmacological research and pharmaceutical development must now focus on complementary or even alternative mechanisms of action to address unmet medical needs, i.e. poorly treated domains of schizophrenia, improved acceptance by patients, better adherence to medication, safety in psychoses in demented patients, and avoiding cardiac and metabolic adverse effects. The first completely novel mechanisms evolving from our insights into the pathophysiology of psychotic disorders, especially the role of glutamatergic mechanisms in schizophrenia, are now under development, and further principles are on the horizon. This situation, in many respects similar to that when the initial second-generation antipsychotics became available, can be rewarding for all. Preclinical and clinical researchers now have the opportunity to confirm their hypotheses and the pharmaceutical industry may be able to develop really novel classes of therapeutics. When we were approached by the publishers of the Handbook of Experimental Pharmacology to prepare a new volume on antipsychotics, our intention was to capture both, the accumulated preclinical and clinical knowledge about current antipsychotics as well as prospects for new and potentially more specific antischizophrenia principles. These efforts should be based on the pathophysiology of the diseases and the affected neurotransmitter systems. Since preclinical research on antipsychotic compounds is only reliable when intimately linked through translational aspects to clinical results, we decided to include clinical science as well. It turned out that that this endeavor could not be covered by a single volume. We thank the editorial board and the publishers for supporting our decision to prepare two volumes: Current Antipsychotics and Novel Antischizophrenia Treatments. These topics cannot really be separated from one another and should be seen as a composite entity despite the somewhat arbitrary separation of contributions into two volumes. The continuing challenges of developing improved and safer antipsychotic medications remain of concern and are discussed in the first volume. The new opportunities for the field to develop and license adjunctive treatments for the negative symptoms and cognitive deficits that are treated inadequately by existing compounds have been incentivized recently and provide the focus for the second volume. We hope these collective contributions will facilitate the development of improved treatments for the full range of symptomatology seen in the group of schizophrenias and other major psychotic disorders. Gerhard Gross, Ludwigshafen, Germany Mark A. Geyer, La Jolla, CA This volume will try to put current therapy - achievements, shortcomings, remaining medical needs - and emerging new targets into the context of increasing knowledge regarding the genetic and neurodevelopmental contributions to the pathophysiology of schizophrenia. Some of the chapters will also deal with respective experimental and clinical methodology, biomarkers, and translational aspects of drug development. Non-schizophrenia indications will be covered to some extent, but not exhaustively.
Atypical Antipsychotics
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Author : John C. Csernansky
language : en
Publisher: CRC Press
Release Date : 2004-04-20
Atypical Antipsychotics written by John C. Csernansky and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-04-20 with Medical categories.
Showcasing the latest studies in the field, this reference unveils recent breakthroughs in the use of atypical antipsychotics for the treatment of a variety of patient populations-tracking developments in the management of patients with schizophrenia and affective psychotic disorders, as well as therapeutic regimens for children and adolescents.
Drugging Our Children
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Author : Sharna Olfman
language : en
Publisher: Bloomsbury Publishing USA
Release Date : 2012-02-27
Drugging Our Children written by Sharna Olfman and has been published by Bloomsbury Publishing USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-27 with Psychology categories.
This book exposes the skyrocketing rate of antipsychotic drug prescriptions for children, identifies grave dangers when children's mental health care is driven by market forces, describes effective therapeutic care for children typically prescribed antipsychotics, and explains how to navigate a drug-fueled mental health system. Since 2001, there has been a dramatic increase in the use of antipsychotics to treat children for an ever-expanding list of symptoms. The prescription rate for toddlers, preschoolers, and middle-class children has doubled, while the prescribing rate for low-income children covered by Medicaid has quadrupled. In a majority of cases, these drugs are neither FDA-approved nor justified by research for the children's conditions. This book examines the reasons behind the explosion of antipsychotic drug prescriptions for children, spotlighting the historical and cultural factors as well as the role of the pharmaceutical industry in this trend; and discusses the ethical and legal responsibilities and ramifications for non-MDs—psychologists in particular—who work with children treated with antipsychotics. Contributors explain how the pharmaceutical industry has inserted itself into every step of medical education, rendering objectivity in the scientific understanding, use, and approvals of such drugs impossible. The text describes the relentless marketing behind the drug sales, even going as far as to provide coloring and picture books for children related to the drug at issue. Valuable information about legal recourse that families and therapists can take when their children or patients have been harmed by antipsychotic drugs and alternative approaches to working with children with emotional and behavioral challenges is also provided.
The American Psychiatric Association Practice Guideline On The Use Of Antipsychotics To Treat Agitation Or Psychosis In Patients With Dementia
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Author : American Psychiatric Association
language : en
Publisher: American Psychiatric Pub
Release Date : 2016
The American Psychiatric Association Practice Guideline On The Use Of Antipsychotics To Treat Agitation Or Psychosis In Patients With Dementia written by American Psychiatric Association and has been published by American Psychiatric Pub this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Antipsychotic drugs categories.
The guideline offers clear, concise, and actionable recommendation statements to help clinicians to incorporate recommendations into clinical practice, with the goal of improving quality of care. Each recommendation is given a rating that reflects the level of confidence that potential benefits of an intervention outweigh potential harms.
Antipsychotic Drugs And Their Side Effects
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Author : Thomas R.E. Barnes
language : en
Publisher: Academic Press
Release Date : 2013-10-22
Antipsychotic Drugs And Their Side Effects written by Thomas R.E. Barnes and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Medical categories.
In line with other volumes in the Neuroscience Perspectives Series, this volume covers the background, pharmacology, molecular biology, and biochemistry of antipsychotic drugs, together with an overview assessment of the therapeutic considerations. Over the past 40 years, the effectiveness of conventional neuroleptic agents for psychotic illness has been offset by a wide range of adverse side-effects, including motor side-effects like parkinsonism. Studies show that lowering doses may still produce the antipsychotic effect while lessening the risk of side-effects. As all available antispychotic drugs are able to block dopamine, specifically D2 receptors, doses below the threshold level for producing acute motor disorder can still be therapeutically effective. With the identification and characterization of multiple dopamine receptors, the possibility of more selective drugs with better side-effect potential has arisen. Other novel antipsychotic agents include D1 receptor blockers, partial dopamine agonists and non-dopamine drugs such as 5-HT receptor blockers, sigma receptor antagonists and NMDA receptor agonists. This volume reviews both the basic science of the conventional and atypical neuroleptics and their present and potential therapeutic use.