Assessing Ocular Toxicology In Laboratory Animals
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Assessing Ocular Toxicology In Laboratory Animals
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Author : Andrea B Weir
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-04
Assessing Ocular Toxicology In Laboratory Animals written by Andrea B Weir and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-04 with Medical categories.
Ocular toxicity is routinely assessed in toxicology studies conducted for regulatory purposes. Ocular anatomy and physiology and the assessment of ocular toxicity itself can be challenging to scientists involved in the safety assessment of pharmaceuticals, pesticides and other agents. Anatomical and physiological differences between species can impact the nature of ocular effects observed following intended or unintended exposure of ocular tissues to xenobiotics. Ocular Toxicity in Laboratory Animals provides a concise reference addressing ocular anatomy and physiology across species that will enhance the design and interpretation of toxicology studies conducted for regulatory purposes. The book provides an overview of routine and advanced techniques that are used to assess ocular toxicity including slit lamp biomicroscopy, indirect ophthalmoscopy, electrophysiology and imaging methods for the anterior and posterior segments of the eye. Additionally, the book defines the regulatory expectations for pharmaceuticals intended to treat ocular diseases and for other non-pharmaceutical regulated chemicals. With contributions from experts in the field, Ocular Toxicity in Laboratory Animals is an authoritative, accessible guide for toxicologists and other scientists involved in conducting toxicology studies for regulatory purposes and/or reviewing data from such studies.
Standards For Ocular Toxicology And Inflammation
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Author : Brian C. Gilger
language : en
Publisher: Springer
Release Date : 2018-08-31
Standards For Ocular Toxicology And Inflammation written by Brian C. Gilger and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-31 with Medical categories.
This book is an international effort to standardize the language, terms, and methods used in ocular toxicology.With over 300 color illustrations this consensus volume provides standards and harmonization for procedures, terminology, and scoring schemes for ocular toxicology. it is essential for industry, pharmaceutical companies, and governmental agencies to help improve the drug development process and to reduce and refine the use of animals in research. Standards for Ocular Toxicology and Inflammation is endorsed by the American College of Veterinary Ophthalmologists.
Reducing Refining And Replacing The Use Of Animals In Toxicity Testing
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Author : David G. Allen
language : en
Publisher: Royal Society of Chemistry
Release Date : 2013
Reducing Refining And Replacing The Use Of Animals In Toxicity Testing written by David G. Allen and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Medical categories.
This thought-provoking book describes the ever-expanding "toolbox" of methods now available to reduce, refine, or replace animal usage in toxicity testing.
Principles And Procedures For Evaluating The Toxicity Of Household Substances
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Author : National Research Council (U.S.). Committee for the Revision of NAS publication 1138, Principles and Procedures for Evaluating the Toxicity of Household Substances
language : en
Publisher:
Release Date : 1977
Principles And Procedures For Evaluating The Toxicity Of Household Substances written by National Research Council (U.S.). Committee for the Revision of NAS publication 1138, Principles and Procedures for Evaluating the Toxicity of Household Substances and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with Medical categories.
The Draize Eye Irritancy Test
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Author : Janice C. Swanson
language : en
Publisher:
Release Date : 1988
The Draize Eye Irritancy Test written by Janice C. Swanson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Eye categories.
Oecd Guidelines For The Testing Of Chemicals Oecd Series On Testing And Assessment Guidance Document On The Recognition Assessment And Use Of Clinical Signs As Human Endpoints For Experimental Animals Used In Safety Evaluation
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2002-05-10
Oecd Guidelines For The Testing Of Chemicals Oecd Series On Testing And Assessment Guidance Document On The Recognition Assessment And Use Of Clinical Signs As Human Endpoints For Experimental Animals Used In Safety Evaluation written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-05-10 with categories.
The purpose of this Guidance Document is to apply the principles of the Three Rs to the use of animals in regulatory toxicity tests.
Ophthalmic Toxicology
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Author : G. C. Y. Chiou
language : en
Publisher: CRC Press
Release Date : 1999-07-01
Ophthalmic Toxicology written by G. C. Y. Chiou and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-07-01 with Medical categories.
Thoroughly revised and updates, this new edition of Ophthalmic Toxicology retains its uniqueness in covering all aspects of ophthalmic toxicology. With chapters from leading authorities incorporating the latest developments in the field, including a new chapter on the molecular basis of ophthalmic toxicity, this edition covers such topics as: *t
The Clinical Chemistry Of Laboratory Animals
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Author : David M. Kurtz
language : en
Publisher: CRC Press
Release Date : 2017-10-18
The Clinical Chemistry Of Laboratory Animals written by David M. Kurtz and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-18 with Medical categories.
Key features: Serves as the detailed, authoritative source of the clinical chemistry of the most commonly used laboratory animals Includes detailed chapters dedicated to descriptions of clinical chemistry-related topics specific to each laboratory species as well as organ/class-specific chapters Presents information regarding evaluation and interpretation of a variety of individual clinical chemistry end points Concludes with detailed chapters dedicated to descriptions of statistical analyses and biomarker development of clinical chemistry-related topics Provides extensive reference lists at the end of each chapter to facilitate further study Extensively updated and expanded since the publication of Walter F. Loeb and Fred W. Quimby’s second edition in 1999, the new The Clinical Chemistry of Laboratory Animals, Third Edition continues as the most comprehensive reference on in vivo animal studies. By organizing the book into species- and organ/class-specific chapters, this book provides information to enable a conceptual understanding of clinical chemistry across laboratory species as well as information on evaluation and interpretation of clinical chemistry data relevant to specific organ systems. Now sponsored by the American College of Laboratory Animal Medicine (ACLAM), this well-respected resource includes chapters on multiple laboratory species and provides pertinent information on their unique physiological characteristics, methods for sample collection, and preanalytical sources of variation for the particular species. Basic methodology for common procedures for each species is also discussed. New Chapters in the Third Edition Include: The Laboratory Zebrafish and Other Fishes Evaluation of Cardiovascular and Pulmonary Function and Injury Evaluation of Skeletal Muscle Function and Injury Evaluation of Bone Function and Injury Vitamins Development of Biomarkers Statistical Methods The Clinical Chemistry of Laboratory Animals, Third Edition is intended as a reference for use by veterinary students, clinical veterinarians, verterinary toxicologists, veterinary clinical pathologists, and laboratory animal veterinarians to aid in study design, collection of samples, and interpretation of clinical chemistry data for laboratory species.
Histologic Basis Of Ocular Disease In Animals
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Author : Bruce Grahn
language : en
Publisher: John Wiley & Sons
Release Date : 2018-11-20
Histologic Basis Of Ocular Disease In Animals written by Bruce Grahn and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-20 with Medical categories.
Histologic Basis of Ocular Disease in Animals is a comprehensive reference covering pathology of the eye in a spectrum of animal species, including domestic animals, fish, birds, and laboratory animals. Offers a comprehensive resource on diseases and conditions of the eye and orbit in a wide range of species Covers domestic animals, fish, birds, and laboratory animals Presents more than 1200 high-quality images carefully selected to illustrate the ocular conditions covered Emphasizes unique pathological responses where necessary
Dermal And Ocular Toxicology
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Author : David W. Hobson
language : en
Publisher: CRC Press
Release Date : 2020-11-26
Dermal And Ocular Toxicology written by David W. Hobson and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-26 with Medical categories.
Dermal and Ocular Toxicology: Fundamentals and Methods is a procedurally-oriented volume of detailed methods and practical examples discussing the dermal and ocular aspects of toxicology. The book is divided into a dermal section and an ocular section. Each section begins with a chapter on the anatomy and physiology of each organ system and then progresses to more specialized chapters discussing such topics as the toxicological pathology of each system, state-of-the-art in vitro and in vivo evaluatory procedures, statistical considerations for test design and data interpretation, and the utilization of test findings. Test methods are provided for acute dermal exposure effects, dermal hypersensitivity and photoallergy assessment, dermal and ocular 0.pharmacokinetics, skin flap and skin grafting techniques, and in vitro alternative methods. This book can be used as an instructional text or as a sourcebook for practicing toxicologists, pharmacologists, industrial hygienists, occupational health professionals, and graduate students.
