Applications Of Rna Seq In Cancer And Tumor Research

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Applications Of Rna Seq In Cancer And Tumor Research

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Author : Jidong Lang
language : en
Publisher: Frontiers Media SA
Release Date : 2023-12-05

Applications Of Rna Seq In Cancer And Tumor Research written by Jidong Lang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-05 with Science categories.

Deep Learning For Cancer Diagnosis

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Author : Utku Kose
language : en
Publisher: Springer Nature
Release Date : 2020-09-12

Deep Learning For Cancer Diagnosis written by Utku Kose and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-12 with Technology & Engineering categories.

This book explores various applications of deep learning to the diagnosis of cancer,while also outlining the future face of deep learning-assisted cancer diagnostics. As is commonly known, artificial intelligence has paved the way for countless new solutions in the field of medicine. In this context, deep learning is a recent and remarkable sub-field, which can effectively cope with huge amounts of data and deliver more accurate results. As a vital research area, medical diagnosis is among those in which deep learning-oriented solutions are often employed. Accordingly, the objective of this book is to highlight recent advanced applications of deep learning for diagnosing different types of cancer. The target audience includes scientists, experts, MSc and PhD students, postdocs, and anyone interested in the subjects discussed. The book can be used as a reference work to support courses on artificial intelligence, medical and biomedicaleducation.

Cancer Evolution

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Author : Charles Swanton
language : en
Publisher: Perspectives Cshl
Release Date : 2017

Cancer Evolution written by Charles Swanton and has been published by Perspectives Cshl this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Medical categories.

Tumor progression is driven by mutations that confer growth advantages to different subpopulations of cancer cells. As a tumor grows, these subpopulations expand, accumulate new mutations, and are subjected to selective pressures from the environment, including anticancer interventions. This process, termed clonal evolution, can lead to the emergence of therapy-resistant tumors and poses a major challenge for cancer eradication efforts. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines cancer progression as an evolutionary process and explores how this way of looking at cancer may lead to more effective strategies for managing and treating it. The contributors review efforts to characterize the subclonal architecture and dynamics of tumors, understand the roles of chromosomal instability, driver mutations, and mutation order, and determine how cancer cells respond to selective pressures imposed by anticancer agents, immune cells, and other components of the tumor microenvironment. They compare cancer evolution to organismal evolution and describe how ecological theories and mathematical models are being used to understand the complex dynamics between a tumor and its microenvironment during cancer progression. The authors also discuss improved methods to monitor tumor evolution (e.g., liquid biopsies) and the development of more effective strategies for managing and treating cancers (e.g., immunotherapies). This volume will therefore serve as a vital reference for all cancer biologists as well as anyone seeking to improve clinical outcomes for patients with cancer.

Translational Research And Onco Omics Applications In The Era Of Cancer Personal Genomics

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Author : Erika Ruiz-Garcia
language : en
Publisher: Springer Nature
Release Date : 2019-11-11

Translational Research And Onco Omics Applications In The Era Of Cancer Personal Genomics written by Erika Ruiz-Garcia and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-11 with Science categories.

Being a complex disease that affects millions of people world over, cancer research has assumed great significance. Translational cancer research transforms scientific discoveries in the laboratory into clinical application to reduce incidence of cancer, morbidity and mortality. On the other hand, personalized medicine in cancer is the concept that selection of a treatment should be tailored according to the individual patient’s specific genomic characteristics, including mutations, chromosomal aberrations, protein interactions, and SNPs, and even more, taking into account the inmume system, the metabolism and maybe in the next future also the microbiome.

Application Of Bioinformatics In Cancers

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Author : Chad Brenner
language : en
Publisher: MDPI
Release Date : 2019-11-20

Application Of Bioinformatics In Cancers written by Chad Brenner and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-20 with Medical categories.

This collection of 25 research papers comprised of 22 original articles and 3 reviews is brought together from international leaders in bioinformatics and biostatistics. The collection highlights recent computational advances that improve the ability to analyze highly complex data sets to identify factors critical to cancer biology. Novel deep learning algorithms represent an emerging and highly valuable approach for collecting, characterizing and predicting clinical outcomes data. The collection highlights several of these approaches that are likely to become the foundation of research and clinical practice in the future. In fact, many of these technologies reveal new insights about basic cancer mechanisms by integrating data sets and structures that were previously immiscible. Accordingly, the series presented here bring forward a wide range of artificial intelligence approaches and statistical methods that can be applied to imaging and genomics data sets to identify previously unrecognized features that are critical for cancer. Our hope is that these articles will serve as a foundation for future research as the field of cancer biology transitions to integrating electronic health record, imaging, genomics and other complex datasets in order to develop new strategies that improve the overall health of individual patients.

The Application Of Sequencing Technologies And Bioinformatics Methods In Cancer Biology

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Author : Geng Chen
language : en
Publisher: Frontiers Media SA
Release Date : 2022-10-17

The Application Of Sequencing Technologies And Bioinformatics Methods In Cancer Biology written by Geng Chen and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-17 with Science categories.

Applications Of Rna Seq And Omics Strategies

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Author : Fabio Marchi
language : en
Publisher: BoD – Books on Demand
Release Date : 2017-09-13

Applications Of Rna Seq And Omics Strategies written by Fabio Marchi and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-13 with Medical categories.

The large potential of RNA sequencing and other "omics" techniques has contributed to the production of a huge amount of data pursuing to answer many different questions that surround the science's great unknowns. This book presents an overview about powerful and cost-efficient methods for a comprehensive analysis of RNA-Seq data, introducing and revising advanced concepts in data analysis using the most current algorithms. A holistic view about the entire context where transcriptome is inserted is also discussed here encompassing biological areas with remarkable technological advances in the study of systems biology, from microorganisms to precision medicine.

Application Of Multi Omics Analysis In Thoracic Cancer Immunotherapy

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Author : Attila Szöllősi
language : en
Publisher: Frontiers Media SA
Release Date : 2024-11-19

Application Of Multi Omics Analysis In Thoracic Cancer Immunotherapy written by Attila Szöllősi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-19 with Medical categories.

Based on statistical data provided by the World Health Organization, cancer is widely acknowledged as the foremost contributor to global mortality and persists as a significant concern in the contemporary era. In recent times, immunotherapy has been demonstrated as an efficacious approach in diverse advanced solid tumors, especially in thoracic tumors, consequently emerging as a prominent area of focus in the investigation of antitumor pharmaceuticals. The utilization of immunotherapy directed towards programmed death ligand-1 (PD-L1) and programmed cell death protein-1 (PD-1) has emerged as a valid approach, resulting in substantial enhancements in both disease-free and overall survival rates among cancer patients. Moreover, applications of multi-omics analyses in thoracic tumors have made great progress. However, it also ushered in new challenges. Certain subtypes of thoracic cancer have been identified as immune-quiescent tumors, indicating that only a limited number of patients would derive benefits from immunotherapy while also experiencing a high incidence of severe adverse events. Besides, multi-omics analyses reveal patterns of drug resistance and relapse in the treatment of thoracic tumors, which help us identify the molecular mechanisms that lead to drug resistance and provide clues for overcoming it. Meanwhile, exploring the role of the tumor microenvironment (TME) in the development and metastasis of thoracic tumors can help us better understand the potential mechanisms of tumor spread and find approaches to intervene.

Genomic Applications In Pathology

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Author : George Jabboure Netto
language : en
Publisher: Springer
Release Date : 2018-12-10

Genomic Applications In Pathology written by George Jabboure Netto and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-10 with Medical categories.

​The recent advances in genomics are continuing to reshape our approach to diagnostics, prognostics and therapeutics in oncologic and other disorders. A paradigm shift in pharmacogenomics and in the diagnosis of genetic inherited diseases and infectious diseases is unfolding as the result of implementation of next generation genomic technologies. With rapidly growing knowledge and applications driving this revolution, along with significant technologic and cost changes, genomic approaches are becoming the primary methods in many laboratories and for many diseases. As a result, a plethora of clinical genomic applications have been implemented in diagnostic pathology laboratories, and the applications and demands continue to evolve rapidly. This has created a tremendous need for a comprehensive resource on genomic applications in clinical and anatomic pathology. We believe that our current textbook provides such a resource to practicing molecular pathologists, hematopathologists and other subspecialized pathologists, general pathologists, pathology and other trainees, oncologists, geneticists and a growing spectrum of other clinicians. With periodic updates and a sufficiently rapid time from submission to publication, this textbook will be the resource of choice for many professionals and teaching programs. Its focus on genomics parallels the evolution of these technologies as primary methods in the clinical lab. The rapid evolution of genomics and its applications in medicine necessitates the (frequent) updating of this publication. This text will provide a state-of-the art review of the scientific principles underlying next generation genomic technologies and the required bioinformatics approaches to analyses of the daunting amount of data generated by current and emerging genomic technologies. Implementation roadmaps for various clinical assays such as single gene, gene panels, whole exome and whole genome assays will be discussed together with issues related to reporting and the pathologist’s role in interpretation and clinical integration of genomic tests results. Genomic applications for site-specific solid tumors and hematologic neoplasms will be detailed. Genomic applications in pharmacogenomics, inherited genetic diseases and infectious diseases will also be discussed. The latest iteration of practice recommendations or guidelines in genomic testing put forth by stakeholder professional organizations such as the College of American Pathology and the Association for Molecular Pathology, will be discussed as well as regulatory issues and laboratory accreditation related to genomic testing. All chapters will be written by experts in their fields and will include the most up to date scientific and clinical information.

Rna Seq Analysis Methods Applications And Challenges

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Author : Filippo Geraci
language : en
Publisher: Frontiers Media SA
Release Date : 2020-06-08

Rna Seq Analysis Methods Applications And Challenges written by Filippo Geraci and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-08 with categories.