Apolipoprotein E And Alzheimer S Disease
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Apolipoprotein E And Alzheimer S Disease
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Author : A.D. Roses
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Apolipoprotein E And Alzheimer S Disease written by A.D. Roses and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
There is now considerable genetic evidence that the type 4 allele of the apolipoprotein E gene is a major susceptibility factor associated with late-onset Alzheimer's disease, the common form of the disease defined as starting after sixty years of age. The role of apolipoprotein E in normal brain metabolism and in the pathogenesis of Alzheimer's disease are new and exciting avenues of research. This book, written by the most outstanding scientists in this new filed, is the first presentation of results concerning the implications of apolipoprotein E on the genetics, cell biology, neuropathology, biochemistry, and therapeutic management of Alzheimer's disease.
Apolipoprotein E Genotyping In Alzheimer S Disease
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Author : Norman R. Relkin
language : en
Publisher:
Release Date : 1996
Apolipoprotein E Genotyping In Alzheimer S Disease written by Norman R. Relkin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Medical categories.
This volume addresses what is currently known about the use of ApoE genotyping in diagnosing and predicting Alzheimer's disease. Because ApoE genetic testing has such far-reaching consequences, this volume will be of use not only to those in the medical and scientific community involved in the care of patients with Alzheimer's disease, but also to those concerned with the ethical, legal, epidemiological and public health policy issues as well. A summary will also be included of the results of working groups defining the issues, asking methodological questions, and discussing issues concerning genetic counselling and research-related questions.
Neurodegeneration And Alzheimer S Disease
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Author : Ralph N. Martins
language : en
Publisher: John Wiley & Sons
Release Date : 2019-07-10
Neurodegeneration And Alzheimer S Disease written by Ralph N. Martins and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-10 with Technology & Engineering categories.
Understanding the impact of diet, exercise, genetics, and hormones on the risk and development of Alzheimer’s and other neurogenerative diseases Diet is widely known to impact on neurological function. Nevertheless, academic texts discussing this relationship are relatively few in number. This book therefore fills an important gap in the current literature. Opening with an overview of neurodegenerative diseases, particularly Alzheimer’s disease, the text then focuses on explaining the means by which glycemic control and lipid metabolism – and associated nutritional and lifestyle variables – may factor into such disorders’ prevention and treatment. An international group of experts in the fields of food science and neurodegeneration have contributed chapters that examine Alzheimer’s disease within a broad range of contexts. Offering dietary, genetic, and hormonal perspectives, the authors explore topics ranging from sugar consumption to digestive fermentation, and Alzheimer’s disease animal models to the cognition-enhancing effects of physical exercise. Also included are overviews of the latest research into current and developing methods of treatment and diagnosis, as well as differential diagnostics. This groundbreaking book: Explores how glucose metabolism, insulin resistance, lipid metabolism, and high intake of refined carbohydrates are linked to Alzheimer's disease Discusses how genetic makeup can impact risk of Alzheimer’s and Parkinson’s disease Examines cognitive changes in neurodegeneration, lists current tests for determining cognitive impairment, and provides information concerning differential diagnosis Discusses potential advantages of increasing antioxidant and micronutrient intake Reviews hormonal influences on neurodegeneration Examines the links between protein intake and Alzheimer’s disease. Neurodegeneration and Alzheimer's Disease is an essential resource for researchers, medical practitioners, dietitians, and students with an interest in neurological diseases and their diagnosis and risk factors, as well as diet-related conditions such as diabetes and obesity. Lifestyle and diet influence neurodegeneration risk, and a better understanding of this evidence amongst health professionals will hopefully lead to greater public awareness of how to reduce the likelihood of these widespread conditions.
The Role Of Apolipoprotein E In Neurodegeneration
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Author : Isaac Veinbergs
language : en
Publisher:
Release Date : 2002
The Role Of Apolipoprotein E In Neurodegeneration written by Isaac Veinbergs and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
The Role Of Apolipoprotein E In Alzheimer S Disease
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Author : Haroon M. Mojaddidi
language : en
Publisher:
Release Date : 1994
The Role Of Apolipoprotein E In Alzheimer S Disease written by Haroon M. Mojaddidi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with categories.
Apolipoprotein E In Alzheimer S Disease
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Author : Uwe Beffert
language : en
Publisher:
Release Date : 1999
Apolipoprotein E In Alzheimer S Disease written by Uwe Beffert and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with categories.
"Alzheimer's disease (AD) is the most important cause of dementia, but the mechanism of pathogenesis remains unknown. The epsilon4 allele of apolipoprotein E (apoE) has been confirmed as the most important genetic risk factor for most cases of AD and is associated with Abeta-containing senile plaques, one of the neuropathological hallmarks of AD. We determined the neuronal binding, internalization and degradation of human apoE isoforms apoE3 and apoE4 in the presence and absence of Abeta peptides using primary hippocampal neurons from rat. The findings demonstrate apoE binding and internalization in neurons without endogenous synthesis. Increased apoE3 degradation was observed relative to the apoE4 isoform. Lipophilic Abeta peptides increased apoE binding to hippocampal neurons; the increase was greater for the apoE4 isoform than for the apoE3 isoform. Abeta uptake by hippocampal neurons was increased in the presence of apoE, more so in the presence of the apoE4 than apoE3 isoform. Further, apoE was shown to reduce the extracellular level of Abeta in hippocampal cultures. We also find that all three major apoE isoforms were equally potent inhibitors of Abeta fibril formation, which is thought to be necessary for in vitro neurotoxicity and possibly the neuronal degeneration observed in AD. Further, when apoE was associated with cholesterol-containing liposomes or very low density lipoproteins, its ability to prevent Abeta fibril formation was diminished. In two brain regions affected by AD neuropathology, the hippocampus and frontal cortex, apoE levels were found to be decreased while Abeta levels were increased. Levels of apoE and Abeta1--40 were found to be apoE genotype dependent, with lowest levels of apoE and highest levels of Abeta occurring in epsilon4 allele carriers, suggesting that a reduction in apoE levels may give rise to increased deposition of amyloid peptides in AD brain. The low density lipoprotein receptor-related protein, an important neuronal ap" --
The Proteolysis Of Apolipoprotein E In Alzheimer S Disease
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Author : Julia Love
language : en
Publisher:
Release Date : 2016
The Proteolysis Of Apolipoprotein E In Alzheimer S Disease written by Julia Love and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Alzheimer's disease categories.
"Harboring the apolipoprotein E4 (APOE4) allele is the greatest genetic risk factor associated with late-onset (sporadic) Alzheimer's disease (AD), however the mechanism by which apoE4 contributes to the pathology of AD is unknown. The proteolysis of apoE4 has been suggested to contribute to AD pathology due to a possible toxic gain, or loss of function. In order to determine if apoE4 is being cleaved, we designed and characterized a site-directed cleavage antibody directed at position D151 of full length human apoE4. The antibody (nApoECFp17) detected a predicted ~17 kDa fragment following incubation with the proteases Type-1 collagenase, and matrix metalloproteinase (MMP)-1and 9. Once the nApoECFp17 amino-terminal antibody was applied to frontal cortex AD brain sections, it revealed nuclear labeling of glial cells and neurofibrillary tangles (NFTs). In addition, nApoECFp17 regionally localized with the protease MMP-9 in plaque-rich regions in vivo, suggesting apoE4 may be cleaved extracellularly. Together these data suggest a novel cleavage event of apoE4 by Type-I collagenase and MMP-1 and 9, generating an amino-terminal fragment that is then taken up by glial cells and localizes to the nucleus. This fragment localizing to the nucleus purposes a new role of apoE4 in AD pathology where apoE may alter gene expression."--Boise State University ScholarWorks.
The Role Of Apolipoprotein E In Alzheimer S Disease And Other Amyloidoses
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Author : Reuben Benjamin
language : en
Publisher:
Release Date : 1994
The Role Of Apolipoprotein E In Alzheimer S Disease And Other Amyloidoses written by Reuben Benjamin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with categories.
Molecular Mechanisms Of Dementia
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Author : Wilma Wasco
language : en
Publisher: Springer Science & Business Media
Release Date : 1996-11-01
Molecular Mechanisms Of Dementia written by Wilma Wasco and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-11-01 with Medical categories.
The past decade has witnessed a revolution in the attempts of scientists to under stand the molecular basis of dementia. Although dementia, as defined by global cogni tive decline involving gradual loss of memory, reasoning, judgment, and orientation, presents most commonly in the form of Alzheimer's disease (AD), an assortment of other less common disorders, such as prion and Pick's disease, can also lead to symp toms that are similar to those observed in patients with AD. The primary goal of Molecular Mechanisms of Dementia is to address the various mechanisms and multi faceted approaches currently being employed to more clearly delineate the etiological and pathogenic events responsible for the onset of dementia. Perhaps the greatest boon to obtaining a clearer understanding of the causes of AD has come from genetic and molecular biological studies carried out over the past decade. At the genetic level, it has become increasingly clear that AD is a heteroge neous disorder that can be broadly classified into two categories. "Late onset" (>60 yr) cases, which account for the vast majority of AD, genetically involve "susceptibility" genes representing risk factors for the disease (e. g. , inheritance of the 84 allele of the Apolipoprotein E gene). In many cases, the susceptibility gene can act as a "modifier" that modulates the pathogenic cascade occurring subsequent to a separate etiological event "initiating" or "causing" the disorder.
Neurobiology Of Alzheimer S Disease
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Author : David Dawbarn
language : en
Publisher:
Release Date : 2007
Neurobiology Of Alzheimer S Disease written by David Dawbarn and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Medical categories.
Alzheimer's disease is the most common form of dementia in the elderly; 450,000 people in the UK and 4.5 million people in the USA suffer with this disease. This 3rd edition of Neurobiology of Alzheimer's Disease gives a comprehensive and readable introduction to the disease, from molecular pathology to clinical practice. The book is intended for readers new to the field, and it also covers an extensive range of themes for those with in-depth knowledge of Alzheimer's disease. It will therefore act either as an introduction to the whole field of neurodegeneration or it will help experienced researchers to access the latest research in specialist topics. Each chapter is written by eminent scientists leading their fields in neuropathology, clinical practice and molecular neurobiology; appendices detail disease-associate proteins, their sequences, familial mutations and known structures. It will be essential reading for students interested in neurodegeneration and for researchers and clinicians, giving a coherent and cohesive approach to the whole area of research, and allowing access at different levels. For those in the pharmaceutical industry it describes the underlying molecular mechanisms involved in the pathogenesis of Alzheimer's disease and explains how current and potential therapeutics may work.