The Development Of Metal Complexes As Artificial Nucleases
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The Development Of Metal Complexes As Artificial Nucleases
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Author : Lisa A. Buttrey
language : en
Publisher:
Release Date : 1993
The Development Of Metal Complexes As Artificial Nucleases written by Lisa A. Buttrey and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with categories.
Artificial Nucleases
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Author : Marina A. Zenkova
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Artificial Nucleases written by Marina A. Zenkova and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The development of agents capable of cleaving RNA and DNA has attracted considerable attention from researchers in the last few years, because of the immediate and very important applications they can find in the emerging fields of biotechnology and pharmacology. There are essentially two classes of these agents - nucleases that occur naturally inside cells and synthetically produced artificial nucleases. The first class includes protein enzyme nucle ases and catalytic RNA structured ribozymes that perform cleavage of the phosphodiester bonds in nucleic acids according to a hydrolytic pathway in the course of different biochemical processes in the cell. A different pathway is used by some antibiotics which cleave DNA via redox-based mechanisms resulting in oxidative damage of nucleotide units and breakage of the DNA backbone. The above molecules are indispensable tools for manipulating nucleic acids and processing RNA; DNA-cleaving antibiotics and cytotoxic ribonucleases have demonstrated utility as chemotherapeutic agents. The second class, artificial nucleases, are rationally designed to imitate the active centers of natural enzymes by simple structures possessing minimal sets of the most important characteristics that are essential for catalysis. A dif ferent approach, in vitro selection, was also used to create artificial RNA and DNA enzymes capable of cleaving RNA. Being less efficient and specific as compared to the natural enzymes, the primitive mimics are smaller and robust and can function in a broad range of conditions.
Metal Complex Dna Interactions
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Author : Nick Hadjiliadis
language : en
Publisher: John Wiley & Sons
Release Date : 2009-03-30
Metal Complex Dna Interactions written by Nick Hadjiliadis and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-30 with Science categories.
Metal ions and metal complexes have long been recognized ascritically important components of nucleic acid chemistry, both inregulation of gene expression and as promising therapeutic agents.Understanding how metal complexes interact with DNA has become anactive research area at the interface between chemistry, molecularbiology and medicine. Metal Complex - DNA Interactions provides a comprehensiveoverview of this increasingly diverse field, presenting recentdevelopments and the latest research with particular emphasis onmetal-based drugs and metal ion toxicity. The text is divided intofour parts: Basic Structural and Kinetic Aspects: includes chapterson sequence-selective metal binding to DNA and thermodynamicmodels. Medical Applications: focuses on anticancer platinumdrugs, including discussions on DNA repair in antitumor effects ofplatinum drugs and photo-dynamic therapy. DNA-Recognition - Nucleases and Sensor: describesprobes for DNA recognition, artificial restriction agents,metallo-DNAzymes for metal sensing applications and metal iondependent catalysis in nucleic acid enzymes. Toxicological Aspects: deals with structural studies ofmercury–DNA interactions, chromium-induced DNA damage andrepair, and the effect of arsenic and nickel on DNAintegrity. This book will be a valuable resource for academic researchersand professionals from a range of pharmaceutical and chemicalindustries, particularly those involved in the development of newand less toxic anticancer metallo-drugs, and in the field ofenvironmental and toxicological chemistry.
Substrate Selective Copper Catalysts As Catalytic Metallodrugs
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Author : Zhen Yu (Ph. D. in chemistry)
language : en
Publisher:
Release Date : 2017
Substrate Selective Copper Catalysts As Catalytic Metallodrugs written by Zhen Yu (Ph. D. in chemistry) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Chemistry categories.
Metal complexes that catalyze inactivation and degradation of biomolecular targets can be developed into novel therapeutics (catalytic metallodrugs) against a variety of diseases and molecular tools to study biology. Despite recent advances in the field, a lack of substrate selectivity is a major hindrance to the development of metal catalysts for biological application. Improved targeting can enhance catalytic efficiency and minimize nonselective activity and the potential for side effects in clinical practice. We employed the strategy of substrate-selective catalytic metallodrugs and designed selective copper catalysts that target disease-associated biomolecules including G-quadruplex telomeric DNA and L-fucose.
Advances In The Development Of Artificial Metalloenzymes
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Author : Tatjana N. Parac-Vogt
language : en
Publisher: Frontiers Media SA
Release Date : 2019-11-05
Advances In The Development Of Artificial Metalloenzymes written by Tatjana N. Parac-Vogt and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-05 with categories.
Reactions catalyzed by metalloenzymes have great potential for applications in the biotechnology and pharmaceutical industries. While only a few of these enzymes have yet been used in such applications, in the last few decades numerous efficient, selective, environmentally friendly and economical synthetic analogues have been described, including supramolecular, polymeric, nanoparticulate and lowmolecular- weight organometallic complexes, and metal organic frameworks. In this Research Topic, we present a collection of original research and review articles that show significant recent advances made in the rational design of such artificial metalloenzymes.
Inorganic Chemical Biology
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Author : Gilles Gasser
language : en
Publisher: John Wiley & Sons
Release Date : 2014-06-23
Inorganic Chemical Biology written by Gilles Gasser and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-23 with Science categories.
Understanding, identifying and influencing the biological systems are the primary objectives of chemical biology. From this perspective, metal complexes have always been of great assistance to chemical biologists, for example, in structural identification and purification of essential biomolecules, for visualizing cellular organelles or to inhibit specific enzymes. This inorganic side of chemical biology, which continues to receive considerable attention, is referred to as inorganic chemical biology. Inorganic Chemical Biology: Principles, Techniques and Applications provides a comprehensive overview of the current and emerging role of metal complexes in chemical biology. Throughout all of the chapters there is a strong emphasis on fundamental theoretical chemistry and experiments that have been carried out in living cells or organisms. Outlooks for the future applications of metal complexes in chemical biology are also discussed. Topics covered include: • Metal complexes as tools for structural biology • IMAC, AAS, XRF and MS as detection techniques for metals in chemical biology • Cell and organism imaging and probing DNA using metal and metal carbonyl complexes • Detection of metal ions, anions and small molecules using metal complexes • Photo-release of metal ions in living cells • Metal complexes as enzyme inhibitors and catalysts in living cells Written by a team of international experts, Inorganic Chemical Biology: Principles, Techniques and Applications is a must-have for bioinorganic, bioorganometallic and medicinal chemists as well as chemical biologists working in both academia and industry.
Comprehensive Supramolecular Chemistry Ii
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Author : George W. Gokel
language : en
Publisher: Elsevier
Release Date : 2017-06-22
Comprehensive Supramolecular Chemistry Ii written by George W. Gokel and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-22 with Science categories.
Comprehensive Supramolecular Chemistry II, Second Edition, Nine Volume Set is a ‘one-stop shop’ that covers supramolecular chemistry, a field that originated from the work of researchers in organic, inorganic and physical chemistry, with some biological influence. The original edition was structured to reflect, in part, the origin of the field. However, in the past two decades, the field has changed a great deal as reflected in this new work that covers the general principles of supramolecular chemistry and molecular recognition, experimental and computational methods in supramolecular chemistry, supramolecular receptors, dynamic supramolecular chemistry, supramolecular engineering, crystallographic (engineered) assemblies, sensors, imaging agents, devices and the latest in nanotechnology. Each section begins with an introduction by an expert in the field, who offers an initial perspective on the development of the field. Each article begins with outlining basic concepts before moving on to more advanced material. Contains content that begins with the basics before moving on to more complex concepts, making it suitable for advanced undergraduates as well as academic researchers Focuses on application of the theory in practice, with particular focus on areas that have gained increasing importance in the 21st century, including nanomedicine, nanotechnology and medicinal chemistry Fully rewritten to make a completely up-to-date reference work that covers all the major advances that have taken place since the First Edition published in 1996
Principles Of Bioinorganic Chemistry
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Author : Stephen J. Lippard
language : en
Publisher: University Science Books
Release Date : 1994
Principles Of Bioinorganic Chemistry written by Stephen J. Lippard and has been published by University Science Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Medical categories.
The use of unnatural metals - which have been introduced into human biology as diagnostic probes and drugs - is another active area of tremendous medical significance.
Supramolecular Systems In Biomedical Fields
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Author : Hans-Jorg Schneider
language : en
Publisher: Royal Society of Chemistry
Release Date : 2013-09-06
Supramolecular Systems In Biomedical Fields written by Hans-Jorg Schneider and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-06 with Science categories.
Non-covalent interactions, which are the heart of supramolecular chemistry are also the basis of most important functions of living systems. The ability to apply supramolecular chemistry principles to the life sciences, such as designing synthetic host compounds to selectively interact within biological targets, has gained wide appeal due the vast number of potential applications. Supramolecular Systems for Biomedical Fields provides in sixteen chapters a comprehensive overview of these applications. Each chapter covers a specific topic and is written by internationally renowned experts in that area. Sensing of bioactive inorganic ions and organic substrates is the focus of several contributions, as well as interactions with proteins and nucleic acids. Specific chapters are devoted to cyclodextrins, calixarenes and cucurbiturils as most frequently used receptors, including applications such as drug delivery and protection, gene transfer and others. Other chapters address the use of combinatorial libraries, molecular imprinting techniques, enzyme assays, supramolecular gels, bioimaging, drug activation, photodynamic therapy, and antitumour metal complexes. This timely publication will appeal to graduate students and researchers from chemical, pharmaceutical, biological, and medicinal fields interested in the supramolecular chemistry of biological systems and their practical potentials.
Comprehensive Inorganic Chemistry Ii
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Author :
language : en
Publisher: Newnes
Release Date : 2013-07-23
Comprehensive Inorganic Chemistry Ii written by and has been published by Newnes this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-23 with Science categories.
Comprehensive Inorganic Chemistry II, Nine Volume Set reviews and examines topics of relevance to today’s inorganic chemists. Covering more interdisciplinary and high impact areas, Comprehensive Inorganic Chemistry II includes biological inorganic chemistry, solid state chemistry, materials chemistry, and nanoscience. The work is designed to follow on, with a different viewpoint and format, from our 1973 work, Comprehensive Inorganic Chemistry, edited by Bailar, Emeléus, Nyholm, and Trotman-Dickenson, which has received over 2,000 citations. The new work will also complement other recent Elsevier works in this area, Comprehensive Coordination Chemistry and Comprehensive Organometallic Chemistry, to form a trio of works covering the whole of modern inorganic chemistry. Chapters are designed to provide a valuable, long-standing scientific resource for both advanced students new to an area and researchers who need further background or answers to a particular problem on the elements, their compounds, or applications. Chapters are written by teams of leading experts, under the guidance of the Volume Editors and the Editors-in-Chief. The articles are written at a level that allows undergraduate students to understand the material, while providing active researchers with a ready reference resource for information in the field. The chapters will not provide basic data on the elements, which is available from many sources (and the original work), but instead concentrate on applications of the elements and their compounds. Provides a comprehensive review which serves to put many advances in perspective and allows the reader to make connections to related fields, such as: biological inorganic chemistry, materials chemistry, solid state chemistry and nanoscience Inorganic chemistry is rapidly developing, which brings about the need for a reference resource such as this that summarise recent developments and simultaneously provide background information Forms the new definitive source for researchers interested in elements and their applications; completely replacing the highly cited first edition, which published in 1973