Artificial Intelligence In The Production Of Biotherapeutics
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Artificial Intelligence In The Production Of Biotherapeutics
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Author : Alok Kumar Srivastav
language : en
Publisher: CRC Press
Release Date : 2025-08-29
Artificial Intelligence In The Production Of Biotherapeutics written by Alok Kumar Srivastav and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-08-29 with Science categories.
The transformative role of artificial intelligence (AI) in modern biomanufacturing focuses on key areas such as process analytical technology (PAT), Good Manufacturing Practice (GMP) compliance, predictive analytics, and AI-driven quality systems. It bridges cutting-edge AI applications with the complexities of biotherapeutic production, offering insights into automation, real-time monitoring, and process optimization. Delving into the core of biomanufacturing, the book provides a structured journey through its critical phases. It begins with an introduction to modern biomanufacturing principles, quality by design approaches, and the integration of AI. Subsequent chapters examine raw material management, lean manufacturing practices, and the application of predictive analytics to optimize supply chains. Readers will explore advanced tools such as AI-enhanced data acquisition in PAT, automated standard operating procedures (SOPs), and AI-driven process controls for fermenters and chromatography systems. The text also addresses GMP essentials, including personnel management, hygienic facility design, and pharmaceutical water systems. Key chapters highlight AI’s role in validation processes, sterile packaging, and regulatory compliance, referencing global guidelines from organizations such as the WHO, FDA, and ICH. Real-world case studies featuring therapeutic proteins, monoclonal antibodies, and vaccines underscore the practical applications of AI in scaling and maintaining biotherapeutic production. This book equips readers with a comprehensive understanding of AI’s potential to enhance efficiency, accuracy, and compliance in biomanufacturing. Whether you are a professional, researcher, or student, this guide offers actionable insights into leveraging AI to revolutionize biotherapeutic production while adhering to the highest industry standards. What You Will Learn: Understand how AI enhances every phase of biotherapeutic production, from raw material management to regulatory compliance, optimizing efficiency, accuracy, and quality. Explore the role of AI in advanced data acquisition, process control, and continuous improvement, including applications in fermenters, flow filtration, and chromatography systems. Gain insights into leveraging AI for automating standard operating procedures (SOPs), predictive maintenance, quality assurance, and adhering to global GMP standards like WHO and FDA guidelines. Learn how AI transforms upstream and downstream processes, ensures sterility in packaging, and supports case studies on therapeutic proteins, monoclonal antibodies, and human vaccines. Discover the potential of AI in shaping the future of biomanufacturing, including challenges, data security, and the ethical implications of AI-driven automation.
Artificial Intelligence In The Production Of Biotherapeutics
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Author : Alok Kumar Srivastav
language : en
Publisher: CRC Press
Release Date : 2025-07-29
Artificial Intelligence In The Production Of Biotherapeutics written by Alok Kumar Srivastav and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-07-29 with Medical categories.
The transformative role of artificial intelligence (AI) in modern biomanufacturing, focusing on key areas such as Process Analytical Technology (PAT), Good Manufacturing Practice (GMP) compliance, predictive analytics, and AI-driven quality systems. It bridges cutting-edge AI applications with the complexities of biotherapeutic production, offering insights into automation, real-time monitoring, and process optimization. Delving into the core of biomanufacturing, the book provides a structured journey through its critical phases. It begins with an introduction to modern biomanufacturing principles, quality-by-design approaches, and the integration of AI. Subsequent chapters examine raw material management, lean manufacturing practices, and the application of predictive analytics to optimize supply chains. Readers will explore advanced tools such as AI-enhanced data acquisition in PAT, automated standard operating procedures (SOPs), and AI-driven process controls for fermenters and chromatography systems. The text also addresses GMP essentials, including personnel management, hygienic facility design, and pharmaceutical water systems. Key chapters highlight AI's role in validation processes, sterile packaging, and regulatory compliance, referencing global guidelines from organizations such as the WHO, FDA, and ICH. Real-world case studies featuring therapeutic proteins, monoclonal antibodies, and vaccines underscore the practical applications of AI in scaling and maintaining biotherapeutic production. This book equips readers with a comprehensive understanding of AI's potential to enhance efficiency, accuracy, and compliance in biomanufacturing. Whether you are a professional, researcher, or student, this guide offers actionable insights into leveraging AI to revolutionize biotherapeutic production while adhering to the highest industry standards. What You Will Learn - Understand how AI enhances every phase of biotherapeutic production, from raw material management to regulatory compliance, optimizing efficiency, accuracy, and quality. - Explore the role of AI in advanced data acquisition, process control, and continuous improvement, including applications in fermenters, flow filtration, and chromatography systems. - Gain insights into leveraging AI for automating standard operating procedures (SOPs), predictive maintenance, quality assurance, and adhering to global GMP standards like WHO and FDA guidelines. - Learn how AI transforms upstream and downstream processes, ensures sterility in packaging, and supports case studies on therapeutic proteins, monoclonal antibodies, and human vaccines. - Discover the potential of AI in shaping the future of biomanufacturing, including challenges, data security, and the ethical implications of AI-driven automation.
Synthetic Biology For Therapeutics
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Author : Urartu Ozgur Safak Seker
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2024-11-18
Synthetic Biology For Therapeutics written by Urartu Ozgur Safak Seker and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-18 with Science categories.
Synthetic biology is enabling scientists to use engineered genetic circuits in the cells as the basis for the development of new living therapeutics and as a powerful new weapon in the fight against diseases, especially cancer. Bacteria-mediated therapy is a promising alternative cancer treatment. The book covers the recent developments of cellular therapies from a synthetic biology perspective including engineered microbial therapies, CAR-T therapies etc. and is an indispensable guide to scientists in both biotechnology and medicine.
Microbial Enzymes As Potential Biotherapeutics In Human Healthcare
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Author : Dileep Francis
language : en
Publisher: CRC Press
Release Date : 2025-08-04
Microbial Enzymes As Potential Biotherapeutics In Human Healthcare written by Dileep Francis and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-08-04 with Science categories.
This book comprehensively reviews the diverse potential of microbial enzymes with therapeutic applications, covering their production, purification, and utilization. It examines their roles in combating various diseases, including inflammation, bacterial infections, cardiovascular conditions, and thrombotic disorders. The book highlights their pharmaceutical applications in drug formulation and bioactive compound production, with the aim of enhancing drug bioavailability, stability, and efficacy. Furthermore, the book explores the potential of microbial fibrinolytic enzymes to revolutionize treatments for thrombotic disorders. It also outlines the applications of microbial enzymes in targeting cancer cells, emphasizing their pivotal role in innovative treatment modalities. Additionally, the book presents the therapeutic applications of microbial lipases, from their use in lipid-lowering medications to the creation of lipase-based pharmaceuticals. The chapters discuss the potential of microbial uricases in managing uric-acid-related disorders and the contribution of microbial enzymes in enhancing digestion and alleviating digestive disorders. Finally, the book delves into the vital role of regulatory authorities and intellectual property rights (IPR) in the commercialization of therapeutic microbial enzymes. As such, this book serves as a valuable resource for researchers, professionals, and students of microbiology, biotechnology, and pharmaceutical sciences. Key Features: Reviews the therapeutic potential of microbial enzymes and their production and purification Examines the roles of microbial enzymes in combating a wide range of diseases, including inflammation, bacterial infections, cardiovascular conditions, and thrombotic disorders Highlights the pharmaceutical applications of microbial enzymes, focusing on drug formulation and the production of bioactive compounds to enhance drug bioavailability, stability, and efficacy Explores the therapeutic applications of microbial lipases, from lipid-lowering medications to the creation of lipase-based pharmaceuticals Presents the vital role of regulatory authorities and intellectual property rights (IPR) in the commercialization of therapeutic microbial enzymes
World Local Production Forum Enhancing Access To Medicines And Other Health Technologies Report Of The First Wlpf 21 25 June 2021
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Author :
language : en
Publisher: World Health Organization
Release Date : 2021-07-30
World Local Production Forum Enhancing Access To Medicines And Other Health Technologies Report Of The First Wlpf 21 25 June 2021 written by and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-30 with Medical categories.
The World Local Production Forum: Enhancing access to medicines and other health technologies (WLPF) brings the global community – foremost government leaders, industry associations, technology experts and innovators, civil society, the international community, and other stakeholders – together under the auspices of WHO to shape the development of local production and highlight the challenges and opportunities for the sector for public health impact. This report summarizes the first World Local Production Forum which was held virtually from 21-25 June 2021. The Forum brought together over 70 speakers and panellists and was attended by delegates from over 100 countries, industry associations, finance providers, civil society groups, UN agencies and international partners. Topics that are key in promoting sustainable local production in the current COVID-19 situation and beyond were explored and discussed more deeply in the Forum: partnerships and cooperation business ecosystem, regulatory systems, licensing and technology transfer, financing, vaccines, and innovation, artificial intelligence (AI) and the digital revolution.
Remington
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Author : Adeboye Adejare
language : en
Publisher: Academic Press
Release Date : 2020-11-03
Remington written by Adeboye Adejare and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-03 with Science categories.
The PCP's Bicentennial Edition Remington: The Science and Practice of Pharmacy, Twenty Third Edition, offers a trusted, completely updated source of information for education, training, and development of pharmacists. Published for the first time with Elsevier, this edition includes coverage of biologics and biosimilars as uses of those therapeutics have increased substantially since the previous edition. Also discussed are formulations, drug delivery (including prodrugs, salts, polymorphism. With clear, detailed color illustrations, fundamental information on a range of pharmaceutical science areas, and information on new developments in industry, pharmaceutical industry scientists, especially those involved in drug discovery and development will find this edition of Remington an essential reference. Intellectual property professionals will also find this reference helpful to cite in patents and resulting litigations. Additional graduate and postgraduate students in Pharmacy and Pharmaceutical Sciences will refer to this book in courses dealing with medicinal chemistry and pharmaceutics. - Contains a comprehensive source of principles of drug discovery and development topics, especially for scientists that are new in the pharmaceutical industry such as those with trainings/degrees in chemistry and engineering - Provides a detailed source for formulation scientists and compounding pharmacists, from produg to excipient issues - Updates this excellent source with the latest information to verify facts and refresh on basics for professionals in the broadly defined pharmaceutical industry
Manufacturing Driving Circular Economy
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Author : Holger Kohl
language : en
Publisher: Springer Nature
Release Date : 2023-05-27
Manufacturing Driving Circular Economy written by Holger Kohl and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-27 with Technology & Engineering categories.
This is an open access book. It gathers the proceedings of the 18th Global Conference on Sustainable Manufacturing, held on October 5-7, 2022, as a hybrid event, in/from Berlin, Germany. With a focus on manufacturing advances and practices driving the circular economy, the chapters selected for this book report on sustainable manufacturing technologies for the mobility, energy and construction sector, and for machines and equipments, covering applications of artificial intelligence and industry 4.0. Moreover, they discuss energy-efficient process, waste reuse, and CO2 neutral production, giving a special emphasis to developing sustainable manufacturing in emerging countries. This book offers extensive and timely information for both researchers and professionals in the field of manufacturing and business development.
Probiotics As Live Biotherapeutics For Veterinary And Human Health Volume 1
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Author : Birbal Singh
language : en
Publisher: Springer Nature
Release Date : 2024-11-11
Probiotics As Live Biotherapeutics For Veterinary And Human Health Volume 1 written by Birbal Singh and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-11 with Medical categories.
This Volume 1 of a two-volume work provides an up-to-date overview of the latest advances in live biotherapeutics research. It focuses on key areas within probiotics and microbiome studies from the veterinary sciences including their translation into commercial applications. The book is divided into three sections, comprising (I) fundamentals about probiotic resources, (II) probiotics for veterinary health, with chapters on farm animals, pets, wildlife and aquaculture, and (III) industrial applications of probiotics. The broad spectrum of industry-relevant contributions makes this work a valuable resource for industry professionals as well as researchers in functional feed and food biotechnology, applied veterinary microbiology and gastroenterology. Presenting novel and evidence-based research, this volume will drive the commercial enterprise and meets the great demand for good probiotic products in the veterinary medical sector.
Translational Biotechnology
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Author : Yasha Hasija
language : en
Publisher: Academic Press
Release Date : 2021-01-17
Translational Biotechnology written by Yasha Hasija and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-17 with Medical categories.
Translational Biotechnology: A Journey from Laboratory to Clinics presents an integrative and multidisciplinary approach to biotechnology to help readers bridge the gaps between fundamental and functional research. The book provides state-of-the-art and integrative views of translational biotechnology by covering topics from basic concepts to novel methodologies. Topics discussed include biotechnology-based therapeutics, pathway and target discovery, biological therapeutic modalities, translational bioinformatics, and system and synthetic biology. Additional sections cover drug discovery, precision medicine and the socioeconomic impact of translational biotechnology. This book is valuable for bioinformaticians, biotechnologists, and members of the biomedical field who are interested in learning more about this promising field. - Explains biotechnology in a different light by using an application-oriented approach - Discusses practical approaches in the development of precision medicine tools, systems and dynamical medicine approaches - Promotes research in the field of biotechnology that is translational in nature, cost-effective and readily available to the community
Biopharmaceutical Informatics
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Author : Sandeep Kumar
language : en
Publisher: CRC Press
Release Date : 2025-01-22
Biopharmaceutical Informatics written by Sandeep Kumar and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-22 with Science categories.
Despite the phenomenal clinical success of antibody-based biopharmaceuticals in recent years, discovery and development of these novel biomedicines remains a costly, time-consuming, and risky endeavor with low probability of success. To bring better biomedicines to patients faster, we have come up with a strategic vision of Biopharmaceutical Informatics which calls for syncretic use of computation and experiment at all stages of biologic drug discovery and pre-clinical development cycles to improve probability of successful clinical outcomes. Biopharmaceutical Informatics also encourages industry and academic scientists supporting various aspects of biotherapeutic drug discovery and development cycles to learn from our collective experiences of successes and, more importantly, failures. The insights gained from such learnings shall help us improve the rate of successful translation of drug discoveries into drug products available to clinicians and patients, reduce costs, and increase the speed of biologic drug discovery and development. Hopefully, the efficiencies gained from implementing such insights shall make novel biomedicines more affordable for patients. This unique volume describes ways to invent and commercialize biomedicines more efficiently: Calls for digital transformation of biopharmaceutical industry by appropriately collecting, curating, and making available discovery and pre-clinical development project data using FAIR principles Describes applications of artificial intelligence and machine learning (AIML) in discovery of antibodies in silico (DAbI) starting with antigen design, constructing inherently developable antibody libraries, finding hits, identifying lead candidates, and optimizing them Details applications of AIML, physics-based computational design methods, and other bioinformatics tools in fields such as developability assessments, formulation and excipient design, analytical and bioprocess development, and pharmacology Presents pharmacokinetics/pharmacodynamics (PK/PD) and Quantitative Systems Pharmacology (QSP) models for biopharmaceuticals Describes uses of AIML in bispecific and multi-specific formats Dr Sandeep Kumar has also edited a collection of articles dedicated to this topic which can be found in the Taylor and Francis journal mAbs.