Applied Mechanics And Bio Microfluidic Applications For Open Microfluidic Systems
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Applied Mechanics And Bio Microfluidic Applications For Open Microfluidic Systems
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Author : Jue Nee Tan
language : en
Publisher:
Release Date : 2014
Applied Mechanics And Bio Microfluidic Applications For Open Microfluidic Systems written by Jue Nee Tan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
Microfluidics is attractive in many aspects and advancement of technology on these micron-scales have led to the development of devices often used in industries such as clinical and forensic analysis; micro-reaction engineering; surface patterning; and optical engineering. Despite its popularity, traditional microfluidic applications however, are known to have large dead volume; awkward chip-to-world interfaces; difficulty in exchanging solutions; and limited parallelization. Recent progresses in open microfluidic systems have shown great potential in addressing the aforementioned limitations.The aim of this thesis is to expand our understanding regarding fluid behaviour and interaction in the micro-domain scale of an open environment. Knowledge obtained through these studies could then be implemented in developing systems involving microfluidic components and bio-microfluidic applications. As a prelude to the main body of work, a basic theoretical framework on the background of microfluidics and the physics of the micro-scale is presented. The research can be divided into two major components, Part I: Open Microchannels and Part II: Microdroplets. These components were then further sub-categorized according to their applications including microfluidic pumping; mixing; liquid transfer; cell lysis; and concentration gradient generation. In all these, an open environment allowing for external interaction and manipulation was implemented. In Part I, flows on open channels and films was investigated. The open structures include a straight open channel defined by a narrow strip of solid surface and a wider structure allowing for multiple inputs and outputs. Computational models were also developed for fluid flow and the findings used to describe the factors affecting the stability of the system in both structures. The system can be seen as either a self-contained open fluidic device, or an open section in an otherwise enclosed system. Following on, the mixing mechanism of a Y-junction open raised channel was examined. The open nature of the channel employed allowed introduction of external shear stresses on the interfacial surface to aid in the mixing process, while maintaining the simplicity of the system as a whole. This mode of mixing provides a versatile platform where alterations can be made to the open system to accommodate mixing without the added complexities. In Part II, investigation was first carried out on two different mechanisms of vertical liquid transfer. The first is through the formation and detachment of a liquid bridge and the second is through the liquid jet formed upon rupture of an encapsulated bubble within a microdroplet. Both mechanisms demonstrated selective transfer of discrete volumes of fluid, a process that will prove useful in many droplet-based microfluidic applications. From the results gathered, the role of the bubble in inducing cell lysis in a controlled and repeatable environment was explored. The fluid jet was then presented as a method capable of causing effective 100% cell lysis of a droplet of suspended cells. Apart from that, a method using microdroplets administered on a planar surface to produce a gradient of droplet concentrations over an array of open wells is presented. The system was tailored to generate concentration gradients in a close quantitative agreement to a two-fold dilution system akin to routine pipetting operations. The findings presented in this thesis are unique in their nature as the methods and applications demonstrated were able to extract the advantages of open microfluidics. Benefits include and are not limited to minimal fabrication and consequently lower production costs involved; small sample volume requirements; selectivity; rapid operation time; and greater control. It is hoped that these results would promote the use of open microfluidics and encourage further exploration of this topic in the future.
Microfluidics
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Author : Yu Song
language : en
Publisher: John Wiley & Sons
Release Date : 2018-05-07
Microfluidics written by Yu Song and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-07 with Science categories.
The first book offering a global overview of fundamental microfluidics and the wide range of possible applications, for example, in chemistry, biology, and biomedical science. As such, it summarizes recent progress in microfluidics, including its origin and development, the theoretical fundamentals, and fabrication techniques for microfluidic devices. The book also comprehensively covers the fluid mechanics, physics and chemistry as well as applications in such different fields as detection and synthesis of inorganic and organic materials. A useful reference for non-specialists and a basic guideline for research scientists and technicians already active in this field or intending to work in microfluidics.
Applications Of Microfluidic Systems In Biology And Medicine
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Author : Manabu Tokeshi
language : en
Publisher: Springer Nature
Release Date : 2024-10-02
Applications Of Microfluidic Systems In Biology And Medicine written by Manabu Tokeshi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-02 with Science categories.
This book is the second edition of the one originally published in 2016, which focused on state-of-the-art microfluidic research in medical and biological applications. Similar to the first edition, beginners in the field —undergraduates, engineers, biologists, medical and pharmaceutical researchers—will easily learn to understand microfluidic-based medical and biological applications. Because a wide range of topics is summarized here, it also helps experts to learn more about fields outside their own specialties. In this second edition, significant revisions have been made to chapters covering technologies that have seen major advancements, such as acoustofluidics, protein crystallography, organ-on-a-chip systems, nanopore sensing, and paper-based microfluidics. In addition, the chapters on cancer diagnosis using exosomes and single-cell sequencing using droplet microfluidics, which are attracting attention as new technologies, have been newly added. Readers will be convinced that microfluidic devices have great potential for medical and biological applications.
Microfluidic Devices For Biomedical Applications
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Author : Xiujun (James) Li
language : en
Publisher: Elsevier
Release Date : 2013-10-31
Microfluidic Devices For Biomedical Applications written by Xiujun (James) Li and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-31 with Science categories.
Microfluidics or lab-on-a-chip (LOC) is an important technology suitable for numerous applications from drug delivery to tissue engineering. Microfluidic devices for biomedical applications discusses the fundamentals of microfluidics and explores in detail a wide range of medical applications.The first part of the book reviews the fundamentals of microfluidic technologies for biomedical applications with chapters focussing on the materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologies. Chapters in part two examine applications in drug discovery and controlled-delivery including micro needles. Part three considers applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds and stem cell engineering. The final part of the book covers the applications of microfluidic devices in diagnostic sensing, including genetic analysis, low-cost bioassays, viral detection, and radio chemical synthesis.Microfluidic devices for biomedical applications is an essential reference for medical device manufacturers, scientists and researchers concerned with microfluidics in the field of biomedical applications and life-science industries. - Discusses the fundamentals of microfluidics or lab-on-a-chip (LOC) and explores in detail a wide range of medical applications - Considers materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologies - Considers applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds and stem cell engineering
Biomedical Applications Of Microfluidic Devices
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Author : Michael R. Hamblin
language : en
Publisher: Academic Press
Release Date : 2020-11-12
Biomedical Applications Of Microfluidic Devices written by Michael R. Hamblin and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-12 with Technology & Engineering categories.
Biomedical Applications of Microfluidic Devices introduces the subject of microfluidics and covers the basic principles of design and synthesis of actual microchannels. The book then explores how the devices are coupled to signal read-outs and calibrated, including applications of microfluidics in areas such as tissue engineering, organ-on-a-chip devices, pathogen identification, and drug/gene delivery. This book covers high-impact fields (microarrays, organ-on-a-chip, pathogen detection, cancer research, drug delivery systems, gene delivery, and tissue engineering) and shows how microfluidics is playing a key role in these areas, which are big drivers in biomedical engineering research. This book addresses the fundamental concepts and fabrication methods of microfluidic systems for those who want to start working in the area or who want to learn about the latest advances being made. The subjects covered are also an asset to companies working in this field that need to understand the current state-of-the-art. The book is ideal for courses on microfluidics, biosensors, drug targeting, and BioMEMs, and as a reference for PhD students. The book covers the emerging and most promising areas of biomedical applications of microfluidic devices in a single place and offers a vision of the future. - Covers basic principles and design of microfluidics devices - Explores biomedical applications to areas such as tissue engineering, organ-on-a-chip, pathogen identification, and drug and gene delivery - Includes chemical applications in organic and inorganic chemistry - Serves as an ideal text for courses on microfluidics, biosensors, drug targeting, and BioMEMs, as well as a reference for PhD students
Open Space Microfluidics
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Author : Emmanuel Delamarche
language : en
Publisher: John Wiley & Sons
Release Date : 2018-01-18
Open Space Microfluidics written by Emmanuel Delamarche and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-18 with Technology & Engineering categories.
Summarizing the latest trends and the current state of this research field, this up-to-date book discusses in detail techniques to perform localized alterations on surfaces with great flexibility, including microfluidic probes, multifunctional nanopipettes and various surface patterning techniques, such as dip pen nanolithography. These techniques are also put in perspective in terms of applications and how they can be transformative of numerous (bio)chemical processes involving surfaces. The editors are from IBM Zurich, the pioneers and pacesetters in the field at the forefront of research in this new and rapidly expanding area.
Proceedings Of Isss International Conference On Micro Nano And Smart Systems
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Author : Ashok Kumar Pandey
language : en
Publisher: Springer Nature
Release Date : 2025-06-14
Proceedings Of Isss International Conference On Micro Nano And Smart Systems written by Ashok Kumar Pandey and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-14 with Technology & Engineering categories.
This book presents select proceedings of the ISSS International Conference on Micro, Nano, and Smart Systems (IC-MNSS) in IISc Bengaluru during July 9 to 12, 2024 and presents different applications of smart materials and systems in aerospace, robotics, quantum, agriculture, and biomedical technologies followed by microfabrication processes and packaging technologies required to design and develop different sensors on micro and nanoscale. The first few chapters cover shape memory alloys (SMA) and its modelling and remaining chapters outline the application of smart systems and materials in quantum technology, digital agriculture, and healthcare. After describing the microfabrication processes in bulk and surface micromachining processes, the design and development of various sensors are demonstrated in the last few chapters. The book is valuable to researchers and professionals working in the area of micro and nano-based design, fabrication, and development of sensors, and their application in smart systems, water purification, and energy harvesting.
Open Microfluidics
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Author : Jean Berthier
language : en
Publisher: John Wiley & Sons
Release Date : 2016-07-11
Open Microfluidics written by Jean Berthier and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-11 with Science categories.
Open microfluidics or open-surface is becoming fundamental in scientific domains such as biotechnology, biology and space. First, such systems and devices based on open microfluidics make use of capillary forces to move fluids, without any need for external energy. Second, the "openness" of the flow facilitates the accessibility to the liquid in biotechnology and biology, and reduces the weight in space applications. This book has been conceived to give the reader the fundamental basis of open microfluidics. It covers successively The theory of spontaneous capillary flow, with the general conditions for spontaneous capillary flow, and the dynamic aspects of such flows. The formation of capillary filaments which are associated to small contact angles and sharp grooves. The study of capillary flow in open rectangular, pseudo-rectangular and trapezoidal open microchannels. The dynamics of open capillary flows in grooves with a focus on capillary resistors. The case of very viscous liquids is analyzed. An analysis of suspended capillary flows: such flows move in suspended channels devoid of top cover and bottom plate. Their accessibility is reinforced, and such systems are becoming fundamental in biology. An analysis of “rails” microfluidics, which are flows that move in channels devoid of side walls. This geometry has the advantage to be compatible with capillary networks, which are now of great interest in biotechnology, for molecular detection for example. Paper-based microfluidics where liquids wick flat paper matrix. Applications concern bioassays such as point of care devices (POC). Thread-based microfluidics is a new domain of investigation. It is seeing presently many new developments in the domain of separation and filtration, and opens the way to smart bandages and tissue engineering. The book is intended to cover the theoretical aspects of open microfluidics, experimental approaches, and examples of application.
Microfluidics For Cellular Applications
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Author : Gerardo Perozziello
language : en
Publisher: Elsevier
Release Date : 2023-04-13
Microfluidics For Cellular Applications written by Gerardo Perozziello and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-13 with Technology & Engineering categories.
Microfluidics for Cellular Applications describes microfluidic devices for cell screening from a physical, technological and applications point-of-view, presenting a comparison with the cell microenvironment and conventional instruments used in medicine. Microfluidic technologies, protocols, devices for cell screening and treatment have reached an advanced state but are mainly used in research. Sections break them down into practical applications and conventional medical procedures and offers insights and analysis on how higher resolutions and fast operations can be reached. This is an important resource for those from an engineering and technology background who want to understand more and gain additional insights on cell screening processes. - Outlines the major applications of microfluidic devices in medicine and biotechnology - Assesses the major challenges of using microfluidic devices in terms of complexity of the control set-up, ease of use, integration capability, automation level, analysis throughput, content and costs - Describes the major fabrication techniques for assembling effective microfluidic devices for bioapplications
Advances In Applied Mechanics
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Author :
language : en
Publisher: Elsevier
Release Date : 2023-05-08
Advances In Applied Mechanics written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-08 with Science categories.
Advances in Applied Mechanics, Volume 56 in this ongoing series, highlights new advances in the field, with this new volume presenting interesting chapters on From Digital Control to Digital Twins in Medicine: A brief review and future perspectives, Predicting Nonlinear Deformation and Yarn Kinematics of Plain Weave Fabrics with Multiscale Recursive Micromechanics, Mechanics Theories for Anisotropic or Composite Materials, Historical purview and recent advances in fracture mechanics of elastomeric matrix composites, Mechanics constitutive models for viscoelastic solid materials: Development and a critical review, and more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Advances in Applied Mechanics series