The Proteolysis Of Apolipoprotein E In Alzheimer S Disease
DOWNLOAD
Download The Proteolysis Of Apolipoprotein E In Alzheimer S Disease PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get The Proteolysis Of Apolipoprotein E In Alzheimer S Disease book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
The Proteolysis Of Apolipoprotein E In Alzheimer S Disease
DOWNLOAD
Author : Julia Love
language : en
Publisher:
Release Date : 2016
The Proteolysis Of Apolipoprotein E In Alzheimer S Disease written by Julia Love and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Alzheimer's disease categories.
"Harboring the apolipoprotein E4 (APOE4) allele is the greatest genetic risk factor associated with late-onset (sporadic) Alzheimer's disease (AD), however the mechanism by which apoE4 contributes to the pathology of AD is unknown. The proteolysis of apoE4 has been suggested to contribute to AD pathology due to a possible toxic gain, or loss of function. In order to determine if apoE4 is being cleaved, we designed and characterized a site-directed cleavage antibody directed at position D151 of full length human apoE4. The antibody (nApoECFp17) detected a predicted ~17 kDa fragment following incubation with the proteases Type-1 collagenase, and matrix metalloproteinase (MMP)-1and 9. Once the nApoECFp17 amino-terminal antibody was applied to frontal cortex AD brain sections, it revealed nuclear labeling of glial cells and neurofibrillary tangles (NFTs). In addition, nApoECFp17 regionally localized with the protease MMP-9 in plaque-rich regions in vivo, suggesting apoE4 may be cleaved extracellularly. Together these data suggest a novel cleavage event of apoE4 by Type-I collagenase and MMP-1 and 9, generating an amino-terminal fragment that is then taken up by glial cells and localizes to the nucleus. This fragment localizing to the nucleus purposes a new role of apoE4 in AD pathology where apoE may alter gene expression."--Boise State University ScholarWorks.
Apolipoprotein E And Alzheimer S Disease
DOWNLOAD
Author : A.D. Roses
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Apolipoprotein E And Alzheimer S Disease written by A.D. Roses and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
There is now considerable genetic evidence that the type 4 allele of the apolipoprotein E gene is a major susceptibility factor associated with late-onset Alzheimer's disease, the common form of the disease defined as starting after sixty years of age. The role of apolipoprotein E in normal brain metabolism and in the pathogenesis of Alzheimer's disease are new and exciting avenues of research. This book, written by the most outstanding scientists in this new filed, is the first presentation of results concerning the implications of apolipoprotein E on the genetics, cell biology, neuropathology, biochemistry, and therapeutic management of Alzheimer's disease.
Cellular Peptidases In Immune Functions And Diseases 2
DOWNLOAD
Author : Jürgen Langner
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-04-11
Cellular Peptidases In Immune Functions And Diseases 2 written by Jürgen Langner and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-11 with Medical categories.
Of the many special roles played by proteolytic enzymes in immune reactions, this book addresses different aspects of membrane peptidases, signal transduction via ligation of membrane peptidases (especially of dipeptidyl peptidase IV/CD26 and aminopeptidase N/CD13), and regulation of membrane peptidases in vivo and in vitro. A number of newly discovered peptidases (including cathepsin F, W and X, carboxypeptidase X, attractin) are described, with special emphasis given to the role of peptidases in immune and defense reactions and in the pathogenesis of inflammatory and other diseases, including rheumatoid arthritis, pancreatitis, multiple sclerosis, Alzheimer's disease and tumours of various origins. The focus on the involvement of a selection of proteolytic enzymes in immune reactions and diseases is a unique feature of this multifaceted work , which combines biochemical, immunological and clinical research reports with literary reviews of the field.
Pathobiology Of Alzheimer S Disease
DOWNLOAD
Author :
language : en
Publisher: Elsevier
Release Date : 1995-10-17
Pathobiology Of Alzheimer S Disease written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-10-17 with Medical categories.
Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences. Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas. The last decade has seen tremendous advances in our understanding of the pathobiology of Alzheimer's disease. These will lead to the first generation of drugs aimed at prevention rather than cure. This book covers some of the most important and exciting of these advances, with chapters written by many of the leading researchers in the field. With genetic studies as a backbone to this volume many chapters are devoted to the function and regulation of amyloid b-protein precursor (APP) and apolipoprotein E (ApoE). Other chapters describe cell biological approaches helping to piece together the link between the genetic alterations and the phenotype we call Alzheimer's disease. Although APP and its proteolytic cleavage product, amyloid b-protein, do not answer all the questions, detailed research into this system has undoubtedly increased our knowledge of the pathobiology of AD and has lead to the identification of other risk factors. Understanding the role of ApoE in the pathology of Alzheimer's disease promises to open a whole new field in AD research. * * Reviews the current knowledge of the pathogenesis of Alzheimer's Disease from a clinical perspective to a genetic and cell biological perspective * A comprehensive description of the role of amyloid B-protein precursor in Alzheimer's disease. * Up-to-date research data * Clear illustrations complement the text
Molecular Biology Of Alzheimer S Disease
DOWNLOAD
Author : Christian Haass
language : en
Publisher: CRC Press
Release Date : 2003-09-02
Molecular Biology Of Alzheimer S Disease written by Christian Haass and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-09-02 with Science categories.
Highlighting the latest and the most timely aspects of Alzheimer's disease research, this text will enable scientists in related research fields, as well as physicians working with Alzheimer's disease patients, to obtain a quick and complete overview of the current state of the art in one of the most exciting fields in neuroscience research. Leading scientists have contributed articles focusing on key developments in this field. This includes an overview about the pathology, the genetics of familial Alzheimer's disease, proteolytic generation and aggregation of amyloid -peptide, presenilins, risk factors such as ApoE, and transgenic animal models. Some of the latest developments in Alzheimer's disease research, including the effect of presenilin knock outs on amyloid -peptide generation, are also included.
Neurodegeneration And Alzheimer S Disease
DOWNLOAD
Author : Ralph N. Martins
language : en
Publisher: John Wiley & Sons
Release Date : 2019-07-10
Neurodegeneration And Alzheimer S Disease written by Ralph N. Martins and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-10 with Technology & Engineering categories.
Understanding the impact of diet, exercise, genetics, and hormones on the risk and development of Alzheimer’s and other neurogenerative diseases Diet is widely known to impact on neurological function. Nevertheless, academic texts discussing this relationship are relatively few in number. This book therefore fills an important gap in the current literature. Opening with an overview of neurodegenerative diseases, particularly Alzheimer’s disease, the text then focuses on explaining the means by which glycemic control and lipid metabolism – and associated nutritional and lifestyle variables – may factor into such disorders’ prevention and treatment. An international group of experts in the fields of food science and neurodegeneration have contributed chapters that examine Alzheimer’s disease within a broad range of contexts. Offering dietary, genetic, and hormonal perspectives, the authors explore topics ranging from sugar consumption to digestive fermentation, and Alzheimer’s disease animal models to the cognition-enhancing effects of physical exercise. Also included are overviews of the latest research into current and developing methods of treatment and diagnosis, as well as differential diagnostics. This groundbreaking book: Explores how glucose metabolism, insulin resistance, lipid metabolism, and high intake of refined carbohydrates are linked to Alzheimer's disease Discusses how genetic makeup can impact risk of Alzheimer’s and Parkinson’s disease Examines cognitive changes in neurodegeneration, lists current tests for determining cognitive impairment, and provides information concerning differential diagnosis Discusses potential advantages of increasing antioxidant and micronutrient intake Reviews hormonal influences on neurodegeneration Examines the links between protein intake and Alzheimer’s disease. Neurodegeneration and Alzheimer's Disease is an essential resource for researchers, medical practitioners, dietitians, and students with an interest in neurological diseases and their diagnosis and risk factors, as well as diet-related conditions such as diabetes and obesity. Lifestyle and diet influence neurodegeneration risk, and a better understanding of this evidence amongst health professionals will hopefully lead to greater public awareness of how to reduce the likelihood of these widespread conditions.
Molecular Mechanisms Of Dementia
DOWNLOAD
Author : Wilma Wasco
language : en
Publisher: Springer Science & Business Media
Release Date : 1996-11-01
Molecular Mechanisms Of Dementia written by Wilma Wasco and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-11-01 with Medical categories.
The past decade has witnessed a revolution in the attempts of scientists to under stand the molecular basis of dementia. Although dementia, as defined by global cogni tive decline involving gradual loss of memory, reasoning, judgment, and orientation, presents most commonly in the form of Alzheimer's disease (AD), an assortment of other less common disorders, such as prion and Pick's disease, can also lead to symp toms that are similar to those observed in patients with AD. The primary goal of Molecular Mechanisms of Dementia is to address the various mechanisms and multi faceted approaches currently being employed to more clearly delineate the etiological and pathogenic events responsible for the onset of dementia. Perhaps the greatest boon to obtaining a clearer understanding of the causes of AD has come from genetic and molecular biological studies carried out over the past decade. At the genetic level, it has become increasingly clear that AD is a heteroge neous disorder that can be broadly classified into two categories. "Late onset" (>60 yr) cases, which account for the vast majority of AD, genetically involve "susceptibility" genes representing risk factors for the disease (e. g. , inheritance of the 84 allele of the Apolipoprotein E gene). In many cases, the susceptibility gene can act as a "modifier" that modulates the pathogenic cascade occurring subsequent to a separate etiological event "initiating" or "causing" the disorder.
Apolipoprotein E Genotyping In Alzheimer S Disease
DOWNLOAD
Author : Norman R. Relkin
language : en
Publisher:
Release Date : 1996
Apolipoprotein E Genotyping In Alzheimer S Disease written by Norman R. Relkin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Medical categories.
This volume addresses what is currently known about the use of ApoE genotyping in diagnosing and predicting Alzheimer's disease. Because ApoE genetic testing has such far-reaching consequences, this volume will be of use not only to those in the medical and scientific community involved in the care of patients with Alzheimer's disease, but also to those concerned with the ethical, legal, epidemiological and public health policy issues as well. A summary will also be included of the results of working groups defining the issues, asking methodological questions, and discussing issues concerning genetic counselling and research-related questions.
Alzheimer S Disease
DOWNLOAD
Author : Nigel M. Hooper
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-02
Alzheimer S Disease written by Nigel M. Hooper and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-02 with Medical categories.
Alzheimer's disease is the most common cause of senile dementia. Since the discovery in 1984 of the amyloid ?-peptide (A?) as the core protein of the senile plaques present in the brains of Alzheimer's disease sufferers, an immense amount of research has gone into mapping out the molecular basis of this debilitating disease. The aim of Alzheimer's Disease: Methods and Protocols is to bring together the main biochemical, cell biological, and molecular biological techniques and approaches that are being used to investigate the molecular basis of Alzheimer's disease. This volume begins with chapters of an introductory/ review nature. Chapter 1 provides a historical introduction to Alzheimer's d- ease with particular emphasis on the central role played by A? and its re- tion to tau. Chapter 2 examines the genetics underlying this neurodegenerative disease, covering the amyloid precursor protein, apolipoprotein E, and the presenilins. Chapter 3 presents an overview of currently available therapeutic agents and prospects for drugs of the future.
A Beta Metabolism And Alzheimer S Disease
DOWNLOAD
Author : Takaomi Comings Saido
language : en
Publisher: CRC Press
Release Date : 2003-02-18
A Beta Metabolism And Alzheimer S Disease written by Takaomi Comings Saido and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-02-18 with Science categories.
This book provides information regarding three major aspects of Aβ metabolism: generation from its precursor, degradation within the brain, and transport out of the brain. It is useful for graduate students, post-doctoral fellows, and scientists both in this and other disciplines.