Substrate Selective Copper Catalysts As Catalytic Metallodrugs
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Substrate Selective Copper Catalysts As Catalytic Metallodrugs
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Author : Zhen Yu (Ph. D. in chemistry)
language : en
Publisher:
Release Date : 2017
Substrate Selective Copper Catalysts As Catalytic Metallodrugs written by Zhen Yu (Ph. D. in chemistry) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Chemistry categories.
Metal complexes that catalyze inactivation and degradation of biomolecular targets can be developed into novel therapeutics (catalytic metallodrugs) against a variety of diseases and molecular tools to study biology. Despite recent advances in the field, a lack of substrate selectivity is a major hindrance to the development of metal catalysts for biological application. Improved targeting can enhance catalytic efficiency and minimize nonselective activity and the potential for side effects in clinical practice. We employed the strategy of substrate-selective catalytic metallodrugs and designed selective copper catalysts that target disease-associated biomolecules including G-quadruplex telomeric DNA and L-fucose.
Non Noble Metal Catalysis
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Author : Robertus J. M. Klein Gebbink
language : en
Publisher: John Wiley & Sons
Release Date : 2019-04-29
Non Noble Metal Catalysis written by Robertus J. M. Klein Gebbink and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-29 with Technology & Engineering categories.
An expert overview of current research, applications, and economic and environmental advantages The study and development of new homogeneous catalysts based on first-row metals (Mn, Fe, Co, Ni, and Cu) has grown significantly due to the economic and environmental advantages that non-noble metals present. Base metals offer reduced cost, greater supply, and lower toxicity levels than noble metals?enabling greater opportunity for scientific investigation and increased development of practical applications. Non-Noble Metal Catalysis provides an authoritative survey of the field, from fundamental concepts and computational methods to industrial applications and reaction classes. Recognized experts in organometallic chemistry and homogeneous catalysis, the authors present a comprehensive overview of the conceptual and practical aspects of non-noble metal catalysts. Examination of topics including non-innocent ligands, proton-coupled electron transfer, and multi-nuclear complexes provide essential background information, while areas such as kinetic lability and lifetimes of intermediates reflect current research and shifting trends in the field. This timely book demonstrates the efficacy of base metal catalysts in the pharmaceutical, fine-chemical, and agrochemical industries, addressing both environmental and economic concerns. Providing essential conceptual and practical exploration, this valuable resource: -Illustrates how unravelling new reactivity patterns can lead to new catalysts and new applications -Highlights the multiple advantages of using non-noble metals in homogenous catalysis -Demonstrates how the availability of non-noble metal catalysis reduces costs and leads to immense savings for the chemical industry -Reveals how non-noble metal catalysis are more sustainable than noble metals such as palladium or platinum Non-Noble Metal Catalysis: Molecular Approaches and Reactions is an indispensable source of up-to-date information for catalytic chemists, organic chemists, industrial chemists, organometallic chemists, and those seeking to broaden their knowledge of catalytic chemistry.
Copper Catalysis In Organic Synthesis
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Author : Gopinathan Anilkumar
language : en
Publisher: John Wiley & Sons
Release Date : 2020-12-07
Copper Catalysis In Organic Synthesis written by Gopinathan Anilkumar and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-07 with Technology & Engineering categories.
The most current information on growing field of copper catalysis Copper Catalysis in Organic Synthesis contains an up-to-date overview of the most important reactions in the presence of copper catalysts. The contributors—noted experts on the topic—provide an introduction to the field of copper catalysis, reviewing its development, scope, and limitations, as well as providing descriptions of various homo- and cross-coupling reactions. In addition, information is presented on copper-catalyzed C–H activation, amination, carbonylation, trifluoromethylation, cyanation, and click reactions. Comprehensive in scope, the book also describes microwave-assisted and multi-component transformations as well as copper-catalyzed reactions in green solvents and continuous flow reactors. The authors highlight the application of copper catalysis in asymmetric synthesis and total synthesis of natural products and heterocycles as well as nanocatalysis. This important book: Examines copper and its use in organic synthesis as a more cost-effective and sustainable for researchers in academia and industry Offers the first up-to-date book to explore copper as a first line catalyst for many organic reactions Presents the most significant developments in the area, including cross-coupling reactions, C–H activation, asymmetric synthesis, and total synthesis of natural products and heterocycles Contains over 20 contributions from leaders in the field Written for catalytic chemists, organic chemists, natural products chemists, pharmaceutical chemists, and chemists in industry, Copper Catalysis in Organic Synthesis offers a book on the growing field of copper catalysis, covering cross-coupling reactions, C–H activation, and applications in the total synthesis of natural products.
Advances In Metallodrugs
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Author : Shahid Ul-Islam
language : en
Publisher: John Wiley & Sons
Release Date : 2020-07-08
Advances In Metallodrugs written by Shahid Ul-Islam and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-08 with Science categories.
This book is organized into 12 important chapters that focus on the progress made by metal-based drugs as anticancer, antibacterial, antiviral, anti-inflammatory, and anti-neurodegenerative agents, as well as highlights the application areas of newly discovered metallodrugs. It can prove beneficial for researchers, investigators and scientists whose work involves inorganic and coordination chemistry, medical science, pharmacy, biotechnology and biomedical engineering.
Advances In Organometallic Chemistry And Catalysis
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Author : Armando J. L. Pombeiro
language : en
Publisher: John Wiley & Sons
Release Date : 2013-10-11
Advances In Organometallic Chemistry And Catalysis written by Armando J. L. Pombeiro and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-11 with Science categories.
A contemporary compilation of recent achievements in organometallic chemistry The prestigious International Conference on Organometallic Chemistry (ICOMC) was launched in 1963, providing a forum for researchers from around the world to share their findings and explore new paths to advance our knowledge and application of organometallic chemistry. The 25th ICOMC, held in Lisbon in 2012, gathered more than 1,200 participants from 54 countries. This volume celebrates the 25th Silver Edition and the 50th Gold Year of the ICOMC. Featuring contributions from invited 25th ICOMC speakers, Advances in Organometallic Chemistry and Catalysis highlights recent achievements and new and emerging areas of research in the field. Its seven sections cover: Activation and Functionalization of Carbon Single Bonds and Small Molecules Organometallic Synthesis and Catalysis Organometallic Polymerization Catalysis Organometallic Polymers and Materials Organometallic Chemistry and Sustainable Energy Bioorganometallic Chemistry Organometallic Electrochemistry Chapters discuss fundamental underlying concepts, offer illustrative examples and cases, and explore future avenues for continued research. Readers will discover basic principles and properties of organometallic compounds, reaction mechanisms, and detailed descriptions of current applications. Collectively, these chapters underscore the versatility, richness, and potential of modern organometallic chemistry, including its interrelationships with other scientific disciplines. All the contributions are extensively referenced, providing a gateway to the most important original research papers and reviews in organometallic chemistry. Presenting a contemporary understanding of organometallic chemistry and its many applications, Advances in Organometallic Chemistry and Catalysis is recommended for all researchers in the field, from students to advanced investigators.
Medicinal Inorganic Chemistry
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Author : Jonathan L. Sessler
language : en
Publisher:
Release Date : 2005
Medicinal Inorganic Chemistry written by Jonathan L. Sessler and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Medical categories.
This book reviews the current diagnostic and therapeutic uses of metal-containing compounds in medicine, as well as the role of metals in disease.
Polyoxometalates In Catalysis Biology Energy And Materials Science
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Author : Soumyajit Roy
language : en
Publisher: Frontiers Media SA
Release Date : 2019-12-05
Polyoxometalates In Catalysis Biology Energy And Materials Science written by Soumyajit Roy and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-05 with categories.
Multicomponent Reactions
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Author : K.L. Ameta, Ph.D.
language : en
Publisher: CRC Press
Release Date : 2017-09-20
Multicomponent Reactions written by K.L. Ameta, Ph.D. and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-20 with Medical categories.
This timely book provides a succinct summary of methods for the synthesis of bioactive heterocycles using a multicomponent reaction (MCR) approach. The majority of pharmaceuticals and biologically active agrochemicals are heterocycles while countless additives and modifiers used in industrial applications are heterocyclic in nature. With the recent introduction of high-throughput biological evaluation, the importance of MCRs for drug discovery has been recognized and considerable efforts have been focused especially on the design and development of multi-component procedures for the generation of various bioactive heterocycles due to their significant therapeutic potential.
Single Chain Polymer Nanoparticles
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Author : José A. Pomposo
language : en
Publisher: John Wiley & Sons
Release Date : 2017-08-18
Single Chain Polymer Nanoparticles written by José A. Pomposo and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-18 with Technology & Engineering categories.
This first book on this important and emerging topic presents an overview of the very latest results obtained in single-chain polymer nanoparticles obtained by folding synthetic single polymer chains, painting a complete picture from synthesis via characterization to everyday applications. The initial chapters describe the synthetics methods as well as the molecular simulation of these nanoparticles, while subsequent chapters discuss the analytical techniques that are applied to characterize them, including size and structural characterization as well as scattering techniques. The final chapters are then devoted to the practical applications in nanomedicine, sensing, catalysis and several other uses, concluding with a look at the future for such nanoparticles. Essential reading for polymer and materials scientists, materials engineers, biochemists as well as environmental chemists.
Organotransition Metal Chemistry From Bonding To Catalysis
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Author : John F. Hartwig
language : en
Publisher:
Release Date : 2010-02-10
Organotransition Metal Chemistry From Bonding To Catalysis written by John F. Hartwig and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-02-10 with Science categories.
Based on Collman et al.'s best-selling classic book, Principles and Applications of Organotransition Metal Chemistry, Hartwig's text consists of new or thoroughly updated and restructured chapters and provides an in-depth view into mechanism, reaction scope, and applications. It covers the most important developments in the field over the last twenty years with great clarity with a selective, but thorough and authoritative coverage of the fundamentals of organometallic chemistry, the elementary reactions of these complexes, and many catalytic processes occurring through organometallic intermediates, making this the Organotransition Metal Chemistry text for a new generation of scientists.