Applying Genomic And Proteomic Microarray Technology In Drug Discovery
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Applying Genomic And Proteomic Microarray Technology In Drug Discovery
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Author : Robert S. Matson
language : en
Publisher: CRC Press
Release Date : 2004-12-28
Applying Genomic And Proteomic Microarray Technology In Drug Discovery written by Robert S. Matson and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-12-28 with Medical categories.
Microarrays play an increasingly significant role in drug discovery. Written by a leader in the field, Applying Genomic and Proteomic Microarray Technology in Drug Discovery highlights, describes, and evaluates current scientific research using microarray technology in genomic and proteomic applications. The author addresses the drawbacks, helping
Applying Genomic And Proteomic Microarray Technology In Drug Discovery Second Edition
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Author : Robert S. Matson
language : en
Publisher: CRC Press
Release Date : 2013-03-13
Applying Genomic And Proteomic Microarray Technology In Drug Discovery Second Edition written by Robert S. Matson and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-13 with Medical categories.
Microarrays play an increasingly significant role in drug discovery. The commercial landscape has changed dramatically over the past few years and researchers have made great advancements with regard to construction and use. Now in its second edition, Applying Genomic and Proteomic Microarray Technology in Drug Discovery highlights, describes, and evaluates current scientific research using microarray technology in genomic and proteomic applications. Updated and revised to reflect recent progress in the field, the second edition discusses: Expanded omics-driven applications, including the areas of metabolomics and chemical biology The commercialization of the microarray platform, with a historical perspective aimed at recognizing key technological developments Solid-supports (substrates) and surface chemistries currently used in the creation of nucleic acid and protein microarrays Different approaches to producing microarrays that achieve spot equality with the same number of molecules properly oriented The development of the gene expression microarray and representative applications The development of protein microarray technology, including its history and key applications Unique to this edition is a new chapter on multiplex assays that examines the development and applications of arrays across diverse platforms. It discusses applications for qPCR, multiplex lateral flow, and multiplex bead assays. It also presents platform-to-platform comparisons. Microarrays remain an invaluable tool for omics-based research not only in drug discovery, but in the life sciences, in clinical research, and for diagnostic applications worldwide. This volume presents the current state of the art on the utility of this technology to solve a host of important biological problems.
Microarray Innovations
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Author : Gary Hardiman
language : en
Publisher: CRC Press
Release Date : 2009-04-02
Microarray Innovations written by Gary Hardiman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-02 with Science categories.
In recent years, high-density DNA microarrays have revolutionized biomedical research and drug discovery efforts by the pharmaceutical industry. Their efficacy in identifying and prioritizing drug targets based on their ability to confirm a large number of gene expression measurements in parallel has become a key element in drug discovery. Microarray Innovations: Technology and Experimentation examines the incredibly powerful nature of array technology and the ways in which it can be applied to understanding the genomic basis of disease. Explores a myriad of applications in use today This volume explores recent innovations in the microarray field and tracks the evolution of the major platforms currently used. The international panel of contributors presents a survey of the past five years’ research and advancements in microarray methods and applications and their usage in drug discovery and biomedical research. The contributions discuss improvements in automation (array fabrication and hybridization), new substrates for printing arrays, platform comparisons and contrasts, experimental design, and data normalization and mining schemes. They also review epigenomic array studies, electronic microarrays, comparative genomic hybridization, microRNA arrays, and mutational analyzes. In addition, the book provides coverage of important clinical diagnostic arrays, protein arrays, and neuroscience applications. Examines improved methodologies As microarrays have evolved steadily over time from archetypical in-house complementary DNA (cDNA) arrays to robust commercial oligonucleotide platforms, there has been a migration to higher density biochips with increasing content and better analytical methodologies. This compendium summarizes the vast advances that have been made in this technology, highlighting the supreme advantages of microarray-based approaches in the field of biomedical research. Daniel E. Levy, editor of the Drug Discovery Series, is the founder of DEL BioPharma, a consulting service for drug discovery programs. He also maintains a blog that explores organic chemistry.
Genomics In Drug Discovery And Development
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Author : Dimitri Semizarov
language : en
Publisher: John Wiley & Sons
Release Date : 2008-11-03
Genomics In Drug Discovery And Development written by Dimitri Semizarov and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-03 with Medical categories.
Early characterization of toxicity and efficacy would significantly impact the overall productivity of pharmaceutical R&D and reduce drug candidate attrition and failure. By describing the available platforms and weighing their relative advantages and disadvantages, including microarray data analysis, Genomics in Drug Discovery and Development introduces readers to the biomarker, pharmacogenomic, and toxicogenomics toolbox. The authors provide a valuable resource for pharmaceutical discovery scientists, preclinical drug safety department personnel, regulatory personnel, discovery toxicologists, and safety scientists, drug development professionals, and pharmaceutical scientists.
Biomems And Biomedical Nanotechnology
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Author : Mihrimah Ozkan
language : en
Publisher: Springer
Release Date : 2016-08-23
Biomems And Biomedical Nanotechnology written by Mihrimah Ozkan and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-23 with Technology & Engineering categories.
Protein Microarray Technology
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Author : Dev Kambhampati
language : en
Publisher: John Wiley & Sons
Release Date : 2006-03-06
Protein Microarray Technology written by Dev Kambhampati and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-06 with Science categories.
This book is the first of its kind in the field of protein microarrays and addresses novel strategies for constructing highly functional and biocompatible microarrays for screening proteins. The list of authors consisting of world leading experts provide a roadmap for solving the complex challenges that are currently faced while monitoring protein-protein interactions over a wide range of microarray platforms. In doing so, they also offer a comprehensive overview of microarray surface chemistry, detection technologies, fabrication options for array development, and data analysis of numerous types of protein interactions. Topics covered include: -Types of biomolecular interactions -Surface chemistry -Detection technologies -Spotting technologies -Bioinformatics/data analysis. While primarily intended to serve as a reference for researchers and students embarking on the exciting fields of proteomics, drug discovery and clinical diagnostics, this technology is also expected to potentially impact the areas of food diagnostics, environmental monitoring and national security.
Integrated Drug Discovery Technologies
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Author : Houng-Yau Mei
language : en
Publisher: CRC Press
Release Date : 2002-03-19
Integrated Drug Discovery Technologies written by Houng-Yau Mei and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-03-19 with Science categories.
Integrated Drug Discovery Technologies provides a global overview of emerging drug development technologies by presenting and integrating new techniques from the disciplines of chemistry, biology, and computational sciences. It combines integration of contemporary mechanization with strategies in drug delivery. Topics include: functional genomics, microfabrication techniqes, integrated proteomics technologies, high throughput screening, and fluorescence correlation spectroscopy methods.
Bioinformatics And Drug Discovery
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Author : Richard S. Larson
language : en
Publisher: Humana
Release Date : 2010-12-09
Bioinformatics And Drug Discovery written by Richard S. Larson and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-09 with Medical categories.
A collection of readily reproducible bioinformatic methods to advance the drug discovery process from gene identification to protein modeling to the identification of specific drug candidates. The authors demonstrate these techniques, including microarray analysis, the analysis of genes as potential drug targets, virtual screening and in silico protein design, and cheminformatics, in a variety of practical situations. Because these technologies are still emergent, each chapter contains an extended introduction that explains the theory and application of the technology and techniques described.
Tissue Proteomics
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Author : Brian Liu
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-01-31
Tissue Proteomics written by Brian Liu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-31 with Science categories.
In one volume this book provides useful and innovative protocols developed specifically for the proteomic profiling of human tissues. The book provides high-throughput gel-based techniques, microarrays and a number of other methods used in proteomic research. This important book will prove indispensable to investigators of biomarker discovery and therapeutic response profiling, as well as those forging new paths in the fields of theranostics and personalized medicine.
Fundamentals Of Data Mining In Genomics And Proteomics
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Author : Werner Dubitzky
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-04-13
Fundamentals Of Data Mining In Genomics And Proteomics written by Werner Dubitzky and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-04-13 with Science categories.
This book presents state-of-the-art analytical methods from statistics and data mining for the analysis of high-throughput data from genomics and proteomics. It adopts an approach focusing on concepts and applications and presents key analytical techniques for the analysis of genomics and proteomics data by detailing their underlying principles, merits and limitations.