The Role Of Apolipoprotein E In Alzheimer S Disease

DOWNLOAD

Download The Role Of Apolipoprotein E In Alzheimer S Disease PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get The Role Of Apolipoprotein E In Alzheimer S Disease book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page

Apolipoprotein E And Alzheimer S Disease

DOWNLOAD
Author : A.D. Roses
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Apolipoprotein E And Alzheimer S Disease written by A.D. Roses and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

There is now considerable genetic evidence that the type 4 allele of the apolipoprotein E gene is a major susceptibility factor associated with late-onset Alzheimer's disease, the common form of the disease defined as starting after sixty years of age. The role of apolipoprotein E in normal brain metabolism and in the pathogenesis of Alzheimer's disease are new and exciting avenues of research. This book, written by the most outstanding scientists in this new filed, is the first presentation of results concerning the implications of apolipoprotein E on the genetics, cell biology, neuropathology, biochemistry, and therapeutic management of Alzheimer's disease.

The Role Of Apolipoprotein E In Neurodegeneration

DOWNLOAD
Author : Isaac Veinbergs
language : en
Publisher:
Release Date : 2002

The Role Of Apolipoprotein E In Neurodegeneration written by Isaac Veinbergs and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.

The Role Of Apolipoprotein E In Alzheimer S Disease

DOWNLOAD
Author : Haroon M. Mojaddidi
language : en
Publisher:
Release Date : 1994

The Role Of Apolipoprotein E In Alzheimer S Disease written by Haroon M. Mojaddidi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with categories.

The Role Of Apolipoprotein E In Alzheimer S Disease And Other Amyloidoses

DOWNLOAD
Author : Reuben Benjamin
language : en
Publisher:
Release Date : 1994

The Role Of Apolipoprotein E In Alzheimer S Disease And Other Amyloidoses written by Reuben Benjamin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with categories.

Neurodegeneration And Alzheimer S Disease

DOWNLOAD
Author : Ralph N. Martins
language : en
Publisher: John Wiley & Sons
Release Date : 2019-07-10

Neurodegeneration And Alzheimer S Disease written by Ralph N. Martins and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-10 with Technology & Engineering categories.

Understanding the impact of diet, exercise, genetics, and hormones on the risk and development of Alzheimer’s and other neurogenerative diseases Diet is widely known to impact on neurological function. Nevertheless, academic texts discussing this relationship are relatively few in number. This book therefore fills an important gap in the current literature. Opening with an overview of neurodegenerative diseases, particularly Alzheimer’s disease, the text then focuses on explaining the means by which glycemic control and lipid metabolism – and associated nutritional and lifestyle variables – may factor into such disorders’ prevention and treatment. An international group of experts in the fields of food science and neurodegeneration have contributed chapters that examine Alzheimer’s disease within a broad range of contexts. Offering dietary, genetic, and hormonal perspectives, the authors explore topics ranging from sugar consumption to digestive fermentation, and Alzheimer’s disease animal models to the cognition-enhancing effects of physical exercise. Also included are overviews of the latest research into current and developing methods of treatment and diagnosis, as well as differential diagnostics. This groundbreaking book: Explores how glucose metabolism, insulin resistance, lipid metabolism, and high intake of refined carbohydrates are linked to Alzheimer's disease Discusses how genetic makeup can impact risk of Alzheimer’s and Parkinson’s disease Examines cognitive changes in neurodegeneration, lists current tests for determining cognitive impairment, and provides information concerning differential diagnosis Discusses potential advantages of increasing antioxidant and micronutrient intake Reviews hormonal influences on neurodegeneration Examines the links between protein intake and Alzheimer’s disease. Neurodegeneration and Alzheimer's Disease is an essential resource for researchers, medical practitioners, dietitians, and students with an interest in neurological diseases and their diagnosis and risk factors, as well as diet-related conditions such as diabetes and obesity. Lifestyle and diet influence neurodegeneration risk, and a better understanding of this evidence amongst health professionals will hopefully lead to greater public awareness of how to reduce the likelihood of these widespread conditions.

Apolipoprotein E Genotyping In Alzheimer S Disease

DOWNLOAD
Author : Norman R. Relkin
language : en
Publisher:
Release Date : 1996

Apolipoprotein E Genotyping In Alzheimer S Disease written by Norman R. Relkin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Medical categories.

This volume addresses what is currently known about the use of ApoE genotyping in diagnosing and predicting Alzheimer's disease. Because ApoE genetic testing has such far-reaching consequences, this volume will be of use not only to those in the medical and scientific community involved in the care of patients with Alzheimer's disease, but also to those concerned with the ethical, legal, epidemiological and public health policy issues as well. A summary will also be included of the results of working groups defining the issues, asking methodological questions, and discussing issues concerning genetic counselling and research-related questions.

Exploring The Role Of Apolipoprotein E Through Apoe Knockout Mice Connections To Alzheimer S Disease

DOWNLOAD
Author : Vanessa Wun-Siu Liu
language : en
Publisher:
Release Date : 1996

Exploring The Role Of Apolipoprotein E Through Apoe Knockout Mice Connections To Alzheimer S Disease written by Vanessa Wun-Siu Liu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Alzheimer's disease categories.

The Potential Role Of Apolipoprotein E In The Pathogenesis Of Alzheimer S Disease

DOWNLOAD
Author : Scott Jason Peak
language : en
Publisher:
Release Date : 1996

The Potential Role Of Apolipoprotein E In The Pathogenesis Of Alzheimer S Disease written by Scott Jason Peak and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.

The Role Of Apolipoprotein E In Alzheimer Disease

DOWNLOAD
Author : Tien-Phat Vuong Huynh
language : en
Publisher:
Release Date : 2020

The Role Of Apolipoprotein E In Alzheimer Disease written by Tien-Phat Vuong Huynh and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Electronic dissertations categories.

Alzheimer's disease (AD) is a neurodegenerative disorder associated with irreversible damage to the brain, which manifests in cognitive dysfunction, memory loss, and eventual death. The pathological hallmarks of AD are amyloid plaques, which are cerebral aggregates consisting of fibrils of the amyloid [beta]-protein (A[beta]), and filamentous lesions of the microtubule-associated protein tau known as neurofibrillary tangles. In the early 1990s, the apolipoprotein E (apoE) was found to co-localize with amyloid plaques. The [epsilon]4 allele of the APOE gene was sequentially identified as the strongest genetic risk factor for AD, increasing the risk by 4 - 12-fold, whereas the [epsilon]2 allele is protective relative to the prevalent [epsilon]3 allele. Since then, multiple lines of evidence suggest that the major mechanism by which apoE influences AD pathology is via its effects on A[beta] metabolism, particularly aggregation and clearance. An ongoing debate in the field is whether the [epsilon]4 allele impose a loss of protective function or a gain of toxic function. In support of the latter hypothesis, our colleagues previously demonstrated that APP/PS1-21 mice with only one copy of human apoE3 or apoE4 have significantly less amyloid plaque deposition and microglial activation compared to their homozygous littermates. However, the effect of apoE reduction during the post-natal period or adulthood is unknown. To address this gap in knowledge, we utilized an apoE antisense oligonucleotide (ASO) to reduce apoE expression in the adult APP/PS1-21 mice homozygous for the human [epsilon]4 allele of APOE. Despite achieving reduction of apoE expression by more than 50% starting at the onset of amyloid deposition, no reduction of A[beta] pathology was detected when mice were assessed at 4 months of age. Though there was not an overall reduction in amyloid deposition, there was a clear effect of reducing apoE4 on A[beta] plaque morphology. Interestingly, ASO treatment starting after birth led to a strong and significant decrease in A[beta] pathology when mice were assessed at 4 months of age. These results suggest that apoE levels can strongly affect the initiation of A[beta] pathology in vivo but that once A[beta] plaque pathology is present, reducing apoE does not have a strong effect on further amyloid deposition. This previously unknown age-dependent effect of apoE in the early stages of A[beta] plaque formation suggest the important implication that decreasing brain apoE levels would be useful for primary prevention of amyloid deposition but not for decreasing or removing amyloid plaques once they have begun depositing. Strikingly, we observed a marked decrease in neuritic dystrophy around the plaques in APP/PS1-21/[epsilon]4 mice treated with ASO under either treatment paradigm, independent of plaque size or plaque load. This suggests a general role of apoE4 in modulating the brain's response to neurotoxic insults (such as A[beta] plaques), independent of its effects on A[beta] metabolism. The The aggregation of A[beta] into higher-order species follow nucleation-dependent kinetics in vitro. Our work suggested apoE affects the earliest stages of plaque formation (the nucleation phase), but it remains unclear whether apoE isoforms exert differential effects. We utilize an established in vivo seeding protocol to investigate the possibility that apoE can influence the formation and/or potency of the A[beta] seeds in an isoform-dependent manner. We inoculated PBS-soluble brain extracts (containing A[beta] seeds) isolated from aged APP/PS1-21 donor brains expressing different human APOE alleles ([epsilon]4/[epsilon]4, [epsilon]4/[epsilon]4, [epsilon]4/[epsilon]4) in the hippocampus of an APP-expressing host. Following a defined incubation period, we analyzed the seeding patterns and found that brain extracts from APP/PS1 donors with different APOE backgrounds induce A[beta] seeding patterns that are distinct from each other. Specifically, seeded A[beta] species from [epsilon]4 donors have a diffuse pattern with minimal fibrillar content, while those from [epsilon]4 donors appear more punctate-like and are mostly fibrillar. Brain extracts from [epsilon]4 mice produced plaques with an intermediate phenotype. These results suggest that human APOE isoforms may differentially affect the properties of A[beta] seeds, thus creating different strains of A[beta] with distinct structural features and seeding capabilities. This isoform-dependent effect of apoE on A[beta] may contribute to the overall AD risk associated with the different APOE isoforms. Further studies are needed to investigate the consequences of this isoform-specific difference in plaque morphology. As apoE is produced both inside and outside of the central nervous system (astrocytes and microglia in the brain, and hepatocytes in the periphery), the specific contributions of different apoE pools to AD pathogenesis remain unknown. To address some aspects of this question, we generated new lines of APOE knock-in (APOE-KI) mice ([epsilon]4/[epsilon]4, [epsilon]4/[epsilon]4, and [epsilon]4/[epsilon]4) where the exons in the coding region of APOE are flanked by loxP sites, allowing for cell type-specific manipulation of gene expression. We assessed these mice both alone as well as after crossing them with mice with and without amyloid deposition in the brain as well as after removing apoE expression from hepatocytes using biochemical and histological methods. Consistent with prior studies, our analyses demonstrated apoE protein was present predominantly in astrocytes in the brain under basal conditions and was also detected in reactive microglia surrounding amyloid plaques. Primary cultured astrocytes and microglia from the APOE KI mice secreted apoE in lipoprotein particles of distinct size distribution upon native gel analysis with microglia particles being substantially smaller than the HDL-like particles secreted by astrocytes. Crossing of APP/PS1 transgenic mice to the different APOE-KI mice recapitulated the previously described isoform-specific effect ([epsilon]4 > [epsilon]4) on amyloid plaque and A[beta] accumulation. Deletion of APOE in hepatocytes did not alter brain apoE levels but did lead to a marked decrease in plasma apoE levels and changes in plasma lipid profile. Despite these changes in peripheral apoE and on plasma lipids, cerebral accumulation of amyloid plaques in APP/PS1 mice was not affected. Altogether, our new APOE knock-in strains offer a novel and dynamic tool to study the role of APOE in AD pathogenesis in a spatially and temporally controlled manner.

New Role For Apolipoprotein E And Homocysteine In The Pathoganesis Of Alzheimer S Disease

DOWNLOAD
Author : Kirk Jihyon Pak
language : en
Publisher:
Release Date : 2005

New Role For Apolipoprotein E And Homocysteine In The Pathoganesis Of Alzheimer S Disease written by Kirk Jihyon Pak and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Alzheimer's disease categories.