Artificial Self Assembling Systems For Gene Delivery
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Artificial Self Assembling Systems For Gene Delivery
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Author : Philip L. Felgner
language : en
Publisher:
Release Date : 1996
Artificial Self Assembling Systems For Gene Delivery written by Philip L. Felgner and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Language Arts & Disciplines categories.
Discusses recent advances in artificial self-assembling systems, including retrotransposon vectors, hairpin ribozymes, triple-helix-forming oligonucleotides, liposome-mediated transfection, and photonic nanostructures. Addresses developing efficient synthetic vectors such as modular self-assembling systems mimicking important features of viral vectors. Presents new developments in synthetic self-assembling gene delivery systems, including innovations in nonviral systems, targeting nucleic acids, ligand-polylysine mediated transfer, dendrimer-mediated transfection, cationic liposomes, and polylysine DNA complexes.
Self Assembling Complexes For Gene Delivery
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Author : Alexander V. Kabanov
language : en
Publisher: Wiley-Blackwell
Release Date : 1998-05-29
Self Assembling Complexes For Gene Delivery written by Alexander V. Kabanov and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-05-29 with Medical categories.
Recent years have witnessed an explosion of activity in the field of gene therapy. Following advances in our understanding of the molecular basis of disease, hopes are high that the tremendous potential market for drugs employing antisense nucleotides and genes will one day be fulfilled. However, many obstacles remain, not least problems in the technology of gene delivery systems. Much of today's research focuses on non-viral approaches to gene delivery. Of particular importance are supramolecular complexes formed between DNA and various natural and synthetic polymers and lipids, otherwise known as 'self-assembling complexes for gene delivery'. In view of this fact, the editors of this volume have assembled an international team of contributors to present up-to-date reviews of the major chemical, biological and clinical aspects of such gene delivery vectors. Reflecting the diversity of research in this field, this book comprehensively covers: * the principles of self-assembly * natural mechanisms for gene delivery to cells * cationic lipids and liposomes * polyelectrolyte DNA complexes * systemic biodistribution of drug delivery systems * targeting of conjugates for gene delivery * new approaches to gene delivery * clinical evaluation Self-assembling Complexes for Gene Delivery is an essential reference for all professionals with an interest in gene and antisense therapy or novel drug delivery systems, including medicinal and pharmaceutical chemists, clinicians, human geneticists, molecular biologists and pharmacologists.
Synthetic Dna Delivery Systems
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Author : Dan Luo
language : en
Publisher: Springer Science & Business Media
Release Date : 2003-09-30
Synthetic Dna Delivery Systems written by Dan Luo and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-09-30 with Science categories.
DNA delivery into cells is a rapidly developing area in gene therapy and biotechnology. Moreover, it is a powerful research tool to determine gene structure, regulation, and function. Viral methods of DNA delivery are well-characterized and efficient, but little is known about the toxicity and immunogenecity of viral vectors. As a result, non-viral, transfection methods of DNA delivery are of increasing interest. Synthetic DNA Delivery Systems is a comprehensive and current resource on DNA transfection. The use of histidine-rich peptides and polypeptides as DNA delivery systems and self-assembled delivery systems based on cationic lipids and polymers are discussed. Targeted delivery to organelles, tumor cells and dendritic cells comprise an important topic.
Gene Transfer In The Cardiovascular System
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Author : Keith L. March
language : en
Publisher: Springer
Release Date :
Gene Transfer In The Cardiovascular System written by Keith L. March and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on with Medical categories.
The goal of gene transfer is protein expression. a process brought about by the insertion of a gene coding for a foreign protein into target cells resulting in the synthesis of the foreign protein For gene therapy, a tmnsferred therapeutic gene must be expressed at a level beneficial for the patient. This chapter provides an introductory overview of the rapidly evolving field of non-viral approaches for gene delivery to rnarnrnalian cells. Although currently there are fewer ongoing clinical trials using non-viral approaches than those using viral based systems, the number of non-viral trials is increasing. The long range goal of some research groups is the development of a genetically engineered artificial virus targeted to specific cells in the human body. An arurual conference, organized by Cambridge Healthtech Institute entitled "Artificial Self-Assembling Systems for Gene Transfer", brings together researchers interested in this field [1]. Assembly of an artificial virus is very complex; other research groups aim to develop simpler delivery systems consisting of a plasmid combined with delivery agents. Viral-based systems are very successful for gene delivery, but despite their successes, viral-based systems have some geneml limitations and system-specific limitations. When employing a viml-based system, the following limitations should be considered: • size limitation of the inserted gene due to packaging constraints (e. g. adenovirus, retrovirus) . • potential tumorigenesis (e. g. retrovirus) • potential for insertional mutagenesis (greater than plasmid based systems) • potential imrnunogenicity (e. g.
Design Of Self Assembling Materials
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Author : Ivan Coluzza
language : en
Publisher: Springer
Release Date : 2018-03-23
Design Of Self Assembling Materials written by Ivan Coluzza and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-23 with Medical categories.
This book provides in-depth insights into assembling dynamics of proteins, DNA and other nanoparticles. The applications of basic knowledge in the development of artificial self-assembling systems will be discussed and state of the art methodology in the field will be presented.This interdisciplinary work brings together aspects of different fields of expertise such as Biology, Physics and Material Sciences and is intended for researchers, professors and graduate students interested in the design of self-assembling materials.
Systems Self Assembly
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Author :
language : en
Publisher: Elsevier
Release Date : 2011-09-22
Systems Self Assembly written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-22 with Science categories.
Systems Self-Assembly is the only book to showcase state-of-the-art self-assembly systems that arise from the computational, biological, chemical, physical and engineering disciplines. Written by world experts in each area, it provides a coherent, integrated view of both book practice examples and new trends with a clearly presented computational flavor. The unifying thread throughout the text is the computational nature of self-assembling systems. This book consists of 13 chapters dealing with a variety of topics such as the patterns of self-organised nanoparticle assemblies; biomimetic design of dynamic self-assembling systems; computing by self-assembly involving DNA molecules, polyominoes, and cells; evolutionary design of a model of self-assembling chemical structures; self-assembly as an engineering concept across size scales; and probabilistic analysis of self-assembled molecular networks. Other chapters focus on the programming language of dynamic self-assembly; self-assembled computer architectures; simulation of self-assembly processes using abstract reduction systems; computer aided search for optimal self-assembly systems; theoretical aspects of programmable self-assembly; emergent cooperativity in large-scale patterns; and automated self-assembling programming. Systems Self-Assembly is an ideal reference for scientists, researchers and post-graduate students; practitioners in industry, engineering and science; and managers, decision-makers and policy makers. *The only book to showcases state-of-the-art self-assembly systems that arise from the computational, biological, chemical, physical and engineering disciplines *Coherent, integrated view of both book practice examples and new trends with a clearly presented computational flavor *Written by world experts in each area
Progress In Drug Research
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Author : Ernst Jucker
language : en
Publisher: Birkhäuser
Release Date : 2013-03-12
Progress In Drug Research written by Ernst Jucker and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-12 with Medical categories.
Liposomes In Gene Delivery
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Author : Danilo D. Lasic
language : en
Publisher: CRC Press
Release Date : 2019-07-23
Liposomes In Gene Delivery written by Danilo D. Lasic and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-23 with Science categories.
Many specialists are not familiar with both drug delivery and the molecular biology of DNA vectors. Liposomes in Gene Delivery covers both-molecular biologists will gain a basic knowledge of lipids, liposomes, and other gene delivery vehicles; lipid and drug delivery scientists will better understand DNA, molecular biology, and DNA manipulation. Topics include an introduction to nucleic acids, a theoretical description of DNA, recombinant technology, lipids and liposomes, stability and interaction properties of lipids and liposomes, complexation of lipids and liposomes with DNA plasmids, gene expression of genosomes in various models, structure-activity relationships, and transfection models. This is an excellent introductory text for graduate students, scientists, and researchers in molecular and cell biology, genetics, biochemistry, physical chemistry, colloid science, pharmacology, molecular science, and medicine.
Gene Transfer In The Cardiovascular System
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Author : Keith L. March
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Gene Transfer In The Cardiovascular System written by Keith L. March and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The goal of gene transfer is protein expression. a process brought about by the insertion of a gene coding for a foreign protein into target cells resulting in the synthesis of the foreign protein For gene therapy, a tmnsferred therapeutic gene must be expressed at a level beneficial for the patient. This chapter provides an introductory overview of the rapidly evolving field of non-viral approaches for gene delivery to rnarnrnalian cells. Although currently there are fewer ongoing clinical trials using non-viral approaches than those using viral based systems, the number of non-viral trials is increasing. The long range goal of some research groups is the development of a genetically engineered artificial virus targeted to specific cells in the human body. An arurual conference, organized by Cambridge Healthtech Institute entitled "Artificial Self-Assembling Systems for Gene Transfer", brings together researchers interested in this field [1]. Assembly of an artificial virus is very complex; other research groups aim to develop simpler delivery systems consisting of a plasmid combined with delivery agents. Viral-based systems are very successful for gene delivery, but despite their successes, viral-based systems have some geneml limitations and system-specific limitations. When employing a viml-based system, the following limitations should be considered: • size limitation of the inserted gene due to packaging constraints (e. g. adenovirus, retrovirus) . • potential tumorigenesis (e. g. retrovirus) • potential for insertional mutagenesis (greater than plasmid based systems) • potential imrnunogenicity (e. g.
Progress In Gene Therapy
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Author : Roger Bertolotti
language : en
Publisher: VSP
Release Date : 2000-09-28
Progress In Gene Therapy written by Roger Bertolotti and has been published by VSP this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-09-28 with Science categories.
Gene Therapy is expected to revolutionize the practice of medicine at the turn of the third Millennium. Therapeutic/prophylactic benefits should arise from both gene transfer and gene repair/inactivation protocols devised for patient's somatic cells. Gene expression cassettes, designed for the production of therapeutic proteins and non-coding RNA, are thus experimented together with emerging gene repair/inactivation techniques on a variety of inherited, acquired and infectious/parasitic diseases, including complex neuro-degenerative processes. This book presents a collection of chapters on the main aspects of Gene Therapy, some of which have already been treated in the past, and updates and further develops the current survey. It is aimed at understanding why Human Gene Therapy is likely to be a medical breakthrough, although definitive clinical success still needs time to accomplish. The contributions focus on both technical/biomedical concepts and on experimental/clinical data that appear to confer potential universality to Gene Therapy. This book does not claim to provide an exhaustive review of the pathologies, which are currently approached with Gene Therapy. The presentation of current and emerging approaches, together with problems and tentative issues aims to serve as a booster for the development of new applications in every field of medicine and will, therefore, be of value and interest to researchers in this exciting field.