Open Space Microfluidics
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Open Space Microfluidics
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Author : Emmanuel Delamarche
language : en
Publisher: John Wiley & Sons
Release Date : 2018-04-30
Open Space Microfluidics written by Emmanuel Delamarche and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-30 with Technology & Engineering categories.
Summarizing the latest trends and the current state of this research field, this up-to-date book discusses in detail techniques to perform localized alterations on surfaces with great flexibility, including microfluidic probes, multifunctional nanopipettes and various surface patterning techniques, such as dip pen nanolithography. These techniques are also put in perspective in terms of applications and how they can be transformative of numerous (bio)chemical processes involving surfaces. The editors are from IBM Zurich, the pioneers and pacesetters in the field at the forefront of research in this new and rapidly expanding area.
Open Microfluidics
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Author : Jean Berthier
language : en
Publisher: John Wiley & Sons
Release Date : 2016-07-20
Open Microfluidics written by Jean Berthier and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-20 with Science categories.
Open microfluidics or open-surface is becoming fundamental in scientific domains such as biotechnology, biology and space. First, such systems and devices based on open microfluidics make use of capillary forces to move fluids, without any need for external energy. Second, the “openness” of the flow facilitates the accessibility to the liquid in biotechnology and biology, and reduces the weight in space applications. This book has been conceived to give the reader the fundamental basis of open microfluidics. It covers successively The theory of spontaneous capillary flow, with the general conditions for spontaneous capillary flow, and the dynamic aspects of such flows. The formation of capillary filaments which are associated to small contact angles and sharp grooves. The study of capillary flow in open rectangular, pseudo-rectangular and trapezoidal open microchannels. The dynamics of open capillary flows in grooves with a focus on capillary resistors. The case of very viscous liquids is analyzed. An analysis of suspended capillary flows: such flows move in suspended channels devoid of top cover and bottom plate. Their accessibility is reinforced, and such systems are becoming fundamental in biology. An analysis of “rails” microfluidics, which are flows that move in channels devoid of side walls. This geometry has the advantage to be compatible with capillary networks, which are now of great interest in biotechnology, for molecular detection for example. Paper-based microfluidics where liquids wick flat paper matrix. Applications concern bioassays such as point of care devices (POC). Thread-based microfluidics is a new domain of investigation. It is seeing presently many new developments in the domain of separation and filtration, and opens the way to smart bandages and tissue engineering. The book is intended to cover the theoretical aspects of open microfluidics, experimental approaches, and examples of application.
Open Channel Microfluidics
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Author : Jean Berthier
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2019-09-04
Open Channel Microfluidics written by Jean Berthier and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-04 with Technology & Engineering categories.
Open microfluidics, the study of microflows having a boundary with surrounding air, encompasses different aspects such as paper or thread-based microfluidics, droplet microfluidics and open-channel microfluidics. Open-channel microflow is a flow at the micro-scale, guided by solid structures, and having at least a free boundary (with air or vapor) other than the advancing meniscus. This book is devoted to the study of open-channel microfluidics which (contrary to paper or thread or droplet microfluidics) is still very sparsely documented, but bears many new applications in biology, biotechnology, medicine, material and space sciences. Capillarity being the principal force triggering an open microflow, the principles of capillarity are first recalled. The onset of open-channel microflow is next analyzed and the fundamental notion of generalized Cassie angle (the apparent contact angle which accounts for the presence of air) is presented. The theory of the dynamics of open-channel microflows is then developed, using the notion of averaged friction length which accounts for the presence of air along the boundaries of the flow domain. Different channel morphologies are studied and geometrical features such as valves and capillary pumps are examined. An introduction to two-phase open-channel microflows is also presented showing that immiscible plugs can be transported by an open-channel flow. Finally, a selection of interesting applications in the domains of space, materials, medicine and biology is presented, showing the potentialities of open-channel microfluidics.
Microscale Physico Chemical Interactions Between Hydrodynamically Confined Liquids And Immersed Biological Surfaces
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Author : David Philipp Taylor
language : en
Publisher:
Release Date : 2019
Microscale Physico Chemical Interactions Between Hydrodynamically Confined Liquids And Immersed Biological Surfaces written by David Philipp Taylor and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Mots-clés de l'auteur: Open-space microfluidics ; liquid scanning probes ; microfluidic probe ; biological interfaces ; hydrodynamic confinement ; surface processing.
Optimization Of Trustworthy Biomolecular Quantitative Analysis Using Cyber Physical Microfluidic Platforms
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Author : Mohamed Ibrahim
language : en
Publisher: CRC Press
Release Date : 2020-05-31
Optimization Of Trustworthy Biomolecular Quantitative Analysis Using Cyber Physical Microfluidic Platforms written by Mohamed Ibrahim and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-31 with Technology & Engineering categories.
A microfluidic biochip is an engineered fluidic device that controls the flow of analytes, thereby enabling a variety of useful applications. According to recent studies, the fields that are best set to benefit from the microfluidics technology, also known as lab-on-chip technology, include forensic identification, clinical chemistry, point-of-care (PoC) diagnostics, and drug discovery. The growth in such fields has significantly amplified the impact of microfluidics technology, whose market value is forecast to grow from $4 billion in 2017 to $13.2 billion by 2023. The rapid evolution of lab-on-chip technologies opens up opportunities for new biological or chemical science areas that can be directly facilitated by sensor-based microfluidics control. For example, the digital microfluidics-based ePlex system from GenMarkDx enables automated disease diagnosis and can bring syndromic testing near patients everywhere. However, as the applications of molecular biology grow, the adoption of microfluidics in many applications has not grown at the same pace, despite the concerted effort of microfluidic systems engineers. Recent studies suggest that state-of-the-art design techniques for microfluidics have two major drawbacks that need to be addressed appropriately: (1) current lab-on-chip systems were only optimized as auxiliary components and are only suitable for sample-limited analyses; therefore, their capabilities may not cope with the requirements of contemporary molecular biology applications; (2) the integrity of these automated lab-on-chip systems and their biochemical operations are still an open question since no protection schemes were developed against adversarial contamination or result-manipulation attacks. Optimization of Trustworthy Biomolecular Quantitative Analysis Using Cyber-Physical Microfluidic Platforms provides solutions to these challenges by introducing a new design flow based on the realistic modeling of contemporary molecular biology protocols. It also presents a microfluidic security flow that provides a high-level of confidence in the integrity of such protocols. In summary, this book creates a new research field as it bridges the technical skills gap between microfluidic systems and molecular biology protocols but it is viewed from the perspective of an electronic/systems engineer.
Biological Applications Of Microfluidics
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Author : Frank A. Gomez
language : en
Publisher: John Wiley & Sons
Release Date : 2008-02-15
Biological Applications Of Microfluidics written by Frank A. Gomez and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-15 with Science categories.
Microfluidics has numerous potential applications in biotechnology, pharmaceuticals, the life sciences, defense, public health, and agriculture. This book details recent advances in the biological applications of microfluidics, including cell sorting, DNA sequencing on-a-chip, microchip capillary electrophoresis, and synthesis on a microfluidic format. It covers microfabricated LOC technologies, advanced microfluidic tools, microfluidic culture platforms for stem cell and neuroscience research, and more. This is an all-in-one, hands-on resource for analytical chemists and researchers and an excellent text for students.
Open Microfluidic Technologies For Fundamental And Applied Studies Of Human Health And The Environment
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Author : Ulri Nicole Lee
language : en
Publisher:
Release Date : 2022
Open Microfluidic Technologies For Fundamental And Applied Studies Of Human Health And The Environment written by Ulri Nicole Lee and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.
This dissertation discusses the applications for open microfluidics in emerging technologies for studying human health and the environment. Open microfluidics is a sub-field of microfluidics that is quickly gaining traction for technologies across biology and the environment. The open nature of the microchannels enables flexibility to the user for adding or removing components and makes it simple to use. Chapter 1 introduces how microfluidics has traditionally been used and provides a background of open microfluidics and the common methods used to fabricate devices. Chapter 2 evaluates rapid injection molding, a more economical version of traditional injection molding, for open microfluidic cell-based technologies. Minimum dimensions and dimension accuracy are investigated for applications with fluorescence imaging. Chapter 3 highlights a novel method for generating droplets in an open microfluidic device that utilizes natural hydrostatic pressure and therefore does not require pumps or external equipment to generate the droplets. Additionally, potential use cases are presented for applications in droplet manipulation, patterning, splitting, and fusion. Chapter 4 presents a layer-by-layer hydrogel patterning method made possible by spontaneous capillary flow. An open microfluidic rail-based device is used to pattern entire layers of hydrogels for biological applications in tissue engineering, organoid development, and 3D cell culture. Chapter 5 presents a novel method for capturing airborne particles using microdroplets and open microfluidic channels for shuttling the collected sample across the device. The work presented here demonstrates fundamental open microfluidic principles for droplet generation and fabrication as well as how open microfluidics can be applied to diverse fields of study such as hydrogel patterning and environmental sampling.
Microfluidics For Biological Applications
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Author : Wei-Cheng Tian
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-03-02
Microfluidics For Biological Applications written by Wei-Cheng Tian and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-02 with Technology & Engineering categories.
Microfluidics for Biological Applications provides researchers and scientists in the biotechnology, pharmaceutical, and life science industries with an introduction to the basics of microfluidics and also discusses how to link these technologies to various biological applications at the industrial and academic level. Readers will gain insight into a wide variety of biological applications for microfluidics. The material presented here is divided into four parts, Part I gives perspective on the history and development of microfluidic technologies, Part II presents overviews on how microfluidic systems have been used to study and manipulate specific classes of components, Part III focuses on specific biological applications of microfluidics: biodefense, diagnostics, high throughput screening, and tissue engineering and finally Part IV concludes with a discussion of emerging trends in the microfluidics field and the current challenges to the growth and continuing success of the field.
Microfluidics For Biologists
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Author : Chandra K. Dixit
language : en
Publisher: Springer
Release Date : 2016-10-24
Microfluidics For Biologists written by Chandra K. Dixit and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-24 with Medical categories.
This book describes novel microtechnologies and integration strategies for developing a new class of assay systems to retrieve desired health information from patients in real-time. The selection and integration of sensor components and operational parameters for developing point-of-care (POC) are also described in detail. The basics that govern the microfluidic regimen and the techniques and methods currently employed for fabricating microfluidic systems and integrating biosensors are thoroughly covered. This book also describes the application of microfluidics in the field of cell and molecular biology, single cell biology, disease diagnostics, as well as the commercially available systems that have been either introduced or have the potential of being used in research and development. This is an ideal book for aiding biologists in understanding the fundamentals and applications of microfluidics. This book also: Describes the preparatory methods for developing 3-dimensional microfluidic structures and their use for Lab-on-a-Chip design Explains the significance of miniaturization and integration of sensing components to develop wearable sensors for point-of-care (POC) Demonstrates the application of microfluidics to life sciences and analytical chemistry, including disease diagnostics and separations Motivates new ideas related to novel platforms, valving technology, miniaturized transduction methods, and device integration to develop next generation sequencing Discusses future prospects and challenges of the field of microfluidics in the areas of life sciences in general and diagnostics in particular
Microfluidics History Theory And Applications
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Author : William B. J. Zimmerman
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-06-27
Microfluidics History Theory And Applications written by William B. J. Zimmerman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-06-27 with Science categories.
Microfluidics is a microtechnological field dealing with the precise transport of fluids (liquids or gases) in small amounts (e.g. microliters, nanoliters or even picoliters). This book provides a useful introduction into this burgeoning field, and a specific application of microfluidics is presented. It also gives a survey of microfluidics.