Metal Complex Dna Interactions
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Metal Complex Dna Interactions
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Author : Nick Hadjiliadis
language : en
Publisher: John Wiley & Sons
Release Date : 2009-03-30
Metal Complex Dna Interactions written by Nick Hadjiliadis and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-30 with Science categories.
Metal ions and metal complexes have long been recognized ascritically important components of nucleic acid chemistry, both inregulation of gene expression and as promising therapeutic agents.Understanding how metal complexes interact with DNA has become anactive research area at the interface between chemistry, molecularbiology and medicine. Metal Complex - DNA Interactions provides a comprehensiveoverview of this increasingly diverse field, presenting recentdevelopments and the latest research with particular emphasis onmetal-based drugs and metal ion toxicity. The text is divided intofour parts: Basic Structural and Kinetic Aspects: includes chapterson sequence-selective metal binding to DNA and thermodynamicmodels. Medical Applications: focuses on anticancer platinumdrugs, including discussions on DNA repair in antitumor effects ofplatinum drugs and photo-dynamic therapy. DNA-Recognition - Nucleases and Sensor: describesprobes for DNA recognition, artificial restriction agents,metallo-DNAzymes for metal sensing applications and metal iondependent catalysis in nucleic acid enzymes. Toxicological Aspects: deals with structural studies ofmercury–DNA interactions, chromium-induced DNA damage andrepair, and the effect of arsenic and nickel on DNAintegrity. This book will be a valuable resource for academic researchersand professionals from a range of pharmaceutical and chemicalindustries, particularly those involved in the development of newand less toxic anticancer metallo-drugs, and in the field ofenvironmental and toxicological chemistry.
A Commemorative Issue In Honor Of Professor Nick Hadjiliadis Metal Complex Interactions With Nucleic Acids And Or Dna
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Author : Sotiris K Hadjikakou
language : en
Publisher: MDPI
Release Date : 2019-02-05
A Commemorative Issue In Honor Of Professor Nick Hadjiliadis Metal Complex Interactions With Nucleic Acids And Or Dna written by Sotiris K Hadjikakou and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-05 with Biochemistry categories.
This book is a printed edition of the Special Issue "A Commemorative Issue in Honor of Professor Nick Hadjiliadis: Metal Complex Interactions with Nucleic Acids and/or DNA" that was published in IJMS
Metal Ligand Interactions
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Author : N. Russo
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Metal Ligand Interactions written by N. Russo and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
In September 2002, a NATO-ASI was held in Cetraro (CS), Italy on the theme of "Metal-Ligand Interactions in Molecular-, Nano-, Micro-, and Macro-systems in Complex Environments". This event has followed the previous ones held in the same place in 1991, 1994 and 1998. In the present and the previous schools a broad interdisciplinary cross-section of experimental and theoretical researchers, interested in a better understanding of metal-ligand interactions from different viewpoints, was linked together to exchange experience, to review the state-of-the-art, to indicate new techniques and methods, to explore new fields and perspectives. Particular emphasis was given to the problems related with the crossing from molecular systems to nano-, macro-and micro-scale materials and to the effects of the environment on the properties of the molecular systems. The school was organized around lectures and special research seminares given by leading experts in the following fields: • metal clusters • inorganic complexes and materials • surface phenomena • adsorption and catalysis • organic and bio-inorganic systems • ab initio theory • density functional theory • classical and quantum dynamics This volume contains the formal lectures and selected contributed papers and describes the main aspects and problems tackled during the 12 days of the event.
Metal Ions In Biological Systems
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Author : Astrid Sigel
language : en
Publisher: CRC Press
Release Date : 1996-02-29
Metal Ions In Biological Systems written by Astrid Sigel and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-02-29 with Science categories.
"Volume 33 focuses on the vibrant research area of probing nucleic acids--the carriers of the genetic code--by metal ion complexes of small molecules providing an authoritative, timely account of this fascinating topic by over 50 distinguished experts."
A Commemorative Issue In Honor Of Professor Nick Hadjiliadis Metal Complex Interactions With Nucleic Acids And Or Dna
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Author : Sotiris K. Hadjikakou
language : en
Publisher:
Release Date : 2019
A Commemorative Issue In Honor Of Professor Nick Hadjiliadis Metal Complex Interactions With Nucleic Acids And Or Dna written by Sotiris K. Hadjikakou and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Electronic books categories.
This Special Issue of the International Journal of Molecular Science comprises a comprehensive study on "Metal Complex Interactions with Nucleic Acids and/or DNA". This Special Issue has been inspired by the important contribution of Prof. Nick Hadjiliadis to the field of palladium or/and platinum/nucleic acid interactions. It covers a selection of recent research and review articles in the field of metal complex interactions with nucleic acids and/or DNA. Moreover, this Special Issue on "Metal Complexes Interactions with Nucleic Acids and/or DNA" provides an overview of this increasingly diverse field, presenting recent developments and the latest research with particular emphasis on metal-based drugs and metal ion toxicity.
Dna Targeting Molecules As Therapeutic Agents
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Author : Michael J. Waring
language : en
Publisher: Royal Society of Chemistry
Release Date : 2018-03-12
Dna Targeting Molecules As Therapeutic Agents written by Michael J. Waring and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-12 with Science categories.
There have been remarkable advances towards discovering agents that exhibit selectivity and sequence-specificity for DNA, as well as understanding the interactions that underlie its propensity to bind molecules. This progress has important applications in many areas of biotechnology and medicine, notably in cancer treatment as well as in future gene targeting therapies. The editor and contributing authors are leaders in their fields and provide useful perspectives from diverse and interdisciplinary backgrounds on the current status of this broad area. The role played by chemistry is a unifying theme. Early chapters cover methodologies to evaluate DNA-interactive agents and then the book provides examples of DNA-interactive molecules and technologies in development as therapeutic agents. DNA-binding metal complexes, peptide and polyamide–DNA interactions, and gene targeting tools are some of the most compelling topics treated in depth. This book will be a valuable resource for postgraduate students and researchers in chemical biology, biochemistry, structural biology and medicinal fields. It will also be of interest to supramolecular chemists and biophysicists.
Nucleic Acid Metal Ion Interactions
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Author : Thomas G. Spiro
language : en
Publisher: John Wiley & Sons
Release Date : 1980-02-27
Nucleic Acid Metal Ion Interactions written by Thomas G. Spiro and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980-02-27 with Science categories.
First volume in this series which surveys new insights and directions emerging from research into the structural chemistry operating at the biological sites where metal ions are found. Examines a newly emergent focus of research activity—interactions of metal ions with nucleic acids. Selected papers describe important ongoing investigations in five key areas: discovery and therapeutic application of the anticancer properties of cis-dichlorodiammine platinum (II) and related metal complexes; possible modes of action of platinum anticancer agents, also uses of heavy metal complex in probing structure of nucleic acids; metals as mutagens and carcinogens; metal ion interactions with transfer RNA (the one nucleic acid having high-resolution three-dimensional crystal structures); and modes whereby metal ions may interact with constituents of nucleic acids.
Metallointercalators
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Author : Janice Aldrich-Wright
language : en
Publisher: Springer
Release Date : 2011-04-06
Metallointercalators written by Janice Aldrich-Wright and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-06 with Science categories.
A comprehensive treatment of the characterisation techniques used in investigating inorganic and organic molecules that interact with biomolecules is presented to the reader in a clear fashion. The work consists of two parts: (i) synthetic aspects of metallointercalators along with targeting and improving transport and (ii) the various techniques that are used for probing their interactions, such as; DNA-NMR, PGSE-NMR, DNA ESI-MS, Linear and Circular Dichroism, Fluorescence Spectroscopy, Confocal Microscopy, Viscosity, TGA and dialysis, Microarrays, biological analysis. Chapters are devoted to the synthesis and the techniques used to study the interactions of inorganic complexes with biomolecules. Considerably detailed examples are used to help illustrate the application of these techniques. This book is a useful resource for an array of inorganic and organic advanced undergraduate and graduate courses and for researchers in drug discovery.
Dna Ligand Interactions
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Author : W. Guschlbauer
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Dna Ligand Interactions written by W. Guschlbauer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
This volume contains the texts of the nineteen lectures presented at the NATO-ASI - FEBS Course on "DNA - ligand interactions: from drugs to proteins." The Advanced Study Institute (ASIl was held from August 30th to September 11th. 1986 in the Abbey of Fontevraud (France). The ASI was attended by 112 participants from a wide scientific horizon and from twentyone different countries. It was in some way a follow-up of the ASI held in Maratea. Italy in May 1981 and which was published in the NATO ASI Life Science series as volume 45. While much has been learned about the way the cellular machinery maintains and transmits the genetic heritage. as well as how these processes are regulated. little is Known about how the interactions between the various partners involved are taKing place. The interactions of drugs and proteins with nucleic acids are of evident importance in the understanding of these problems. The spectacular advances in recombinant DNA technology and the increased sophistication of biophysical techniques. in particular >:-ray diffraction and nuclear magnetic resonance. have created a scientific environment which is highly promising for the future of research in molecular biology. These advances permH the serious hope that biology on the molecular level may become a r-eality. Some of the contributions at the ASI presented the most recent advances in this e>:citing field.
Modern Avenues In Metal Nucleic Acid Chemistry
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Author : Jens Müller
language : en
Publisher: CRC Press
Release Date : 2023-04-24
Modern Avenues In Metal Nucleic Acid Chemistry written by Jens Müller and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-24 with Medical categories.
Volume 25, entitled Modern Avenues in Metal-Nucleic Acid Chemistry, of the series Metal Ions in Life Sciences (MILS), provides a timely overview of selected relevant developments in a field which previously had a pronounced focus on fundamental chemistry aspects such as coordination principles, structural chemistry, and consequences for biological processes and disease-related medicinal issues. More recently, also as a consequence of the advent of supramolecular chemistry, advancements in nanochemistry, and new bio-analytical methods, novel aspects of this field have emerged. MILS-25 gives a state-of-the-art account on the present state of research in this field, addressing, among others, porous materials, non-covalent interactions, stimuli-responsive bioconjugates, DNA-templated metal arrays and nanoclusters, genotyping, guanine quadruplexes, and riboswitches. It consists of 15 comprehensive chapters with over 1600 citations, 160 figures (90 of them in color), with key contributions from 40 international experts from Europe, Asia, and America. It is an essential resource for scientists from numerous disciplines, ranging from materials science to biochemistry, by way of classical chemistry and physics. • It offers an update on nucleic acid – metal complex bioconjugates and their applications • It provides an insight into coordination polymers involving nucleic acid components • It covers a wide range of nucleic acids, from DNA duplexes, triplexes and quadruplexes to RNA