Self Assembling Complexes For Gene Delivery
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Self Assembling Complexes For Gene Delivery
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Author : Alexander V. Kabanov
language : en
Publisher: Wiley-Blackwell
Release Date : 1998-05-29
Self Assembling Complexes For Gene Delivery written by Alexander V. Kabanov and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-05-29 with Medical categories.
Recent years have witnessed an explosion of activity in the field of gene therapy. Following advances in our understanding of the molecular basis of disease, hopes are high that the tremendous potential market for drugs employing antisense nucleotides and genes will one day be fulfilled. However, many obstacles remain, not least problems in the technology of gene delivery systems. Much of today's research focuses on non-viral approaches to gene delivery. Of particular importance are supramolecular complexes formed between DNA and various natural and synthetic polymers and lipids, otherwise known as 'self-assembling complexes for gene delivery'. In view of this fact, the editors of this volume have assembled an international team of contributors to present up-to-date reviews of the major chemical, biological and clinical aspects of such gene delivery vectors. Reflecting the diversity of research in this field, this book comprehensively covers: * the principles of self-assembly * natural mechanisms for gene delivery to cells * cationic lipids and liposomes * polyelectrolyte DNA complexes * systemic biodistribution of drug delivery systems * targeting of conjugates for gene delivery * new approaches to gene delivery * clinical evaluation Self-assembling Complexes for Gene Delivery is an essential reference for all professionals with an interest in gene and antisense therapy or novel drug delivery systems, including medicinal and pharmaceutical chemists, clinicians, human geneticists, molecular biologists and pharmacologists.
Artificial Self Assembling Systems For Gene Delivery
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Author : Philip L. Felgner
language : en
Publisher:
Release Date : 1996
Artificial Self Assembling Systems For Gene Delivery written by Philip L. Felgner and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Language Arts & Disciplines categories.
Discusses recent advances in artificial self-assembling systems, including retrotransposon vectors, hairpin ribozymes, triple-helix-forming oligonucleotides, liposome-mediated transfection, and photonic nanostructures. Addresses developing efficient synthetic vectors such as modular self-assembling systems mimicking important features of viral vectors. Presents new developments in synthetic self-assembling gene delivery systems, including innovations in nonviral systems, targeting nucleic acids, ligand-polylysine mediated transfer, dendrimer-mediated transfection, cationic liposomes, and polylysine DNA complexes.
Synthetic Dna Delivery Systems
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Author : Dan Luo
language : en
Publisher: Springer Science & Business Media
Release Date : 2003-09-30
Synthetic Dna Delivery Systems written by Dan Luo and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-09-30 with Science categories.
DNA delivery into cells is a rapidly developing area in gene therapy and biotechnology. Moreover, it is a powerful research tool to determine gene structure, regulation, and function. Viral methods of DNA delivery are well-characterized and efficient, but little is known about the toxicity and immunogenecity of viral vectors. As a result, non-viral, transfection methods of DNA delivery are of increasing interest. Synthetic DNA Delivery Systems is a comprehensive and current resource on DNA transfection. The use of histidine-rich peptides and polypeptides as DNA delivery systems and self-assembled delivery systems based on cationic lipids and polymers are discussed. Targeted delivery to organelles, tumor cells and dendritic cells comprise an important topic.
Systems Self Assembly
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Author :
language : en
Publisher: Elsevier
Release Date : 2011-09-22
Systems Self Assembly written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-22 with Science categories.
Systems Self-Assembly is the only book to showcase state-of-the-art self-assembly systems that arise from the computational, biological, chemical, physical and engineering disciplines. Written by world experts in each area, it provides a coherent, integrated view of both book practice examples and new trends with a clearly presented computational flavor. The unifying thread throughout the text is the computational nature of self-assembling systems. This book consists of 13 chapters dealing with a variety of topics such as the patterns of self-organised nanoparticle assemblies; biomimetic design of dynamic self-assembling systems; computing by self-assembly involving DNA molecules, polyominoes, and cells; evolutionary design of a model of self-assembling chemical structures; self-assembly as an engineering concept across size scales; and probabilistic analysis of self-assembled molecular networks. Other chapters focus on the programming language of dynamic self-assembly; self-assembled computer architectures; simulation of self-assembly processes using abstract reduction systems; computer aided search for optimal self-assembly systems; theoretical aspects of programmable self-assembly; emergent cooperativity in large-scale patterns; and automated self-assembling programming. Systems Self-Assembly is an ideal reference for scientists, researchers and post-graduate students; practitioners in industry, engineering and science; and managers, decision-makers and policy makers. *The only book to showcases state-of-the-art self-assembly systems that arise from the computational, biological, chemical, physical and engineering disciplines *Coherent, integrated view of both book practice examples and new trends with a clearly presented computational flavor *Written by world experts in each area
Designer Biopolymers
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Author : Ayae Sugawara-Narutaki
language : en
Publisher: MDPI
Release Date : 2020-12-14
Designer Biopolymers written by Ayae Sugawara-Narutaki and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-14 with Science categories.
Nature has evolved sequence-controlled polymers, such as DNA and proteins, over its long history. The recent progress of synthetic chemistry, DNA recombinant technology, and computational science, as well as the elucidation of molecular mechanisms in biological processes, drive us to design ingenious polymers that are inspired by naturally occurring polymers, but surpass them in specialized functions. The term “designer biopolymers” refers to polymers which consist of biological building units, such as nucleotides, amino acids, and monosaccharides, in a sequence-controlled manner. This book particularly focuses on the self-assembling aspect of designer biopolymers. Self-assembly is one common feature in biopolymers that is used to realize their dynamic biological activities and is strictly controlled by the sequence of biopolymers. In a broad sense, the self-assembly of biopolymers includes a double-helix formation of DNA, protein folding, and higher-order protein assembly (e.g., viral capsids). Designer biopolymers are now going beyond what nature evolved: researchers have generated DNA origami, protein cages, peptide nanofibers, and gels. This book illustrates the latest interdisciplinary work on self-assembling designer biopolymers. As shown by this book, the self-assembly of biopolymers has a great impact on a variety of research fields, including molecular biology, neurodegenerative diseases, drug delivery, gene therapy, regenerative medicine, and biomineralization. Designer biopolymers will help researchers to better understand biological processes, as well as to create innovative molecular systems. We believe that this book will provide readers with new ideas for their molecular design strategies for frontier research.
Self Assembly Of Cationic Lipoplexes From Liposomes And Plasmids Of Variable Size
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Author : Elisabete Gonçalves
language : en
Publisher:
Release Date : 2003
Self Assembly Of Cationic Lipoplexes From Liposomes And Plasmids Of Variable Size written by Elisabete Gonçalves and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with DNA. categories.
Gene Transfer In The Cardiovascular System
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Author : Keith L. March
language : en
Publisher: Springer
Release Date :
Gene Transfer In The Cardiovascular System written by Keith L. March and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on with Medical categories.
The goal of gene transfer is protein expression. a process brought about by the insertion of a gene coding for a foreign protein into target cells resulting in the synthesis of the foreign protein For gene therapy, a tmnsferred therapeutic gene must be expressed at a level beneficial for the patient. This chapter provides an introductory overview of the rapidly evolving field of non-viral approaches for gene delivery to rnarnrnalian cells. Although currently there are fewer ongoing clinical trials using non-viral approaches than those using viral based systems, the number of non-viral trials is increasing. The long range goal of some research groups is the development of a genetically engineered artificial virus targeted to specific cells in the human body. An arurual conference, organized by Cambridge Healthtech Institute entitled "Artificial Self-Assembling Systems for Gene Transfer", brings together researchers interested in this field [1]. Assembly of an artificial virus is very complex; other research groups aim to develop simpler delivery systems consisting of a plasmid combined with delivery agents. Viral-based systems are very successful for gene delivery, but despite their successes, viral-based systems have some geneml limitations and system-specific limitations. When employing a viml-based system, the following limitations should be considered: • size limitation of the inserted gene due to packaging constraints (e. g. adenovirus, retrovirus) . • potential tumorigenesis (e. g. retrovirus) • potential for insertional mutagenesis (greater than plasmid based systems) • potential imrnunogenicity (e. g.
Nonviral Vectors For Gene Therapy
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Author : Mark A. Findeis
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-02
Nonviral Vectors For Gene Therapy written by Mark A. Findeis and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-02 with Science categories.
The purpose of this volume of Methods in Molecular Medicine is to set forth examples of the great variety of techniques and applications that are now emerging in the field of nonviral gene therapy. The book emphasizes not only specific approaches to gene delivery but, in particular, the best current me- ods to prepare, handle, and characterize gene delivery agents. These topics are of very broad importance since gene therapy evolves from its mostly ac- emy-based experimental and clinical research to the ever increasing number of industry-driven programs directed toward commercial development. S- cessful introduction of nonviral gene therapy agents into the clinic should be expected to require rigorous manufacturing and analytical methods that readily meet the regulatory guidelines under which new drug candidates are reviewed for marketing approval. Exactly what those guidelines will prove to be c- tainly depends on the established guidelines for review of both biological and chemical therapeutics. Additionally, many new techniques are being devised and applied to gene therapy research; these techniques will be instrumental in developing and characterizing successful gene delivery agents. Nonviral Vectors for Gene Therapy: Methods and Protocols has two main sections. To start with, there is a series of chapters on specific protocols for the synthesis, characterization, and application of gene delivery agents. S- eral chapters address the topic of materials to bind with DNA to form the compact condensed phases that facilitate cellular delivery.
Macromolecular Self Assembly
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Author : Laurent Billon
language : en
Publisher: John Wiley & Sons
Release Date : 2016-09-06
Macromolecular Self Assembly written by Laurent Billon and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-06 with Technology & Engineering categories.
This book describes techniques of synthesis and self-assembly of macromolecules for developing new materials and improving functionality of existing ones. Because self-assembly emulates how nature creates complex systems, they likely have the best chance at succeeding in real-world biomedical applications. • Employs synthetic chemistry, physical chemistry, and materials science principles and techniques • Emphasizes self-assembly in solutions (particularly, aqueous solutions) and at solid-liquid interfaces • Describes polymer assembly driven by multitude interactions, including solvophobic, electrostatic, and obligatory co-assembly • Illustrates assembly of bio-hybrid macromolecules and applications in biomedical engineering
Gene Delivery To Mammalian Cells
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Author : William C. Heiser
language : en
Publisher: Humana Press
Release Date : 2003-10-28
Gene Delivery To Mammalian Cells written by William C. Heiser and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-10-28 with Science categories.
Highly experienced researchers describe in step-by-step detail methods that have proven most useful in delivering genes to mammalian cells. Volume 1: Nonviral Gene Transfer Techniques focuses on gene delivery by a variety of chemical and physical methods, including ultrasound, biolistics, peptides, PNA clamps, liposomes, microinjection, electroporation, particle bombardment, dendrimers, and hydrodynamics. An accompanying volume, Volume 2: Viral Gene Transfer Techniques, details procedures for delivering genes to cells in vitro and in vivo, including the use of lentiviral vectors.