Artificial Nucleases
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Artificial Nucleases
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Author : Marina A. Zenkova
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Artificial Nucleases written by Marina A. Zenkova and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The development of agents capable of cleaving RNA and DNA has attracted considerable attention from researchers in the last few years, because of the immediate and very important applications they can find in the emerging fields of biotechnology and pharmacology. There are essentially two classes of these agents - nucleases that occur naturally inside cells and synthetically produced artificial nucleases. The first class includes protein enzyme nucle ases and catalytic RNA structured ribozymes that perform cleavage of the phosphodiester bonds in nucleic acids according to a hydrolytic pathway in the course of different biochemical processes in the cell. A different pathway is used by some antibiotics which cleave DNA via redox-based mechanisms resulting in oxidative damage of nucleotide units and breakage of the DNA backbone. The above molecules are indispensable tools for manipulating nucleic acids and processing RNA; DNA-cleaving antibiotics and cytotoxic ribonucleases have demonstrated utility as chemotherapeutic agents. The second class, artificial nucleases, are rationally designed to imitate the active centers of natural enzymes by simple structures possessing minimal sets of the most important characteristics that are essential for catalysis. A dif ferent approach, in vitro selection, was also used to create artificial RNA and DNA enzymes capable of cleaving RNA. Being less efficient and specific as compared to the natural enzymes, the primitive mimics are smaller and robust and can function in a broad range of conditions.
Artificial Nucleases
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Author : Kimberly Kolasa Lotter
language : en
Publisher:
Release Date : 1994
Artificial Nucleases written by Kimberly Kolasa Lotter and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with categories.
Caribbean Overseas Trade In Agricultural And Forest Products
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Author :
language : en
Publisher:
Release Date : 1952
Caribbean Overseas Trade In Agricultural And Forest Products written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1952 with categories.
The Development Of Metal Complexes As Artificial Nucleases
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Author : Lisa A. Buttrey
language : en
Publisher:
Release Date : 1993
The Development Of Metal Complexes As Artificial Nucleases written by Lisa A. Buttrey and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with categories.
Lanthanide Ions In The Development Of Artificial Nucleases
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Author : Bryan K. Takasaki
language : en
Publisher:
Release Date : 1994
Lanthanide Ions In The Development Of Artificial Nucleases written by Bryan K. Takasaki and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with categories.
"La(III) hydroxide clusters formed from the combination of La(III) (20 mM) and NaOM (40 mM) rapidly converts an RNA dinucleotide (ApA) to the monophosphates (2$ sp prime$-AMP and 3$ sp prime$-AMP) (t$ sb{1/2}$ = 8 sec at pH 8.7, 20$ sp circ$C). The presence of molecular oxygen does not improve the efficiency of Ce(III) in cleaving ApA; however, it does assist in the cleavage of the monophosphates which are not cleaved by Ce(III) in the absence of O$ sb2$ or La(III)." --
Lanthanide Ions In The Development Of Artificial Nucleases Microform
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Author : Bryan K. Takasaki
language : en
Publisher: National Library of Canada = Bibliothèque nationale du Canada
Release Date : 1994
Lanthanide Ions In The Development Of Artificial Nucleases Microform written by Bryan K. Takasaki and has been published by National Library of Canada = Bibliothèque nationale du Canada this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with categories.
Synthetic Sequence Specific Nucleases
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Author : David S. Sigman
language : en
Publisher:
Release Date : 1988
Synthetic Sequence Specific Nucleases written by David S. Sigman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with categories.
The principal objective of this grant is to target the nuclease activity of 1,10-phenanthroline-copper ion using synthetic peptides and genetically engineered DNA-binding proteins. These engineered nucleases could be used as artificial restriction enzymes and in the study of amino acid-nucleotide interactions essential for site specific binding. Keywords: Synthetic nucleases, Artificial enzymes, DNA scission, 1,10-phenanthroline-copper ion, Peptides. (KT).
Copper Complexes With Bpa And Phen Based Ligands As Artificial Nucleases
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Author : Airlangga Arya Janitra Sudarga Tjakraatmadja
language : en
Publisher:
Release Date : 2016
Copper Complexes With Bpa And Phen Based Ligands As Artificial Nucleases written by Airlangga Arya Janitra Sudarga Tjakraatmadja and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
Studies On Phosphate Ester Cleavage And Development Of Oligonucleotide Based Artificial Nucleases Oban S
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Author : Hans Åström
language : en
Publisher:
Release Date : 2004
Studies On Phosphate Ester Cleavage And Development Of Oligonucleotide Based Artificial Nucleases Oban S written by Hans Åström and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
Developing Artificial Proteases And Nucleases
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Author : Jung-Hee Kim
language : en
Publisher:
Release Date : 1992
Developing Artificial Proteases And Nucleases written by Jung-Hee Kim and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with categories.
"Cis-diaqua cobalt complex ((L)Co(III)(OH$ sb2) sb2 rbrack sp{3+}$ promoted hydrolyses of phosphate esters, nitriles and carboxy amides are examined (L represents 1,4,7,10-tetraazacyclododecane (cyclen) and its N-methylated derivatives). ((Cyclen)Co(OH$ sb2) sb2 rbrack sp{3+}$ is more active than any other catalysts reported to date for hydrolyzing dimethyl phosphate, acetonitrile and formyl morpholine." --