Automated Three Dimensional Segmentation Of Intraretinal Layers From Optical Coherence Tomography Images Centered On The Optic Nerve Head
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Automated Three Dimensional Segmentation Of Intraretinal Layers From Optical Coherence Tomography Images Centered On The Optic Nerve Head
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Author : Bhavna Josephine Antony
language : en
Publisher:
Release Date : 2009
Automated Three Dimensional Segmentation Of Intraretinal Layers From Optical Coherence Tomography Images Centered On The Optic Nerve Head written by Bhavna Josephine Antony and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.
Automated 3 D Segmentation Of Intraretinal Surfaces From Optical Coherence Tomography Images Centered On The Optic Nerve Head
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Author : Bhavna Josephine Antony
language : en
Publisher:
Release Date : 2009
Automated 3 D Segmentation Of Intraretinal Surfaces From Optical Coherence Tomography Images Centered On The Optic Nerve Head written by Bhavna Josephine Antony and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Glaucoma categories.
Optical coherence tomography (OCT), being a noninvasive imaging modality, has begun to find vast use in the diagnosis and management of retinal diseases. These high-resolution images of the retina allow structural changes to be detected and tracked. For instance, in glaucoma, the retinal nerve fiber layer (RNFL) has been known to thin. The recent availability of the considerably larger volumetric data from the spectral-domain OCT scanners has further increased the need for new processing techniques. This body of work is centered around an automated 3-D graph-theoretic approach for the segmentation of 7 surfaces (6 layers) of the retina from 3-D spectral-domain OCT images centered on the optic nerve head (ONH). The multiple surfaces are detected through the computation of a minimum-cost closed set in a vertex-weighted graph constructed using edge/regional information, and subject to a priori determined varying surface interaction and smoothness constraints. The method also addresses the challenges posed by presence of the neural canal and the large blood vessels found at the ONH. The method was used to study RNFL thickness maps of normal and glaucomatous eyes, which showed average thicknesses of 73.72 +/- 32.72um and 60.38 +/- 25.22um (p
Retina E Book
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Author : Charles P. Wilkinson
language : en
Publisher: Elsevier Health Sciences
Release Date : 2012-11-01
Retina E Book written by Charles P. Wilkinson and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-01 with Medical categories.
Unequalled in scope, depth, and clinical precision, Retina, 5th Edition keeps you at the forefront of today’s new technologies, surgical approaches, and diagnostic and therapeutic options for retinal diseases and disorders. Comprehensively updated to reflect everything you need to know regarding retinal diagnosis, treatment, development, structure, function, and pathophysiology, this monumental ophthalmology reference work equips you with expert answers to virtually any question you may face in practice. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Examine and evaluate the newest diagnostic technologies and approaches that are changing the management of retinal disease, including future technologies which will soon become the standard. Put the very latest scientific and genetic discoveries, diagnostic imaging methods, drug therapies, treatment recommendations, and surgical techniques to work in your practice. Benefit from the extensive knowledge and experience of esteemed editor Dr. Stephen Ryan, five expert co-editors, and a truly global perspective from 358 other world authorities across Europe, Asia, Australasia, and the Americas. Make the best use of new technologies with expanded and updated coverage of optical coherence tomography (OCT), fundus imaging, and autofluorescence imaging. Apply the latest knowledge on anti-VEGF therapy for age related macular degeneration, diabetic retinopathy and vein disease. Learn about artificial vision, drug delivery to the posterior segment, advances in macular surgery, vitrectomy, and complex retinal detachment, with updates on tumors, retinal genetics, cell biology, important basic science topics, and much more. Get the most out of new pharmacologic approaches in the management of age-related macular degeneration and diabetic retinopathy. In your practice, diagnostic evaluations, and now even treatments, will be influenced by recent scientific discoveries such as in the areas of nanotechnology, neuro protection, stem cells and gene therapy, among other scientific contributions. View videos of surgical procedures and access the complete contents of Retina, 5th Edition online at www.expertconsult.com, fully searchable, with regular updates and a downloadable image gallery.
Retina
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Author : David R. Hinton
language : en
Publisher: Elsevier Health Sciences
Release Date : 2013
Retina written by David R. Hinton and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Medical categories.
Unequalled in scope, depth, and clinical precision, Retina, 5th Edition keeps you at the forefront of today's new technologies, surgical approaches, and diagnostic and therapeutic options for retinal diseases and disorders. Comprehensively updated to reflect everything you need to know regarding retinal diagnosis, treatment, development, structure, function, and pathophysiology, this monumental ophthalmology reference work equips you with expert answers to virtually any question you may face in practice. Benefit from the extensive knowledge and experience of esteemed editor Dr. Stephen Ryan, five expert co-editors, and a truly global perspective from 358 other world authorities across Europe, Asia, Australasia the Americas.Examine and evaluate the newest diagnostic technologies and approaches that are changing the management of retinal disease, including future technologies which will soon become the standard.Put the very latest scientific and genetic discoveries, diagnostic imaging methods, drug therapies, treatment recommendations, and surgical techniques to work in your practice.
Ryan S Retina E Book
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Author : Charles P. Wilkinson
language : en
Publisher: Elsevier Health Sciences
Release Date : 2017-04-17
Ryan S Retina E Book written by Charles P. Wilkinson and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-17 with Medical categories.
The undisputed gold standard text in the field, Ryan's Retina is your award-winning choice for the most current, authoritative information on new technologies, surgical approaches, scientific advances and diagnostic and therapeutic options for retinal diseases and disorders. Packed with timely updates throughout, new illustrations, and a dedicated team of editors who extend Dr. Ryan’s legacy in retina, this outstanding 6th Edition is a must-have reference for retinal specialists, ophthalmologists, and fellows in training. Offers the most comprehensive content available on retina, balancing the latest scientific research and clinical correlations, covering everything you need to know on retinal diagnosis, treatment, development, structure, function, and pathophysiology. Provides a truly global perspective from five highly esteemed section editors and more than 350 other world authorities from across Europe, Asia, Australasia, and the Americas. Bullets Includes new chapters on widefield imaging, intraoperative OCT imaging, medical management of diabetes mellitus and age-related macular degeneration, and senile retinoschisis. Includes more than 1,150 brand-new illustrations, scans, and photographs throughout. Covers the explosion of new imaging options across optical coherence tomography (OCT), fundus imaging, and autofluorescence imaging, including a greatly expanded OCT imaging chapter that features crucial information on OCT-Angiography (OCT-A). Presents new pharmacotherapy data and the latest approaches in anti-VEGF therapy for age-related macular degeneration, diabetic retinopathy, and venous occlusive disease. Features an expanded online video library highlighting the latest surgical techniques and new coverage of complications of vitreoretinal surgery. Contains thorough content updates in every area of retina, including advanced imaging technologies, gene therapy, inflammation and immune responses, white dot syndromes, epigenetic mechanisms, transplantation frontiers to improve retinal function, macular hole, myopic eye disease, ocular trauma, drug delivery to the posterior segment, advances in macular surgery, vitrectomy and complex retinal detachment, tumors, and retinal genetics and biology. Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.
Assessing Ocular Toxicology In Laboratory Animals
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Author : Andrea B Weir
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-04
Assessing Ocular Toxicology In Laboratory Animals written by Andrea B Weir and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-04 with Medical categories.
Ocular toxicity is routinely assessed in toxicology studies conducted for regulatory purposes. Ocular anatomy and physiology and the assessment of ocular toxicity itself can be challenging to scientists involved in the safety assessment of pharmaceuticals, pesticides and other agents. Anatomical and physiological differences between species can impact the nature of ocular effects observed following intended or unintended exposure of ocular tissues to xenobiotics. Ocular Toxicity in Laboratory Animals provides a concise reference addressing ocular anatomy and physiology across species that will enhance the design and interpretation of toxicology studies conducted for regulatory purposes. The book provides an overview of routine and advanced techniques that are used to assess ocular toxicity including slit lamp biomicroscopy, indirect ophthalmoscopy, electrophysiology and imaging methods for the anterior and posterior segments of the eye. Additionally, the book defines the regulatory expectations for pharmaceuticals intended to treat ocular diseases and for other non-pharmaceutical regulated chemicals. With contributions from experts in the field, Ocular Toxicity in Laboratory Animals is an authoritative, accessible guide for toxicologists and other scientists involved in conducting toxicology studies for regulatory purposes and/or reviewing data from such studies.
Clinical Oct Angiography Atlas
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Author : Marco Rispoli
language : en
Publisher: Jaypee Brothers Medical Publishers
Release Date : 2021-11-30
Clinical Oct Angiography Atlas written by Marco Rispoli and has been published by Jaypee Brothers Medical Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-30 with Medical categories.
Optical coherence tomography angiography (OCTA) is a non-invasive technique for imaging the microvasculature of the retina and the choroid. The advent of OCTA has allowed ophthalmologists to identify new pathologies, recognise new syndromes, and organise disorders with new classifications. This atlas provides clinicians with state-of-the-art principles of clinical OCTA imaging, helping them interpret and understand the features of the angiographic images. Following the success of the first edition (9789351528999) published in 2015, this second edition has been fully revised, with all chapters rewritten and new topics added to provide the very latest advances in the field. New knowledge about existing diseases and new disorders are described in depth, and operating principles, clinical applications, and future developments are explained thoroughly by the pioneers of the technology. The first part of the atlas covers the basic principles of OCT angiography, methods and technology, image interpretation, vascular anatomy of the retina, and clinical applications. Part two provides a general update on current research into OCT angiography in various retinal, choroid and anterior chamber disorders. The third and final part of the book describes future clinical applications and implications of next generation devices. This new edition is an invaluable guide for ophthalmologists and trainees for use in everyday practice.
High Resolution Imaging In Microscopy And Ophthalmology
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Author : Josef F. Bille
language : en
Publisher: Springer
Release Date : 2019-08-13
High Resolution Imaging In Microscopy And Ophthalmology written by Josef F. Bille and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-13 with Medical categories.
This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.
Automated Retinal Layer Segmentation And Pre Apoptotic Monitoring For Three Dimensional Optical Coherence Tomography
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Author : Vedran Kajic
language : en
Publisher:
Release Date : 2011
Automated Retinal Layer Segmentation And Pre Apoptotic Monitoring For Three Dimensional Optical Coherence Tomography written by Vedran Kajic and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
The aim of this PhD thesis was to develop segmentation algorithm adapted and optimized to retinal OCT data that will provide objective 3D layer thickness which might be used to improve diagnosis and monitoring of retinal pathologies. Additionally, a 3D stack registration method was produced by modifying an existing algorithm. A related project was to develop a pre-apoptotic retinal monitoring based on the changes in texture parameters of the OCT scans in order to enable treatment before the changes become irreversible; apoptosis refers to the programmed cell death that can occur in retinal tissue and lead to blindness. These issues can be critical for the examination of tissues within the central nervous system. A novel statistical model for segmentation has been created and successfully applied to a large data set. A broad range of future research possibilities into advanced pathologies has been created by the results obtained. A separate model has been created for choroid segmentation located deep in retina, as the appearance of choroid is very different from the top retinal layers. Choroid thickness and structure is an important index of various pathologies (diabetes etc.). As part of the pre-apoptotic monitoring project it was shown that an increase in proportion of apoptotic cells in vitro can be accurately quantified. Moreover, the data obtained indicates a similar increase in neuronal scatter in retinal explants following axotomy (removal of retinas from the eye), suggesting that UHR-OCT can be a novel non-invasive technique for the in vivo assessment of neuronal health. Additionally, an independent project within the computer science department in collaboration with the school of psychology has been successfully carried out, improving analysis of facial dynamics and behaviour transfer between individuals. Also, important improvements to a general signal processing algorithm, dynamic time warping (DTW), have been made, allowing potential application in a broad signal processing field.
Automated Segmentation Of Retinal Optical Coherence Tomography Images
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Author : Priyanka Roy
language : en
Publisher:
Release Date : 2018
Automated Segmentation Of Retinal Optical Coherence Tomography Images written by Priyanka Roy and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Optical coherence tomography categories.
Aim. Optical Coherence Tomography (OCT) is a fast and non-invasive medical imaging technique which helps in the investigation of each individual retinal layer structure. For early detection of retinal diseases and the study of their progression, segmentation of the OCT images into the distinct layers of the retina plays a crucial role. However, segmentation done by the clinicians manually is extremely tedious, time-consuming and variable with respect to the expertise level. Hence, there is an utmost necessity to develop an automated segmentation algorithm for retinal OCT images which is fast, accurate, and eases clinical decision making. Methods. Graph-theoretical methods have been implemented to develop an automated segmentation algorithm for spectral domain OCT (SD-OCT) images of the retina. As a pre-processing step, the best method for denoising the SD-OCT images prior to graph-based segmentation was determined by comparison between simple Gaussian filtering and an advanced wavelet-based denoising technique. A shortest-path based graph search technique was implemented to accurately delineate intra-retinal layer boundaries within the SD-OCT images. The results from the automated algorithm were also validated by comparison with manual segmentation done by an expert clinician using a specially designed graphical user interface (GUI). Results. The algorithm delineated seven intra-retinal boundaries thereby segmenting six layers of the retina along with computing their thicknesses. The thickness results from the automated algorithm when compared to normative layer thickness values from a published study showed no significant differences (p > 0.05) for all layers except layer 4 (p = 0.04). Furthermore, when a comparative analysis was done between the results from the automated segmentation algorithm and that from manual segmentation by an expert, the accuracy of the algorithm varied between 74.58% (layer 2) to 98.90% (layer 5). Additionally, the comparison of two different denoising techniques revealed that there was no significant impact of an advanced wavelet-based denoising technique over the use of simple Gaussian filtering on the accuracy of boundary detection by the graph-based algorithm. Conclusion. An automated graph-based algorithm was developed and implemented in this thesis for the segmentation of seven intra-retinal boundaries and six layers in SD-OCT images which is as good as manual segmentation by an expert clinician. This thesis also concludes on the note that simple Gaussian filters are sufficient to denoise the images in graph-based segmentation techniques and does not require an advanced denoising technique. This makes the complexity of implementation far more simple and efficient in terms of time and memory requirements.