Biopharmaceutical Informatics
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Biopharmaceutical Informatics
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Author : Sandeep Kumar
language : en
Publisher: CRC Press
Release Date : 2025-01-22
Biopharmaceutical Informatics written by Sandeep Kumar and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-22 with Science categories.
Despite the phenomenal clinical success of antibody-based biopharmaceuticals in recent years, discovery and development of these novel biomedicines remains a costly, time-consuming, and risky endeavor with low probability of success. To bring better biomedicines to patients faster, we have come up with a strategic vision of Biopharmaceutical Informatics which calls for syncretic use of computation and experiment at all stages of biologic drug discovery and pre-clinical development cycles to improve probability of successful clinical outcomes. Biopharmaceutical Informatics also encourages industry and academic scientists supporting various aspects of biotherapeutic drug discovery and development cycles to learn from our collective experiences of successes and, more importantly, failures. The insights gained from such learnings shall help us improve the rate of successful translation of drug discoveries into drug products available to clinicians and patients, reduce costs, and increase the speed of biologic drug discovery and development. Hopefully, the efficiencies gained from implementing such insights shall make novel biomedicines more affordable for patients. This unique volume describes ways to invent and commercialize biomedicines more efficiently: Calls for digital transformation of biopharmaceutical industry by appropriately collecting, curating, and making available discovery and pre-clinical development project data using FAIR principles Describes applications of artificial intelligence and machine learning (AIML) in discovery of antibodies in silico (DAbI) starting with antigen design, constructing inherently developable antibody libraries, finding hits, identifying lead candidates, and optimizing them Details applications of AIML, physics-based computational design methods, and other bioinformatics tools in fields such as developability assessments, formulation and excipient design, analytical and bioprocess development, and pharmacology Presents pharmacokinetics/pharmacodynamics (PK/PD) and Quantitative Systems Pharmacology (QSP) models for biopharmaceuticals Describes uses of AIML in bispecific and multi-specific formats Dr Sandeep Kumar has also edited a collection of articles dedicated to this topic which can be found in the Taylor and Francis journal mAbs.
Progress And Challenges In Computational Structure Based Design And Development Of Biologic Drugs
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Author : Traian Sulea
language : en
Publisher: Frontiers Media SA
Release Date : 2024-03-25
Progress And Challenges In Computational Structure Based Design And Development Of Biologic Drugs written by Traian Sulea and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-25 with Science categories.
Bioprocessing Bioengineering And Process Chemistry In The Biopharmaceutical Industry
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Author : Kumar Gadamasetti
language : en
Publisher: Springer Nature
Release Date : 2024-11-23
Bioprocessing Bioengineering And Process Chemistry In The Biopharmaceutical Industry written by Kumar Gadamasetti and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-23 with Technology & Engineering categories.
This book outlines how advances in the diverse scientific and engineering disciplines of synthetic biology, DNA synthesis, production of protein therapeutics, and bioinformatics have led to the commercialization of new complex biotherapeutic modalities in modern era, including monoclonal and multi-specific antibodies, antibody drug conjugates (ADC), fusion proteins, CAR-T and CRISPR technologies and applications, mRNA vaccines and more. Enabling operations to bring these life-changing medicines into the hands of the needy patients include regulatory submissions to authorities across the globe, as well as streamlined production across manufacturing networks deemed necessary and are outlined in dedicated chapters. Bioprocessing, Bioengineering and Process Chemistry in the Biopharmaceutical Industry: Using Chemistry and Bioengineering to Improve the Performance of Biologics captures the state of the art for many of these new modalities, offering innovative approaches to treat, prevent, and in some providential cases, cure the disease. This book will be of significant interest for many disciplines engaged jointly as teams convergently in delivering these medicines: bioprocess engineers, biologists, chemists, bioengineers, genetic engineers, healthcare professionals, regulatory bodies, among pharmaceutical industry professionals as well as in academic circles.
Developability Of Biotherapeutics
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Author : Sandeep Kumar
language : en
Publisher: CRC Press
Release Date : 2015-11-18
Developability Of Biotherapeutics written by Sandeep Kumar and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-18 with Medical categories.
Biopharmaceuticals are emerging as frontline medicines to combat several life-threatening and chronic diseases. However, such medicines are expensive to develop and produce on a commercial scale, contributing to rising healthcare costs. Developability of Biotherapeutics: Computational Approaches describes applications of computational and molecular
Approaches In Integrative Bioinformatics
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Author : Ming Chen
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-01-18
Approaches In Integrative Bioinformatics written by Ming Chen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-18 with Computers categories.
Approaches in Integrative Bioinformatics provides a basic introduction to biological information systems, as well as guidance for the computational analysis of systems biology. This book also covers a range of issues and methods that reveal the multitude of omics data integration types and the relevance that integrative bioinformatics has today. Topics include biological data integration and manipulation, modeling and simulation of metabolic networks, transcriptomics and phenomics, and virtual cell approaches, as well as a number of applications of network biology. It helps to illustrate the value of integrative bioinformatics approaches to the life sciences. This book is intended for researchers and graduate students in the field of Bioinformatics. Professor Ming Chen is the Director of the Bioinformatics Laboratory at the College of Life Sciences, Zhejiang University, Hangzhou, China. Professor Ralf Hofestädt is the Chair of the Department of Bioinformatics and Medical Informatics, Bielefeld University, Germany.
Biopharmaceutical Production Technology
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Author : Ganapathy Subramanian
language : en
Publisher: John Wiley & Sons
Release Date : 2012-05-14
Biopharmaceutical Production Technology written by Ganapathy Subramanian and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-05-14 with Medical categories.
Cost-effective manufacturing of biopharmaceutical products is rapidly gaining in importance, while healthcare systems across the globe are looking to contain costs and improve efficiency. To adapt to these changes, industries need to review and streamline their manufacturing processes. This two volume handbook systematically addresses the key steps and challenges in the production process and provides valuable information for medium to large scale producers of biopharmaceuticals. It is divided into seven major parts: - Upstream Technologies - Protein Recovery - Advances in Process Development - Analytical Technologies - Quality Control - Process Design and Management - Changing Face of Processing With contributions by around 40 experts from academia as well as small and large biopharmaceutical companies, this unique handbook is full of first-hand knowledge on how to produce biopharmaceuticals in a cost-effective and quality-controlled manner.
Bioinformatics Research And Applications
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Author : Mitra Basu
language : en
Publisher: Springer
Release Date : 2014-06-23
Bioinformatics Research And Applications written by Mitra Basu and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-23 with Computers categories.
This book constitutes the refereed proceedings of the 10th International Symposium on Bioinformatics Research and Applications, ISBRA 2014, held in Zhangjiajie, China, in June 2014. The 33 revised full papers and 31 one-page abstracts included in this volume were carefully reviewed and selected from 119 submissions. The papers cover a wide range of topics in bioinformatics and computational biology and their applications including the development of experimental or commercial systems.
Characterizing Biotherapeutics
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Author : Jennie R. Lill
language : en
Publisher: John Wiley & Sons
Release Date : 2025-06-04
Characterizing Biotherapeutics written by Jennie R. Lill and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-04 with Science categories.
Provides detailed and up-to-date coverage of analytical approaches for biologic drug modalities The development of innovative biologic therapies has revolutionized medicine, but their complexity demands equally advanced analytical approaches. Characterizing Biotherapeutics: Analytical Methods for Diverse Modalities introduces the tools and techniques used to analyze these groundbreaking therapies. Designed to help readers characterize and troubleshoot increasingly diverse and sophisticated therapeutic molecules, this in-depth guide addresses different biologic drugs, their unique analytical challenges, and the methods that enable their analysis. Organized into two comprehensive sections, Characterizing Biotherapeutics first delves into the fundamentals of analytical platforms, providing a robust foundation in techniques such as mass spectrometry and biophysical assays. The second section applies these methods to real-world scenarios, focusing on drug discovery, clinical evaluation, and commercial considerations in drug development. Authors Jennie R. Lill and Wendy Sandoval provide clear guidance tailored to the evolving demands of therapeutic innovations such as structural characterization, high-throughput biophysical assays, and RNA-based therapeutics. Equipping researchers with the knowledge to navigate the challenges posed by increasingly complex biologics, Characterizing Biotherapeutics: Analytical Methods for Diverse Modalities: Discusses new and emerging biological molecule diversity and both traditional analytical methods Provides characterization strategies for large molecule (protein/antibody) based therapeutics Summarizes cutting-edge technologies for novel modalities and antibody protein therapeutics Incorporates the latest advancements in mass spectrometry, functional assays, and biophysical methods Addresses specialized analytical issues for membrane proteins and other challenging targets Presents methodologies for assessing safety and therapeutic potential Characterizing Biotherapeutics: Analytical Methods for Diverse Modalities is an essential reference for analytical scientists, biologists, and mass spectrometrists involved in biomolecule analysis. It is also a valuable resource for graduate students taking advanced courses in biotechnology, drug development, and biotherapeutic analysis, as well as professionals in biotechnology and pharmaceutical industries working to advance biotherapeutic research and development.
Bioinformatics And Computational Biology
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Author : Tiratha Raj Singh
language : en
Publisher: CRC Press
Release Date : 2023-12-13
Bioinformatics And Computational Biology written by Tiratha Raj Singh and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-13 with Computers categories.
Bioinformatics and Computational Biology: Technological Advancements, Applications and Opportunities is an invaluable resource for general and applied researchers who analyze biological data that is generated, at an unprecedented rate, at the global level. After careful evaluation of the requirements for current trends in bioinformatics and computational biology, it is anticipated that the book will provide an insightful resource to the academic and scientific community. Through a myriad of computational resources, algorithms, and methods, it equips readers with the confidence to both analyze biological data and estimate predictions. The book offers comprehensive coverage of the most essential and emerging topics: Cloud-based monitoring of bioinformatics multivariate data with cloud platforms Machine learning and deep learning in bioinformatics Quantum machine learning for biological applications Integrating machine learning strategies with multiomics to augment prognosis in chronic diseases Biomedical engineering Next generation sequencing techniques and applications Computational systems biology and molecular evolution While other books may touch on some of the same issues and nuances of biological data analysis, they neglect to feature bioinformatics and computational biology exclusively, and as exhaustively. This book's abundance of several subtopics related to almost all of the regulatory activities of biomolecules from where real data is being generated brings an added dimension.
Post Pandemic Digital Transformation In The Biopharmaceutical Industry Leveraging Ai For Remote Clinical Trials And Telemedicine
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Author : Mahesh Recharla
language : en
Publisher: Global Pen Press UK
Release Date :
Post Pandemic Digital Transformation In The Biopharmaceutical Industry Leveraging Ai For Remote Clinical Trials And Telemedicine written by Mahesh Recharla and has been published by Global Pen Press UK this book supported file pdf, txt, epub, kindle and other format this book has been release on with Computers categories.
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