Apolipoprotein E Genotyping In Alzheimer S Disease

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Apolipoprotein E Genotyping In Alzheimer S Disease

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Author : Norman R. Relkin
language : en
Publisher:
Release Date : 1996

Apolipoprotein E Genotyping In Alzheimer S Disease written by Norman R. Relkin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Medical categories.

This volume addresses what is currently known about the use of ApoE genotyping in diagnosing and predicting Alzheimer's disease. Because ApoE genetic testing has such far-reaching consequences, this volume will be of use not only to those in the medical and scientific community involved in the care of patients with Alzheimer's disease, but also to those concerned with the ethical, legal, epidemiological and public health policy issues as well. A summary will also be included of the results of working groups defining the issues, asking methodological questions, and discussing issues concerning genetic counselling and research-related questions.

Apolipoprotein E And Alzheimer S Disease

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Author : A.D. Roses
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Apolipoprotein E And Alzheimer S Disease written by A.D. Roses and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

There is now considerable genetic evidence that the type 4 allele of the apolipoprotein E gene is a major susceptibility factor associated with late-onset Alzheimer's disease, the common form of the disease defined as starting after sixty years of age. The role of apolipoprotein E in normal brain metabolism and in the pathogenesis of Alzheimer's disease are new and exciting avenues of research. This book, written by the most outstanding scientists in this new filed, is the first presentation of results concerning the implications of apolipoprotein E on the genetics, cell biology, neuropathology, biochemistry, and therapeutic management of Alzheimer's disease.

Genetic Testing For Alzheimer Disease

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Author : Stephen Garrard Post
language : en
Publisher:
Release Date : 1998

Genetic Testing For Alzheimer Disease written by Stephen Garrard Post and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Family & Relationships categories.

The genetics of Alzheimer disease has been a point of intense concern and immense informational confusion for families in which a loved one is diagnosed with dementia. In recent years, however, scientists have begun to uncover the genetic bases for some forms of Alzheimer disease. Once a chromosomal defect is identified, it becomes possible to devise a test for its presence. The far-reaching implications of such tests are the focus of the present volume. In Genetic Testing for Alzheimer Disease, Stephen G. Post and Peter J. Whitehouse bring together experts from the fields of ethics, genetics, policy, neurology, philosophy, and anthropology to examine the ethical and social aspects of genetic testing for Alzheimer disease. The authors begin by focusing on current genetic findings and their clinical applicability. They then address ethical issues in genetic testing and genetic counseling for Alzheimer disease. They examine social issues such as confidentiality, discrimination, and fairness in health care. Finally, they discuss ways to educate professionals and laypeople regarding these issues. Contributors: Robert H. Binstock, Ph.D.?Thomas D. Bird, M.D. ? Robert Mullan Cook-Deegan, M.D.? Leonard Fleck, Ph.D. ? Atwood D. Gaines, Ph.D, M.P.H. ? Eric T. Juengst, Ph.D. ? Harry Karlinsky, M.D. ? Steven Miles, M.D. ? Thomas H. Murray, Ph.D. ? Stephen G. Post, Ph.D. ? Kimberly A. Quaid, Ph.D. ? Allen D. Roses, M.D. ? Greg A. Sachs, M.D. ? Peter H. St. George-Hyslop, M.D. ? Bonnie Steinbock, Ph.D. ? Arthur B. Zinn, M.D., Ph.D.

Apolipoprotein E Genotype And Severity Of Cognitive And Psychotic Symptoms In Alzheimer S Disease

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Author : Monique Grey
language : en
Publisher:
Release Date : 2002

Apolipoprotein E Genotype And Severity Of Cognitive And Psychotic Symptoms In Alzheimer S Disease written by Monique Grey and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Medicine categories.

Longitudinal Morphometric Study Of Genetic Influence Of Apoe E4 Genotype On Hippocampal Atrophy An N

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Author : Bolun Li
language : en
Publisher:
Release Date : 2015

Longitudinal Morphometric Study Of Genetic Influence Of Apoe E4 Genotype On Hippocampal Atrophy An N written by Bolun Li and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Alzheimer's disease categories.

The apolipoprotein E (APOE) e4 genotype is the most prevalent known genetic risk factor for Alzheimer's disease (AD). In this paper, we examined the longitudinal effect of APOE e4 on hippocampal morphometry in Alzheimer's Disease Neuroimaging Initiative (ADNI). Generally, atrophy of hippocampus has more chance occurs in AD patients who carrying the APOE e4 allele than those who are APOE e4 noncarriers. Also, brain structure and function depend on APOE genotype not just for Alzheimer's disease patients but also in health elderly individuals, so APOE genotyping is considered critical in clinical trials of Alzheimer's disease. We used a large sample of elderly participants, with the help of a new automated surface registration system based on surface conformal parameterization with holomorphic 1-forms and surface fluid registration. In this system, we automatically segmented and constructed hippocampal surfaces from MR images at many different time points, such as 6 months, 1- and 2-year follow up. Between the two different hippocampal surfaces, we did the high-order correspondences, using a novel inverse consistent surface fluid registration method. At each time point, using Hotelling's T^2 test, we found significant morphological deformation in APOE e4 carriers relative to noncarriers in the entire cohort as well as in the non-demented (pooled MCI and control) subjects, affecting the left hippocampus more than the right, and this effect was more pronounced in e4 homozygotes than heterozygotes.

The Role Of Apolipoprotein E In Neurodegeneration

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Author : Isaac Veinbergs
language : en
Publisher:
Release Date : 2002

The Role Of Apolipoprotein E In Neurodegeneration written by Isaac Veinbergs and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.

Meeting The Challenges Of Alzheimer S Disease

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Author : United States. Congress. Senate. Committee on Labor and Human Resources. Subcommittee on Aging
language : en
Publisher:
Release Date : 1997

Meeting The Challenges Of Alzheimer S Disease written by United States. Congress. Senate. Committee on Labor and Human Resources. Subcommittee on Aging and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Medical categories.

Using Apoe Genotype To Identify New Biomarkers Of Alzheimer S Disease Risk

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Author : Sonya Benjamina E. Dumanis
language : en
Publisher:
Release Date : 2013

Using Apoe Genotype To Identify New Biomarkers Of Alzheimer S Disease Risk written by Sonya Benjamina E. Dumanis and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Neurosciences categories.

To do this, we utilized APOE Targeted Replacement (TR) mice. These animals express the human APOE alleles

Apolipoprotein E As An Hereditary Risk Factor For Nondisjunction

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Author : Nicole M. Jones
language : en
Publisher:
Release Date : 2002

Apolipoprotein E As An Hereditary Risk Factor For Nondisjunction written by Nicole M. Jones and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Chromosome abnormalities categories.

The Effect Of Apoe Genotype On Astrocytic Phenotypes In Sporadic Alzheimer S Disease

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Author : Adele Pryce-Roberts
language : en
Publisher:
Release Date : 2020

The Effect Of Apoe Genotype On Astrocytic Phenotypes In Sporadic Alzheimer S Disease written by Adele Pryce-Roberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.